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Research Output

2014

High-frequency percussive ventilation improves oxygenation and ventilation in pediatric patients with acute respiratory failure

Rizkalla, N. A., Dominick, C. L., Fitzgerald, J. C., Thomas, N. J. & Yehya, N., Jan 1 2014, In : Journal of Critical Care. 29, 2, p. 314.e1-314.e7

Research output: Contribution to journalArticle

10 Scopus citations
25 Scopus citations

Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study

Silveyra, P., Chroneos, Z. C., Diangelo, S. L., Thomas, N. J., Noutsios, G. T., Tsotakos, N., Howrylak, J. A., Umstead, T. M. & Floros, J., Sep 2014, In : Experimental Lung Research. 40, 7, p. 354-366 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Outcome of pediatric acute myeloid leukemia patients receiving intensive care in the United States

Maude, S. L., Fitzgerald, J. C., Fisher, B. T., Li, Y., Huang, Y. S., Torp, K., Seif, A. E., Kavcic, M., Walker, D. M., Leckerman, K. H., Kilbaugh, T. J., Rheingold, S. R., Sung, L., Zaoutis, T. E., Berg, R. A., Nadkarni, V. M., Thomas, N. J. & Aplenc, R., Feb 1 2014, In : Pediatric Critical Care Medicine. 15, 2, p. 112-120 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Post-ICU admission fluid balance and pediatric septic shock outcomes: A risk-stratified analysis

Abulebda, K., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Weiss, S. L., Chopra, A., Banschbach, S., Beckman, E., Lindsell, C. J. & Wong, H. R., Feb 1 2014, In : Critical care medicine. 42, 2, p. 397-403 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Surfactant therapy

Thomas, N. J., Tamburro, R. F., Willson, D. F. & Notter, R. H., Jan 1 2014, Respiratory, Cardiovascular and Central Nervous Systems. Springer-Verlag London Ltd, Vol. 2. p. 195-213 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model

Wong, H. R., Weiss, S. L., Giuliano, J. S., Wainwright, M. S., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Chopra, A., Fitzgerald, J. C., Gedeit, R. & 5 others, Banschbach, S., Beckman, E., Lahn, P., Hart, K. & Lindsell, C. J., Jan 29 2014, In : PloS one. 9, 1, e86242.

Research output: Contribution to journalArticle

47 Scopus citations

The authors reply

Willson, D. F., Thomas, N., Tamburro, R., Truemper, E., Truwit, J., Conaway, M., Traul, C. & Egan, E. E., Feb 1 2014, In : Pediatric Critical Care Medicine. 15, 2, p. 184-185 2 p.

Research output: Contribution to journalLetter

The authors reply

Willson, D. F., Thomas, N. J., Tamburro, R., Truemper, E., Truwit, J., Conaway, M., Traul, C. & Egan, E. E., May 2014, In : Pediatric Critical Care Medicine. 15, 4, p. 385-386 2 p.

Research output: Contribution to journalLetter

The impact of a locally applied vibrating device on outpatient venipuncture in children

Whelan, H. M., Kunselman, A. R., Thomas, N. J., Moore, J. & Tamburro, R. F., Jan 1 2014, In : Clinical Pediatrics. 53, 12, p. 1189-1195 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

The temporal version of the pediatric sepsis biomarker risk model

Wong, H. R., Weiss, S. L., Giuliano, J. S., Wainwright, M. S., Cvijanovich, N. Z., Thomas, N. J., Allen, G. L., Anas, N., Bigham, M. T., Hall, M., Freishtat, R. J., Sen, A., Meyer, K., Checchia, P. A., Shanley, T. P., Nowak, J., Quasney, M., Chopra, A., Fitzgerald, J. C., Gedeit, R. & 5 others, Banschbach, S., Beckman, E., Harmon, K., Lahni, P. & Lindsell, C. J., Mar 13 2014, In : PloS one. 9, 3, e92121.

Research output: Contribution to journalArticle

27 Scopus citations

Understanding the global epidemiology of pediatric critical illness: The power, pitfalls, and practicalities of point prevalence studies

Weiss, S. L., Fitzgerald, J. C., Faustino, E. V., Festa, M. S., Fink, E. L., Jouvet, P., Bush, J. L., Kissoon, N., Marshall, J., Nadkarni, V. M. & Thomas, N. J., Jan 1 2014, In : Pediatric Critical Care Medicine. 15, 7, p. 660-666 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Acute lung injury in children - Kids really aren't just "Little Adults"

Thomas, N. J., Jouvet, P. & Willson, D., May 1 2013, In : Pediatric Critical Care Medicine. 14, 4, p. 429-432 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Assessing pulmonary arterial hypertension in infants with severe chronic lung disease of infancy: A role for a pulmonary artery catheter?

