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Research Output

Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability

Fitzgerald, J. C., Basu, R. K., Akcan-Arikan, A., Izquierdo, L. M., Piñeres Olave, B. E., Hassinger, A. B., Szczepanska, M., Deep, A., Williams, D., Sapru, A., Roy, J. A., Nadkarni, V. M., Thomas, N. J., Weiss, S. L. & Furth, S., Dec 1 2016, In : Critical care medicine. 44, 12, p. 2241-2250 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Acute lung injury in children - Kids really aren't just "Little Adults"

Thomas, N. J., Jouvet, P. & Willson, D., May 1 2013, In : Pediatric Critical Care Medicine. 14, 4, p. 429-432 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing

Li, H., Torab, P., Mach, K. E., Surrette, C., England, M. R., Craft, D. W., Thomas, N. J., Liao, J. C., Puleo, C. & Wong, P. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 21, p. 10270-10279 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Age and Mortality in Pediatric Severe Traumatic Brain Injury: Results from an International Study

For the Investigators of the ADAPT Trial, Jun 1 2018, In : Neurocritical Care. 28, 3, p. 302-313 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan

Thomas, N. J., Umstead, T. M. & Phelps, D. S., Mar 2005, In : Journal of pediatric surgery. 40, 3, p. 464-469 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome

Yehya, N., Bhalla, A. K., Thomas, N. J. & Khemani, R. G., Feb 1 2016, In : Pediatric Critical Care Medicine. 17, 2, p. 101-109 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Amantadine penetration into cerebrospinal fluid of a child with influenza A encephalitis

Geskey, J. M. & Thomas, N. J., Mar 1 2004, In : Pediatric Infectious Disease Journal. 23, 3, p. 270-272 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

A multibiomarker-based model for estimating the risk of septic acute kidney injury

Wong, H. R., Cvijanovich, N. Z., Anas, N., Allen, G. L., Thomas, N. J., Bigham, M. T., Weiss, S. L., Fitzgerald, J., Checchia, P. A., Meyer, K., Shanley, T. P., Quasney, M., Hall, M., Gedeit, R., Freishtat, R. J., Nowak, J., Raj, S. S., Gertz, S., Dawson, E., Howard, K. & 5 others, Harmon, K., Lahni, P., Frank, E., Hart, K. W. & Lindsell, C. J., Jan 1 2015, In : Critical care medicine. 43, 8, p. 1646-1653 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis

Gao, J., Jeffries, L., Mach, K. E., Craft, D. W., Thomas, N. J., Gau, V., Liao, J. C. & Wong, P. K., Aug 1 2017, In : SLAS Technology. 22, 4, p. 466-474 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections

Kurundu Hewage, E. M. K., Spear, D., Umstead, T. M., Hu, S., Wang, M., Wong, P. K., Chroneos, Z., Halstead, E. S. & Thomas, N., Dec 1 2017, In : SLAS Technology. 22, 6, p. 616-625 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Anemia, blood loss, and blood transfusions in North American children in the intensive care unit

Bateman, S. T., Lacroix, J., Boven, K., Forbes, P., Barton, R., Thomas, N. J., Jacobs, B., Markovitz, B., Hanson, J. H., Li, H. A., Abd-Allah, S., Randolph, A., Healey, H., Besunder, J., Blumer, J., Cheiftez, I., Bass, A., Dalton, H., Dobyns, E., Fitch, J. & 21 others, Gedeit, R., Goldstein, B., Grzeszczak, M., Hasan, R., Jefferson, L., Levin, D., Jarvis, D., Newth, C., Randolph, A. G., Auw, L., Patel, V., Ron, S., Correa, C. S., Seferian, E., Hess, J., Stokes, J., Willson, D., Cox, P., Joffe, A., Menon, K. & Wensley, D., Jul 1 2008, In : American journal of respiratory and critical care medicine. 178, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

159 Scopus citations

An international assessment of a web-based diagnostic tool in critically ill children

Thomas, N. J., Ramnarayan, P., Bell, M. J., Maheshwari, P., Wilson, S., Nazarian, E. B., Phipps, L. M., Stockwell, D. C., Engel, M., Maffei, F. A., Vyas, H. G. & Britto, J., Jul 29 2008, In : Technology and Health Care. 16, 2, p. 103-110 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure

Thomas, N. J., Guardia, C. G., Moya, F. R., Cheifetz, I. M., Markovitz, B., Cruces, P., Barton, P., Segal, R., Simmons, P. & Randolph, A. G., Nov 1 2012, In : Pediatric Critical Care Medicine. 13, 6, p. 646-653 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
Open Access
4 Scopus citations

A randomized controlled trial comparing three different techniques of nasojejunal feeding tube placement in critically III children

Phipps, L. M., Weber, M. D., Ginder, B. R., Hulse, M. A. & Thomas, N. J., Jan 1 2005, In : Journal of Parenteral and Enteral Nutrition. 29, 6, p. 420-424 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Assessing pulmonary arterial hypertension in infants with severe chronic lung disease of infancy: A role for a pulmonary artery catheter?

Baloglu, O., Aluquin, V. P. R., Tamburro, R. F., Thomas, N. J., Lucking, S. E., Ceneviva, G. D., Nkromah, T., Schneider, B. R., Lewellen, E. & Dettorre, M. D., Aug 1 2013, In : Pediatric cardiology. 34, 6, p. 1330-1334 5 p.

Research output: Contribution to journalArticle

Assessment of parental presence during bedside pediatric intensive care unit rounds: Effect on duration, teaching, and privacy

Phipps, L. M., Bartke, C. N., Spear, D. A., Jones, L. F., Foerster, C. P., Killian, M. E., Hughes, J. R., Hess, J. C., Johnson, D. R. & Thomas, N. J., May 2007, In : Pediatric Critical Care Medicine. 8, 3, p. 220-224 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: Insight into the timing and severity of injury in child abuse

Berger, R. P., Heyes, M. P., Wisniewski, S. R., Adelson, P. D., Thomas, N. & Kochanek, P. M., Sep 1 2004, In : Journal of Neurotrauma. 21, 9, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Association between Tidal Volumes Adjusted for Ideal Body Weight and Outcomes in Pediatric Acute Respiratory Distress Syndrome∗

Imber, D. A., Thomas, N. J. & Yehya, N., Mar 1 2019, In : Pediatric Critical Care Medicine. 20, 3, p. E145-E153

Research output: Contribution to journalArticle

3 Scopus citations

Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis

Han, M., Fitzgerald, J. C., Balamuth, F., Keele, L., Alpern, E. R., Lavelle, J., Chilutti, M., Grundmeier, R. W., Nadkarni, V. M., Thomas, N. J. & Weiss, S. L., Jul 1 2017, In : Shock. 48, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest secondary analysis of a randomized clinical trial

Topjian, A. A., Moler, F. W., Telford, R., Holubkov, R., Nadkarni, V. M., Berg, R. A., Dean, J. M., Meert, K. L., Hutchinson, J. S., Newth, C. J. L., Bennett, K. S., Berger, J. T., Pineda, J. A., Koch, J. D., Schleien, C. L., Dalton, H. J., Ofori-Amanfo, G., Goodman, D. M., Fink, E. L., McQuillen, P. & 24 others, Zimmerman, J. J., Thomas, N. J., Van Der Jagt, E. W., Porter, M. B., Meyer, M. T., Harrison, R., Pham, N., Schwarz, A. J., Nowak, J. E., Alten, J., Wheeler, D. S., Bhalala, U. S., Lidsky, K., Lloyd, E., Mathur, M., Shah, S., Wu, T., Theodorou, A. A., Sanders, R. C., Silverstein, F. S., Christensen, J. R., Slomine, B. S., Pemberton, V. L. & Browning, B., Feb 2018, In : JAMA Pediatrics. 172, 2, p. 143-153 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Association of response to inhaled nitric oxide and duration of mechanical ventilation in pediatric acute respiratory distress syndrome

Dowell, J. C., Thomas, N. J. & Yehya, N., Nov 2017, In : Pediatric Critical Care Medicine. 18, 11, p. 1019-1026 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association of the haem oxygenase-1 gene with inflammatory bowel disease

Lin, Z., Hao, H., Hegarty, J. P., Lin, T. R., Wang, Y., Harris, L. R., Xu, H. N., Wu, R., Thomas, N. J. & Floros, J., Aug 2 2017, In : Swiss Medical Weekly. 147, w14456.

