Mark Hedglin, PhD

Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Huck Institutes of the Life Sciences
Penn State Cancer Institute
Cancer Institute, Mechanisms of Carcinogenesis

Source: Scopus
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1 Finished

Polymerase Switching During Translesion DNA Synthesis within the Human System
Hedglin, M., HEDGLIN, M. & HEDGLIN, M.
National Cancer Institute
9/1/12 → 8/31/15
Project: Research project

498 Citations
10 h-Index
16 Article
1 Review article

Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA
Li, M., Larsen, L. & Hedglin, M., Feb 4 2020, In : Biochemistry. 59, 4, p. 407-416 10 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase
Shin, Y., Hedglin, M. & Murakami, K. S., Feb 28 2020, In : Nucleic acids research. 48, 4, p. 2144-2155 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch
Gaubitz, C., Liu, X., Magrino, J., Stone, N. P., Landeck, J., Hedglin, M. & Kelch, B. A., Sep 22 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23571-23580 10 p.
Research output: Contribution to journal › Article › peer-review
Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen
Hedglin, M., Aitha, M., Pedley, A. & Benkovic, S. J., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5157-5168 12 p.
Research output: Contribution to journal › Article › peer-review
8 Scopus citations
Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle
Hedglin, M. & Benkovic, S. J., Jun 28 2017, In : Chemical Reviews. 117, 12, p. 7857-7877 21 p.
Research output: Contribution to journal › Review article › peer-review
21 Scopus citations

Polymerase Switching During Translesion DNA Synthesis within the Human System

Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase

Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle