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Research Output 1996 2020

2020

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Alkaloids
Modulators
Cells
Breast Neoplasms
Derivatives
2019
5 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Ca2+ channels in cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102083.

Research output: Contribution to journalEditorial

Neoplasms

Ca2+ homeostasis and cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102084.

Research output: Contribution to journalEditorial

Homeostasis
Neoplasms
17 Citations (Scopus)

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T. J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F. & Prabhu, K. S., Nov 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12838-12852 15 p.

Research output: Contribution to journalArticle

Macrophages
Lipopolysaccharides
Down-Regulation
Chemical activation
Prostaglandins
13 Citations (Scopus)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V. & 416 others, Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Čičin-Šain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., Oct 1 2019, In : European Journal of Immunology. 49, 10, p. 1457-1973 517 p.

Research output: Contribution to journalArticle

Open Access
Flow Cytometry
Guidelines
Allergy and Immunology
Phenotype
Research
8 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Glioblastoma
Amlodipine
Calcium
Growth

MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure

Gabani, M., Liu, J., Ait-Aissa, K., Koval, O., Kim, Y. R., Castañeda, D., Vikram, A., Jacobs, J. S., Grumbach, I., Trebak, M., Irani, K. & Kassan, M., Jun 1 2019, In : Cell Calcium. 80, p. 18-24 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Pressure
Angiotensin II
Mesenteric Arteries
3 Citations (Scopus)

ORAI channels in cellular remodeling of cardiorespiratory disease

Johnson, M. & Trebak, M., May 2019, In : Cell Calcium. 79, p. 1-10 10 p.

Research output: Contribution to journalReview article

Ion Channels
Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
Smooth Muscle
Atherosclerosis
6 Citations (Scopus)

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

Xu, M., Almasi, S., Yang, Y., Yan, C., Sterea, A. M., Rizvi Syeda, A. K., Shen, B., Richard Derek, C., Huang, P., Gujar, S., Wang, J., Zong, W. X., Trebak, M., El Hiani, Y. & Dong, X. P., May 2019, In : Cell Calcium. 79, p. 80-88 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Drug Delivery Systems
Tumor Microenvironment
Down-Regulation
Adenosine Triphosphate

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D. L., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access
Remote control
calcium
Molecules
Cell membranes
Ion Channels
2018
20 Citations (Scopus)

Crosslink between calcium and sodium signalling

Verkhratsky, A., Trebak, M., Perocchi, F., Khananshvili, D. & Sekler, I., Feb 1 2018, In : Experimental Physiology. 103, 2, p. 157-169 13 p.

Research output: Contribution to journalReview article

Calcium Signaling
Transient Receptor Potential Channels
Sodium
Ions
Synaptic Transmission
20 Citations (Scopus)

Cross-linking of Orai1 channels by STIM proteins

Zhou, Y., Nwokonko, R. M., Cai, X., Loktionova, N. A., Abdulqadir, R., Xin, P., Niemeyer, B. A., Wang, Y., Trebak, M. & Gill, D. L., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. E3398-E3407

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Cluster Analysis
Fluorescence Recovery After Photobleaching
Protein Unfolding
14 Citations (Scopus)

Mitochondrial Ca2+ signaling

Pathak, T. & Trebak, M., Dec 2018, In : Pharmacology and Therapeutics. 192, p. 112-123 12 p.

Research output: Contribution to journalReview article

Homeostasis
Mitochondrial Proteins
Energy Metabolism
Membrane Proteins
Calcium
7 Citations (Scopus)

Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

Pierro, C., Zhang, X., Kankeu, C., Trebak, M., Bootman, M. D. & Roderick, H. L., Jun 2018, In : Cell Calcium. 72, p. 70-80 11 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colorectal Neoplasms
Cell Line
Cell Movement
Alleles
2 Citations (Scopus)

Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

Cai, X., Nwokonko, R. M., Loktionova, N. A., Abdulqadir, R., Baraniak, J. H., Wang, Y., Trebak, M., Zhou, Y. & Gill, D. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12962-12974 13 p.

