Mack Ruffin, MD, MPH

    • 5904 Citations
    • 40 h-Index
    1988 …2019
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    Research Output 1988 2019

    2019
    1 Citation (Scopus)

    Fecal short-chain fatty acids are not predictive of colonic tumor status and cannot be predicted based on bacterial community structure

    Sze, M. A., Topçuoğlu, B. D., Lesniak, N. A., Ruffin, M. T. & Schloss, P. D., Jul 1 2019, In : mBio. 10, 4, e01454-19.

    Research output: Contribution to journalArticle

    Open Access
    Bacterial Structures
    Volatile Fatty Acids
    Neoplasms
    Metagenomics
    Colorectal Neoplasms
    1 Citation (Scopus)

    Increases in colonic bacterial diversity after ω-3 fatty acid supplementation predict decreased colonic prostaglandin E2 concentrations in healthy adults

    Djuric, Z., Bassis, C. M., Plegue, M. A., Sen, A., Turgeon, D. K., Herman, K., Young, V. B., Brenner, D. E. & Ruffin, M. T., Jan 1 2019, In : Journal of Nutrition. 149, 7, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

    Dinoprostone
    Fatty Acids
    Biopsy
    Dietary Supplements
    Bacteria

    Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

    Knobloch, T. J., Peng, J., Hade, E. M., Cohn, D. E., Ruffin, M. T., Schiano, M. A., Calhoun, B. C., McBee, W. C., Lesnock, J. L., Gallion, H. H., Pollock, J., Lu, B., Oghumu, S., Zhang, Z., Sears, M. T., Ogbemudia, B. E., Perrault, J. T., Weghorst, L. C., Strawser, E., DeGraffinreid, C. R. & 2 others, Paskett, E. D. & Weghorst, C. M., Oct 1 2019, In : Cancer Causes and Control. 30, 10, p. 1087-1100 14 p.

    Research output: Contribution to journalArticle

    Uterine Cervical Neoplasms
    Transforming Growth Factor beta
    Coitus
    Alleles
    Logistic Models

    Interactivity in a Decision Aid: Findings From a Decision Aid to Technologically Enhance Shared Decision Making RCT

    Jimbo, M., Sen, A., Plegue, M. A., Hawley, S., Kelly-Blake, K., Rapai, M., Zhang, M., Zhang, Y., Xie, X. & Ruffin, M., Jul 1 2019, In : American Journal of Preventive Medicine. 57, 1, p. 77-86 10 p.

    Research output: Contribution to journalArticle

    Decision Support Techniques
    Early Detection of Cancer
    Colorectal Neoplasms
    Decision Making
    Office Visits

    Results of a Pilot Study of a Mail-Based Human Papillomavirus Self-Testing Program for Underscreened Women from Appalachian Ohio

    Reiter, P. L., Shoben, A. B., McDonough, D., Ruffin, M., Steinau, M., Unger, E. R., Paskett, E. D. & Katz, M. L., Mar 1 2019, In : Sexually transmitted diseases. 46, 3, p. 185-190 6 p.

    Research output: Contribution to journalArticle

    Postal Service
    Papanicolaou Test
    Uterine Cervical Neoplasms
    Pamphlets
    Control Groups

    Using pharmacogenomic testing in primary care: Protocol for a pilot randomized controlled study

    Mitrzyk, B. M., Kadri, R., Farris, K. B., Ellingrod, V. L., Klinkman, M. S., Ruffin, M. T., Plegue, M. A. & Buis, L. R., Jan 1 2019, In : Journal of medical Internet research. 21, 8, e13848.

    Research output: Contribution to journalArticle

    Open Access
    Primary Health Care
    Antidepressive Agents
    Physicians
    Demography
    Depression

    Vaccine refusals and regulations

    Ruffin, M. T. & Hausman, B. L., Sep 2019, In : Family medicine. 51, 9, 1 p.

