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Research Output 1995 2019

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Article
2019
2 Citations (Scopus)

Identifying the Components of Acidosis in Patients with Severe Plasmodium falciparum Malaria Using Metabolomics

Leopold, S. J., Ghose, A., Allman, E. L., Kingston, H. W. F., Hossain, A., Dutta, A. K., Plewes, K., Chotivanich, K., Day, N. P. J., Tarning, J., Winterberg, M., White, N. J., Llinas, M. & Dondorp, A. M., Jun 1 2019, In : Journal of Infectious Diseases. 219, 11, p. 1766-1776 11 p.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Falciparum Malaria
Acidosis
Acids
Malaria
1 Citation (Scopus)

Plasmodium niemann-pick type C1- related protein is a druggable target required for parasite membrane homeostasis

Istvan, E. S., Das, S., Bhatnagar, S., Beck, J. R., Owen, E., Llinas, M., Ganesan, S. M., Niles, J. C., Winzeler, E., Vaidya, A. B. & Goldberg, D. E., Mar 2019, In : eLife. 8, e40529.

Research output: Contribution to journalArticle

Open Access
Plasmodium
Plasmodium falciparum
Parasites
Homeostasis
Membranes

The g9a histone methyltransferase inhibitor BIX-01294 modulates gene expression during plasmodium falciparum gametocyte development and transmission

Ngwa, C. J., Kiesow, M. J., Orchard, L. M., Farrukh, A., Llinás, M. & Pradel, G., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5087.

Research output: Contribution to journalArticle

Open Access
gametocytes
Methylation
gene expression
Plasmodium falciparum
Gene expression
2018
1 Citation (Scopus)

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum

Bennink, S., von Bohl, A., Ngwa, C. J., Henschel, L., Kuehn, A., Pilch, N., Weißbach, T., Rosinski, A. N., Scheuermayer, M., Repnik, U., Przyborski, J. M., Minns, A. M., Orchard, L. M., Griffiths, G., Lindner, S. E., Llinas, M. & Pradel, G., Aug 1 2018, In : PLoS Pathogens. 14, 8, e1007249.

Research output: Contribution to journalArticle

Plasmodium falciparum
Heat-Shock Proteins
Culicidae
Parasites
Proteins
4 Citations (Scopus)

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Lee, A. H., Dhingra, S. K., Lewis, I. A., Singh, M. K., Siriwardana, A., Dalal, S., Rubiano, K., Klein, M. S., Baska, K. S., Krishna, S., Klemba, M., Roepe, P. D., Llinas, M., Garcia, C. R. S. & Fidock, D. A., Dec 1 2018, In : Scientific reports. 8, 1, 13578.

Research output: Contribution to journalArticle

Parasites
Hemoglobins
Amodiaquine
Protein Isoforms
Chloroquine
11 Citations (Scopus)

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Painter Ponton, H. J., Chung, N. C., Sebastian, A., Albert, I., Storey, J. D. & Llinas, M., Dec 1 2018, In : Nature communications. 9, 1, 2656.

Research output: Contribution to journalArticle

genome
Plasmodium falciparum
blood
Blood
Genes
2 Citations (Scopus)

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii

Shukla, A., Olszewski, K. L., Llinas, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Xia, D., Wastling, J., Beiting, D., Roos, D. S. & Shanmugam, D., Oct 1 2018, In : International Journal for Parasitology. 48, 12, p. 955-968 14 p.

Research output: Contribution to journalArticle

Toxoplasma
Glycolysis
Cysts
Parasites
Growth
4 Citations (Scopus)

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

van Biljon, R., Niemand, J., van Wyk, R., Clark, K., Verlinden, B., Abrie, C., von Grüning, H., Smidt, W., Smit, A., Reader, J., Painter Ponton, H. J., Llinas, M., Doerig, C. & Birkholtz, L. M., Dec 1 2018, In : Scientific reports. 8, 1, 16581.

Research output: Contribution to journalArticle

Falciparum Malaria
Cell Cycle Checkpoints
Cell Cycle
Parasites
Malaria
3 Citations (Scopus)

Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy

Aronson, M. R., Simonson, A. W., Orchard, L. M., Llinas, M. & Medina, S. H., Oct 15 2018, In : Acta Biomaterialia. 80, p. 269-277 9 p.

