• 671 Citations
  • 15 h-Index
20072019
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Research Output 2007 2019

  • 671 Citations
  • 15 h-Index
  • 26 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina

Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura, Y., Salzberg, A. C., Kimball, S., Jefferson, L. J. & Dennis, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5508-5520 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Retina
Messenger RNA
Ribosomes
Eukaryotic Initiation Factors
1 Citation (Scopus)

REDD1 activates a ROS-generating feedback loop in the retina of diabetic mice

Miller, W. P., Toro, A. L., Barber, A. & Dennis, M., May 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 6, p. 2369-2379 11 p.

Research output: Contribution to journalArticle

Open Access
Retina
Reactive Oxygen Species
Cysteine
Mitochondrial Membrane Potential
Hydrogen Peroxide
2018
2 Citations (Scopus)

Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression

Dai, W., Dierschke, S. K., Toro, A. L. & Dennis, M., Dec 1 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 12, p. 3568-3576 9 p.

Research output: Contribution to journalArticle

Nuclear Receptor Subfamily 4, Group A, Member 1
High Fat Diet
Retina
Palmitates
Cell Culture Techniques
3 Citations (Scopus)

Deletion of the Akt/mTORC1 repressor REDD1 prevents visual dysfunction in a rodent model of type 1 diabetes

Miller, W. P., Yang, C., Mihailescu, M. L., Moore, J. A., Dai, W., Barber, A. J. & Dennis, M. D., Jan 1 2018, In : Diabetes. 67, 1, p. 110-119 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Rodentia
Cell Death
Retina
Contrast Sensitivity
2 Citations (Scopus)

Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation

Dai, W., Miller, W. P., Toro, A. L., Black, A. J., Dierschke, S. K., Feehan, R. P., Kimball, S. & Dennis, M., Dec 1 2018, In : FASEB Journal. 32, 12, p. 6883-6897 15 p.

Research output: Contribution to journalArticle

Ceramides
Cell death
Nutrition
Heat-Shock Proteins
Thioredoxins
2017
5 Citations (Scopus)

Activation of the stress response kinase JNK (c-Jun N-terminal kinase) attenuates insulin action in retina through a p70S6K1-dependent mechanism

Miller, W. P., Ravi, S., Martin, T. D., Kimball, S. & Dennis, M., Feb 3 2017, In : Journal of Biological Chemistry. 292, 5, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

Phosphorylation
JNK Mitogen-Activated Protein Kinases
Retina
Phosphotransferases
High Fat Diet
2016
3 Citations (Scopus)

Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells

Moore, J. A., Miller, W. P. & Dennis, M., May 1 2016, In : Cellular Signalling. 28, 5, p. 384-390 7 p.

Research output: Contribution to journalArticle

Glucosamine
Insulin
Insulin Resistance
Hexosamines
Biosynthetic Pathways
16 Citations (Scopus)

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

Kimball, S., Gordon, B. S., Moyer, J. E., Dennis, M. & Jefferson, L. J., Aug 1 2016, In : Cellular Signalling. 28, 8, p. 896-906 11 p.

Research output: Contribution to journalArticle

Leucine
Phosphorylation
Amino Acids
Essential Amino Acids
mechanistic target of rapamycin complex 1
2 Citations (Scopus)

Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum

Black, A. J., Gordon, B. S., Dennis, M., Jefferson, L. J. & Kimball, S., Dec 1 2016, In : Biochemistry and Biophysics Reports. 8, p. 296-301 6 p.

Research output: Contribution to journalArticle

Leucine
DNA Damage
Messenger RNA
DNA
Serum
8 Citations (Scopus)

The translational repressor 4E-BP1 contributes to diabetes-induced visual dysfunction

Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A., Kimball, S., Jefferson, L. J. & Dennis, M., Mar 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 3, p. 1327-1337 11 p.

Research output: Contribution to journalArticle

Retina
Rodentia
Hyperglycemia
Proteins
RNA Cap-Binding Proteins
2015
10 Citations (Scopus)

Amino acid-induced activation of mTORC1 in rat liver is attenuated by short-term consumption of a high-fat diet

Kimball, S., Ravi, S., Gordon, B. S., Dennis, M. & Jefferson, L. J., Jan 1 2015, In : Journal of Nutrition. 145, 11, p. 2496-2502 7 p.