    Research output: Contribution to journalLetter

    Open Access
    Family Physicians
    Surveys and Questionnaires
    Vaccination Refusal
    2018
    1 Citation (Scopus)

    A web-based decision tool to improve contraceptive counseling for women with chronic medical conditions: Protocol for a mixed methods implementation study

    Wu, J. P., Damschroder, L. J., Fetters, M. D., Zikmund-Fisher, B. J., Crabtree, B. F., Hudson, S. V., Ruffin, M. T., Fucinari, J., Kang, M., Susan Taichman, L. & Creswell, J. W., Apr 2018, In : Journal of medical Internet research. 20, 4, e107.

    Research output: Contribution to journalArticle

    Contraceptive Agents
    Counseling
    Primary Health Care
    Guidelines
    Decision Making
    3 Citations (Scopus)

    Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations

    Djuric, Z., Bassis, C. M., Plegue, M. A., Ren, J., Chan, R., Sidahmed, E. K., Turgeon, D. K., Ruffin, M., Kato, I. & Sen, A., Apr 1 2018, In : Journal of the Academy of Nutrition and Dietetics. 118, 4, p. 606-616.e3

    Research output: Contribution to journalArticle

    Carotenoids
    carotenoids
    Bacteria
    bacteria
    Serum
    18 Citations (Scopus)

    Diagnostic potential and interactive dynamics of the colorectal cancer virome

    Hannigan, G. D., Duhaime, M. B., Ruffin, M. T., Koumpouras, C. C. & Schloss, P. D., Nov 1 2018, In : mBio. 9, 6, e02248-18.

    Research output: Contribution to journalArticle

    Colorectal Neoplasms
    Viruses
    Neoplasms
    Metagenomics
    Bacteriophages
    3 Citations (Scopus)

    Effects of an Education Intervention about HPV Self-Testing for Healthcare Providers and Staff

    Presser, B. E., Katz, M. L., Shoben, A. B., Moore, D., Ruffin, M., Paskett, E. D. & Reiter, P. L., Oct 1 2018, In : Journal of Cancer Education. 33, 5, p. 954-959 6 p.

    Research output: Contribution to journalArticle

    Health Personnel
    Education
    Early Detection of Cancer
    Uterine Cervical Neoplasms
    Surveys and Questionnaires
    Cyclooxygenase 2
    Dietary Supplements
    Dinoprostone
    Fatty Acids
    Genes
    8 Citations (Scopus)

    Spatial variation of the native colon microbiota in healthy adults

    Flynn, K. J., Ruffin, M., Kim Turgeon, D. & Schloss, P. D., Jul 1 2018, In : Cancer Prevention Research. 11, 7, p. 393-401 9 p.

    Research output: Contribution to journalArticle

    Microbiota
    Colon
    Mucous Membrane
    Area Under Curve
    Porphyromonas
    2017
    3 Citations (Scopus)

    Correlates of Patient Intent and Preference on Colorectal Cancer Screening

    Jimbo, M., Sen, A., Plegue, M. A., Hawley, S. T., Kelly-Blake, K., Rapai, M., Zhang, M., Zhang, Y. & Ruffin, M., Apr 1 2017, In : American Journal of Preventive Medicine. 52, 4, p. 443-450 8 p.

    Research output: Contribution to journalArticle

    Patient Preference
    Self Efficacy
    Early Detection of Cancer
    Colorectal Neoplasms
    Decision Support Techniques
    30 Citations (Scopus)

    Direct-to-consumer genetic testing: User motivations, decision making, and perceived utility of results

    Roberts, J. S., Gornick, M. C., Carere, D. A., Uhlmann, W. R., Ruffin, M. & Green, R. C., Jun 1 2017, In : Public health genomics. 20, 1, p. 36-45 10 p.

    Research output: Contribution to journalArticle

    Genetic Testing
    Motivation
    Decision Making
    Health
    Heart Diseases
    10 Citations (Scopus)

    Normalization of the microbiota in patients after treatment for colonic lesions

    Sze, M. A., Baxter, N. T., Ruffin, M., Rogers, M. A. M. & Schloss, P. D., Nov 16 2017, In : Microbiome. 5, 1, 1 p.