Research output: Contribution to journalArticle

1 Scopus citations

Bicycle-related head injuries in South Carolina children: what can we do to prevent them?

Thomas, N. J., Key, J. D. & Ector, W. L., Jan 1 1994, In : Journal of the South Carolina Medical Association (1975). 90, 8, p. 355-359 5 p.

Research output: Contribution to journalReview article

7 Scopus citations

CALIPSO: A Randomized Controlled Trial of Calfactant for Acute Lung Injury in Pediatric Stem Cell and Oncology Patients

for the CALIPSO Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network, Dec 2018, In : Biology of Blood and Marrow Transplantation. 24, 12, p. 2479-2486 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cardiac contractility in endotoxemic rats treated with catecholamines is improved by high dose type IV phosphodiesterase (PDE4) inhibition with Ro 20-1724

Thomas, N. J., Carcillo, J. A., Herzer, W. A., Mi, Z. & Jackson, E. K., 1999, In : Critical Care Medicine. 27, 1 SUPPL.

Research output: Contribution to journalArticle

Cardiac failure in hemolytic uremic syndrome and rescue with extracorporeal life support

Thomas, N. J., Messina, J. J., Debruin, W. J. & Carcillo, J. A., Feb 1 2005, In : Pediatric Cardiology. 26, 1, p. 104-106 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cerebrospinal fluid biomarkers versus Glasgow Coma Scale and Glasgow Outcome Scale in pediatric traumatic brain injury: The role of young age and inflicted injury

Shore, P. M., Berger, R. P., Varma, S., Janesko, K. L., Wisniewski, S. R., Clark, R. S. B., Adelson, P. D., Thomas, N. J., Lai, Y. C., Bayir, H. & Kochanek, P. M., Jan 1 2007, In : Journal of Neurotrauma. 24, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

for the Investigators of the ADAPT Study, Oct 1 2017, In : Child's Nervous System. 33, 10, p. 1663-1667 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
6 Scopus citations

Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health

Tagaram, H. R. S., Wang, G., Umstead, T. M., Mikerov, A. N., Thomas, N. J., Graff, G. R., Hess, J. C., Thomassen, M. J., Kavuru, M. S., Phelps, D. S. & Floros, J., May 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 5, p. L1052-L1063

Research output: Contribution to journalArticle

44 Scopus citations

Characterizing degree of lung injury in pediatric acute respiratory distress syndrome

Yehya, N., Servaes, S. & Thomas, N. J., May 20 2015, In : Critical care medicine. 43, 5, p. 937-946 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
9 Scopus citations

Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome

Yehya, N., Thomas, N. J., Meyer, N. J., Christie, J. D., Berg, R. A. & Margulies, S. S., Jul 1 2016, In : Intensive Care Medicine. 42, 7, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Circulating nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome

Yehya, N., Thomas, N. J. & Margulies, S. S., Jun 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 11, p. L1177-L1184

Research output: Contribution to journalArticle

1 Scopus citations

Combining Prognostic and Predictive Enrichment Strategies to Identify Children with Septic Shock Responsive to Corticosteroids

Wong, H. R., Atkinson, S. J., Cvijanovich, N. Z., Anas, N., Allen, G. L., Thomas, N. J., Bigham, M. T., Weiss, S. L., Fitzgerald, J. C., Checchia, P. A., Meyer, K., Quasney, M., Hall, M., Gedeit, R., Freishtat, R. J., Nowak, J., Raj, S. S., Gertz, S. & Lindsell, C. J., Oct 1 2016, In : Critical care medicine. 44, 10, p. e1000-e1003

