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Research Output 1995 2019

163 Citations (Scopus)

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Sinha, A., Hughes, K. R., Modrzynska, K. K., Otto, T. D., Pfander, C., Dickens, N. J., Religa, A. A., Bushell, E., Graham, A. L., Cameron, R., Kafsack, B. F. C., Williams, A. E., Llinás, M., Berriman, M., Billker, O. & Waters, A. P., Jan 1 2014, In : Nature. 507, 7491, p. 253-257 5 p.

Research output: Contribution to journalArticle

Sexual Development
Plasmodium
DNA-Binding Proteins
Parasites
Malaria
1 Citation (Scopus)
Tissue Plasminogen Activator
Ketones
Labeling
Catalytic Domain
Enzymes
36 Citations (Scopus)

An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface

Tamez, P. A., Bhattacharjee, S., Van Ooij, C., Hiller, N. L., Llinás, M., Balu, B., Adams, J. H. & Haldar, K., Aug 1 2008, In : PLoS pathogens. 4, 8, e1000118.

Research output: Contribution to journalArticle

Malaria
Parasites
Erythrocytes
Lipids
Proteins
17 Citations (Scopus)

A new system for comparative functional genomics of Saccharomyces yeasts

Caudy, A. A., Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., Scott Breunig, J., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A. & 54 others, Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. H. H., Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G. & Dunham, M. J., Sep 17 2013, In : Genetics. 195, 1, p. 275-287 13 p.

Research output: Contribution to journalArticle

Saccharomyces
Genomics
Yeasts
Genes
Genome

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Schalkwijk, J., Allman, E. L., Jansen, P. A. M., De Vries, L. E., Verhoef, J. M. J., Jackowski, S., Botman, P. N. M., Beuckens-Schortinghuis, C. A., Koolen, K. M. J., Bolscher, J. M., Vos, M. W., Miller, K., Reeves, S. A., Pett, H., Trevitt, G., Wittlin, S., Scheurer, C., Sax, S., Fischli, C., Angulo-Barturen, I. & 11 others, Jiménez-Diaz, M. B., Josling, G., Kooij, T. W. A., Bonnert, R., Campo, B., Blaauw, R. H., Rutjes, F. P. J. T., Sauerwein, R. W., Llinás, M., Hermkens, P. H. H. & Dechering, K. J., Sep 18 2019, In : Science Translational Medicine. 11, 510, eaas9917.

Research output: Contribution to journalArticle

Acetyl Coenzyme A
Antimalarials
Plasmodium falciparum
Parasites
Malaria
48 Citations (Scopus)

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Toxoplasma
Cysts
Antigens
Messenger RNA
89 Citations (Scopus)

A Plasmodium falciparum Histone Deacetylase regulates antigenic variation and gametocyte conversion

Coleman, B. I., Skillman, K. M., Jiang, R. H. Y., Childs, L. M., Altenhofen, L. M., Ganter, M., Leung, Y., Goldowitz, I., Kafsack, B. F. C., Marti, M., Llinas, M., Buckee, C. O. & Duraisingh, M. T., Aug 13 2014, In : Cell Host and Microbe. 16, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

Antigenic Variation
Histone Deacetylases
Plasmodium falciparum
Histone Deacetylase 2
Virulence
2 Citations (Scopus)

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

Bennink, S., von Bohl, A., Ngwa, C. J., Henschel, L., Kuehn, A., Pilch, N., Weißbach, T., Rosinski, A. N., Scheuermayer, M., Repnik, U., Przyborski, J. M., Minns, A. M., Orchard, L. M., Griffiths, G., Lindner, S. E., Llinás, M. & Pradel, G., Aug 2018, In : PLoS pathogens. 14, 8, e1007249.

Research output: Contribution to journalArticle

Plasmodium falciparum
Heat-Shock Proteins
Culicidae
Parasites
Proteins
54 Citations (Scopus)

A tetracycline-repressible transactivator system to study essential genes in malaria parasites

Pino, P., Sebastian, S., Kim, E. A., Bush, E., Brochet, M., Volkmann, K., Kozlowski, E., Llinás, M., Billker, O. & Soldati-Favre, D., Dec 13 2012, In : Cell Host and Microbe. 12, 6, p. 824-834 11 p.

Research output: Contribution to journalArticle

Trans-Activators
Essential Genes
Tetracycline
Malaria
Parasites
167 Citations (Scopus)

A transcriptional switch underlies commitment to sexual development in malaria parasites

Kafsack, B. F. C., Rovira-Graells, N., Clark, T. G., Bancells, C., Crowley, V. M., Campino, S. G., Williams, A. E., Drought, L. G., Kwiatkowski, D. P., Baker, D. A., Cortés, A. & Llinás, M., Jan 1 2014, In : Nature. 507, 7491, p. 248-252 5 p.

Research output: Contribution to journalArticle

Sexual Development
Malaria
Parasites
Plasmodium malariae
Reverse Genetics
6 Citations (Scopus)

Beyond the E-Value: Stratified Statistics for Protein Domain Prediction

Ochoa, A., Storey, J. D., Llinás, M. & Singh, M., Nov 2015, In : PLoS computational biology. 11, 11, e1004509.

Research output: Contribution to journalArticle

statistics
Statistics
Proteins
Protein
protein
97 Citations (Scopus)

Branched tricarboxylic acid metabolism in Plasmodium falciparum

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinas, M., Aug 5 2010, In : Nature. 466, 7307, p. 774-778 5 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Plasmodium falciparum
Acetyl Coenzyme A
Parasites
Carbon
14 Citations (Scopus)

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum

Painter, H. J., Carrasquilla, M. & Llinás, M., Jun 2017, In : Genome research. 27, 6, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

Falciparum Malaria
Parasites
RNA
Messenger RNA
Pyrimidines
44 Citations (Scopus)

Central carbon metabolism of Plasmodium parasites

Olszewski, K. L. & Llinas, M., Feb 1 2011, In : Molecular and biochemical parasitology. 175, 2, p. 95-103 9 p.

Research output: Contribution to journalReview article

Plasmodium
Parasites
Carbon
Malaria
Carbon Cycle
11 Citations (Scopus)

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

Shears, M. J., MacRae, J. I., Mollard, V., Goodman, C. D., Sturm, A., Orchard, L. M., Llinas, M., McConville, M. J., Botté, C. Y. & McFadden, G. I., Jan 1 2017, In : Cellular Microbiology. 19, 1, e12633.

Research output: Contribution to journalArticle

Apicoplasts
Acyltransferases
Plasmodium falciparum
Plasmodium berghei
Malaria
38 Citations (Scopus)

Clonally variant gene families in Plasmodium falciparum share a common activation factor

Howitt, C. A., Willnski, D., Llinás, M., Templeton, T. J., Dzlkowski, R. & Deitsch, K. W., Sep 1 2009, In : Molecular Microbiology. 73, 6, p. 1171-1185 15 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Genes
Down-Regulation
Parasites
Antigenic Variation
51 Citations (Scopus)

Co-inhibition of Plasmodium falciparum S-Adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses

van Brumelen, A. C., Olszewski, K. L., Willinski, D., Llinás, M., Louw, A. I. & Birkholtz, L. M., Feb 13 2009, In : Journal of Biological Chemistry. 284, 7, p. 4635-4646 12 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Ornithine Decarboxylase
Metabolome
Polyamines
Proteome

Comment on emerging functions of transcription factors in malaria parasite

Painter, H. J. & Llinás, M., Jun 20 2012, In : Journal of Biomedicine and Biotechnology. 2012, 754054.

Research output: Contribution to journalLetter

Gene Expression Regulation
Plasmodium falciparum
Malaria
Parasites
Transcription Factors

Commitment Isn't for Everyone

Josling, G. A. & Llinas, M., Jun 1 2019, In : Trends in Parasitology. 35, 6, p. 381-383 3 p.

Research output: Contribution to journalShort survey

Parasites
Culicidae
Malaria
Infection
210 Citations (Scopus)

Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains

Llinás, M., Bozdech, Z., Wong, E. D., Adai, A. T. & DeRisi, J. L., Mar 1 2006, In : Nucleic acids research. 34, 4, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Plasmodium falciparum
Transcriptome
Genome
Phenotype
8 Citations (Scopus)

Cross-reactive immune responses as primary drivers of malaria chronicity

Klein, E. Y., Graham, A. L., Llinás, M. & Levin, S., Jan 1 2014, In : Infection and Immunity. 82, 1, p. 140-151 12 p.