    Research output: Contribution to journalArticle

    Microbiota
    Adenoma
    Carcinoma
    Therapeutics
    rRNA Genes
    11 Citations (Scopus)

    Personal genomic testing for cancer risk: Results from the impact of personal genomics study

    Gray, S. W., Gollust, S. E., Carere, D. A., Chen, C. A., Cronin, A., Kalia, S. S., Rana, H. Q., Ruffin Iv, M. T., Wang, C., Roberts, J. S. & Green, R. C., Feb 20 2017, In : Journal of Clinical Oncology. 35, 6, p. 636-644 9 p.

    Research output: Contribution to journalArticle

    Genomics
    Neoplasms
    Vitamins
    Exercise
    Diet
    5 Citations (Scopus)
    Pharmacogenetics
    Genomics
    Prescriptions
    Health Personnel
    Drug-Related Side Effects and Adverse Reactions
    6 Citations (Scopus)

    The anti-inflammatory effect of personalized omega-3 fatty acid dosing for reducing prostaglandin E2 in the colonic mucosa is attenuated in obesity

    Djuric, Z., Turgeon, D. K., Sen, A., Ren, J., Herman, K., Ramaswamy, D., Zhao, L., Ruffin, M. T., Normolle, D. P., Smith, W. L. & Brenner, D. E., Dec 1 2017, In : Cancer Prevention Research. 10, 12, p. 729-737 9 p.

    Research output: Contribution to journalArticle

    Omega-3 Fatty Acids
    Dinoprostone
    Mucous Membrane
    Anti-Inflammatory Agents
    Obesity
    2 Citations (Scopus)

    The Effect of Perceived Stress on Epstein-Barr Virus Antibody Titers in Appalachian Ohio Women

    Brook, M. J., Christian, L. M., Hade, E. M. & Ruffin, M., Oct 1 2017, In : NeuroImmunoModulation. 24, 2, p. 67-73 7 p.

    Research output: Contribution to journalArticle

    Viral Load
    Human Herpesvirus 4
    Antibodies
    Social Support
    Health Behavior
    2016
    10 Citations (Scopus)

    Building research & scholarship capacity in departments of family medicine: A new joint ADFM-NAPCRG initiative

    Ewigman, B., Davis, A., Vansaghi, T., Cole, A., deGruy, F., Green, L., King, D., Kuzel, T., Lindbloom, E., Meadows, L., Miser, F., Nease, D. & Ruffin, M., Jan 1 2016, In : Annals of family medicine. 14, 1, p. 82-83 2 p.

    Research output: Contribution to journalComment/debate

    5 Citations (Scopus)

    Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue

    Sidahmed, E. K., Sen, A., Ren, J., Patel, A., Turgeon, D. K., Ruffin, M., Brenner, D. E. & Djuric, Z., Oct 2 2016, In : Nutrition and cancer. 68, 7, p. 1192-1201 10 p.

    Research output: Contribution to journalArticle

    Dinoprostone
    Colon
    Fatty Acids
    Diet
    Colonic Neoplasms
    47 Citations (Scopus)

    Consumer perceptions of interactions with primary care providers after direct-to-consumer personal genomic testing

    for the Impact of Personal Genomics Study Group, Apr 19 2016, In : Annals of internal medicine. 164, 8, p. 513-522 10 p.

    Research output: Contribution to journalArticle

    Primary Health Care
    Health Personnel
    Appointments and Schedules
    Cohort Studies
    Prospective Studies

    Diseases of the pancreas

    Young, A. P., De La, M. S. D. & Ruffin, M. T., Jan 1 2016, Family Medicine: Principles and Practice. Springer International Publishing, p. 1157-1166 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Pancreatic Cyst
    Pancreatic Diseases
    Family Physicians
    Pancreatitis
    Pancreas
    12 Citations (Scopus)

    DNA from fecal immunochemical test can replace stool for detection of colonic lesions using a microbiota-based model

    Baxter, N. T., Koumpouras, C. C., Rogers, M. A. M., Ruffin, M. T. & Schloss, P. D., Jan 1 2016, In : Microbiome. 4, 59.

