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Research Output 2007 2019

  • 435 Citations
  • 10 h-Index
  • 13 Article
  • 1 Review article
2007
135 Citations (Scopus)

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

KrennHrubec, K., Marshall, B. L., Hedglin, M., Verdin, E. & Ulrich, S. M., May 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 10, p. 2874-2878 5 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Catalytic Domain
Scaffolds
Inhibitory Concentration 50
2008
44 Citations (Scopus)

Human alkyladenine DNA glycosylase employs a processive search for DNA damage

Hedglin, M. & O'Brien, P. J., Nov 4 2008, In : Biochemistry. 47, 44, p. 11434-11445 12 p.

Research output: Contribution to journalArticle

3-methyladenine-DNA glycosylase
DNA Damage
DNA
Repair
DNA Repair
2010
45 Citations (Scopus)

Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein

Hedglin, M. & O'Brien, P. J., Apr 16 2010, In : ACS chemical biology. 5, 4, p. 427-436 10 p.

Research output: Contribution to journalArticle

3-methyladenine-DNA glycosylase
DNA Glycosylases
DNA Repair
Repair
DNA
2013
21 Citations (Scopus)

Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase

Hedglin, M., Zhang, Y. & O'Brien, P. J., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24550-24559 10 p.

Research output: Contribution to journalArticle

3-methyladenine-DNA glycosylase
DNA
Facilitated Diffusion
Assays
Binding Sites
47 Citations (Scopus)

Replication clamps and clamp loaders

Hedglin, M., Kumar, R. & Benkovic, S. J., Apr 1 2013, In : Cold Spring Harbor Perspectives in Biology. 5, 4, p. 1-19 19 p.

Research output: Contribution to journalArticle

Loaders
Clamping devices
DNA
Bacteriophage T4
DNA-Directed DNA Polymerase
16 Citations (Scopus)

Stepwise assembly of the human replicative polymerase holoenzyme

Hedglin, M., Perumal, S. K., Hu, Z. & Benkovic, S., Apr 2 2013, In : eLife. 2013, 2, e00278.

Research output: Contribution to journalArticle

Holoenzymes
Proliferating Cell Nuclear Antigen
Clamping devices
DNA
Loaders
2015
8 Citations (Scopus)

Probing the DNA structural requirements for facilitated diffusion

Hedglin, M., Zhang, Y. & O'Brien, P. J., Jan 20 2015, In : Biochemistry. 54, 2, p. 557-566 10 p.

Research output: Contribution to journalArticle

3-methyladenine-DNA glycosylase
Facilitated Diffusion
Single-Stranded DNA
DNA
Nucleotides
39 Citations (Scopus)

Regulation of Rad6/Rad18 Activity during DNA Damage Tolerance

Hedglin, M. & Benkovic, S., Jun 22 2015, In : Annual Review of Biophysics. 44, p. 207-228 22 p.

Research output: Contribution to journalArticle

Damage tolerance
DNA Damage
DNA
Proliferating Cell Nuclear Antigen
Ubiquitin
2016
22 Citations (Scopus)

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

Hedglin, M., Pandey, B. & Benkovic, S. J., Oct 22 2016, In : eLife. 5, OCTOBER2016, e19788.

Research output: Contribution to journalArticle

DNA
Proliferating Cell Nuclear Antigen
DNA-Directed DNA Polymerase
Ubiquitination
Post Translational Protein Processing
28 Citations (Scopus)
Holoenzymes
Proliferating Cell Nuclear Antigen
DNA
Saccharomyces
Recycling
2017
16 Citations (Scopus)

Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle

Hedglin, M. & Benkovic, S., Jun 28 2017, In : Chemical Reviews. 117, 12, p. 7857-7877 21 p.

Research output: Contribution to journalReview article

DNA
Damage tolerance
Cells
Cell death
DNA-Directed DNA Polymerase
4 Citations (Scopus)

Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA

Hedglin, M., Aitha, M. & Benkovic, S., Jul 11 2017, In : Biochemistry. 56, 27, p. 3415-3421 7 p.

Research output: Contribution to journalArticle

Single-Stranded DNA
Proliferating Cell Nuclear Antigen
Monitoring
DNA
Proteins
9 Citations (Scopus)

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

Hedglin, M. & Benkovic, S., Apr 4 2017, In : Biochemistry. 56, 13, p. 1824-1835 12 p.

Research output: Contribution to journalArticle

Replication Protein A
Single-Stranded DNA
Clamping devices
Proliferating Cell Nuclear Antigen
DNA
2019
1 Citation (Scopus)

Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen

Hedglin, M., Aitha, M., Pedley, A. & Benkovic, S. J., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5157-5168 12 p.

Research output: Contribution to journalArticle

Replication Protein A
Proliferating Cell Nuclear Antigen
DNA
Post Translational Protein Processing
DNA Replication