Research output: Contribution to journalArticle

Peptides
Cells
Lipids
Neoplasms
Membranes
39 Citations (Scopus)

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Cowell, A. N., Istvan, E. S., Lukens, A. K., Gomez-Lorenzo, M. G., Vanaerschot, M., Sakata-Kato, T., Flannery, E. L., Magistrado, P., Owen, E., Abraham, M., La Monte, G., Painter, H. J., Williams, R. M., Franco, V., Linares, M., Arriaga, I., Bopp, S., Corey, V. C., Gnädig, N. F., Coburn-Flynn, O. & 24 others, Reimer, C., Gupta, P., Murithi, J. M., Moura, P. A., Fuchs, O., Sasaki, E., Kim, S. W., Teng, C. H., Wang, L. T., Akidil, A., Adjalley, S., Willis, P. A., Siegel, D., Tanaseichuk, O., Zhong, Y., Zhou, Y., Llinás, M., Ottilie, S., Gamo, F. J., Lee, M. C. S., Goldberg, D. E., Fidock, D. A., Wirth, D. F. & Winzeler, E. A., Jan 12 2018, In : Science. 359, 6372, p. 191-199 9 p.

Research output: Contribution to journalArticle

Malaria
Parasites
Gene Amplification
Genome
Plasmodium falciparum
11 Citations (Scopus)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Antonova-Koch, Y., Meister, S., Abraham, M., Luth, M. R., Ottilie, S., Lukens, A. K., Sakata-Kato, T., Vanaerschot, M., Owen, E., Jado Rodriguez, J. C., Maher, S. P., Calla, J., Plouffe, D., Zhong, Y., Chen, K., Chaumeau, V., Conway, A. J., McNamara, C. W., Ibanez, M., Gagaring, K. & 18 others, Serrano, F. N., Eribez, K., Taggard, C. M. L., Cheung, A. L., Lincoln, C., Ambachew, B., Rouillier, M., Siegel, D., Nosten, F., Kyle, D. E., Gamo, F. J., Zhou, Y., Llinás, M., Fidock, D. A., Wirth, D. F., Burrows, J., Campo, B. & Winzeler, E. A., Dec 7 2018, In : Science. 362, 6419, eaat9446.

Research output: Contribution to journalArticle

Open Access
Antimalarials
Plasmodium
Parasitemia
Chemoprevention
Luciferases
5 Citations (Scopus)

Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site

Gisselberg, J. E., Herrera, Z., Orchard, L. M., Llinas, M. & Yeh, E., Feb 15 2018, In : Cell Chemical Biology. 25, 2, p. 185-193.e5

Research output: Contribution to journalArticle

Geranyltranstransferase
Farnesyltranstransferase
Diphosphonates
Antimalarials
Malaria
2017
13 Citations (Scopus)

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum

Painter, H. J., Carrasquilla, M. & Llinás, M., Jun 2017, In : Genome research. 27, 6, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

Falciparum Malaria
Parasites
RNA
Messenger RNA
Pyrimidines
11 Citations (Scopus)

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

Shears, M. J., MacRae, J. I., Mollard, V., Goodman, C. D., Sturm, A., Orchard, L. M., Llinas, M., McConville, M. J., Botté, C. Y. & McFadden, G. I., Jan 1 2017, In : Cellular Microbiology. 19, 1, e12633.

Research output: Contribution to journalArticle

Apicoplasts
Acyltransferases
Plasmodium falciparum
Plasmodium berghei
Malaria
31 Citations (Scopus)

Nutrient sensing modulates malaria parasite virulence

Mancio-Silva, L., Slavic, K., Grilo Ruivo, M. T., Grosso, A. R., Modrzynska, K. K., Vera, I. M., Sales-Dias, J., Gomes, A. R., Macpherson, C. R., Crozet, P., Adamo, M., Baena-Gonzalez, E., Tewari, R., Llinás, M., Billker, O. & Mota, M. M., Jul 13 2017, In : Nature. 547, 7662, p. 213-216 4 p.