Research output: Contribution to journalArticle

Malaria
Infection
Parasites
Antigenic Variation
Immune System
30 Citations (Scopus)

Crystal structure of arginase from plasmodium falciparum and implications for l -arginine depletion in malarial infection

Dowling, D. P., Ilies, M., Olszewski, K. L., Portugal, S., Mota, M. M., Llinás, M. & Christianson, D. W., Jul 6 2010, In : Biochemistry. 49, 26, p. 5600-5608 9 p.

Research output: Contribution to journalArticle

Arginase
Plasmodium falciparum
Arginine
Crystal structure
Infection

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium

Lee, M. C. S., Lindner, S. E., Lopez-Rubio, J. J. & Llinás, M., Sep 24 2019, In : Briefings in functional genomics. 18, 5, p. 281-289 9 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Plasmodium
Malaria
Parasites
Genes
51 Citations (Scopus)

Eating at the Table of Another: Metabolomics of Host-Parasite Interactions

Kafsack, B. F. C. & Llinas, M., Feb 18 2010, In : Cell Host and Microbe. 7, 2, p. 90-99 10 p.

Research output: Contribution to journalReview article

Host-Parasite Interactions
Metabolomics
Parasites
Eating
Parasitic Diseases
35 Citations (Scopus)

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites

Mira-Martínez, S., Rovira-Graells, N., Crowley, V. M., Altenhofen, L. M., Llinás, M. & Cortés, A., Nov 1 2013, In : Cellular Microbiology. 15, 11, p. 1913-1923 11 p.

Research output: Contribution to journalArticle

Epigenomics
Malaria
Parasites
Poisons
Gene Expression

Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum (Nature (2010) 466 (774-778))

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., Jan 20 2011, In : Nature. 469, 7330, 1 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum (Nature (2010) 466 (774-778) DOI: 10.1038/nature09301)

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., May 30 2013, In : Nature. 497, 7451, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Lee, A. H., Dhingra, S. K., Lewis, I. A., Singh, M. K., Siriwardana, A., Dalal, S., Rubiano, K., Klein, M. S., Baska, K. S., Krishna, S., Klemba, M., Roepe, P. D., Llinás, M., Garcia, C. R. S. & Fidock, D. A., Dec 1 2018, In : Scientific reports. 8, 1, 13578.

Research output: Contribution to journalArticle

Parasites
Hemoglobins
Amodiaquine
Protein Isoforms
Chloroquine
14 Citations (Scopus)

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Gabryszewski, S. J., Dhingra, S. K., Combrinck, J. M., Lewis, I. A., Callaghan, P. S., Hassett, M. R., Siriwardana, A., Henrich, P. P., Lee, A. H., Gnädig, N. F., Musset, L., Llinás, M., Egan, T. J., Roepe, P. D. & Fidock, D. A., Nov 1 2016, In : PLoS pathogens. 12, 11, e1005976.

Research output: Contribution to journalArticle

Digestive System Physiological Phenomena
Vacuoles
Drug Resistance
Parasites
Chloroquine
16 Citations (Scopus)

Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

Birkholtz, L., van Brummelen, A. C., Clark, K., Niemand, J., Maréchal, E., Llinas, M. & Louw, A. I., Jan 1 2008, In : Acta Tropica. 105, 2, p. 113-123 11 p.

Research output: Contribution to journalReview article

Plasmodium
Genomics
genomics
drugs
therapeutics
26 Citations (Scopus)

Exploring subdomain cooperativity in T4 lysozyme I: Structural and energetic studies of a circular permutant and protein fragment

Cellitti, J., Llinas, M., Echols, N., Shank, E. A., Gillespie, B., Kwon, E., Crowder, S. M., Dahlquist, F. W., Alber, T. & Marqusee, S., May 1 2007, In : Protein Science. 16, 5, p. 842-851 10 p.