    Research output: Contribution to journalReview article

    Microbiota
    Colorectal Neoplasms
    DNA
    Buffers
    Bacterial DNA
    4 Citations (Scopus)

    Implications of personal genomic testing for health behaviors: The case of smoking

    PGen Study Group, Jan 1 2016, In : Nicotine and Tobacco Research. 18, 12, p. 2273-2277 5 p.

    Research output: Contribution to journalArticle

    Health Behavior
    Smoking
    Lung Neoplasms
    Inborn Genetic Diseases
    Genomics
    12 Citations (Scopus)

    Markers of systemic exposures to products of intestinal bacteria in a dietary intervention study

    Umoh, F. I., Kato, I., Ren, J., Wachowiak, P. L., Ruffin, M. T., Turgeon, D. K., Sen, A., Brenner, D. E. & Djuric, Z., Mar 1 2016, In : European Journal of Nutrition. 55, 2, p. 793-798 6 p.

    Research output: Contribution to journalArticle

    Bacteria
    Serum
    Fatty Acids
    Diet
    Carotenoids
    65 Citations (Scopus)

    Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions

    Baxter, N. T., Ruffin, M. T., Rogers, M. A. M. & Schloss, P. D., Apr 6 2016, In : Genome Medicine. 8, 1, 37.

    Research output: Contribution to journalArticle

    Microbiota
    Adenoma
    Colorectal Neoplasms
    Neoplasms
    Porphyromonas
    1 Citation (Scopus)

    No evidence in US of HPV16/18 cancer precursor reduction

    Pendleton, M. E., Ruffin, M. & Harper, D. M., Jan 4 2016, In : Vaccine. 34, 2, 1 p.

    Research output: Contribution to journalLetter

    Uterine Cervical Diseases
    Human papillomavirus 18
    Human papillomavirus 16
    Papillomavirus Vaccines
    Cervical Intraepithelial Neoplasia
    2015
    2 Citations (Scopus)

    Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial

    Azrad, M., Vollmer, R. T., Madden, J., Polascik, T. J., Snyder, D. C., Ruffin, M. T., Moul, J. W., Brenner, D., He, X. & Demark-Wahnefried, W., Apr 1 2015, In : Biotechnic and Histochemistry. 90, 3, p. 184-189 6 p.

    Research output: Contribution to journalArticle

    Biological Assay
    Prostate
    Randomized Controlled Trials
    Serum
    Neoplasms
    4 Citations (Scopus)

    Effects of a Mediterranean Diet Intervention on Anti- and Pro-Inflammatory Eicosanoids, Epithelial Proliferation, and Nuclear Morphology in Biopsies of Normal Colon Tissue

    Djuric, Z., Turgeon, D. K., Ren, J., Neilson, A., Plegue, M., Waters, I. G., Chan, A., Askew, L. M., Ruffin, M., Sen, A. & Brenner, D. E., Jul 4 2015, In : Nutrition and cancer. 67, 5, p. 721-729 9 p.

    Research output: Contribution to journalArticle

    Mediterranean Diet
    Eicosanoids
    Colon
    Anti-Inflammatory Agents
    Biopsy
    7 Citations (Scopus)

    Effects of vitamin E from supplements and diet on colonic α-and γ-tocopherol concentrations in persons at increased colon cancer risk

    Li, Y., Sen, A., Ren, J., Askew, L. M., Sidahmed, E., Brenner, D. E., Ruffin, M. T., Turgeon, D. K. & Djuric, Z., Jan 2 2015, In : Nutrition and cancer. 67, 1, p. 73-81 9 p.

    Research output: Contribution to journalArticle

    Tocopherols
    Vitamin E
    Colonic Neoplasms
    Diet
    Colon
    39 Citations (Scopus)

    How Well Do Customers of Direct-to-Consumer Personal Genomic Testing Services Comprehend Genetic Test Results? Findings from the Impact of Personal Genomics Study for the PGen Study Group

    Ostergren, J. E., Gornick, M. C., Carere, D. A., Kalia, S. S., Uhlmann, W. R., Ruffin, M. T., Mountain, J. L., Green, R. C. & Roberts, J. S., Jul 25 2015, In : Public health genomics. 18, 4, p. 216-224 9 p.

