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Personal profile

Research interests

Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.

Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.

Education/Academic qualification

Postdoctoral Fellow, Albany Medical College

20072011

Postdoctoral Fellow, Duke University Medical Center

20042007

PhD, University of Queensland

… → 2004

BSc (Hons), University of Queensland

… → 1999

Fingerprint Dive into the research topics where Nadine Hempel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Oxidation-Reduction Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Ovarian Neoplasms Medicine & Life Sciences
Urinary Bladder Neoplasms Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Cells Chemical Compounds
Growth Factor Receptors Medicine & Life Sciences

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Projects 2008 2024

Ovarian Neoplasms
Survival
Neoplasm Metastasis
Ascites
Neoplasms
Oxidation-Reduction
Reactive Oxygen Species
Neoplasm Metastasis
Neoplasms
Urinary Bladder Neoplasms
Superoxide Dismutase
Cell Movement
Reactive Oxygen Species
Neoplasms
Focal Adhesion Protein-Tyrosine Kinases

Research Output 2000 2019

  • 1555 Citations
  • 17 h-Index
  • 30 Article
  • 6 Review article
  • 1 Chapter
  • 1 Short survey
1 Citation (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J., Timmins, P. F., Kesterson, J., Phaeton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. & Hempel, N., Jan 1 2018, (Accepted/In press) In : Redox Biology.

Research output: Contribution to journalArticle

Glutathione Peroxidase
Ovarian Neoplasms
Oxidation-Reduction
Ascites
Adenocarcinoma
2 Citations (Scopus)

Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis

Singh, P., Jenkins, L. M., Horst, B., Alers, V., Pradhan, S., Kaur, P., Srivastava, T., Hempel, N., Gyorffy, B., Broude, E. V., Lee, N. Y. & Mythreye, K., Jun 1 2018, In : Cancer Research. 78, 11, p. 2978-2989 12 p.

Research output: Contribution to journalArticle

Inhibins
Angiogenesis Inducing Agents
Neoplasm Metastasis
Neoplasms
Antibodies
6 Citations (Scopus)

TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

Shah, N., Kumar, S., Zaman, N., Pan, C. C., Bloodworth, J. C., Lei, W., Streicher, J. M., Hempel, N., Mythreye, K. & Lee, N. Y., Dec 1 2018, In : Nature communications. 9, 1, 1696.

Research output: Contribution to journalArticle

Cell growth
Microtubules
Phosphotransferases
Chemical activation
activation