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Research Output 1995 2019

9 Citations (Scopus)

Mining the malaria transcriptome

Llinás, M. & Del Portillo, H. A., Aug 1 2005, In : Trends in Parasitology. 21, 8, p. 350-352 3 p.

Research output: Contribution to journalShort survey

Transcriptome
Malaria
Plasmodium falciparum
Parasitic Diseases
Proteomics
22 Citations (Scopus)

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

Pulcini, S., Staines, H. M., Lee, A. H., Shafik, S. H., Bouyer, G., Moore, C. M., Daley, D. A., Hoke, M. J., Altenhofen, L. M., Painter, H. J., Mu, J., Ferguson, D. J. P., Llinás, M., Martin, R. E., Fidock, D. A., Cooper, R. A. & Krishna, S., Sep 30 2015, In : Scientific reports. 5, 14552.

Research output: Contribution to journalArticle

Chloroquine
Vacuoles
Parasites
Food
Mutation
15 Citations (Scopus)

New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community

Kafsack, B. F. C., Painter, H. J. & Llinás, M., Jun 12 2012, In : Malaria journal. 11, 187.

Research output: Contribution to journalArticle

Plasmodium malariae
Plasmodium berghei
Gene Expression Profiling
Plasmodium falciparum
Microarray Analysis
205 Citations (Scopus)

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq

Otto, T. D., Wilinski, D., Assefa, S., Keane, T. M., Sarry, L. R., Böhme, U., Lemieux, J., Barrell, B., Pain, A., Berriman, M., Newbold, C. & Llinás, M., Apr 2010, In : Molecular Microbiology. 76, 1, p. 12-24 13 p.

Research output: Contribution to journalArticle

Plasmodium falciparum
Transcriptome
Alternative Splicing
RNA
Parasites
34 Citations (Scopus)

Nutrient sensing modulates malaria parasite virulence

Mancio-Silva, L., Slavic, K., Grilo Ruivo, M. T., Grosso, A. R., Modrzynska, K. K., Vera, I. M., Sales-Dias, J., Gomes, A. R., Macpherson, C. R., Crozet, P., Adamo, M., Baena-Gonzalez, E., Tewari, R., Llinás, M., Billker, O. & Mota, M. M., Jul 13 2017, In : Nature. 547, 7662, p. 213-216 4 p.

Research output: Contribution to journalArticle

Malaria
Virulence
Parasites
Food
Plasmodium malariae
13 Citations (Scopus)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Antonova-Koch, Y., Meister, S., Abraham, M., Luth, M. R., Ottilie, S., Lukens, A. K., Sakata-Kato, T., Vanaerschot, M., Owen, E., Jado Rodriguez, J. C., Maher, S. P., Calla, J., Plouffe, D., Zhong, Y., Chen, K., Chaumeau, V., Conway, A. J., McNamara, C. W., Ibanez, M., Gagaring, K. & 18 others, Serrano, F. N., Eribez, K., Taggard, C. M. L., Cheung, A. L., Lincoln, C., Ambachew, B., Rouillier, M., Siegel, D., Nosten, F., Kyle, D. E., Gamo, F. J., Zhou, Y., Llinás, M., Fidock, D. A., Wirth, D. F., Burrows, J., Campo, B. & Winzeler, E. A., Dec 7 2018, In : Science. 362, 6419, eaat9446.

Research output: Contribution to journalArticle

Open Access
Antimalarials
Plasmodium
Parasitemia
Chemoprevention
Luciferases
98 Citations (Scopus)

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L. & 167 others, Bowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Rizk, M. A., Ruecker, A., St. Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N. A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. & Willis, P. A., Jul 2016, In : PLoS pathogens. 12, 7, e1005763.

Research output: Contribution to journalArticle

Neglected Diseases
Drug Discovery
Malaria
Pharmaceutical Chemistry
Information Dissemination
21 Citations (Scopus)

Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis

Llinás, M. & DeRisi, J. L., Aug 1 2004, In : Current Opinion in Microbiology. 7, 4, p. 382-387 6 p.

Research output: Contribution to journalReview article

Plasmodium falciparum
Genome
Malaria
Plasmodium
Antimalarials
10 Citations (Scopus)

PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs

Eshar, S., Altenhofen, L., Rabner, A., Ross, P., Fastman, Y., Mandel-Gutfreund, Y., Karni, R., Llinás, M. & Dzikowski, R., Jun 1 2015, In : Molecular Microbiology. 96, 6, p. 1283-1297 15 p.

