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Research Output 1995 2019

1995
1 Citation (Scopus)
Tissue Plasminogen Activator
Ketones
Labeling
Catalytic Domain
Enzymes
1998
53 Citations (Scopus)

Subdomain interactions as a determinant in the folding and stability of T4 lysozyme

Llinás, M. & Marqusee, S., Jan 1998, In : Protein Science. 7, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

Muramidase
Proteins
Acids
Protein Stability
Protein C
1999
188 Citations (Scopus)

Solution structure of syrian hamster prion protein rPrP(90-231)

Liu, H., Farr-Jones, S., Ulyanov, N. B., Llinas, M., Marqusee, S., Groth, D., Cohen, F. E., Prusiner, S. B. & James, T. L., Apr 27 1999, In : Biochemistry. 38, 17, p. 5362-5377 16 p.

Research output: Contribution to journalArticle

Prion Diseases
Mesocricetus
Prions
Nuclear magnetic resonance
Scrapie
101 Citations (Scopus)

The energetics of T4 lysozyme reveal a hierarchy of conformations

Llinas, M., Gillespie, B., Dahlquist, F. W. & Marqusee, S., Nov 17 1999, In : Nature Structural Biology. 6, 11, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

Muramidase
Conformations
Protein Folding
Proteins
Mirrors
2003
1107 Citations (Scopus)

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

Bozdech, Z., Llinás, M., Pulliam, B. L., Wong, E. D., Zhu, J. & DeRisi, J. L., Dec 1 2003, In : PLoS biology. 1, 1

Research output: Contribution to journalArticle

Plasmodium falciparum
Transcriptome
transcriptome
Genes
genes
2004
62 Citations (Scopus)

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

Galgoczy, D. J., Cassidy-Stone, A., Llinás, M., O'Rourke, S. M., Herskowitz, I., DeRisi, J. L. & Johnson, A. D., Dec 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 18069-18074 6 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Dissection
Saccharomycetales
Chromatin Immunoprecipitation
Eukaryota
21 Citations (Scopus)

Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis

Llinás, M. & DeRisi, J. L., Aug 1 2004, In : Current Opinion in Microbiology. 7, 4, p. 382-387 6 p.

Research output: Contribution to journalReview article

Plasmodium falciparum
Genome
Malaria
Plasmodium
Antimalarials
2005
9 Citations (Scopus)

Mining the malaria transcriptome

Llinás, M. & Del Portillo, H. A., Aug 1 2005, In : Trends in Parasitology. 21, 8, p. 350-352 3 p.

Research output: Contribution to journalShort survey

Transcriptome
Malaria
Plasmodium falciparum
Parasitic Diseases
Proteomics
2006
210 Citations (Scopus)

Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains

Llinás, M., Bozdech, Z., Wong, E. D., Adai, A. T. & DeRisi, J. L., Mar 1 2006, In : Nucleic acids research. 34, 4, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Plasmodium falciparum
Transcriptome
Genome
Phenotype
2007
26 Citations (Scopus)

Exploring subdomain cooperativity in T4 lysozyme I: Structural and energetic studies of a circular permutant and protein fragment

Cellitti, J., Llinas, M., Echols, N., Shank, E. A., Gillespie, B., Kwon, E., Crowder, S. M., Dahlquist, F. W., Alber, T. & Marqusee, S., May 1 2007, In : Protein Science. 16, 5, p. 842-851 10 p.

Research output: Contribution to journalArticle

Muramidase
Proteins
X Ray Crystallography
Hydrophobic and Hydrophilic Interactions
X ray crystallography
35 Citations (Scopus)

Mechanisms of gene regulation in Plasmodium

Deitsch, K., Duraisingh, M., Dzikowski, R., Gunasekera, A., Khan, S., Le Roch, K., Llinas, M., Mair, G., McGovern, V., Roos, D., Shock, J., Sims, J., Wiegand, R., Winzeler, E. & Wirth, D. F., Aug 1 2007, In : American Journal of Tropical Medicine and Hygiene. 77, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

Plasmodium
Genes
Parasites
Life Cycle Stages
Proteomics
45 Citations (Scopus)

Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy

Hu, G., Llinás, M., Li, J., Preiser, P. R. & Bozdech, Z., Sep 19 2007, In : BMC bioinformatics. 8, 350.

Research output: Contribution to journalArticle

Oligonucleotides
Microarrays
Gene expression
Microarray
Gene Expression
2008
36 Citations (Scopus)

An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface

Tamez, P. A., Bhattacharjee, S., Van Ooij, C., Hiller, N. L., Llinás, M., Balu, B., Adams, J. H. & Haldar, K., Aug 1 2008, In : PLoS pathogens. 4, 8, e1000118.

