Projects per year
Personal profile
Research interests
Dr. Nadine Hempel's research interests center on understanding molecular mechanisms that regulate metastasis and tumor recurrence of ovarian cancer, with the ultimate goal of identifying novel targets for therapy of advanced-stage disease.
Her research group uses a variety of molecular, cellular, imaging and in vivo techniques to focus on two research areas in ovarian cancer biology: first, the role of mitochondrial antioxidants and reactive oxygen species during metastatic progression; and second, the regulation of mitochondrial dynamics and metabolism in ovarian cancer.
Teaching and educational interests
Dr. Nadine Hempel is a graduate faculty member of the Biomedical Sciences Graduate Program, Clinical and Translational Science Research Training Program and MD/PhD Medical Scientist Training Program at Penn State College of Medicine.
Dr. Hempel is involved in graduate education and curricular development in her role as director of the Translational Therapeutics track in the Biomedical Sciences Graduate Program.
She is currently serving as a College of Medicine representative on Penn State's Graduate Council.
Education/Academic qualification
Postdoctoral Fellow, Albany Medical College
2007 → 2011
Postdoctoral Fellow, Duke University Medical Center
2004 → 2007
PhD, University of Queensland
… → 2004
BSc (Hons), University of Queensland
… → 1999
External positions
Council Member, Society for Redox Biology and Medicine
2014 → 2018Fingerprint
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Projects
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Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
4/8/20 → 3/31/21
Project: Research project
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Role of Sox2 in Stress Adaptations to Ovarian Cancer Anchorage Independence
Hempel, N., KARTHIKEYAN, M. & KARTHIKEYAN, M.
4/11/19 → 3/31/21
Project: Research project
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Mitochondrial Redox Control of Metastasis
Hempel, N. & HEMPEL, N.
9/9/10 → 3/31/16
Project: Research project
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Regulation of Tumor Cell Migration by Mitochondrial Superoxide Dismutase
Hempel, N. & HEMPEL, N.
8/25/08 → 9/9/10
Project: Research project
Research Output
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Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells
Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In: Oncogene. 39, 8, p. 1619-1633 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis
Pathak, T., Gueguinou, M., Walter, V., Delierneux, C., Johnson, M. T., Zhang, X., Xin, P., Yoast, R. E., Emrich, S. M., Yochum, G. S., Sekler, I., Koltun, W. A., Gill, D. L., Hempel, N. & Trebak, M., Sep 2020, In: eLife. 9, p. 1-41 41 p., e59686.Research output: Contribution to journal › Article › peer-review
Open Access -
Extracellular glutathione peroxidase GPx3 and its role in cancer
Chang, C., Worley, B. L., Phaeton, R. & Hempel, N., Aug 2020, In: Cancers. 12, 8, p. 1-20 20 p., 2197.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins
Johnson, M. T., Gudlur, A., Zhang, X., Xin, P., Emrich, S. M., Yoast, R. E., Courjaret, R., Nwokonko, R. M., Li, W., Hempel, N., Machaca, K., Gill, D. L., Hogan, P. G. & Trebak, M., Jul 21 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 29, p. 17369-17380 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
The native ORAI channel trio underlies the diversity of Ca2+ signaling events
Yoast, R. E., Emrich, S. M., Zhang, X., Xin, P., Johnson, M. T., Fike, A. J., Walter, V., Hempel, N., Yule, D. I., Sneyd, J., Gill, D. L. & Trebak, M., May 15 2020, In: Nature communications. 11, 1, p. 2444 1 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations