Mark Meadowcroft, PhD

    • 344 Citations
    • 8 h-Index
    20042018
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    Personal profile

    Research interests

    Dr. Mark Meadowcroft’s research focus revolves around the translational usage of in vivo and ex vivo imaging of clinical and preclinical transgenic animal models to study and develop potential treatments and/or biomarkers of neurological diseases and conditions.

    His laboratory is currently undertaking clinical and preclinical studies involving murine (mouse and rat) and lagomorph (rabbit) animal models as well as post-mortem imaging in the study of normal aging, Alzheimer’s disease, Parkinson’s disease, ALS and neurovascular processes. Their multi-model approach tailors the usage of quantitative MRI relaxometry, diffusion, contrast-enhanced and functional metrics paired with genetic, biochemical, histological and molecular technologies to aid in understanding the neurodegenerative disease process to develop biomarker and treatment strategies.

    Dr. Meadowcroft's expertise leverages application of translational neuroimaging techniques coupled with an understanding of the histo-pathological basis of magnetic resonance imaging metrics and genomics and their association to various neurological and neurodegenerative processes. Magnetic resonance imaging has emerged as a powerful tool for soft-tissue imaging of static and time-sensitive biological events in real time, allowing the exploration of novel medical techniques. The aim is to further enhance our understanding of genomics and molecular/biological interactions in neurodegenerative processes and move forward testing and validation of innovative therapeutic strategies. Through this approach, a relationship between MR imaging parametrics, molecular processes, genetics and biochemical histological standards can be ascribed to disease state.

     

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    Projects 2014 2017

    Alzheimer Disease
    Magnetic Resonance Imaging
    Amyloid Plaques
    Disease Progression
    Research

    Research Output 2004 2018

    • 344 Citations
    • 8 h-Index
    • 14 Article
    • 1 Comment/debate
    • 1 Review article
    2 Citations (Scopus)

    Dietary lipophilic iron accelerates regional brain iron-load in C57BL6 mice

    Peters, D. G., Purnell, C. J., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Apr 1 2018, In : Brain Structure and Function. 223, 3, p. 1519-1536 18 p.

    Research output: Contribution to journalArticle

    Dietary Iron
    Iron
    Brain
    Apoferritins
    Diet
    6 Citations (Scopus)

    Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

    Peters, D. G., Pollack, A. N., Cheng, K., Sun, D., Saido, T., Haaf, M. P., Yang, Q., Connor, J. & Meadowcroft, M., Mar 1 2018, In : Metallomics. 10, 3, p. 426-443 18 p.

    Research output: Contribution to journalArticle

    Dietary Iron
    Alzheimer Disease
    Iron
    Brain
    Amyloid

    Gamma Knife radiosurgery of saccular aneurysms in a rabbit model

    Meadowcroft, M., Cooper, T. K., Rupprecht, S., Wright, T. C., Neely, E. E., Ferenci, M., Kang, W., Yang, Q. X., Harbaugh, R., Connor, J. & McInerney, J., Dec 1 2018, In : Journal of neurosurgery. 129, 6, p. 1530-1540 11 p.

    Research output: Contribution to journalArticle

    Radiosurgery
    Aneurysm
    Rabbits
    Rupture
    Arteriovenous Malformations
    1 Citation (Scopus)

    HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity

    Nixon, A. M., Meadowcroft, M., Neely, E. B., Snyder, A., Purnell, C. J., Wright, J., Lamendella, R., Nandar, W., Huang, X. & Connor, J., May 1 2018, In : Journal of neurochemistry. 145, 4, p. 299-311 13 p.

    Research output: Contribution to journalArticle

    Paraquat
    Genotype
    Substantia Nigra
    Tyrosine 3-Monooxygenase
    Iron

    Reduced Cerebral White Matter Integrity Assessed by DTI in Cognitively Normal H63D-HFE Polymorphism Carriers

    Meadowcroft, M., Wang, J., Purnell, C. J., Eslinger, P., Neely, E. B., Yang, Q. & Connor, J., Jan 1 2018, In : Journal of Neuroimaging. 28, 1, p. 126-133 8 p.

    Research output: Contribution to journalArticle

    Single Nucleotide Polymorphism
    Anisotropy
    Magnetic Resonance Imaging
    Myelin Sheath
    Iron

    Prizes