Research output: Contribution to journalArticle

Malaria
Parasites
Erythrocytes
Lipids
Proteins
16 Citations (Scopus)

Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

Birkholtz, L., van Brummelen, A. C., Clark, K., Niemand, J., Maréchal, E., Llinas, M. & Louw, A. I., Jan 1 2008, In : Acta Tropica. 105, 2, p. 113-123 11 p.

Research output: Contribution to journalReview article

Plasmodium
Genomics
genomics
drugs
therapeutics
20 Citations (Scopus)

Plasmodium gene regulation: far more to factor in

Llinás, M., Deitsch, K. W. & Voss, T. S., Dec 1 2008, In : Trends in Parasitology. 24, 12, p. 551-556 6 p.

Research output: Contribution to journalReview article

Plasmodium
Antigenic Variation
Parasites
Inventions
Genes
166 Citations (Scopus)

Specific DNA-binding by Apicomplexan AP2 transcription factors

De Silva, E. K., Gehrke, A. R., Olszewski, K., León, I., Chahal, J. S., Bulyk, M. L. & Llinás, M., Jun 17 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8393-8398 6 p.

Research output: Contribution to journalArticle

Transcription Factors
DNA
Proteins
Plasmodium
Parasites
2009
38 Citations (Scopus)

Clonally variant gene families in Plasmodium falciparum share a common activation factor

Howitt, C. A., Willnski, D., Llinás, M., Templeton, T. J., Dzlkowski, R. & Deitsch, K. W., Sep 1 2009, In : Molecular Microbiology. 73, 6, p. 1171-1185 15 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Genes
Down-Regulation
Parasites
Antigenic Variation
51 Citations (Scopus)

Co-inhibition of Plasmodium falciparum S-Adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses

van Brumelen, A. C., Olszewski, K. L., Willinski, D., Llinás, M., Louw, A. I. & Birkholtz, L. M., Feb 13 2009, In : Journal of Biological Chemistry. 284, 7, p. 4635-4646 12 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Ornithine Decarboxylase
Metabolome
Polyamines
Proteome
177 Citations (Scopus)

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D. & Llinas, M., Feb 19 2009, In : Cell Host and Microbe. 5, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

Host-Parasite Interactions
Metabolomics
Plasmodium falciparum
Parasites
Arginine
23 Citations (Scopus)

Quantitative determination of urea concentrations in cell culture medium

Zawada, R. J. X., Kwan, P., Olszewski, K. L., Llinas, M. & Huang, S. G., Jun 1 2009, In : Biochemistry and Cell Biology. 87, 3, p. 541-544 4 p.

Research output: Contribution to journalArticle

Cell culture
Culture Media
Urea
Cell Culture Techniques
Assays
2010
97 Citations (Scopus)

Branched tricarboxylic acid metabolism in Plasmodium falciparum

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinas, M., Aug 5 2010, In : Nature. 466, 7307, p. 774-778 5 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Plasmodium falciparum
Acetyl Coenzyme A
Parasites
Carbon
30 Citations (Scopus)

Crystal structure of arginase from plasmodium falciparum and implications for l -arginine depletion in malarial infection

Dowling, D. P., Ilies, M., Olszewski, K. L., Portugal, S., Mota, M. M., Llinás, M. & Christianson, D. W., Jul 6 2010, In : Biochemistry. 49, 26, p. 5600-5608 9 p.

Research output: Contribution to journalArticle

Arginase
Plasmodium falciparum
Arginine
Crystal structure
Infection
51 Citations (Scopus)

Eating at the Table of Another: Metabolomics of Host-Parasite Interactions

Kafsack, B. F. C. & Llinas, M., Feb 18 2010, In : Cell Host and Microbe. 7, 2, p. 90-99 10 p.

Research output: Contribution to journalReview article

Host-Parasite Interactions
Metabolomics
Parasites
Eating
Parasitic Diseases
30 Citations (Scopus)

Identification and characterization of a liver stage-specific promoter region of the malaria parasite plasmodium

Helm, S., Lehmann, C., Nagel, A., Stanway, R. R., Horstmann, S., Llinas, M. & Heussler, V. T., Nov 17 2010, In : PloS one. 5, 10, e13653.

Research output: Contribution to journalArticle

Plasmodium malariae
Plasmodium
Genetic Promoter Regions
Liver
malaria
121 Citations (Scopus)

Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 family of regulators from the malaria parasite

Campbell, T. L., de Silva, E. K., Olszewski, K. L., Elemento, O. & Llinás, M., Oct 1 2010, In : PLoS pathogens. 6, 10, e1001165.

