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Personal profile

Research interests

Dr. Nancy Lill's current research focus is identifying mechanisms of protein and drug action that can be manipulated for the development of new anticancer therapies.

She works with Raymond J. Hohl, MD, PhD, director of Penn State Cancer Institute, on synthetic versions of natural compounds known as the schweinfurthins.

Ongoing mechanistic studies involve molecular and cell biology assays of: receptor tyrosine kinase signaling (as for the EGF receptor); protein and lipid trafficking; tumor suppressor inactivation; and cell metabolism.

Fingerprint Dive into the research topics where Nancy Lill is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Epidermal Growth Factor Receptor Medicine & Life Sciences
Protein-Tyrosine Kinases Medicine & Life Sciences
Oncogene Proteins Medicine & Life Sciences
Viral Tumor Antigens Medicine & Life Sciences
Endosomes Medicine & Life Sciences
Simian virus 40 Medicine & Life Sciences
Human papillomavirus 11 Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences

Projects 1993 2013

Epidermal Growth Factor Receptor
Ligands
Ubiquitination
Phosphorylation
Endosomes

Research Output 1986 2012

  • 1799 Citations
  • 15 h-Index
  • 16 Article
  • 2 Review article
12 Citations (Scopus)

A novel biotinylated lipid raft reporter for electron microscopic imaging of plasma membrane microdomains

Krager, K. J., Sarkar, M., Twait, E. C., Lill, N. & Koland, J. G., Oct 1 2012, In : Journal of Lipid Research. 53, 10, p. 2214-2225 12 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Cell membranes
Cell Membrane
Electrons
Lipids
20 Citations (Scopus)

Where EGF receptors transmit their signals

Lill, N. & Sever, N. I., Sep 25 2012, In : Science signaling. 5, 243, pe41.

Research output: Contribution to journalReview article

Endosomal Sorting Complexes Required for Transport
Epidermal Growth Factor Receptor
Endosomes
Receptor Protein-Tyrosine Kinases
Neoplasms
25 Citations (Scopus)

CBL controls EGFR fate by regulating early endosome fusion

Visser Smit, G. D., Place, T. L., Cole, S. L., Clausen, K. A., Vemugantl, S., Zhang, G., Koland, J. G. & Lill, N., Dec 22 2009, In : Science Signaling. 2, 102

Research output: Contribution to journalArticle

Endosomes
Epidermal Growth Factor Receptor
Fusion reactions
Degradation
Mutation
44 Citations (Scopus)

EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate

Stern, K. A., Place, T. L. & Lill, N., Mar 15 2008, In : Biochemical Journal. 410, 3, p. 585-594 10 p.

Research output: Contribution to journalArticle

Endosomes
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Degradation
Ligands
107 Citations (Scopus)

Nedd4 controls animal growth by regulating IGF-1 signaling

Cao, X. R., Lill, N., Boase, N., Shi, P. P., Croucher, D. R., Shan, H., Qu, J., Sweezer, E. M., Place, T., Kirby, P. A., Daly, R. J., Kumar, S. & Yang, B., Sep 23 2008, In : Science Signaling. 1, 38, ra5.

Research output: Contribution to journalArticle

Somatomedins
Somatomedin Receptors
Animals
Fibroblasts
Growth