Research output: Contribution to journalArticle

Malaria
Virulence
Parasites
Food
Plasmodium malariae
6 Citations (Scopus)

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Coetzee, N., Sidoli, S., Van Biljon, R., Painter, H., Llinás, M., Garcia, B. A. & Birkholtz, L. M., Dec 1 2017, In : Scientific reports. 7, 1, 607.

Research output: Contribution to journalArticle

Plasmodium falciparum
Post Translational Protein Processing
Proteomics
Histones
Chromatin
14 Citations (Scopus)

Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor

Santos, J. M., Josling, G., Ross, P., Joshi, P., Orchard, L., Campbell, T., Schieler, A., Cristea, I. M. & Llinas, M., Jun 14 2017, In : Cell Host and Microbe. 21, 6, p. 731-741.e10

Research output: Contribution to journalArticle

Malaria
Parasites
Transcription Factors
Erythrocytes
Nucleotide Motifs
1 Citation (Scopus)

Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite

Turnbull, L. B., Siwo, G. H., Button-Simons, K. A., Tan, A., Checkley, L. A., Painter, H. J., Llinás, M. & Ferdig, M. T., Nov 2017, In : PloS one. 12, 11, e0187595.

Research output: Contribution to journalArticle

Gene expression
malaria
probes (equipment)
Malaria
Alternative Splicing
3 Citations (Scopus)

Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum

Ngwa, C. J., Kiesow, M. J., Papst, O., Orchard, L. M., Filarsky, M., Rosinski, A. N., Voss, T. S., Llinás, M. & Pradel, G., Jul 24 2017, In : Frontiers in Cellular and Infection Microbiology. 7, JUL, 320.

Research output: Contribution to journalArticle

Falciparum Malaria
Regulator Genes
Acetylation
Culicidae
Histones
2016
13 Citations (Scopus)

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Gabryszewski, S. J., Dhingra, S. K., Combrinck, J. M., Lewis, I. A., Callaghan, P. S., Hassett, M. R., Siriwardana, A., Henrich, P. P., Lee, A. H., Gnädig, N. F., Musset, L., Llinás, M., Egan, T. J., Roepe, P. D. & Fidock, D. A., Nov 1 2016, In : PLoS pathogens. 12, 11, e1005976.

Research output: Contribution to journalArticle

Digestive System Physiological Phenomena
Vacuoles
Drug Resistance
Parasites
Chloroquine
32 Citations (Scopus)

Metabolomic profiling of the Malaria Box reveals antimalarial target pathways

Allman, E. L., Painter Ponton, H. J., Samra, J., Carrasquilla, M. & Llinas, M., Nov 1 2016, In : Antimicrobial agents and chemotherapy. 60, 11, p. 6635-6643 9 p.

Research output: Contribution to journalArticle

Metabolomics
Antimalarials
Malaria
Parasites
Pharmaceutical Preparations
93 Citations (Scopus)

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Alemán Resto, Y., Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L. & 167 others, Bowling, T., Bosch, J., Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Belen Cassera, M., Chih-Chien Cheng, K., Chindaudomsate, W., Chubb, A., Colon, B. L., Colón-López, D. D., Corbett, Y., Crowther, G. J., Cowan, N., D’Alessandro, S., Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., Abd El-Salam El-Sayed, S., Ferdig, M. T., Fernández Robledo, J. A., Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. J., Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., Guiguemde, W. A., Gural, N., Guy, R. K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., Hooft van Huijsduijnen, R., Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Naranuntarat Jensen, A., Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. J., Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., Llinás, M., Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Medina Vera, I., Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., Morais Rodrigues da Costa, F., Müller, J., Muriana, A., Nakazawa Hewitt, S., Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Rizk, M. A., Ruecker, A., St. Onge, R., Salgado Ferreira, R., Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Silva Villela, F., Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., Spitzmüller, A., Stamm, S. M., Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., Swamidass, S. J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Voong Vinh, P., Vu, H., Watanabe, N. A., Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, B., Leroy, D., Spangenberg, T., Wells, T. & Willis, P. A., Jul 2016, In : PLoS pathogens. 12, 7, e1005763.