Baloglu, O., Aluquin, V. P. R., Tamburro, R. F., Thomas, N. J., Lucking, S. E., Ceneviva, G. D., Nkromah, T., Schneider, B. R., Lewellen, E. & Dettorre, M. D., Aug 1 2013, In : Pediatric cardiology. 34, 6, p. 1330-1334 5 p.

Research output: Contribution to journalArticle

Differences in medical therapy goals for children with severe traumatic brain injury - An international study

Bell, M. J., Adelson, P. D., Hutchison, J. S., Kochanek, P. M., Tasker, R. C., Vavilala, M. S., Beers, S. R., Fabio, A., Kelsey, S. F., Wisniewski, S. R., Loftis, L., Morris, K., LaRovere, K., Meyer, P., Walson, K., Exo, J., Sarnaik, A., Kilbaugh, T., Miles, D., Wainwright, M. & 26 others, Dean, N., Chima, R., Biagas, K., Peters, M., Balcells, J., Del Toledo, J. S., Robertson, C., Bailey, D., Piper, L., Tsai, W., Ragheb, J., Agbeko, R., O'Brien, N., Young, A., Thomas, N., Buttram, S., Borasino, S., Natale, J., Giza, C., Shellington, D., Stein, D., Clark, R., Au, A., Zimmerman, J., Pineda, J. & Ferrazzano, P., Oct 1 2013, In : Pediatric Critical Care Medicine. 14, 8, p. 811-818 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pediatric calfactant in acute respiratory distress syndrome trial

Willson, D. F., Thomas, N. J., Tamburro, R., Truemper, E., Truwit, J., Conaway, M., Traul, C. & Egan, E. E., Jan 1 2013, In : Pediatric Critical Care Medicine. 14, 7, p. 657-665 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Retrospective outcomes of glucose control in critically ill children

Kandil, S. B., Spear, D., Thomas, N. J., Weinzimer, S. A. & Faustino, E. V. S., Sep 2013, In : Journal of Diabetes Science and Technology. 7, 5, p. 1220-1228 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

The relationship of fluid administration to outcome in the pediatric calfactant in acute respiratory distress syndrome trial

Willson, D. F., Thomas, N. J., Tamburro, R., Truemper, E., Truwit, J., Conaway, M., Traul, C. & Egan, E. E., Jan 1 2013, In : Pediatric Critical Care Medicine. 14, 7, p. 666-672 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
2012

A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure

Thomas, N. J., Guardia, C. G., Moya, F. R., Cheifetz, I. M., Markovitz, B., Cruces, P., Barton, P., Segal, R., Simmons, P. & Randolph, A. G., Nov 1 2012, In : Pediatric Critical Care Medicine. 13, 6, p. 646-653 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury

Khemani, R. G., Thomas, N. J., Venkatachalam, V., Scimeme, J. P., Berutti, T., Schneider, J. B., Ross, P. A., Willson, D. F., Hall, M. W. & Newth, C. J. L., Apr 1 2012, In : Critical care medicine. 40, 4, p. 1309-1316 8 p.

Research output: Contribution to journalReview article

86 Scopus citations

IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants

Floros, J., Londono, D., Gordon, D., Silveyra, P., Diangelo, S. L., Viscardi, R. M., Worthen, G. S., Shenberger, J., Wang, G., Lin, Z. & Thomas, N. J., Jan 1 2012, In : Pediatric Research. 71, 1, p. 107-114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children

Wong, H. R., Cvijanovich, N. Z., Hall, M., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Bigham, M. T., Sen, A., Nowak, J., Quasney, M., Henricksen, J. W., Chopra, A., Banschbach, S., Beckman, E., Harmon, K., Lahni, P. & 1 others, Shanley, T. P., Oct 26 2012, In : Critical Care. 16, 5, R213.

Research output: Contribution to journalArticle

55 Scopus citations
9 Scopus citations

The pediatric sepsis biomarker risk model

Wong, H. R., Salisbury, S., Xiao, Q., Cvijanovich, N. Z., Hall, M., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Sen, A., Nowak, J., Quasney, M., Henricksen, J. W., Chopra, A., Banschbach, S. & 4 others, Beckman, E., Harmon, K., Lahni, P. & Lindsell, C. J., Oct 1 2012, In : Critical Care. 16, 5, R174.