Research output: Contribution to journalArticle

Malaria
Parasites
Genome
Gene Regulatory Networks
DNA
204 Citations (Scopus)

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

Otto, T. D., Wilinski, D., Assefa, S., Keane, T. M., Sarry, L. R., Böhme, U., Lemieux, J., Barrell, B., Pain, A., Berriman, M., Newbold, C. & Llinás, M., Apr 2010, In : Molecular Microbiology. 76, 1, p. 12-24 13 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Transcriptome
Alternative Splicing
RNA
Parasites
97 Citations (Scopus)

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network

Plata, G., Hsiao, T. L., Olszewski, K. L., Llinás, M. & Vitkup, D., Sep 14 2010, In : Molecular Systems Biology. 6, 408.

Research output: Contribution to journalArticle

Metabolic Network
Plasmodium falciparum
Metabolic Networks and Pathways
Genes
Essential Genes
39 Citations (Scopus)

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

Lindner, S. E., De Silva, E. K., Keck, J. L. & Llinas, M., Jan 22 2010, In : Journal of Molecular Biology. 395, 3, p. 558-567 10 p.

Research output: Contribution to journalArticle

DNA
Plasmodium
Sporozoites
Consensus Sequence
Dimerization
2011
44 Citations (Scopus)

Central carbon metabolism of Plasmodium parasites

Olszewski, K. L. & Llinas, M., Feb 1 2011, In : Molecular and biochemical parasitology. 175, 2, p. 95-103 9 p.

Research output: Contribution to journalReview article

Plasmodium
Parasites
Carbon
Malaria
Carbon Cycle

Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum (Nature (2010) 466 (774-778))

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., Jan 20 2011, In : Nature. 469, 7330, 1 p.

Research output: Contribution to journalComment/debate

25 Citations (Scopus)

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

Storm, J., Perner, J., Aparicio, I., Patzewitz, E. M., Olszewski, K., Llinas, M., Engel, P. C. & Müller, S., Jul 26 2011, In : Malaria journal. 10, 193.

Research output: Contribution to journalArticle

Glutamate Dehydrogenase
Plasmodium falciparum
NADP
Parasites
Pharmaceutical Preparations
111 Citations (Scopus)

The Apicomplexan AP2 family: Integral factors regulating Plasmodium development

Painter, H. J., Campbell, T. L. & Llinás, M., Mar 1 2011, In : Molecular and biochemical parasitology. 176, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Plasmodium
Parasites
Malaria
Proteins
DNA-Binding Proteins
12 Citations (Scopus)

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast

Lindner, S. E., Llinas, M., Keck, J. L. & Kappe, S. H. I., Dec 1 2011, In : Molecular and biochemical parasitology. 180, 2, p. 69-75 7 p.

Research output: Contribution to journalArticle

Apicoplasts
DNA Primase
Parasites
DNA Replication
Enzymes
15 Citations (Scopus)

Using context to improve protein domain identification

Ochoa, A., Llinás, M. & Singh, M., Apr 4 2011, In : BMC bioinformatics. 12, 90.

Research output: Contribution to journalArticle

Genome
Proteins
Protein
Falciparum Malaria
Licensure
2012
54 Citations (Scopus)

A tetracycline-repressible transactivator system to study essential genes in malaria parasites

Pino, P., Sebastian, S., Kim, E. A., Bush, E., Brochet, M., Volkmann, K., Kozlowski, E., Llinás, M., Billker, O. & Soldati-Favre, D., Dec 13 2012, In : Cell Host and Microbe. 12, 6, p. 824-834 11 p.

Research output: Contribution to journalArticle

Trans-Activators
Essential Genes
Tetracycline
Malaria
Parasites

Comment on emerging functions of transcription factors in malaria parasite

Painter, H. J. & Llinás, M., Jun 20 2012, In : Journal of Biomedicine and Biotechnology. 2012, 754054.

Research output: Contribution to journalLetter

Gene Expression Regulation
Plasmodium falciparum
Malaria
Parasites
Transcription Factors
15 Citations (Scopus)

New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community

Kafsack, B. F. C., Painter, H. J. & Llinás, M., Jun 12 2012, In : Malaria journal. 11, 187.

Research output: Contribution to journalArticle

Plasmodium malariae
Plasmodium berghei
Gene Expression Profiling
Plasmodium falciparum
Microarray Analysis
53 Citations (Scopus)

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

Babbitt, S. E., Altenhofen, L., Cobbold, S. A., Istvan, E. S., Fennellf, C., Doerig, C., Llinás, M. & Goldberg, D. E., Nov 20 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 47, p. E3278-E3287

Research output: Contribution to journalArticle

Plasmodium falciparum
Starvation
Isoleucine
Parasites
Amino Acids
10 Citations (Scopus)

Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana

Klein, E. Y., Lewis, I. A., Jung, C., Llinás, M. & Levin, S. A., Apr 9 2012, In : Malaria journal. 11, 110.