Research output: Contribution to journalArticle

Neglected Diseases
Drug Discovery
Malaria
Pharmaceutical Chemistry
Information Dissemination
22 Citations (Scopus)

Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite

Cobbold, S. A., Santos, J. M., Ochoa, A., Perlman, D. H. & Llinas, M., Jan 27 2016, In : Scientific reports. 6, 19722.

Research output: Contribution to journalArticle

Proteome
Acetylation
Malaria
Lysine
Parasites
11 Citations (Scopus)

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum

Cobbold, S. A., Llinas, M. & Kirk, K., Jun 1 2016, In : Cellular Microbiology. 18, 6, p. 820-830 11 p., A820.

Research output: Contribution to journalArticle

Falciparum Malaria
Arginine
Parasites
Erythrocytes
Erythrocyte Deformability
2015
6 Citations (Scopus)

Beyond the E-Value: Stratified Statistics for Protein Domain Prediction

Ochoa, A., Storey, J. D., Llinás, M. & Singh, M., Nov 2015, In : PLoS computational biology. 11, 11, e1004509.

Research output: Contribution to journalArticle

statistics
Statistics
Proteins
Protein
protein
54 Citations (Scopus)

Genetic investigation of tricarboxylic acid metabolism during the plasmodium falciparum life cycle

Ke, H., Lewis, I. A., Morrisey, J. M., McLean, K. J., Ganesan, S. M., Painter Ponton, H. J., Mather, M. W., Jacobs-Lorena, M., Llinas, M. & Vaidya, A. B., Apr 7 2015, In : Cell Reports. 11, 1, p. 164-174 11 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Plasmodium falciparum
Life Cycle Stages
Metabolism
Life cycle
8 Citations (Scopus)

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

Adjalley, S. H., Scanfeld, D., Kozlowski, E., Llinás, M. & Fidock, D. A., Dec 21 2015, In : BMC genomics. 16, 1, 1090.

Research output: Contribution to journalArticle

Gene Expression Profiling
Plasmodium falciparum
Vacuoles
Drug Resistance
Genome
21 Citations (Scopus)

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

Pulcini, S., Staines, H. M., Lee, A. H., Shafik, S. H., Bouyer, G., Moore, C. M., Daley, D. A., Hoke, M. J., Altenhofen, L. M., Painter, H. J., Mu, J., Ferguson, D. J. P., Llinás, M., Martin, R. E., Fidock, D. A., Cooper, R. A. & Krishna, S., Sep 30 2015, In : Scientific reports. 5, 14552.

Research output: Contribution to journalArticle

Chloroquine
Vacuoles
Parasites
Food
Mutation
10 Citations (Scopus)

PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs

Eshar, S., Altenhofen, L., Rabner, A., Ross, P., Fastman, Y., Mandel-Gutfreund, Y., Karni, R., Llinás, M. & Dzikowski, R., Jun 1 2015, In : Molecular Microbiology. 96, 6, p. 1283-1297 15 p.

Research output: Contribution to journalArticle

Alternative Splicing
Plasmodium falciparum
RNA
Parasites
Nuclear Pore
2014
158 Citations (Scopus)

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Sinha, A., Hughes, K. R., Modrzynska, K. K., Otto, T. D., Pfander, C., Dickens, N. J., Religa, A. A., Bushell, E., Graham, A. L., Cameron, R., Kafsack, B. F. C., Williams, A. E., Llinas, M., Berriman, M., Billker, O. & Waters, A. P., Jan 1 2014, In : Nature. 507, 7491, p. 253-257 5 p.

Research output: Contribution to journalArticle

Sexual Development
Plasmodium
DNA-Binding Proteins
Parasites
Malaria
86 Citations (Scopus)

A Plasmodium falciparum Histone Deacetylase regulates antigenic variation and gametocyte conversion

Coleman, B. I., Skillman, K. M., Jiang, R. H. Y., Childs, L. M., Altenhofen, L. M., Ganter, M., Leung, Y., Goldowitz, I., Kafsack, B. F. C., Marti, M., Llinas, M., Buckee, C. O. & Duraisingh, M. T., Aug 13 2014, In : Cell Host and Microbe. 16, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

Antigenic Variation
Histone Deacetylases
Plasmodium falciparum
Histone Deacetylase 2
Virulence
162 Citations (Scopus)

A transcriptional switch underlies commitment to sexual development in malaria parasites

Kafsack, B. F. C., Rovira-Graells, N., Clark, T. G., Bancells, C., Crowley, V. M., Campino, S. G., Williams, A. E., Drought, L. G., Kwiatkowski, D. P., Baker, D. A., Cortés, A. & Llinas, M., Jan 1 2014, In : Nature. 507, 7491, p. 248-252 5 p.