Research output: Contribution to journalArticle

33 Scopus citations

Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs

Giuliano, J. S., Markovitz, B. P., Brierley, J., Levin, R., Williams, G., Lum, L. C. S., Dorofaeff, T., Cruces, P., Bush, J. L., Keele, L., Nadkarni, V. M., Thomas, N. J., Fitzgerald, J. C., Weiss, S. L., Fontela, P., Tucci, M., Dumistrascu, M., Skippen, P., Krahn, G., Bezares, E. & 31 others, Puig, G., Puig-Ramos, A., Garcia, R., Villar, M., Bigham, M., Polanski, T., Latifi, S., Giebner, D., Anthony, H., Hume, J., Galster, A., Linnerud, L., Sanders, R., Hefley, G., Madden, K., Thompson, A., Shein, S., Gertz, S., Han, Y., Williams, T., Hughes-Schalk, A., Chandler, H., Orioles, A., Zielinski, E., Doucette, A., Orioles, A., Zielinski, E., Doucette, A., Zebuhr, C., Wilson, T. & Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network, Jun 1 2016, In : Pediatric Critical Care Medicine. 17, 6, p. 522-530 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury

Khemani, R. G., Thomas, N. J., Venkatachalam, V., Scimeme, J. P., Berutti, T., Schneider, J. B., Ross, P. A., Willson, D. F., Hall, M. W. & Newth, C. J. L., Apr 1 2012, In : Critical care medicine. 40, 4, p. 1309-1316 8 p.

Research output: Contribution to journalReview article

85 Scopus citations

Competency in the "Art" of pediatric mechanical ventilation

Krawiec, C. & Thomas, N. J., Jan 1 2014, In : Pediatric Critical Care Medicine. 15, 7, p. 669-670 2 p.

Research output: Contribution to journalEditorial

Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: Effect on biochemical markers

Shore, P. M., Thomas, N. J., Clark, R. S. B., Adelson, P. D., Wisniewski, S. R., Janesko, K. L., Bayir, H., Jackson, E. K. & Kochanek, P. M., Sep 1 2004, In : Journal of Neurotrauma. 21, 9, p. 1113-1122 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Corticosteroid exposure in pediatric acute respiratory distress syndrome

Yehya, N., Servaes, S., Thomas, N. J., Nadkarni, V. M. & Srinivasan, V., Sep 29 2015, In : Intensive Care Medicine. 41, 9, p. 1658-1666 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Corticosteroids and pediatric septic shock outcomes: A risk stratified analysis

Atkinson, S. J., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Weiss, S. L., Banschbach, S., Beckman, E., Howard, K., Frank, E., Harmon, K. & 3 others, Lahni, P., Lindsell, C. J. & Wong, H. R., Nov 11 2014, In : PloS one. 9, 11, e112702.

Research output: Contribution to journalArticle

32 Scopus citations

Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock

Wong, H. R., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Weiss, S. L., Shanley, T. P., Bigham, M. T., Banschbach, S., Beckman, E., Harmon, K. & Zimmerman, J. J., Apr 15 2014, In : American journal of respiratory and critical care medicine. 189, 8, p. 940-946 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cortisol Correlates with Severity of Illness and Poorly Reflects Adrenal Function in Pediatric Acute Respiratory Distress Syndrome

Yehya, N., Vogiatzi, M. G., Thomas, N. J. & Srinivasan, V., Jan 1 2016, In : Journal of Pediatrics. 177, p. 212-218.e1

Research output: Contribution to journalArticle

9 Scopus citations
12 Scopus citations

Decreasing unplanned extubations: Utilization of the Penn State Children's Hospital Sedation Algorithm

Popernack, M. L., Thomas, N. J. & Lucking, S. E., Dec 1 2004, In : Pediatric Critical Care Medicine. 5, 1, p. 58-62 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Defining acute lung disease in children with the oxygenation saturation index*

Thomas, N. J., Shaffer, M. L., Willson, D. F., Shih, M. C. & Curley, M. A. Q., 2010, In : Pediatric Critical Care Medicine. 11, 1, p. 12-17+164+165+166

Research output: Contribution to journalArticle

83 Scopus citations

Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis

Weiss, S. L., Fitzgerald, J. C., Balamuth, F., Alpern, E. R., Lavelle, J., Chilutti, M., Grundmeier, R., Nadkarni, V. M. & Thomas, N. J., Jan 1 2014, In : Critical care medicine. 42, 11, p. 2409-2417 9 p.

Research output: Contribution to journalArticle

124 Scopus citations