Research output: Contribution to journalArticle

Drug-Seeking Behavior
Ghana
Pharmaceutical Preparations
Caregivers
Therapeutics
97 Citations (Scopus)

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Straimer, J., Lee, M. C. S., Lee, A. H., Zeitler, B., Williams, A. E., Pearl, J. R., Zhang, L., Rebar, E. J., Gregory, P. D., Llinas, M., Urnov, F. D. & Fidock, D. A., Oct 1 2012, In : Nature methods. 9, 10, p. 993-998 6 p.

Research output: Contribution to journalArticle

Zinc Fingers
Plasmodium falciparum
Zinc
Parasites
Genes
2013
17 Citations (Scopus)

A new system for comparative functional genomics of Saccharomyces yeasts

Caudy, A. A., Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., Scott Breunig, J., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A. & 54 others, Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. H. H., Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G. & Dunham, M. J., Sep 17 2013, In : Genetics. 195, 1, p. 275-287 13 p.

Research output: Contribution to journalArticle

Saccharomyces
Genomics
Yeasts
Genes
Genome
48 Citations (Scopus)

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Toxoplasma
Cysts
Antigens
Messenger RNA
35 Citations (Scopus)

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites

Mira-Martínez, S., Rovira-Graells, N., Crowley, V. M., Altenhofen, L. M., Llinás, M. & Cortés, A., Nov 1 2013, In : Cellular Microbiology. 15, 11, p. 1913-1923 11 p.

Research output: Contribution to journalArticle

Epigenomics
Malaria
Parasites
Poisons
Gene Expression
6 Citations (Scopus)

Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum (Nature (2010) 466 (774-778) DOI: 10.1038/nature09301)

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., May 30 2013, In : Nature. 497, 7451, 1 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Extraction of hydrophilic metabolites from plasmodium falciparum -infected erythrocytes for metabolomic analysis

Olszewski, K. L. & Llinas, M., Jan 1 2013, Malaria: Methods and Protocols. Humana Press Inc., p. 259-266 8 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolomics
Plasmodium falciparum
Parasites
Erythrocytes
Metabolic Networks and Pathways
40 Citations (Scopus)

Kinetic flux profiling elucidates two independent acetyl-coa biosynthetic pathways in plasmodium falciparum

Cobbold, S. A., Vaughan, A. M., Lewis, I. A., Painter, H. J., Camargo, N., Perlman, D. H., Fishbaugher, M., Healer, J., Cowman, A. F., Kappe, S. H. I. & Llinás, M., Dec 20 2013, In : Journal of Biological Chemistry. 288, 51, p. 36338-36350 13 p.

Research output: Contribution to journalArticle

Acetyl Coenzyme A
Biosynthetic Pathways
Plasmodium falciparum
Fluxes
Parasites

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., May 30 2013, In : Nature. 497, 7451, p. 652 1 p.

Research output: Contribution to journalComment/debate

11 Citations (Scopus)

Whole-genome analysis of plasmodium spp. Utilizing a new agilent technologies DNA microarray platform

Painter Ponton, H. J., Altenhofen, L. M., Kafsack, B. F. C. & Llinas, M., Jan 1 2013, Malaria: Methods and Protocols. Humana Press Inc., p. 213-219 7 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasmodium
Oligonucleotide Array Sequence Analysis
Genome
Technology
Oligonucleotide Probes
2014
163 Citations (Scopus)

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Sinha, A., Hughes, K. R., Modrzynska, K. K., Otto, T. D., Pfander, C., Dickens, N. J., Religa, A. A., Bushell, E., Graham, A. L., Cameron, R., Kafsack, B. F. C., Williams, A. E., Llinás, M., Berriman, M., Billker, O. & Waters, A. P., Jan 1 2014, In : Nature. 507, 7491, p. 253-257 5 p.

Research output: Contribution to journalArticle

Sexual Development
Plasmodium
DNA-Binding Proteins
Parasites
Malaria
89 Citations (Scopus)

A Plasmodium falciparum Histone Deacetylase regulates antigenic variation and gametocyte conversion

Coleman, B. I., Skillman, K. M., Jiang, R. H. Y., Childs, L. M., Altenhofen, L. M., Ganter, M., Leung, Y., Goldowitz, I., Kafsack, B. F. C., Marti, M., Llinas, M., Buckee, C. O. & Duraisingh, M. T., Aug 13 2014, In : Cell Host and Microbe. 16, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

Antigenic Variation
Histone Deacetylases
Plasmodium falciparum
Histone Deacetylase 2
Virulence