Research output: Contribution to journalArticle

Sexual Development
Malaria
Parasites
Plasmodium malariae
Reverse Genetics
8 Citations (Scopus)

Cross-reactive immune responses as primary drivers of malaria chronicity

Klein, E. Y., Graham, A. L., Llinas, M. & Levin, S., Jan 1 2014, In : Infection and Immunity. 82, 1, p. 140-151 12 p.

Research output: Contribution to journalArticle

Malaria
Infection
Parasites
Antigenic Variation
Immune System
42 Citations (Scopus)

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

Lewis, I. A., Wacker, M., Olszewski, K. L., Cobbold, S. A., Baska, K. S., Tan, A., Ferdig, M. T. & Llinás, M., Jan 1 2014, In : PLoS genetics. 10, 1, e1004085.

Research output: Contribution to journalArticle

chloroquine
catabolism
Chloroquine
Plasmodium falciparum
hemoglobin
50 Citations (Scopus)

Supergenomic network compression and the discovery of exp1 as a glutathione transferase inhibited by artesunate

Lisewski, A. M., Quiros, J. P., Ng, C. L., Adikesavan, A. K., Miura, K., Putluri, N., Eastman, R. T., Scanfeld, D., Regenbogen, S. J., Altenhofen, L., Llinas, M., Sreekumar, A., Long, C., Fidock, D. A. & Lichtarge, O., Aug 14 2014, In : Cell. 158, 4, p. 916-928 13 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Genes
Hemin
Antimalarials
Plasmodium falciparum
20 Citations (Scopus)

Targeting NAD + metabolism in the human malaria parasite Plasmodium falciparum

O'Hara, J. K., Kerwin, L. J., Cobbold, S. A., Tai, J., Bedell, T. A., Reider, P. J. & Llinás, M., Apr 18 2014, In : PloS one. 9, 4, e94061.

Research output: Contribution to journalArticle

Falciparum Malaria
NAD (coenzyme)
Plasmodium falciparum
Metabolism
NAD
15 Citations (Scopus)

The Cryptosporidium parvum ApiAP2 gene family: Insights into the evolution of apicomplexan AP2 regulatory systems

Oberstaller, J., Pumpalova, Y., Schieler, A., Llinás, M. & Kissinger, J. C., 2014, In : Nucleic acids research. 42, 13, p. 8271-8284 14 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Genes
E2F Transcription Factors
Regulon
Cryptosporidium
2013
16 Citations (Scopus)

A new system for comparative functional genomics of Saccharomyces yeasts

Caudy, A. A., Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., Scott Breunig, J., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A. & 54 others, Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. H. H., Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G. & Dunham, M. J., Sep 17 2013, In : Genetics. 195, 1, p. 275-287 13 p.

Research output: Contribution to journalArticle

Saccharomyces
Genomics
Yeasts
Genes
Genome
48 Citations (Scopus)

ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Radke, J. B., Lucas, O., De Silva, E. K., Ma, Y., Sullivan, W. J., Weiss, L. M., Llinas, M. & White, M. W., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 6871-6876 6 p.

Research output: Contribution to journalArticle

Transcription Factor AP-2
Toxoplasma
Cysts
Antigens
Messenger RNA
35 Citations (Scopus)

Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites

Mira-Martínez, S., Rovira-Graells, N., Crowley, V. M., Altenhofen, L. M., Llinás, M. & Cortés, A., Nov 1 2013, In : Cellular Microbiology. 15, 11, p. 1913-1923 11 p.

