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Research Output 1996 2020

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2020

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Alkaloids
Modulators
Cells
Breast Neoplasms
Derivatives
2019
5 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T. J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F. & Prabhu, K. S., Nov 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12838-12852 15 p.

Research output: Contribution to journalArticle

Macrophages
Lipopolysaccharides
Down-Regulation
Chemical activation
Prostaglandins
13 Citations (Scopus)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V. & 416 others, Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Čičin-Šain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., Oct 1 2019, In : European Journal of Immunology. 49, 10, p. 1457-1973 517 p.

Research output: Contribution to journalArticle

Open Access
Flow Cytometry
Guidelines
Allergy and Immunology
Phenotype
Research
8 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Glioblastoma
Amlodipine
Calcium
Growth

MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure

Gabani, M., Liu, J., Ait-Aissa, K., Koval, O., Kim, Y. R., Castañeda, D., Vikram, A., Jacobs, J. S., Grumbach, I., Trebak, M., Irani, K. & Kassan, M., Jun 1 2019, In : Cell Calcium. 80, p. 18-24 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Pressure
Angiotensin II
Mesenteric Arteries
6 Citations (Scopus)

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

Xu, M., Almasi, S., Yang, Y., Yan, C., Sterea, A. M., Rizvi Syeda, A. K., Shen, B., Richard Derek, C., Huang, P., Gujar, S., Wang, J., Zong, W. X., Trebak, M., El Hiani, Y. & Dong, X. P., May 2019, In : Cell Calcium. 79, p. 80-88 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Drug Delivery Systems
Tumor Microenvironment
Down-Regulation
Adenosine Triphosphate

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D. L., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access
Remote control
calcium
Molecules
Cell membranes
Ion Channels
2018
20 Citations (Scopus)

Cross-linking of Orai1 channels by STIM proteins

Zhou, Y., Nwokonko, R. M., Cai, X., Loktionova, N. A., Abdulqadir, R., Xin, P., Niemeyer, B. A., Wang, Y., Trebak, M. & Gill, D. L., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. E3398-E3407

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Cell Membrane
Cluster Analysis
Fluorescence Recovery After Photobleaching
Protein Unfolding
7 Citations (Scopus)

Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

Pierro, C., Zhang, X., Kankeu, C., Trebak, M., Bootman, M. D. & Roderick, H. L., Jun 2018, In : Cell Calcium. 72, p. 70-80 11 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Colorectal Neoplasms
Cell Line
Cell Movement
Alleles
2 Citations (Scopus)

Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

Cai, X., Nwokonko, R. M., Loktionova, N. A., Abdulqadir, R., Baraniak, J. H., Wang, Y., Trebak, M., Zhou, Y. & Gill, D. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 33, p. 12962-12974 13 p.

Research output: Contribution to journalArticle

Calcium Channels
Linings
Endoplasmic Reticulum
Dimers
Chemical activation
4 Citations (Scopus)

Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication

Haouzi, P., Gueguinou, M., Sonobe, T., Judenherc-Haouzi, A., Tubbs, N., Trebak, M., Cheung, J. & Bouillaud, F., Sep 2 2018, In : Clinical Toxicology. 56, 9, p. 828-840 13 p.

Research output: Contribution to journalArticle

Methylene Blue
Cyanides
Rats
Adenosine Diphosphate
Animals
2017
2 Citations (Scopus)

Golgi-associated protein kinase C-ϵ is delivered to phagocytic cups: Role of phosphatidylinositol 4-phosphate

Hanes, C. M., D'Amico, A. E., Ueyama, T., Wong, A. C., Zhang, X., Hynes, W. F., Barroso, M. M., Cady, N. C., Trebak, M., Saito, N. & Lennartz, M. R., Jul 1 2017, In : Journal of Immunology. 199, 1, p. 271-277 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
trans-Golgi Network
Phagocytosis
Membrane Fusion
Phosphotransferases
19 Citations (Scopus)

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

Ben-Kasus Nissim, T., Zhang, X., Elazar, A., Roy, S., Stolwijk, J. A., Zhou, Y., Motiani, R. K., Gueguinou, M., Hempel, N., Hershfinkel, M., Gill, D. L., Trebak, M. & Sekler, I., Mar 15 2017, In : EMBO Journal. 36, 6, p. 797-815 19 p.