Research output: Contribution to journalArticle

Aminoacylation
High Fat Diet
Liver
Phosphorylation
70-kDa Ribosomal Protein S6 Kinases
24 Citations (Scopus)
Hyperglycemia
Vascular Endothelial Growth Factor A
DNA Damage
Retina
Rodentia
2014
19 Citations (Scopus)
Skeletal Muscle
Phosphorylation
Insulin-Like Growth Factor I
mechanistic target of rapamycin complex 1
Animal Models
62 Citations (Scopus)
Protein Phosphatase 2
Sirolimus
DNA Damage
Phosphorylation
DNA
26 Citations (Scopus)

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells

Gordon, B. S., Kazi, A., Coleman, C., Dennis, M., Chau, V., Jefferson, L. J. & Kimball, S., Mar 1 2014, In : Cellular Signalling. 26, 3, p. 461-467 7 p.

Research output: Contribution to journalArticle

Yeasts
GTP Phosphohydrolases
Phosphorylation
Sirolimus
mechanistic target of rapamycin complex 1
2013
14 Citations (Scopus)

Hyperglycemia mediates a shift from cap-Dependent to cap-Independent translation Via a 4E-BP1-Dependent mechanism

Dennis, M., Shenberger, J. S., Stanley, B., Kimball, S. & Jefferson, L. J., Jul 1 2013, In : Diabetes. 62, 7, p. 2204-2214 11 p.

Research output: Contribution to journalArticle

Hyperglycemia
Protein Biosynthesis
Gene Expression
Streptozocin
Liver
25 Citations (Scopus)
Raptors
Phosphorylation
Substrates
Liver
Chemical activation
43 Citations (Scopus)
DNA Damage
Cell Survival
Serum
Cell Death
Phosphorylation
60 Citations (Scopus)
70-kDa Ribosomal Protein S6 Kinases
Hindlimb
Leucine
Skeletal Muscle
Phosphorylation
2012
74 Citations (Scopus)
70-kDa Ribosomal Protein S6 Kinases
Apoptosis Regulatory Proteins
Phosphorylation
Cell death
Messenger RNA
2011
15 Citations (Scopus)
Medical problems
Type 1 Diabetes Mellitus
Hyperglycemia
Liver
Phosphorylation
69 Citations (Scopus)

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids

Dennis, M., Baum, J. I., Kimball, S. & Jefferson, L. J., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8287-8296 10 p.

Research output: Contribution to journalArticle

Insulin
Amino Acids
Chemical activation
Leucine
Raptors
54 Citations (Scopus)

Phosphorylation by CK2 enhances the rapid light-induced degradation of phytochrome interacting factor 1 in arabidopsis

Bu, Q., Zhu, L., Dennis, M. D., Yu, L., Lu, S. X., Person, M. D., Tobin, E. M., Browning, K. S. & Huq, E., Apr 8 2011, In : Journal of Biological Chemistry. 286, 14, p. 12066-12074 9 p.

Research output: Contribution to journalArticle

Phytochrome
Phosphorylation
Genetically Modified Plants
Light
Degradation
2009
31 Citations (Scopus)

Differential phosphorylation of plant translation initiation factors by Arabidopsis thaliana CK2 holoenzymes

Dennis, M. & Browning, K. S., Jul 31 2009, In : Journal of Biological Chemistry. 284, 31, p. 20602-20614 13 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Holoenzymes
Phosphorylation
Arabidopsis
Plant Proteins
39 Citations (Scopus)

Evidence for variation in the optimal translation initiation complex: Plant eIF4B, eIF4F, and eIF(iso)4F differentially promote translation of mRNAs

Mayberry, L. K., Leah Allen, M., Dennis, M. & Browning, K. S., Aug 1 2009, In : Plant physiology. 150, 4, p. 1844-1854 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4F
Protein Biosynthesis
translation (genetics)
Alfalfa mosaic virus
Arabidopsis
36 Citations (Scopus)

Phosphorylation of plant translation initiation factors by CK2 enhances the in Vitro interaction of multifactor complex components

Dennis, M., Person, M. D. & Browning, K. S., Jul 31 2009, In : Journal of Biological Chemistry. 284, 31, p. 20615-20628 14 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Phosphorylation
Triticum
Mutagenesis
In Vitro Techniques