Research output: Contribution to journalArticle

Alternative Splicing
Plasmodium falciparum
RNA
Parasites
Nuclear Pore
25 Citations (Scopus)

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

Storm, J., Perner, J., Aparicio, I., Patzewitz, E. M., Olszewski, K., Llinas, M., Engel, P. C. & Müller, S., Jul 26 2011, In : Malaria journal. 10, 193.

Research output: Contribution to journalArticle

Glutamate Dehydrogenase
Plasmodium falciparum
NADP
Parasites
Pharmaceutical Preparations
55 Citations (Scopus)

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

Babbitt, S. E., Altenhofen, L., Cobbold, S. A., Istvan, E. S., Fennellf, C., Doerig, C., Llinás, M. & Goldberg, D. E., Nov 20 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 47, p. E3278-E3287

Research output: Contribution to journalArticle

Plasmodium falciparum
Starvation
Isoleucine
Parasites
Amino Acids
20 Citations (Scopus)

Plasmodium gene regulation: far more to factor in

Llinás, M., Deitsch, K. W. & Voss, T. S., Dec 1 2008, In : Trends in Parasitology. 24, 12, p. 551-556 6 p.

Research output: Contribution to journalReview article

Plasmodium
Antigenic Variation
Parasites
Inventions
Genes
2 Citations (Scopus)

Plasmodium niemann-pick type C1- related protein is a druggable target required for parasite membrane homeostasis

Istvan, E. S., Das, S., Bhatnagar, S., Beck, J. R., Owen, E., Llinas, M., Ganesan, S. M., Niles, J. C., Winzeler, E., Vaidya, A. B. & Goldberg, D. E., Mar 2019, In : eLife. 8, e40529.

Research output: Contribution to journalArticle

Open Access
Plasmodium
Plasmodium falciparum
Parasites
Homeostasis
Membranes
23 Citations (Scopus)

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite

Cobbold, S. A., Santos, J. M., Ochoa, A., Perlman, D. H. & Llinas, M., Jan 27 2016, In : Scientific reports. 6, 19722.

Research output: Contribution to journalArticle

Proteome
Acetylation
Malaria
Lysine
Parasites
7 Citations (Scopus)

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Coetzee, N., Sidoli, S., Van Biljon, R., Painter, H., Llinás, M., Garcia, B. A. & Birkholtz, L. M., Dec 1 2017, In : Scientific reports. 7, 1, 607.

Research output: Contribution to journalArticle

Plasmodium falciparum
Post Translational Protein Processing
Proteomics
Histones
Chromatin
23 Citations (Scopus)

Quantitative determination of urea concentrations in cell culture medium

Zawada, R. J. X., Kwan, P., Olszewski, K. L., Llinas, M. & Huang, S. G., Jun 1 2009, In : Biochemistry and Cell Biology. 87, 3, p. 541-544 4 p.

Research output: Contribution to journalArticle

Cell culture
Culture Media
Urea
Cell Culture Techniques
Assays
97 Citations (Scopus)

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network

Plata, G., Hsiao, T. L., Olszewski, K. L., Llinás, M. & Vitkup, D., Sep 14 2010, In : Molecular Systems Biology. 6, 408.

Research output: Contribution to journalArticle

Metabolic Network
Plasmodium falciparum
Metabolic Networks and Pathways
Genes
Essential Genes
16 Citations (Scopus)

Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor

Santos, J. M., Josling, G., Ross, P., Joshi, P., Orchard, L., Campbell, T., Schieler, A., Cristea, I. M. & Llinás, M., Jun 14 2017, In : Cell Host and Microbe. 21, 6, p. 731-741.e10

Research output: Contribution to journalArticle

Malaria
Parasites
Transcription Factors
Erythrocytes
Nucleotide Motifs
11 Citations (Scopus)

Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites

Josling, G. A., Williamson, K. C. & Llinás, M., Sep 8 2018, In : Annual Review of Microbiology. 72, p. 501-519 19 p.

Research output: Contribution to journalReview article

Culicidae
Malaria
Parasites
Sex Differentiation
Sexual Development
10 Citations (Scopus)

Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana

Klein, E. Y., Lewis, I. A., Jung, C., Llinás, M. & Levin, S. A., Apr 9 2012, In : Malaria journal. 11, 110.