Research output: Contribution to journalArticle

Mitochondria
Inventory control
Oxidation-Reduction
Cell membranes
Ion Channels
2016

A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness

Beardslee, L. A., Stolwijk, J., Khaladj, D. A., Trebak, M., Halman, J., Torrejon, K. Y., Niamsiri, N. & Bergkvist, M., Aug 1 2016, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 104, 6, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

Biodegradable polymers
Membranes
Fabrication
Polycaprolactone
Polymers
22 Citations (Scopus)

Calcium signaling is dispensable for receptor regulation of endothelial barrier function

Stolwijk, J. A., Zhang, X., Gueguinou, M., Zhang, W., Matrougui, K., Renken, C. & Trebak, M., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22894-22912 19 p.

Research output: Contribution to journalArticle

Calcium Signaling
G-Protein-Coupled Receptors
Calcium
Thrombin
Cell Membrane
16 Citations (Scopus)

Essential role of smooth muscle STIM1 in hypertension and cardiovascular dysfunction

Kassan, M., Ait-Aissa, K., Radwan, E., Mali, V., Haddox, S., Gabani, M., Zhang, W., Belmadani, S., Irani, K., Trebak, M. & Matrougui, K., Sep 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 9, p. 1900-1909 10 p.

Research output: Contribution to journalArticle

Smooth Muscle
Endoplasmic Reticulum Stress
Hypertension
Angiotensin II
Pathology
9 Citations (Scopus)

Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity

Shakerley, N. L., Chandrasekaran, A., Trebak, M., Miller, B. A. & Melendez, J. A., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3871-3881 11 p.

Research output: Contribution to journalArticle

Francisella tularensis
Macrophages
Catalase
Actins
Interleukin-6
12 Citations (Scopus)

Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles

Wang, H., Zhang, X., Xue, L., Xing, J., Jouvin, M. H., Putney, J. W., Anderson, M. P., Trebak, M. & Kinet, J. P., Apr 19 2016, In : Immunity. 44, 4, p. 782-794 13 p.

Research output: Contribution to journalArticle

Calcium Channels
Helper-Inducer T-Lymphocytes
Th17 Cells
Th1 Cells
Granulocyte-Macrophage Colony-Stimulating Factor
21 Citations (Scopus)

Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle

Spinelli, A. M. & Trebak, M., Mar 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 6, p. C402-C413

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Proteins
Smooth Muscle
Pathology
Ion Channels
44 Citations (Scopus)

The Orai1 store-operated calcium channel functions as a hexamer

Cai, X., Zhou, Y., Nwokonko, R. M., Loktionova, N. A., Wang, X., Xin, P., Trebak, M., Wang, Y. & Gill, D. L., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 25764-25775 12 p.

Research output: Contribution to journalArticle

Calcium Channels
Dimers
Clustered Regularly Interspaced Short Palindromic Repeats
Biotinylation
Ions
34 Citations (Scopus)

The STIM1-binding site nexus remotely controls Orai1 channel gating

Zhou, Y., Cai, X., Loktionova, N. A., Wang, X., Nwokonko, R. M., Wang, X., Wang, Y., Rothberg, B. S., Trebak, M. & Gill, D. L., Dec 8 2016, In : Nature communications. 7, 13725.

Research output: Contribution to journalArticle

helices
Binding Sites
porosity
mutations
Mutation
2015
7 Citations (Scopus)

Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse

Kassan, M., Ait-Aissa, K., Ali, M., Trebak, M. & Matrougui, K., Jan 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2404-2410 7 p.

Research output: Contribution to journalArticle

NADPH Oxidase
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Mesenteric Arteries
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
10 Citations (Scopus)

Differential role for stromal interacting molecule 1 in the regulation of vascular function

Kassan, M., Zhang, W., Aissa, K. A., Stolwijk, J., Trebak, M. & Matrougui, K., Jun 23 2015, In : Pflugers Archiv European Journal of Physiology. 467, 6, p. 1195-1202 8 p., 4.

Research output: Contribution to journalArticle

Blood Vessels
Endothelial cells
Molecules
Thromboxanes
Endothelium
18 Citations (Scopus)

Emergence of Orai3 activity during cardiac hypertrophy

Saliba, Y., Keck, M., Marchand, A., Atassi, F., Ouillé, A., Cazorla, O., Trebak, M., Pavoine, C., Lacampagne, A., Hulot, J. S., Farès, N., Fauconnier, J. & Lompré, A. M., Jan 1 2015, In : Cardiovascular Research. 105, 3, p. 248-259 12 p.

Research output: Contribution to journalArticle

Cardiomegaly
Cardiac Myocytes
Arachidonic Acid
Macromolecular Substances
Proteins
46 Citations (Scopus)

Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements

Stolwijk, J. A., Matrougui, K., Renken, C. W. & Trebak, M., Oct 13 2015, In : Pflugers Archiv European Journal of Physiology. 467, 10, p. 2193-2218 26 p.