    Research output: Contribution to journalArticle

    Genetic Services
    Genomics
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hispanic Americans
    Phenylketonurias

    Human papillomaviruses

    Unger, E. R., Ruffin, M. & Diaz-Arrastia, C., Jan 1 2015, Clinical Gynecology, Second Edition. Cambridge University Press, p. 371-381 11 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Papillomavirus Infections
    Sexually Transmitted Diseases
    Population
    30 Citations (Scopus)

    Impact of an electronic health record (EHR) reminder on human papillomavirus (HPV) vaccine initiation and timely completion

    Ruffin, M. T., Plegue, M. A., Rockwell, P. G., Young, A. P., Patel, D. A. & Yeazel, M. W., May 1 2015, In : Journal of the American Board of Family Medicine. 28, 3, p. 324-333 10 p.

    Research output: Contribution to journalArticle

    Papillomavirus Vaccines
    Electronic Health Records
    Vaccines
    Reminder Systems
    Community Networks
    7 Citations (Scopus)

    Impact of cervical cancer screening guidelines on screening for chlamydia

    Ursu, A., Sen, A. & Ruffin, M., Jan 1 2015, In : Annals of family medicine. 13, 4, p. 361-363 3 p.

    Research output: Contribution to journalArticle

    Chlamydia
    Early Detection of Cancer
    Uterine Cervical Neoplasms
    Guidelines
    Chlamydia Infections
    12 Citations (Scopus)

    Impact of family history assessment on communication with family members and health care providers: A report from the Family Healthware™ Impact Trial (FHITr)

    Family Healthware™ Impact Trial (FHITr) Group, Aug 1 2015, In : Preventive Medicine. 77, p. 28-34 7 p.

    Research output: Contribution to journalArticle

    Family Health
    Health Personnel
    Communication
    Medical History Taking
    Random Allocation
    41 Citations (Scopus)

    Large-scale identification of core-fucosylated glycopeptide sites in pancreatic cancer serum using mass spectrometry

    Tan, Z., Yin, H., Nie, S., Lin, Z., Zhu, J., Ruffin, M. T., Anderson, M. A., Simeone, D. M. & Lubman, D. M., Apr 3 2015, In : Journal of Proteome Research. 14, 4, p. 1968-1978 11 p.

    Research output: Contribution to journalArticle

    Glycopeptides
    Pancreatic Neoplasms
    Mass spectrometry
    Mass Spectrometry
    Glycosylation
    17 Citations (Scopus)

    Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer

    Zick, S. M., Turgeon, D. K., Ren, J., Ruffin, M. T., Wright, B. D., Sen, A., Djuric, Z. & Brenner, D. E., Sep 1 2015, In : Molecular Carcinogenesis. 54, 9, p. 908-915 8 p.

    Research output: Contribution to journalArticle

    Ginger
    Eicosanoids
    Colorectal Neoplasms
    Mucous Membrane
    Dinoprostone
    9 Citations (Scopus)

    Prompting primary care providers about increased patient risk as a result of family history: Does It work?

    Zazove, P., Plegue, M. A., Uhlmann, W. R. & Ruffin, M. T., May 1 2015, In : Journal of the American Board of Family Medicine. 28, 3, p. 334-342 9 p.

    Research output: Contribution to journalArticle

    Primary Health Care
    Primary Care Physicians
    Documentation
    Physicians
    Aptitude
    2014

    Combined HPV and cytology better than cytology for protection against cervical cancer

    Ruffin, M., Jan 1 2014, In : Evidence-Based Medicine. 19, 4, 1 p.

    Research output: Contribution to journalComment/debate

    Cervical Intraepithelial Neoplasia
    Papillomavirus Infections
    Early Detection of Cancer
    Uterine Cervical Neoplasms
    Cell Biology

    Communication preference moderates the effect of a tailored intervention to increase colorectal cancer screening among African Americans

    Resnicow, K., Zhou, Y., Hawley, S., Jimbo, M., Ruffin, M. T., Davis, R. E., Shires, D. & Lafata, J. E., Dec 1 2014, In : Patient Education and Counseling. 97, 3, p. 370-375 6 p.