Research output: Contribution to journalArticle

Drug-Seeking Behavior
Ghana
Pharmaceutical Preparations
Caregivers
Therapeutics

Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinás, M., May 30 2013, In : Nature. 497, 7451, p. 652 1 p.

Research output: Contribution to journalComment/debate

45 Citations (Scopus)

Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy

Hu, G., Llinás, M., Li, J., Preiser, P. R. & Bozdech, Z., Sep 19 2007, In : BMC bioinformatics. 8, 350.

Research output: Contribution to journalArticle

Oligonucleotides
Microarrays
Gene expression
Microarray
Gene Expression
11 Citations (Scopus)

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum

Cobbold, S. A., Llinás, M. & Kirk, K., Jun 2016, In : Cellular Microbiology. 18, 6, p. 820-830 11 p., A820.

Research output: Contribution to journalArticle

Falciparum Malaria
Arginine
Parasites
Erythrocytes
Erythrocyte Deformability
70 Citations (Scopus)

Sexual development in Plasmodium parasites: Knowing when it's time to commit

Josling, G. A. & Llinas, M., Aug 14 2015, In : Nature Reviews Microbiology. 13, 9, p. 573-587 15 p.

Research output: Contribution to journalReview article

Sexual Development
Plasmodium
Parasites
Sex Differentiation
Culicidae
1 Citation (Scopus)

Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite

Turnbull, L. B., Siwo, G. H., Button-Simons, K. A., Tan, A., Checkley, L. A., Painter, H. J., Llinás, M. & Ferdig, M. T., Nov 2017, In : PloS one. 12, 11, e0187595.

Research output: Contribution to journalArticle

Gene expression
malaria
probes (equipment)
Malaria
Alternative Splicing
100 Citations (Scopus)

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Straimer, J., Lee, M. C. S., Lee, A. H., Zeitler, B., Williams, A. E., Pearl, J. R., Zhang, L., Rebar, E. J., Gregory, P. D., Llinas, M., Urnov, F. D. & Fidock, D. A., Oct 1 2012, In : Nature methods. 9, 10, p. 993-998 6 p.

Research output: Contribution to journalArticle

Zinc Fingers
Plasmodium falciparum
Zinc
Parasites
Genes
188 Citations (Scopus)

Solution structure of syrian hamster prion protein rPrP(90-231)

Liu, H., Farr-Jones, S., Ulyanov, N. B., Llinas, M., Marqusee, S., Groth, D., Cohen, F. E., Prusiner, S. B. & James, T. L., Apr 27 1999, In : Biochemistry. 38, 17, p. 5362-5377 16 p.

Research output: Contribution to journalArticle

Prion Diseases
Mesocricetus
Prions
Nuclear magnetic resonance
Scrapie
166 Citations (Scopus)

Specific DNA-binding by Apicomplexan AP2 transcription factors

De Silva, E. K., Gehrke, A. R., Olszewski, K., León, I., Chahal, J. S., Bulyk, M. L. & Llinás, M., Jun 17 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8393-8398 6 p.

Research output: Contribution to journalArticle

Transcription Factors
DNA
Proteins
Plasmodium
Parasites
7 Citations (Scopus)

Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site

Gisselberg, J. E., Herrera, Z., Orchard, L. M., Llinas, M. & Yeh, E., Feb 15 2018, In : Cell Chemical Biology. 25, 2, p. 185-193.e5

Research output: Contribution to journalArticle

Geranyltranstransferase
Farnesyltranstransferase
Diphosphonates
Antimalarials
Malaria
39 Citations (Scopus)

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

Lindner, S. E., De Silva, E. K., Keck, J. L. & Llinas, M., Jan 22 2010, In : Journal of Molecular Biology. 395, 3, p. 558-567 10 p.

Research output: Contribution to journalArticle

DNA
Plasmodium
Sporozoites
Consensus Sequence
Dimerization
53 Citations (Scopus)

Subdomain interactions as a determinant in the folding and stability of T4 lysozyme

Llinás, M. & Marqusee, S., Jan 1998, In : Protein Science. 7, 1, p. 96-104 9 p.

