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Research interests
The Swulius lab uses a multi-scale imaging approach combined with computer vision to explore the the structural complexity of whole neuronal cells in different stages of development and under stress-induced degeneration. They have 20 years of cryo-electron microscopy and fluorescence microscopy experience, and use this expertise to better understand fundamental mechanisms of neuronal cell biology. They have invested heavily in developing methods for parsing large imaging datasets using deep learning, and push the boundaries of what this machine learning approach is capable of.
The Swulius lab is always interested in meeting students who are curious about their research and the opportunities that exist within the lab.
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Convolutional neural network segmentation of bare and decorated actin filaments in cellular cryo-tomography
Heebner, J., Purnell, C. & Swulius, M. T., Feb 10 2023, In: Biophysical journal. 122, 3S1, p. 409aResearch output: Contribution to journal › Article › peer-review
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Rapid coarse-grained simulation of whole cryo-tomograms
Purnell, C., Heebner, J. & Swulius, M. T., Feb 10 2023, In: Biophysical journal. 122, 3S1, p. 140aResearch output: Contribution to journal › Article › peer-review
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Visualizing Cofilin-Actin Filaments by Immunofluorescence and CryoEM: Essential Steps for Observing Cofilactin in Cells
Minamide, L. S., Hylton, R., Swulius, M. & Bamburg, J. R., 2023, Methods in Molecular Biology. Humana Press Inc., p. 265-281 17 p. (Methods in Molecular Biology; vol. 2593).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Cofilactin filaments regulate filopodial structure and dynamics in neuronal growth cones
Hylton, R. K., Heebner, J. E., Grillo, M. A. & Swulius, M. T., Dec 2022, In: Nature communications. 13, 1, 2439.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (SciVal) -
Deep Learning-Based Segmentation of Cryo-Electron Tomograms
Heebner, J. E., Purnell, C., Hylton, R. K., Marsh, M., Grillo, M. A. & Swulius, M. T., Nov 2022, In: Journal of Visualized Experiments. 2022, 189, e64435.Research output: Contribution to journal › Article › peer-review