Research output: Contribution to journalArticle

Electric batteries
G-Protein-Coupled Receptors
Electric Impedance
Endothelial cells
Substrates
22 Citations (Scopus)

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

Zhang, W., Zhang, X., González-Cobos, J. C., Stolwijk, J. A., Matrougui, K. & Trebak, M., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 5015-5027 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Enzyme Activation
Hyperplasia
Chemical activation
Enzymes
55 Citations (Scopus)

Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message

Desai, P. N., Zhang, X., Wu, S., Janoshazi, A., Bolimuntha, S., Putney, J. W. & Trebak, M., Jul 28 2015, In : Science signaling. 8, 387, ra74.

Research output: Contribution to journalArticle

Calcium Channels
Mammals
Arachidonic Acid
Molecules
Leukotriene C4
23 Citations (Scopus)

Novel protein kinase C-mediated control of orai1 function in invasive melanoma

Hooper, R., Zhang, X., Webster, M., Go, C., Kedra, J., Marchbank, K., Gill, D. L., Weeraratna, A. T., Trebak, M. & Soboloff, J., Jan 1 2015, In : Molecular and cellular biology. 35, 16, p. 2790-2798 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
Melanoma
Calcium
Melanocytes
Cell Lineage
4 Citations (Scopus)

Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice

Kassan, M., Choi, S. K., Galán, M., Trebak, M., Belmadani, S. & Matrougui, K., Jan 1 2015, In : Diabetes/Metabolism Research and Reviews. 31, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Arteries
Thoracic Aorta
Endothelium
Knockout Mice
4 Citations (Scopus)

Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation

Spinelli, A. M., Liu, Y., Sun, L. Y., González-Cobos, J. C., Backs, J., Trebak, M. & Singer, H. A., Dec 1 2015, In : Pflugers Archiv European Journal of Physiology. 467, 12, p. 2541-2554 14 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin
Allergens
Smooth Muscle
Muscle
42 Citations (Scopus)
Neoplasm Metastasis
Carcinogenesis
Calcium-Sensing Receptors
Neoplasms
Proteins
2014
45 Citations (Scopus)

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

Zhang, X., Zhang, W., González-Cobos, J. C., Jardin, I., Romanin, C., Matrougui, K. & Trebak, M., Mar 2014, In : Journal of General Physiology. 143, 3, p. 3450-3359 92 p.

Research output: Contribution to journalArticle

Leukotriene C4
Arachidonic Acid
Endoplasmic Reticulum
HEK293 Cells
Vascular Smooth Muscle
14 Citations (Scopus)

Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice

Kassan, M., Choi, S. K., Galán, M., Lee, Y. H., Trebak, M. & Matrougui, K., Apr 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 7, p. H972-H980

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Blood Vessels
Reactive Oxygen Species
p38 Mitogen-Activated Protein Kinases
NADP
81 Citations (Scopus)

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction

Galán, M., Kassan, M., Kadowitz, P. J., Trebak, M., Belmadani, S. & Matrougui, K., Jun 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 6, p. 1063-1075 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Blood Vessels
Tunicamycin
p38 Mitogen-Activated Protein Kinases
Phosphorylation
9 Citations (Scopus)
Diglycerides
Cations
Type C Phospholipases
Sequence Homology
Ion Channels
11 Citations (Scopus)

Vascular balloon injury and intraluminal administration in rat carotid artery

Zhang, W. & Trebak, M., Dec 23 2014, In : Journal of Visualized Experiments. 94

Research output: Contribution to journalArticle

Vascular System Injuries
Balloons
Carotid Arteries
Rats
Arteries
2013
27 Citations (Scopus)

Emerging roles of Orai3 in pathophysiology

Motiani, R. K., Stolwijk, J. A., Newton, R. L., Zhang, X. & Trebak, M., Sep 1 2013, In : Channels. 7, 5, p. 392-401 10 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Muscle
Up-Regulation
Neurodegenerative diseases
Breast Neoplasms
39 Citations (Scopus)

Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes

Kassan, M., Choi, S. K., Galán, M., Bishop, A., Umezawa, K., Trebak, M., Belmadani, S. & Matrougui, K., Jun 1 2013, In : Diabetes. 62, 6, p. 2078-2087 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Type 2 Diabetes Mellitus
Blood Vessels
Endothelium
Arteries
30 Citations (Scopus)

Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels

Zhang, X., González-Cobos, J. C., Schindl, R., Muik, M., Ruhle, B., Motiani, R. K., Bisaillon, J. M., Zhang, W., Fahrner, M., Barroso, M., Matrougui, K., Romanin, C. & Trebak, M., Sep 11 2013, In : Molecular and cellular biology. 33, 18, p. 3715-3723 9 p.