Research output: Contribution to journalArticle

Muramidase
Proteins
Acids
Protein Stability
Protein C
52 Citations (Scopus)

Supergenomic network compression and the discovery of exp1 as a glutathione transferase inhibited by artesunate

Lisewski, A. M., Quiros, J. P., Ng, C. L., Adikesavan, A. K., Miura, K., Putluri, N., Eastman, R. T., Scanfeld, D., Regenbogen, S. J., Altenhofen, L., Llinás, M., Sreekumar, A., Long, C., Fidock, D. A. & Lichtarge, O., Aug 14 2014, In : Cell. 158, 4, p. 916-928 13 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Genes
Hemin
Antimalarials
Plasmodium falciparum
20 Citations (Scopus)

Targeting NAD + metabolism in the human malaria parasite Plasmodium falciparum

O'Hara, J. K., Kerwin, L. J., Cobbold, S. A., Tai, J., Bedell, T. A., Reider, P. J. & Llinás, M., Apr 18 2014, In : PloS one. 9, 4, e94061.

Research output: Contribution to journalArticle

Falciparum Malaria
NAD (coenzyme)
Plasmodium falciparum
Metabolism
NAD
112 Citations (Scopus)

The Apicomplexan AP2 family: Integral factors regulating Plasmodium development

Painter, H. J., Campbell, T. L. & Llinás, M., Mar 1 2011, In : Molecular and biochemical parasitology. 176, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Plasmodium
Parasites
Malaria
Proteins
DNA-Binding Proteins
15 Citations (Scopus)

The Cryptosporidium parvum ApiAP2 gene family: Insights into the evolution of apicomplexan AP2 regulatory systems

Oberstaller, J., Pumpalova, Y., Schieler, A., Llinás, M. & Kissinger, J. C., 2014, In : Nucleic acids research. 42, 13, p. 8271-8284 14 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Genes
E2F Transcription Factors
Regulon
Cryptosporidium
101 Citations (Scopus)

The energetics of T4 lysozyme reveal a hierarchy of conformations

Llinas, M., Gillespie, B., Dahlquist, F. W. & Marqusee, S., Nov 17 1999, In : Nature Structural Biology. 6, 11, p. 1072-1078 7 p.

Research output: Contribution to journalArticle

Muramidase
Conformations
Protein Folding
Proteins
Mirrors
1 Citation (Scopus)

The g9a histone methyltransferase inhibitor BIX-01294 modulates gene expression during plasmodium falciparum gametocyte development and transmission

Ngwa, C. J., Kiesow, M. J., Orchard, L. M., Farrukh, A., Llinás, M. & Pradel, G., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5087.

Research output: Contribution to journalArticle

Open Access
gametocytes
Methylation
gene expression
Plasmodium falciparum
Gene expression
12 Citations (Scopus)

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast

Lindner, S. E., Llinas, M., Keck, J. L. & Kappe, S. H. I., Dec 1 2011, In : Molecular and biochemical parasitology. 180, 2, p. 69-75 7 p.

Research output: Contribution to journalArticle

Apicoplasts
DNA Primase
Parasites
DNA Replication
Enzymes
1112 Citations (Scopus)

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

Bozdech, Z., Llinás, M., Pulliam, B. L., Wong, E. D., Zhu, J. & DeRisi, J. L., Dec 1 2003, In : PLoS biology. 1, 1

Research output: Contribution to journalArticle

Plasmodium falciparum
Transcriptome
transcriptome
Genes
genes
5 Citations (Scopus)

Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum

Ngwa, C. J., Kiesow, M. J., Papst, O., Orchard, L. M., Filarsky, M., Rosinski, A. N., Voss, T. S., Llinás, M. & Pradel, G., Jul 24 2017, In : Frontiers in Cellular and Infection Microbiology. 7, JUL, 320.

Research output: Contribution to journalArticle

Falciparum Malaria
Regulator Genes
Acetylation
Culicidae
Histones
15 Citations (Scopus)

Using context to improve protein domain identification

Ochoa, A., Llinás, M. & Singh, M., Apr 4 2011, In : BMC bioinformatics. 12, 90.

Research output: Contribution to journalArticle

Genome
Proteins
Protein
Falciparum Malaria
Licensure
11 Citations (Scopus)

Whole-genome analysis of plasmodium spp. Utilizing a new agilent technologies DNA microarray platform

Painter, H. J., Altenhofen, L. M., Kafsack, B. F. C. & Llinás, M., 2013, Malaria: Methods and Protocols. Humana Press Inc., p. 213-219 7 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasmodium
Oligonucleotide Array Sequence Analysis
Genome
Technology
Oligonucleotide Probes