Research Output per year
Personal profile
Research interests
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.
Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.
Teaching and educational interests
Dr. Nadine Hempel is a graduate faculty member of the Biomedical Sciences Graduate Program, Clinical and Translational Science Research Training Program and MD/PhD Medical Scientist Training Program at Penn State College of Medicine.
Dr. Hempel is involved in graduate education and curricular development in her role as director of the Translational Therapeutics track in the Biomedical Sciences Graduate Program.
She is currently serving as a College of Medicine representative on Penn State's Graduate Council.
Education/Academic qualification
Postdoctoral Fellow, Albany Medical College
2007 → 2011
Postdoctoral Fellow, Duke University Medical Center
2004 → 2007
PhD, University of Queensland
… → 2004
BSc (Hons), University of Queensland
… → 1999
External positions
Council Member, Society for Redox Biology and Medicine
2014 → 2018Fingerprint Dive into the research topics where Nadine Hempel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Research Output
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells
Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.Research output: Contribution to journal › Article
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.Research output: Contribution to journal › Article
Open Access
6
Scopus
citations
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity
Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.Research output: Contribution to journal › Article
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J. I., Timmins, P. F., Kesterson, J. P., Phaëton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. M. & Hempel, N., Jul 2019, In : Redox Biology. 25, 101051.Research output: Contribution to journal › Article
5
Scopus
citations
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis
Singh, P., Jenkins, L. M., Horst, B., Alers, V., Pradhan, S., Kaur, P., Srivastava, T., Hempel, N., Gyorffy, B., Broude, E. V., Lee, N. Y. & Mythreye, K., Jun 1 2018, In : Cancer Research. 78, 11, p. 2978-2989 12 p.Research output: Contribution to journal › Article
3
Scopus
citations