Research output: Contribution to journalArticle

Calcium Channels
Linings
Endoplasmic Reticulum
Dimers
Chemical activation
4 Citations (Scopus)

Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication

Haouzi, P., Gueguinou, M., Sonobe, T., Judenherc-Haouzi, A., Tubbs, N., Trebak, M., Cheung, J. & Bouillaud, F., Sep 2 2018, In : Clinical Toxicology. 56, 9, p. 828-840 13 p.

Research output: Contribution to journalArticle

Methylene Blue
Cyanides
Rats
Adenosine Diphosphate
Animals

Slow traffic makes for bad circulation: The case of β1 subunit of bk channels in hypertension

Johnson, M. & Trebak, M., Jan 1 2018, In : Hypertension. 72, 3, p. 585-587 3 p.

Research output: Contribution to journalComment/debate

Large-Conductance Calcium-Activated Potassium Channels
Cerebral Arteries
Hypertension

Study of the Endogenous CRAC Channel Using shRNA-Mediated Gene Silencing

Zhang, X., Spinelli, A. M., Zhang, W. & Trebak, M., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 137-145 9 p. (Methods in Molecular Biology; vol. 1843).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Silencing
Small Interfering RNA
Extracellular Space
Knockout Mice
Proteins
2017
6 Citations (Scopus)

Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders

Tanwar, J., Trebak, M. & Motiani, R. K., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 425-452 28 p. (Advances in Experimental Medicine and Biology; vol. 993).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hemostatic Disorders
Hemostatics
Blood Vessels
Endoplasmic Reticulum
Proteins
43 Citations (Scopus)

Crosstalk between calcium and reactive oxygen species signaling in cancer

Hempel, N. & Trebak, M., May 2017, In : Cell Calcium. 63, p. 70-96 27 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Calcium
Neoplasms
Mitochondria
NADPH Oxidase
2 Citations (Scopus)

Golgi-associated protein kinase C-ϵ is delivered to phagocytic cups: Role of phosphatidylinositol 4-phosphate

Hanes, C. M., D'Amico, A. E., Ueyama, T., Wong, A. C., Zhang, X., Hynes, W. F., Barroso, M. M., Cady, N. C., Trebak, M., Saito, N. & Lennartz, M. R., Jul 1 2017, In : Journal of Immunology. 199, 1, p. 271-277 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
trans-Golgi Network
Phagocytosis
Membrane Fusion
Phosphotransferases
19 Citations (Scopus)

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

Ben-Kasus Nissim, T., Zhang, X., Elazar, A., Roy, S., Stolwijk, J. A., Zhou, Y., Motiani, R. K., Gueguinou, M., Hempel, N., Hershfinkel, M., Gill, D. L., Trebak, M. & Sekler, I., Mar 15 2017, In : EMBO Journal. 36, 6, p. 797-815 19 p.

Research output: Contribution to journalArticle

Mitochondria
Inventory control
Oxidation-Reduction
Cell membranes
Ion Channels
29 Citations (Scopus)

ORAI calcium channels

Trebak, M. & Putney, J. W., Jun 14 2017, In : Physiology. 32, 4, p. 332-342 11 p.

Research output: Contribution to journalReview article

Calcium Channels
Genes
Proteins
5 Citations (Scopus)

Store-independent orai channels regulated by STIM

Zhang, X., Gueguinou, M. & Trebak, M., Jan 1 2017, Calcium Entry Channels in Non-Excitable Cells. CRC Press, p. 197-213 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Calcium
Leukotriene C4
Arachidonic Acid
Proteins
Calcium Signaling
2016

A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness

Beardslee, L. A., Stolwijk, J., Khaladj, D. A., Trebak, M., Halman, J., Torrejon, K. Y., Niamsiri, N. & Bergkvist, M., Aug 1 2016, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 104, 6, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

Biodegradable polymers
Membranes
Fabrication
Polycaprolactone
Polymers
22 Citations (Scopus)

Calcium signaling is dispensable for receptor regulation of endothelial barrier function

Stolwijk, J. A., Zhang, X., Gueguinou, M., Zhang, W., Matrougui, K., Renken, C. & Trebak, M., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22894-22912 19 p.