Research output: Contribution to journalArticle

96 Scopus citations

You must walk before you can run

Willson, D. F., Thomas, N. J. & Jouvet, P. A., Nov 1 2012, In : Pediatric Critical Care Medicine. 13, 6, p. 691-692 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2011

Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray

Basu, R. K., Standage, S. W., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Wheeler, D. S., Devarajan, P., Goldstein, S. L. & Wong, H. R., Nov 18 2011, In : Critical Care. 15, 6, R273.

Research output: Contribution to journalArticle

27 Scopus citations

Surfactant protein genetics in community-acquired pneumonia: Balancing the host inflammatory state

Floros, J. & Thomas, N. J., Apr 21 2011, In : Critical Care. 15, 2, 156.

Research output: Contribution to journalComment/debate

4 Scopus citations

The influence of developmental age on the early transcriptomic response of children with septic shock

Wynn, J. L., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Banschbach, S., Beckman, E. & Wong, H. R., Nov 2011, In : Molecular Medicine. 17, 11, p. 1146-1156 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Validation of a gene expression-based subclassification strategy for pediatric septic shock

Wong, H. R., Cvijanovich, N. Z., Allen, G. L., Thomas, N. J., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Lin, R., Shanley, T. P., Bigham, M. T., Wheeler, D. S., Doughty, L. A., Tegtmeyer, K., Poynter, S. E., Kaplan, J. M., Chima, R. S., Stalets, E., Basu, R. K., Varisco, B. M. & 1 others, Barr, F. E., Nov 2011, In : Critical care medicine. 39, 11, p. 2511-2517 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2010

Defining acute lung disease in children with the oxygenation saturation index*

Thomas, N. J., Shaffer, M. L., Willson, D. F., Shih, M. C. & Curley, M. A. Q., 2010, In : Pediatric Critical Care Medicine. 11, 1, p. 12-17+164+165+166

Research output: Contribution to journalArticle

83 Scopus citations

Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass

Umstead, T. M., Lu, C. J. K., Freeman, W. M., Myers, J. L., Clark, J. B., Thomas, N. J., Chinchilli, V. M., Vrana, K. E., Ündar, A. & Phelps, D. S., Jun 1 2010, In : Pediatric Research. 67, 6, p. 641-649 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women

Lin, Z., Poritz, L., Franke, A., Li, T. Y., Ruether, A., Byrnes, K. A., Wang, Y., Gebhard, A. W., MacNeill, C., Thomas, N. J., Schreiber, S. & Koltun, W. A., Mar 1 2010, In : Digestive Diseases and Sciences. 55, 3, p. 739-746 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
44 Scopus citations

OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease

Lin, Z., Nelson, L., Franke, A., Poritz, L., Li, T. Y., Wu, R., Wang, Y., MacNeill, C., Thomas, N. J., Schreiber, S. & Koltun, W. A., Jun 1 2010, In : Journal of Crohn's and Colitis. 4, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
4 Scopus citations
6 Scopus citations
2009

Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men

Lin, Z., Poritz, L., Franke, A., Li, T. Y., Ruether, A., Byrnes, K. A., Wang, Y., Gebhard, A. W., MacNeill, C., Thomas, N. J., R. Wu, W., Schreiber, S. & Koltun, W. A., 2009, In : Disease Markers. 27, 5, p. 193-201 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

Wong, H. R., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Willson, D. F., Freishtat, R. J., Anas, N., Meyer, K., Checchia, P. A., Monaco, M., Odom, K. & Shanley, T. P., Jul 22 2009, In : BMC Medicine. 7, 34.

Research output: Contribution to journalArticle

117 Scopus citations

Penn state hershey - Center for pediatric cardiovascular research: Guest editorial

Ündar, A., Pauliks, L., Clark, J. B., Zahn, J., Rosenberg, G., Kunselman, A. R., Sun, Q., Pekkan, K., Saliba, K., Carney, E., Thomas, N., Freeman, W., Vrana, K., El-Banayosy, A., Ural, S. H., Wilson, R., Umstead, T. M., Floros, J., Phelps, D. S., Weiss, W. & 15 others, Snyder, A., Yang, S., Kimatian, S., Cyran, S. E., Chinchilli, V. M., Guan, Y., Rider, A., Haines, N., Rogerson, A., Alkan-Bozkaya, T., Akcevin, A., Sun, K., Wang, S., Cun, L. & Myers, J. L., Nov 1 2009, In : Artificial organs. 33, 11, p. 883-887 5 p.

