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Personal profile

Research interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

Teaching and educational interests

Dr. Nadine Hempel is a graduate faculty member of the Biomedical Sciences Graduate Program, Clinical and Translational Science Research Training Program and MD/PhD Medical Scientist Training Program at Penn State College of Medicine.

Dr. Hempel is involved in graduate education and curricular development in her role as director of the Translational Therapeutics track in the Biomedical Sciences Graduate Program.

She is currently serving as a College of Medicine representative on Penn State's Graduate Council.

Education/Academic qualification

Postdoctoral Fellow, Albany Medical College

20072011

Postdoctoral Fellow, Duke University Medical Center

20042007

PhD, University of Queensland

… → 2004

BSc (Hons), University of Queensland

… → 1999

External positions

Council Member, Society for Redox Biology and Medicine

20142018

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Research Output

  • 1724 Citations
  • 19 h-Index
  • 31 Article
  • 6 Review article
  • 1 Chapter
  • 1 Short survey

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

Research output: Contribution to journalArticle

  • A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

    Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations

    Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

    Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

    Research output: Contribution to journalArticle

  • GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

    Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J. I., Timmins, P. F., Kesterson, J. P., Phaëton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. M. & Hempel, N., Jul 2019, In : Redox Biology. 25, 101051.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis

    Singh, P., Jenkins, L. M., Horst, B., Alers, V., Pradhan, S., Kaur, P., Srivastava, T., Hempel, N., Gyorffy, B., Broude, E. V., Lee, N. Y. & Mythreye, K., Jun 1 2018, In : Cancer Research. 78, 11, p. 2978-2989 12 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Prizes