Research output: Contribution to journalArticle

Calcium Signaling
G-Protein-Coupled Receptors
Calcium
Thrombin
Cell Membrane
16 Citations (Scopus)

Essential role of smooth muscle STIM1 in hypertension and cardiovascular dysfunction

Kassan, M., Ait-Aissa, K., Radwan, E., Mali, V., Haddox, S., Gabani, M., Zhang, W., Belmadani, S., Irani, K., Trebak, M. & Matrougui, K., Sep 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 9, p. 1900-1909 10 p.

Research output: Contribution to journalArticle

Smooth Muscle
Endoplasmic Reticulum Stress
Hypertension
Angiotensin II
Pathology
9 Citations (Scopus)

Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity

Shakerley, N. L., Chandrasekaran, A., Trebak, M., Miller, B. A. & Melendez, J. A., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3871-3881 11 p.

Research output: Contribution to journalArticle

Francisella tularensis
Macrophages
Catalase
Actins
Interleukin-6
12 Citations (Scopus)

Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles

Wang, H., Zhang, X., Xue, L., Xing, J., Jouvin, M. H., Putney, J. W., Anderson, M. P., Trebak, M. & Kinet, J. P., Apr 19 2016, In : Immunity. 44, 4, p. 782-794 13 p.

Research output: Contribution to journalArticle

Calcium Channels
Helper-Inducer T-Lymphocytes
Th17 Cells
Th1 Cells
Granulocyte-Macrophage Colony-Stimulating Factor
21 Citations (Scopus)

Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle

Spinelli, A. M. & Trebak, M., Mar 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 6, p. C402-C413

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Proteins
Smooth Muscle
Pathology
Ion Channels
44 Citations (Scopus)

The Orai1 store-operated calcium channel functions as a hexamer

Cai, X., Zhou, Y., Nwokonko, R. M., Loktionova, N. A., Wang, X., Xin, P., Trebak, M., Wang, Y. & Gill, D. L., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 25764-25775 12 p.

Research output: Contribution to journalArticle

Calcium Channels
Dimers
Clustered Regularly Interspaced Short Palindromic Repeats
Biotinylation
Ions
34 Citations (Scopus)

The STIM1-binding site nexus remotely controls Orai1 channel gating

Zhou, Y., Cai, X., Loktionova, N. A., Wang, X., Nwokonko, R. M., Wang, X., Wang, Y., Rothberg, B. S., Trebak, M. & Gill, D. L., Dec 8 2016, In : Nature communications. 7, 13725.

Research output: Contribution to journalArticle

helices
Binding Sites
porosity
mutations
Mutation
2 Citations (Scopus)

Transient receptor potential canonical 7 (TRPC7), a calcium (Ca2+) permeable non-selective cation channel

Zhang, X., Spinelli, A. M., Masiello, T. & Trebak, M., May 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 251-264 14 p. (Advances in Experimental Medicine and Biology; vol. 898).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cations
Gq-G11 GTP-Binding Protein alpha Subunits
Calcium
Diglycerides
Type C Phospholipases
2015
7 Citations (Scopus)

Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse

Kassan, M., Ait-Aissa, K., Ali, M., Trebak, M. & Matrougui, K., Jan 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2404-2410 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Mesenteric Arteries
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
8 Citations (Scopus)

Calcium signals tune the fidelity of transcriptional responses

Zhou, Y., Trebak, M. & Gill, D. L., Apr 16 2015, In : Molecular cell. 58, 2, p. 197-199 3 p.

Research output: Contribution to journalShort survey

Transcription Factors
Calcium
10 Citations (Scopus)

Differential role for stromal interacting molecule 1 in the regulation of vascular function

Kassan, M., Zhang, W., Aissa, K. A., Stolwijk, J., Trebak, M. & Matrougui, K., Jun 23 2015, In : Pflugers Archiv European Journal of Physiology. 467, 6, p. 1195-1202 8 p., 4.

