• 1202 Citations
  • 18 h-Index
1985 …2017
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Personal profile

Research interests

Dr. Michael Katzman's research for more than two decades focused on the structure and function of the retroviral integrase enzyme that catalyzes the permanent integration of a copy of the retroviral genome into the DNA of an infected cell using three systems including human immunodeficiency virus (HIV), avian sarcoma viruses and visna virus. Among other contributions, he participated in the first purification of an enzymatically active retroviral integrase from a bacterial expression system, developed an assay still used to study this enzyme, created chimeric integrases to identify the parts of integrase that interact with viral or human DNA and the parts of viral DNA that interact with integrase, used HIV integrases from infected patients to identify an amino acid in the middle of the protein that contacts human DNA during integration, made mutations at this position to yield novel integrases that were improved at acting on viral DNA but impaired at acting on cellular DNA and explored the potential of stimulating integrase's ability to nick DNA nonspecifically for a novel antiviral strategy of using integrase to damage viral DNA. With the evolution of his career, Dr. Katzman's focus shifted to the appropriate usage of antimicrobial drugs in the healthcare setting, and in 2011 he established, and continues to direct, a successful Antimicrobial Stewardship Program at Penn State Health Milton S. Hershey Medical Center.

Dr. Katzman is a Distinguished Educator at Penn State College of Medicine and Director of the Antimicrobial Stewardship Program at Penn State Health Milton S. Hershey Medical Center.

Education/Academic qualification

Biochemistry and Medicine, Postdoctoral Fellow, Case Western Reserve University

19861989

Infectious Diseases, Fellowship, University Hospitals of Cleveland

19841989

Internal Medicine, Residency, University Hospitals of Cleveland

19811984

MD, Columbia University College of Physicians and Surgeons

19771981

AB, Columbia University

19731977

Fingerprint Dive into the research topics where Michael Katzman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Integrases Medicine & Life Sciences
Viral DNA Medicine & Life Sciences
HIV-1 Medicine & Life Sciences
Visna-maedi virus Medicine & Life Sciences
DNA Medicine & Life Sciences
Visna maedi virus Agriculture & Biology
Human immunodeficiency virus 1 Agriculture & Biology
Endonucleases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1991 2010

Integrases
Anti-Infective Agents
Antiviral Agents
Viral DNA
HIV-1
Integrases
Viral DNA
DNA
Antiviral Agents
Virus Replication

HIV 1 INTEGRATION

Katzman, M.

National Institutes of Health

8/1/915/31/97

Project: Research project

Integrases
DNA
Visna-maedi virus
Lentivirus
Deoxyribonuclease I

Research Output 1985 2017

  • 1202 Citations
  • 18 h-Index
  • 36 Article
  • 2 Letter
  • 1 Comment/debate
  • 1 Review article
5 Citations (Scopus)

Compliance with Clostridium difficile treatment guidelines: Effect on patient outcomes

Crowell, K. T., Julian, K., Katzman, M., Berg, A., Tinsley, A., Williams, E., Koltun, W. & Messaris, E., Aug 1 2017, In : Epidemiology and Infection. 145, 11, p. 2185-2192 8 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Guidelines
Length of Stay
Therapeutics
10 Citations (Scopus)

Severe Babesia microti Infection in an Immunocompetent Host in Pennsylvania

Genda, J., Negron, EA., Lotfipour, M., Balabhadra, S., Desai, D., Craft, D. & Katzman, M., Aug 22 2016, In : Journal of Investigative Medicine High Impact Case Reports. 4, 3

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
Pharmacists
Communicable Diseases
Superinfection
Health Expenditures
Anti-Infective Agents
2 Citations (Scopus)

Antibiotic therapy for Clostridium difficile infection

Katzman, M., Jan 1 2014, In : Seminars in Colon and Rectal Surgery. 25, 3, p. 143-149 7 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Anti-Bacterial Agents
Metronidazole
Guidelines

Isolation without contact

Katzman, M., Jan 1 2014, In : Infection Control and Hospital Epidemiology. 35, 12, 1 p.

Research output: Contribution to journalLetter

Visitors to Patients
Patient Isolation
Cross Infection