Research output: Contribution to journalReview article

4 Scopus citations

Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus

Thomas, N. J., Diangelo, S., Hess, J. C., Fan, R., Ball, M. W., Geskey, J. M., Willson, D. F. & Floros, J., Jul 1 2009, In : Pediatric Research. 66, 1, p. 70-73 4 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008

Anemia, blood loss, and blood transfusions in North American children in the intensive care unit

Bateman, S. T., Lacroix, J., Boven, K., Forbes, P., Barton, R., Thomas, N. J., Jacobs, B., Markovitz, B., Hanson, J. H., Li, H. A., Abd-Allah, S., Randolph, A., Healey, H., Besunder, J., Blumer, J., Cheiftez, I., Bass, A., Dalton, H., Dobyns, E., Fitch, J. & 21 others, Gedeit, R., Goldstein, B., Grzeszczak, M., Hasan, R., Jefferson, L., Levin, D., Jarvis, D., Newth, C., Randolph, A. G., Auw, L., Patel, V., Ron, S., Correa, C. S., Seferian, E., Hess, J., Stokes, J., Willson, D., Cox, P., Joffe, A., Menon, K. & Wensley, D., Jul 1 2008, In : American journal of respiratory and critical care medicine. 178, 1, p. 26-33 8 p.

Research output: Contribution to journalArticle

163 Scopus citations

An international assessment of a web-based diagnostic tool in critically ill children

Thomas, N. J., Ramnarayan, P., Bell, M. J., Maheshwari, P., Wilson, S., Nazarian, E. B., Phipps, L. M., Stockwell, D. C., Engel, M., Maffei, F. A., Vyas, H. G. & Britto, J., Jul 29 2008, In : Technology and Health Care. 16, 2, p. 103-110 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Demographics of abusive head trauma in the Commonwealth of Pennsylvania

Kesler, H., Dias, M. S., Shaffer, M., Rottmund, C., Cappos, K. & Thomas, N. J., May 1 2008, In : Journal of Neurosurgery: Pediatrics. 1, 5, p. 351-356 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass

Lull, M. E., Carkaci-Salli, N., Freeman, W. M., Myers, J. L., Midgley, F. M., Thomas, N. J., Kimatian, S. J., Vrana, K. E. & Ündar, A., Jun 1 2008, In : Pediatric Research. 63, 6, p. 638-644 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Post hoc analysis of calfactant use in immunocompromised children with acute lung injury: Impact and feasibility of further clinical trials

Tamburro, R. F., Thomas, N. J., Pon, S., Jacobs, B. R., Dicarlo, J. V., Markovitz, B. P., Jefferson, L. S. & Willson, D. F., Sep 2008, In : Pediatric Critical Care Medicine. 9, 5, p. 459-464 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Validating the genomic signature of pediatric septic shock

Cvijanovich, N., Shanley, T. P., Lin, R., Allen, G. L., Thomas, N. J., Checchia, P., Anas, N., Freishtat, R. J., Monaco, M., Odoms, K., Sakthivel, B. & Wong, H. R., Jun 1 2008, In : Physiological genomics. 34, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
2007

Assessment of parental presence during bedside pediatric intensive care unit rounds: Effect on duration, teaching, and privacy

Phipps, L. M., Bartke, C. N., Spear, D. A., Jones, L. F., Foerster, C. P., Killian, M. E., Hughes, J. R., Hess, J. C., Johnson, D. R. & Thomas, N. J., May 2007, In : Pediatric Critical Care Medicine. 8, 3, p. 220-224 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

Cerebrospinal fluid biomarkers versus Glasgow Coma Scale and Glasgow Outcome Scale in pediatric traumatic brain injury: The role of young age and inflicted injury

Shore, P. M., Berger, R. P., Varma, S., Janesko, K. L., Wisniewski, S. R., Clark, R. S. B., Adelson, P. D., Thomas, N. J., Lai, Y. C., Bayir, H. & Kochanek, P. M., Jan 1 2007, In : Journal of Neurotrauma. 24, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health

Tagaram, H. R. S., Wang, G., Umstead, T. M., Mikerov, A. N., Thomas, N. J., Graff, G. R., Hess, J. C., Thomassen, M. J., Kavuru, M. S., Phelps, D. S. & Floros, J., May 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 5, p. L1052-L1063

Research output: Contribution to journalArticle

45 Scopus citations