Research output per year
Research output per year
Personal profile
Research interests
Dr. Mechelle Lewis is interested in the how normal and dysfunctional neural circuits contribute to motor, non-motor, cognitive, olfactory and mood/psychiatric conditions. Specifically, she applies several approaches to understanding Parkinson’s disease and other parkinsonisms.
The lab has collected clinical, motor, biofluid, and MRI data longitudinally to investigate both the underpinnings of symptoms and potential therapeutic targets.
Since the etiology of Parkinson’s and parkinsonisms is unknown, Dr. Lewis also is interested in how environemental factors may contribute to the development or exacerbation of these disorders.
Education/Academic qualification
Functional MRI, Fellowship
2005 → 2006
Molecular Pharmacology, Postdoctoral Fellowship
1997 → 1999
Neurobiology, PhD, University of North Carolina at Chapel Hill
… → 1997
Experimental Psychology, MS, Emporia State University
… → 1991
Psychology, BA, Creighton University
… → 1989
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Dopamine D1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior, and neurophysiology
Yang, Y., Lewis, M., Huang, X., Dokholyan, N. V. & Mailman, R., Jul 2022, In: International Journal of Biochemistry and Cell Biology. 148, 106235.Research output: Contribution to journal › Short survey › peer-review
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Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage
Du, G., Wang, E., Sica, C., Chen, H., De Jesus, S., Lewis, M., Kong, L., Connor, J., Mailman, R. B. & Huang, X., 2022, (Accepted/In press) In: Movement Disorders.Research output: Contribution to journal › Article › peer-review
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Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort
Prado-Rico, J. M., Lee, E. Y., Wang, E. W., Yanosky, J. D., Kong, L., Chen, H., Navas-Acien, A., Du, G., Lewis, M., Mailman, R. B. & Huang, X., May 26 2022, In: Toxicological sciences : an official journal of the Society of Toxicology. 187, 2, p. 345-354 10 p.Research output: Contribution to journal › Article › peer-review
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Parkinson's Disease Progression and Statins: Hydrophobicity Matters
Lewis, M. M., Albertson, R. M., Du, G., Kong, L., Foy, A. & Huang, X., 2022, In: Journal of Parkinson's Disease. 12, 3, p. 821-830 10 p.Research output: Contribution to journal › Article › peer-review
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Subcortical Iron Accumulation Pattern May Predict Neuropsychological Outcomes after Subthalamic Nucleus Deep Brain Stimulation: A Pilot Study
Brown, G., Du, G., Farace, E., Lewis, M. M., Eslinger, P. J., McInerney, J., Kong, L., Li, R., Huang, X. & De Jesus, S., 2022, In: Journal of Parkinson's Disease. 12, 3, p. 851-863 13 p.Research output: Contribution to journal › Article › peer-review