Research output: Contribution to journalArticle

Muramidase
Proteins
X Ray Crystallography
Hydrophobic and Hydrophilic Interactions
X ray crystallography
6 Citations (Scopus)

Extraction of hydrophilic metabolites from plasmodium falciparum -infected erythrocytes for metabolomic analysis

Olszewski, K. L. & Llinas, M., Jan 1 2013, Malaria: Methods and Protocols. Humana Press Inc., p. 259-266 8 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolomics
Plasmodium falciparum
Parasites
Erythrocytes
Metabolic Networks and Pathways
55 Citations (Scopus)

Genetic investigation of tricarboxylic acid metabolism during the plasmodium falciparum life cycle

Ke, H., Lewis, I. A., Morrisey, J. M., McLean, K. J., Ganesan, S. M., Painter Ponton, H. J., Mather, M. W., Jacobs-Lorena, M., Llinas, M. & Vaidya, A. B., Apr 7 2015, In : Cell Reports. 11, 1, p. 164-174 11 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Plasmodium falciparum
Life Cycle Stages
Metabolism
Life cycle
14 Citations (Scopus)

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Painter Ponton, H. J., Chung, N. C., Sebastian, A., Albert, I., Storey, J. D. & Llinas, M., Dec 1 2018, In : Nature communications. 9, 1, 2656.

Research output: Contribution to journalArticle

genome
Plasmodium falciparum
blood
Blood
Genes
8 Citations (Scopus)

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

Adjalley, S. H., Scanfeld, D., Kozlowski, E., Llinás, M. & Fidock, D. A., Dec 21 2015, In : BMC genomics. 16, 1, 1090.

Research output: Contribution to journalArticle

Gene Expression Profiling
Plasmodium falciparum
Vacuoles
Drug Resistance
Genome
62 Citations (Scopus)

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae

Galgoczy, D. J., Cassidy-Stone, A., Llinás, M., O'Rourke, S. M., Herskowitz, I., DeRisi, J. L. & Johnson, A. D., Dec 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 52, p. 18069-18074 6 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Dissection
Saccharomycetales
Chromatin Immunoprecipitation
Eukaryota
2 Citations (Scopus)

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii

Shukla, A., Olszewski, K. L., Llinas, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Xia, D., Wastling, J., Beiting, D., Roos, D. S. & Shanmugam, D., Oct 1 2018, In : International Journal for Parasitology. 48, 12, p. 955-968 14 p.

Research output: Contribution to journalArticle

Toxoplasma
Glycolysis
Cysts
Parasites
Growth

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

Van Biljon, R., Van Wyk, R., Painter, H. J., Orchard, L., Reader, J., Niemand, J., Llinás, M. & Birkholtz, L. M., Dec 3 2019, In : BMC genomics. 20, 1, 920.

Research output: Contribution to journalArticle

Sex Differentiation
Plasmodium falciparum
Transcriptome
Malaria
Parasites
177 Citations (Scopus)

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D. & Llinas, M., Feb 19 2009, In : Cell Host and Microbe. 5, 2, p. 191-199 9 p.

Research output: Contribution to journalArticle

Host-Parasite Interactions
Metabolomics
Plasmodium falciparum
Parasites
Arginine
30 Citations (Scopus)

Identification and characterization of a liver stage-specific promoter region of the malaria parasite plasmodium

Helm, S., Lehmann, C., Nagel, A., Stanway, R. R., Horstmann, S., Llinas, M. & Heussler, V. T., Nov 17 2010, In : PloS one. 5, 10, e13653.

Research output: Contribution to journalArticle

Plasmodium malariae
Plasmodium
Genetic Promoter Regions
Liver
malaria
121 Citations (Scopus)

Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 family of regulators from the malaria parasite

Campbell, T. L., de Silva, E. K., Olszewski, K. L., Elemento, O. & Llinás, M., Oct 1 2010, In : PLoS pathogens. 6, 10, e1001165.

Research output: Contribution to journalArticle

Malaria
Parasites
Genome
Gene Regulatory Networks
DNA
3 Citations (Scopus)

Identifying the Components of Acidosis in Patients with Severe Plasmodium falciparum Malaria Using Metabolomics

Leopold, S. J., Ghose, A., Allman, E. L., Kingston, H. W. F., Hossain, A., Dutta, A. K., Plewes, K., Chotivanich, K., Day, N. P. J., Tarning, J., Winterberg, M., White, N. J., Llinás, M. & Dondorp, A. M., Jun 1 2019, In : Journal of Infectious Diseases. 219, 11, p. 1766-1776 11 p.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Falciparum Malaria
Acidosis
Acids
Malaria
6 Citations (Scopus)

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

van Biljon, R., Niemand, J., van Wyk, R., Clark, K., Verlinden, B., Abrie, C., von Grüning, H., Smidt, W., Smit, A., Reader, J., Painter Ponton, H. J., Llinas, M., Doerig, C. & Birkholtz, L. M., Dec 1 2018, In : Scientific reports. 8, 1, 16581.