    Research output: Contribution to journalArticle

    Early Detection of Cancer
    African Americans
    Colorectal Neoplasms
    Communication
    Integrated Delivery of Health Care
    11 Citations (Scopus)

    Communication preference moderates the effect of a tailored intervention to increase colorectal cancer screening among African Americans

    Resnicow, K., Zhou, Y., Hawley, S., Jimbo, M., Ruffin, M., Davis, R. E., Shires, D. & Lafata, J. E., Dec 1 2014, In : Patient Education and Counseling. 97, 3, p. 370-375 6 p.

    Research output: Contribution to journalArticle

    Early Detection of Cancer
    African Americans
    Colorectal Neoplasms
    Communication
    Integrated Delivery of Health Care
    25 Citations (Scopus)
    Genomics
    Cohort Studies
    Prospective Studies
    Health Education
    Health Status
    7 Citations (Scopus)

    Development and initial feedback about a human papillomavirus (HPV) vaccine comic book for adolescents

    Katz, M. L., Oldach, B. R., Goodwin, J., Reiter, P. L., Ruffin, M. & Paskett, E. D., Jan 1 2014, In : Journal of Cancer Education. 29, 2, p. 318-324 7 p.

    Research output: Contribution to journalArticle

    Papillomavirus Vaccines
    Parents
    Vaccination
    Reading
    10 Citations (Scopus)

    Development of exchange lists for Mediterranean and Healthy Eating Diets: Implementation in an intervention trial

    Sidahmed, E., Cornellier, M. L., Ren, J., Askew, L. M., Li, Y., Talaat, N., Rapai, M. S., Ruffin, M. T., Turgeon, D. K., Brenner, D., Sen, A. & Djuric, Z., Oct 1 2014, In : Journal of Human Nutrition and Dietetics. 27, 5, p. 413-425 13 p.

    Research output: Contribution to journalArticle

    Mediterranean Diet
    Vegetables
    Diet
    Counseling
    Weight Loss
    30 Citations (Scopus)

    Diagnosis and management of pancreatic cancer

    De La Cruz, M. S. D., Young, A. P. & Ruffin IV, M. T., Apr 15 2014, In : American family physician. 89, 8, p. 626-632 7 p.

    Research output: Contribution to journalArticle

    gemcitabine
    Pancreatic Neoplasms
    irinotecan
    Pancreas
    Adenocarcinoma
    65 Citations (Scopus)

    Glycoprotein biomarker panel for pancreatic cancer discovered by quantitative proteomics analysis

    Nie, S., Lo, A., Wu, J., Zhu, J., Tan, Z., Simeone, D. M., Anderson, M. A., Shedden, K. A., Ruffin, M. T. & Lubman, D. M., Apr 4 2014, In : Journal of Proteome Research. 13, 4, p. 1873-1884 12 p.

    Research output: Contribution to journalArticle

    Biomarkers
    Pancreatic Neoplasms
    Proteomics
    Glycoproteins
    Area Under Curve
    17 Citations (Scopus)

    Label-free relative quantification of alpha-2-macroglobulin site-specific core-fucosylation in pancreatic cancer by LC-MS/MS

    Lin, Z., Yin, H., Lo, A., Ruffin, M. T., Anderson, M. A., Simeone, D. M. & Lubman, D. M., Aug 2014, In : ELECTROPHORESIS. 35, 15, p. 2108-2115 8 p.

    Research output: Contribution to journalArticle

    alpha-Macroglobulins
    Pancreatic Neoplasms
    Labels
    Assays
    Chronic Pancreatitis
    16 Citations (Scopus)

    Quantitative analysis of single amino acid variant peptides associated with pancreatic cancer in serum by an isobaric labeling quantitative method

    Nie, S., Yin, H., Tan, Z., Anderson, M. A., Ruffin, M. T., Simeone, D. M. & Lubman, D. M., Dec 5 2014, In : Journal of Proteome Research. 13, 12, p. 6058-6066 9 p.

    Research output: Contribution to journalArticle

    Pancreatic Neoplasms
    Labeling
    Amino Acids
    Peptides
    Serum