Projects per year
Personal profile
Research interests
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.
Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.
Education/Academic qualification
Postdoctoral Fellow, Albany Medical College
2007 → 2011
Postdoctoral Fellow, Duke University Medical Center
2004 → 2007
PhD, University of Queensland
… → 2004
BSc (Hons), University of Queensland
… → 1999
Fingerprint Dive into the research topics where Nadine Hempel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Oxidation-Reduction
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Ovarian Neoplasms
Medicine & Life Sciences
Urinary Bladder Neoplasms
Medicine & Life Sciences
Reactive Oxygen Species
Medicine & Life Sciences
Transforming Growth Factors
Medicine & Life Sciences
Cells
Chemical Compounds
Growth Factor Receptors
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2008 2024
Role of Sox2 in Stress Adaptations to Ovarian Cancer Anchorage Independence
Hempel, N. & Karthikeyan, M.
4/11/19 → 3/31/24
Project: Research project
Ovarian Neoplasms
Survival
Neoplasm Metastasis
Ascites
Neoplasms
Oxidation-Reduction
Reactive Oxygen Species
Neoplasm Metastasis
Neoplasms
Urinary Bladder Neoplasms
Regulation of Tumor Cell Migration by Mitochondrial Superoxide Dismutase
8/25/08 → 8/24/11
Project: Research project
Superoxide Dismutase
Cell Movement
Reactive Oxygen Species
Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
Research Output 2000 2019
2
Citations
(Scopus)
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.Research output: Contribution to journal › Article
Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity
Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.Research output: Contribution to journal › Article
Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J., Timmins, P. F., Kesterson, J., Phaeton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. & Hempel, N., Jan 1 2018, (Accepted/In press) In : Redox Biology.Research output: Contribution to journal › Article
Glutathione Peroxidase
Ovarian Neoplasms
Oxidation-Reduction
Ascites
Adenocarcinoma
2
Citations
(Scopus)
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis
Singh, P., Jenkins, L. M., Horst, B., Alers, V., Pradhan, S., Kaur, P., Srivastava, T., Hempel, N., Gyorffy, B., Broude, E. V., Lee, N. Y. & Mythreye, K., Jun 1 2018, In : Cancer Research. 78, 11, p. 2978-2989 12 p.Research output: Contribution to journal › Article
Inhibins
Angiogenesis Inducing Agents
Neoplasm Metastasis
Neoplasms
Antibodies
8
Citations
(Scopus)
TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
Shah, N., Kumar, S., Zaman, N., Pan, C. C., Bloodworth, J. C., Lei, W., Streicher, J. M., Hempel, N., Mythreye, K. & Lee, N. Y., Dec 1 2018, In : Nature communications. 9, 1, 1696.Research output: Contribution to journal › Article
Cell growth
Microtubules
Phosphotransferases
Chemical activation
activation