• 2358 Citations
  • 25 h-Index

Research output per year

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Personal profile

Research interests

Dr. Mechelle Lewis is interested in the how normal and dysfunctional neural circuits contribute to motor, non-motor, cognitive, olfactory and mood/psychiatric conditions. Specifically, she applies several approaches to understanding Parkinson’s disease and other parkinsonisms.

The lab has collected clinical, motor, biofluid, and MRI data longitudinally to investigate both the underpinnings of symptoms and potential therapeutic targets.

Since the etiology of Parkinson’s and parkinsonisms is unknown, Dr. Lewis also is interested in how environemental factors may contribute to the development or exacerbation of these disorders.

Education/Academic qualification

Functional MRI, Fellowship


Molecular Pharmacology, Postdoctoral Fellowship


Neurobiology, PhD, University of North Carolina

… → 1997

Experimental Psychology, MS, Emporia State University

… → 1991

Psychology, BA, Creighton University

… → 1989

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Research Output

  • 2358 Citations
  • 25 h-Index
  • 82 Article
  • 3 Review article
  • 1 Book
  • 1 Comment/debate

Synergic control of action in levodopa-naïve Parkinson’s disease patients: I. Multi-finger interaction and coordination

de Freitas, P. B., Freitas, S. M. S. F., Reschechtko, S., Corson, T., Lewis, M. M., Huang, X. & Latash, M. L., Jan 1 2020, In : Experimental Brain Research. 238, 1, p. 229-245 17 p.

Research output: Contribution to journalArticle

  • Brain cholesterol metabolism and Parkinson's disease

    Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study

    Archer, D. B., Bricker, J. T., Chu, W. T., Burciu, R. G., McCracken, J. L., Lai, S., Coombes, S. A., Fang, R., Barmpoutis, A., Corcos, D. M., Kurani, A. S., Mitchell, T., Black, M. L., Herschel, E., Simuni, T., Parrish, T. B., Comella, C., Xie, T., Seppi, K., Bohnen, N. I. & 11 others, Müller, M. LTM., Albin, R. L., Krismer, F., Du, G., Lewis, M. M., Huang, X., Li, H., Pasternak, O., McFarland, N. R., Okun, M. S. & Vaillancourt, D. E., Sep 2019, In : The Lancet Digital Health. 1, 5, p. e222-e231

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

    Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Kong, L., Yanosky, J. D., Mailman, R. B. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality

    de Freitas, P. B., Freitas, S. M. S. F., Lewis, M. M., Huang, X. & Latash, M. L., Jan 31 2019, In : Experimental Brain Research. 237, 1

    Research output: Contribution to journalArticle

  • 1 Scopus citations