Research output: Contribution to journalArticle

Falciparum Malaria
Cell Cycle Checkpoints
Cell Cycle
Parasites
Malaria
40 Citations (Scopus)

Kinetic flux profiling elucidates two independent acetyl-coa biosynthetic pathways in plasmodium falciparum

Cobbold, S. A., Vaughan, A. M., Lewis, I. A., Painter, H. J., Camargo, N., Perlman, D. H., Fishbaugher, M., Healer, J., Cowman, A. F., Kappe, S. H. I. & Llinás, M., Dec 20 2013, In : Journal of Biological Chemistry. 288, 51, p. 36338-36350 13 p.

Research output: Contribution to journalArticle

Acetyl Coenzyme A
Biosynthetic Pathways
Plasmodium falciparum
Fluxes
Parasites
2 Citations (Scopus)

Less Lipid, More Commitment

Llinas, M., Dec 14 2017, In : Cell. 171, 7, p. 1474-1476 3 p.

Research output: Contribution to journalShort survey

Sex Differentiation
Lysophosphatidylcholines
Malaria
Parasites
Lipids
3 Citations (Scopus)

Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy

Aronson, M. R., Simonson, A. W., Orchard, L. M., Llinás, M. & Medina, S. H., Oct 15 2018, In : Acta Biomaterialia. 80, p. 269-277 9 p.

Research output: Contribution to journalArticle

Peptides
Cells
Lipids
Neoplasms
Membranes
42 Citations (Scopus)

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Cowell, A. N., Istvan, E. S., Lukens, A. K., Gomez-Lorenzo, M. G., Vanaerschot, M., Sakata-Kato, T., Flannery, E. L., Magistrado, P., Owen, E., Abraham, M., La Monte, G., Painter, H. J., Williams, R. M., Franco, V., Linares, M., Arriaga, I., Bopp, S., Corey, V. C., Gnädig, N. F., Coburn-Flynn, O. & 24 others, Reimer, C., Gupta, P., Murithi, J. M., Moura, P. A., Fuchs, O., Sasaki, E., Kim, S. W., Teng, C. H., Wang, L. T., Akidil, A., Adjalley, S., Willis, P. A., Siegel, D., Tanaseichuk, O., Zhong, Y., Zhou, Y., Llinás, M., Ottilie, S., Gamo, F. J., Lee, M. C. S., Goldberg, D. E., Fidock, D. A., Wirth, D. F. & Winzeler, E. A., Jan 12 2018, In : Science. 359, 6372, p. 191-199 9 p.

Research output: Contribution to journalArticle

Malaria
Parasites
Gene Amplification
Genome
Plasmodium falciparum
35 Citations (Scopus)

Mechanisms of gene regulation in Plasmodium

Deitsch, K., Duraisingh, M., Dzikowski, R., Gunasekera, A., Khan, S., Le Roch, K., Llinas, M., Mair, G., McGovern, V., Roos, D., Shock, J., Sims, J., Wiegand, R., Winzeler, E. & Wirth, D. F., Aug 1 2007, In : American Journal of Tropical Medicine and Hygiene. 77, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

Plasmodium
Genes
Parasites
Life Cycle Stages
Proteomics
42 Citations (Scopus)

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

Lewis, I. A., Wacker, M., Olszewski, K. L., Cobbold, S. A., Baska, K. S., Tan, A., Ferdig, M. T. & Llinás, M., Jan 1 2014, In : PLoS genetics. 10, 1, e1004085.

Research output: Contribution to journalArticle

chloroquine
catabolism
Chloroquine
Plasmodium falciparum
hemoglobin
33 Citations (Scopus)

Metabolomic profiling of the Malaria Box reveals antimalarial target pathways

Allman, E. L., Painter, H. J., Samra, J., Carrasquilla, M. & Llinás, M., Nov 2016, In : Antimicrobial agents and chemotherapy. 60, 11, p. 6635-6643 9 p.

Research output: Contribution to journalArticle

Metabolomics
Antimalarials
Malaria
Parasites
Pharmaceutical Preparations