Research output: Contribution to journalArticle

Blood Vessels
Endothelial cells
Molecules
Thromboxanes
Endothelium
18 Citations (Scopus)

Emergence of Orai3 activity during cardiac hypertrophy

Saliba, Y., Keck, M., Marchand, A., Atassi, F., Ouillé, A., Cazorla, O., Trebak, M., Pavoine, C., Lacampagne, A., Hulot, J. S., Farès, N., Fauconnier, J. & Lompré, A. M., Jan 1 2015, In : Cardiovascular Research. 105, 3, p. 248-259 12 p.

Research output: Contribution to journalArticle

Cardiomegaly
Cardiac Myocytes
Arachidonic Acid
Macromolecular Substances
Proteins
46 Citations (Scopus)

Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements

Stolwijk, J. A., Matrougui, K., Renken, C. W. & Trebak, M., Oct 13 2015, In : Pflugers Archiv European Journal of Physiology. 467, 10, p. 2193-2218 26 p.

Research output: Contribution to journalArticle

Electric batteries
G-Protein-Coupled Receptors
Electric Impedance
Endothelial cells
Substrates
22 Citations (Scopus)

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Zhang, W., Zhang, X., González-Cobos, J. C., Stolwijk, J. A., Matrougui, K. & Trebak, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 5015-5027 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Enzyme Activation
Hyperplasia
Chemical activation
Enzymes
55 Citations (Scopus)

Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message

Desai, P. N., Zhang, X., Wu, S., Janoshazi, A., Bolimuntha, S., Putney, J. W. & Trebak, M., Jul 28 2015, In : Science signaling. 8, 387, ra74.

Research output: Contribution to journalArticle

Calcium Channels
Mammals
Arachidonic Acid
Molecules
Leukotriene C4
23 Citations (Scopus)

Novel protein kinase C-mediated control of orai1 function in invasive melanoma

Hooper, R., Zhang, X., Webster, M., Go, C., Kedra, J., Marchbank, K., Gill, D. L., Weeraratna, A. T., Trebak, M. & Soboloff, J., Jan 1 2015, In : Molecular and cellular biology. 35, 16, p. 2790-2798 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Melanoma
Calcium
Melanocytes
Cell Lineage
4 Citations (Scopus)

Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice

Kassan, M., Choi, S. K., Galán, M., Trebak, M., Belmadani, S. & Matrougui, K., Jan 1 2015, In : Diabetes/Metabolism Research and Reviews. 31, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Arteries
Thoracic Aorta
Endothelium
Knockout Mice
4 Citations (Scopus)

Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation

Spinelli, A. M., Liu, Y., Sun, L. Y., González-Cobos, J. C., Backs, J., Trebak, M. & Singer, H. A., Dec 1 2015, In : Pflugers Archiv European Journal of Physiology. 467, 12, p. 2541-2554 14 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin
Allergens
Smooth Muscle
Muscle
42 Citations (Scopus)
Neoplasm Metastasis
Carcinogenesis
Calcium-Sensing Receptors
Neoplasms
Proteins
2014
45 Citations (Scopus)

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

Zhang, X., Zhang, W., González-Cobos, J. C., Jardin, I., Romanin, C., Matrougui, K. & Trebak, M., Mar 2014, In : Journal of General Physiology. 143, 3, p. 3450-3359 92 p.

Research output: Contribution to journalArticle

Leukotriene C4
Arachidonic Acid
Endoplasmic Reticulum
HEK293 Cells
Vascular Smooth Muscle
14 Citations (Scopus)

Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice

Kassan, M., Choi, S. K., Galán, M., Lee, Y. H., Trebak, M. & Matrougui, K., Apr 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 7, p. H972-H980

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Blood Vessels
Reactive Oxygen Species
p38 Mitogen-Activated Protein Kinases
NADP
81 Citations (Scopus)

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction

Galán, M., Kassan, M., Kadowitz, P. J., Trebak, M., Belmadani, S. & Matrougui, K., Jun 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 6, p. 1063-1075 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Blood Vessels
Tunicamycin
p38 Mitogen-Activated Protein Kinases
Phosphorylation