Research output: Contribution to journalArticle

Epigenomics
Malaria
Parasites
Poisons
Gene Expression
39 Citations (Scopus)

Kinetic flux profiling elucidates two independent acetyl-coa biosynthetic pathways in plasmodium falciparum

Cobbold, S. A., Vaughan, A. M., Lewis, I. A., Painter, H. J., Camargo, N., Perlman, D. H., Fishbaugher, M., Healer, J., Cowman, A. F., Kappe, S. H. I. & Llinás, M., Dec 20 2013, In : Journal of Biological Chemistry. 288, 51, p. 36338-36350 13 p.

Research output: Contribution to journalArticle

Acetyl Coenzyme A
Biosynthetic Pathways
Plasmodium falciparum
Fluxes
Parasites
2012
53 Citations (Scopus)

A tetracycline-repressible transactivator system to study essential genes in malaria parasites

Pino, P., Sebastian, S., Kim, E. A., Bush, E., Brochet, M., Volkmann, K., Kozlowski, E., Llinas, M., Billker, O. & Soldati-Favre, D., Dec 13 2012, In : Cell Host and Microbe. 12, 6, p. 824-834 11 p.

Research output: Contribution to journalArticle

Trans-Activators
Essential Genes
Tetracycline
Malaria
Parasites
14 Citations (Scopus)

New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community

Kafsack, B. F. C., Painter Ponton, H. J. & Llinas, M., Jun 12 2012, In : Malaria journal. 11, 187.

Research output: Contribution to journalArticle

Plasmodium malariae
Plasmodium berghei
Gene Expression Profiling
Plasmodium falciparum
Microarray Analysis
53 Citations (Scopus)

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

Babbitt, S. E., Altenhofen, L., Cobbold, S. A., Istvan, E. S., Fennellf, C., Doerig, C., Llinás, M. & Goldberg, D. E., Nov 20 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 47, p. E3278-E3287

Research output: Contribution to journalArticle

Plasmodium falciparum
Starvation
Isoleucine
Parasites
Amino Acids
10 Citations (Scopus)

Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana

Klein, E. Y., Lewis, I. A., Jung, C., Llinas, M. & Levin, S. A., Apr 9 2012, In : Malaria Journal. 11, 110.

Research output: Contribution to journalArticle

Drug-Seeking Behavior
Ghana
Pharmaceutical Preparations
Caregivers
Therapeutics
96 Citations (Scopus)

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Straimer, J., Lee, M. C. S., Lee, A. H., Zeitler, B., Williams, A. E., Pearl, J. R., Zhang, L., Rebar, E. J., Gregory, P. D., Llinas, M., Urnov, F. D. & Fidock, D. A., Oct 1 2012, In : Nature methods. 9, 10, p. 993-998 6 p.

Research output: Contribution to journalArticle

Zinc Fingers
Plasmodium falciparum
Zinc
Parasites
Genes
2011
25 Citations (Scopus)

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

Storm, J., Perner, J., Aparicio, I., Patzewitz, E. M., Olszewski, K., Llinas, M., Engel, P. C. & Müller, S., Jul 26 2011, In : Malaria journal. 10, 193.

Research output: Contribution to journalArticle

Glutamate Dehydrogenase
Plasmodium falciparum
NADP
Parasites
Pharmaceutical Preparations
12 Citations (Scopus)

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast

Lindner, S. E., Llinas, M., Keck, J. L. & Kappe, S. H. I., Dec 1 2011, In : Molecular and biochemical parasitology. 180, 2, p. 69-75 7 p.

Research output: Contribution to journalArticle

Apicoplasts
DNA Primase
Parasites
DNA Replication
Enzymes
15 Citations (Scopus)

Using context to improve protein domain identification

Ochoa, A., Llinás, M. & Singh, M., Apr 4 2011, In : BMC bioinformatics. 12, 90.

Research output: Contribution to journalArticle

Genome
Proteins
Protein
Falciparum Malaria
Licensure
2010
97 Citations (Scopus)

Branched tricarboxylic acid metabolism in Plasmodium falciparum

Olszewski, K. L., Mather, M. W., Morrisey, J. M., Garcia, B. A., Vaidya, A. B., Rabinowitz, J. D. & Llinas, M., Aug 5 2010, In : Nature. 466, 7307, p. 774-778 5 p.

Research output: Contribution to journalArticle

Tricarboxylic Acids
Plasmodium falciparum
Acetyl Coenzyme A
Parasites
Carbon