Research output: Contribution to journalArticle

Leukotriene C4
Thrombin
Fluorescence Resonance Energy Transfer
Lipoprotein Lipase
Platelet-Derived Growth Factor
64 Citations (Scopus)

MiR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat

Merlet, E., Atassi, F., Motiani, R. K., Mougenot, N., Jacquet, A., Nadaud, S., Capiod, T., Trebak, M., Lompré, A. M. & Marchand, A., Jun 1 2013, In : Cardiovascular Research. 98, 3, p. 458-468 11 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Cyclin D1
Phenotype
Carotid Arteries
93 Citations (Scopus)

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

Motiani, R. K., Zhang, X., Harmon, K. E., Keller, R. S., Matrougui, K., Bennett, J. A. & Trebak, M., Jan 1 2013, In : FASEB Journal. 27, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

MCF-7 Cells
Estrogen Receptors
Carcinogenesis
NFATC Transcription Factors
Focal Adhesion Protein-Tyrosine Kinases
6 Citations (Scopus)

PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis

Wood, T. R., Chow, R. Y., Hanes, C. M., Zhang, X., Kashiwagi, K., Shirai, Y., Trebak, M., Loegering, D. J., Saito, N. & Lennartz, M. R., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

Phagosomes
Phagocytosis
Immunoglobulin G
Pseudopodia
Membranes
17 Citations (Scopus)

Redox-control of the alarmin, Interleukin-1α

McCarthy, D. A., Ranganathan, A., Subbaram, S., Flaherty, N. L., Patel, N., Trebak, M., Hempel, N. & Melendez, J. A., Jan 1 2013, In : Redox Biology. 1, 1, p. 218-225 8 p.

Research output: Contribution to journalArticle

Interleukin-1
Oxidation-Reduction
Calpain
Oxidants
Mutagenesis
35 Citations (Scopus)

Redox control of the senescence regulator interleukin-1α and the secretory phenotype

McCarthy, D. A., Clark, R. R., Bartling, T. R., Trebak, M. & Melendez, J. A., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32149-32159 11 p.

Research output: Contribution to journalArticle

Interleukin-1
Oxidation-Reduction
Phenotype
Calpain
Tissue homeostasis
109 Citations (Scopus)

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

Motiani, R. K., Hyzinski-García, M. C., Zhang, X., Henkel, M. M., Abdullaev, I. F., Kuo, Y. H., Matrougui, K., Mongin, A. A. & Trebak, M., Sep 1 2013, In : Pflugers Archiv European Journal of Physiology. 465, 9, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Human Activities
Molecules
Astrocytes
Cell proliferation
59 Citations (Scopus)

STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry

Shinde, A. V., Motiani, R. K., Zhang, X., Abdullaev, I. F., Adam, A. P., González-Cobos, J. C., Zhang, W., Matrougui, K., Vincent, P. A. & Trebak, M., Mar 19 2013, In : Science signaling. 6, 267, p. ra18

Research output: Contribution to journalArticle

Thrombin
Thrombin Receptors
Stress Fibers
Myosin Light Chains
Molecules
71 Citations (Scopus)

Store-independent Orai1/3 channels activated by intracrine leukotrienec4: Role in neointimal hyperplasia

González-Cobos, J. C., Zhang, X., Zhang, W., Ruhle, B., Motiani, R. K., Schindl, R., Muik, M., Spinelli, A. M., Bisaillon, J. M., Shinde, A. V., Fahrner, M., Singer, H. A., Matrougui, K., Barroso, M., Romanin, C. & Trebak, M., Mar 29 2013, In : Circulation research. 112, 7, p. 1013-1025 13 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Neointima
Vascular Diseases
45 Citations (Scopus)

Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation

Rodríguez-Moyano, M., Díaz, I., Dionisio, N., Zhang, X., Ávila-Medina, J., Calderón-Sánchez, E., Trebak, M., Rosado, J. A., Ordóñez, A. & Smani, T., Nov 1 2013, In : Cardiovascular Research. 100, 2, p. 297-306 10 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Vascular Smooth Muscle
Transcriptional Activation
Smooth Muscle Myocytes
Epithelium