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Research Output

2007

DNA methylation markers of surfactant proteins in lung cancer

Lin, Z., Thomas, N. J., Bibikova, M., Seifart, C., Wang, Y., Guo, X., Wang, G., Vollmer, E., Goldmann, T., Garcia, E. W., Zhou, L., Fan, J. B. & Floros, J., Jul 1 2007, In : International journal of oncology. 31, 1, p. 181-191 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome

Wong, H. R., Shanley, T. P., Sakthivel, B., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Tagavilla, M. A., Odoms, K., Dunsmore, K., Barnes, M. & Aronow, B. J., Jul 18 2007, In : Physiological genomics. 30, 2, p. 146-155 10 p.

Research output: Contribution to journalArticle

159 Scopus citations

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock

Shanley, T. P., Cvijanovich, N., Lin, R., Allen, G. L., Thomas, N. J., Doctor, A., Kalyanaraman, M., Tofil, N. M., Penfil, S., Monaco, M., Odoms, K., Barnes, M., Sakthivel, B., Aronow, B. J. & Wong, H. R., Sep 1 2007, In : Molecular Medicine. 13, 9-10, p. 495-508 14 p.

Research output: Contribution to journalArticle

99 Scopus citations
25 Scopus citations

Palivizumab: A review of its use in the protection of high risk infants against respiratory syncytial virus (RSV)

Geskey, J. M., Thomas, N. J. & Brummel, G. L., Dec 1 2007, In : Biologics: Targets and Therapy. 1, 1, p. 33-43 11 p.

Research output: Contribution to journalReview article

14 Scopus citations

Palivizumab in congenital heart disease: Should international guidelines be revised?

Geskey, J. M., Thomas, N. J. & Brummel, G. L., Nov 1 2007, In : Expert Opinion on Biological Therapy. 7, 11, p. 1615-1620 6 p.

Research output: Contribution to journalReview article

10 Scopus citations
24 Scopus citations

Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants

Mikerov, A. N., Wang, G., Umstead, T. M., Zacharatos, M., Thomas, N. J., Phelps, D. S. & Floros, J., Mar 1 2007, In : Infection and Immunity. 75, 3, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Temporal factors and the incidence of physical abuse in young children: decreased nonaccidental trauma during child abuse prevention month

Thomas, N. J., Shaffer, M. L., Rzucidlo, S., Shirk, B. J. & Dias, M. S., Oct 1 2007, In : Journal of pediatric surgery. 42, 10, p. 1735-1739 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

The use of a daily goals sheet to improve communication in the paediatric intensive care unit

Phipps, L. M. & Thomas, N. J., Oct 1 2007, In : Intensive and Critical Care Nursing. 23, 5, p. 264-271 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2006

Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS

Floros, J., Thomas, N. J., Liu, W., Papagaroufalis, C., Xanthou, M., Pereira, S., Fan, R., Guo, X., Diangelo, S. & Pavlovic, J., Apr 1 2006, In : Pediatric Research. 59, 4 PART 1, p. 616-621 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia

Pavlovic, J., Papagaroufalis, C., Xanthou, M., Liu, W., Fan, R., Thomas, N. J., Apostolidou, I., Papathoma, E., Megaloyianni, E., DiAngelo, S. & Floros, J., Jan 1 2006, In : Disease Markers. 22, 5-6, p. 277-291 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

High-throughput DNA methylation profiling using universal bead arrays

Bibikova, M., Lin, Z., Zhou, L., Chudin, E., Garcia, E. W., Wu, B., Doucet, D., Thomas, N. J., Wang, Y., Vollmer, E., Goldmann, T., Seifart, C., Jiang, W., Barker, D. L., Chee, M. S., Floros, J. & Fan, J. B., Mar 1 2006, In : Genome research. 16, 3, p. 383-393 11 p.

Research output: Contribution to journalArticle

480 Scopus citations

Opioids causing a back up in the pediatric intensive care unit? No solution yet

Thomas, N. J. & Tamburro, R. F., May 1 2006, In : Pediatric Critical Care Medicine. 7, 3, p. 287-288 2 p.

Research output: Contribution to journalEditorial

Safety and efficacy of sedation with propofol for transoesophageal echocardiography in children in an outpatient setting

Mart, C. R., Parrish, M., Rosen, K. L., Dettorre, M., Ceneviva, G., Lucking, S. & Thomas, N., Apr 1 2006, In : Cardiology in the Young. 16, 2, p. 152-156 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

The impact of pediatric trauma in the Amish community

Vitale, M. A., Rzucidlo, S., Shaffer, M. L., Ceneviva, G. D. & Thomas, N. J., Mar 1 2006, In : Journal of Pediatrics. 148, 3, p. 359-365 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan

Thomas, N. J., Umstead, T. M. & Phelps, D. S., Mar 2005, In : Journal of pediatric surgery. 40, 3, p. 464-469 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

A randomized controlled trial comparing three different techniques of nasojejunal feeding tube placement in critically III children

Phipps, L. M., Weber, M. D., Ginder, B. R., Hulse, M. A. & Thomas, N. J., Jan 1 2005, In : Journal of Parenteral and Enteral Nutrition. 29, 6, p. 420-424 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cardiac failure in hemolytic uremic syndrome and rescue with extracorporeal life support

Thomas, N. J., Messina, J. J., Debruin, W. J. & Carcillo, J. A., Feb 1 2005, In : Pediatric Cardiology. 26, 1, p. 104-106 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
12 Scopus citations

Deletions within a CA-repeat-rich region of intron 4 of the human SP-B gene affect mRNA splicing

Lin, Z., Thomas, N. J., Wang, Y., Guo, X., Seifart, C., Shakoor, H. & Floros, J., Jul 15 2005, In : Biochemical Journal. 389, 2, p. 403-412 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Duration of cardiopulmonary resuscitation before extracorporeal rescue: How long is not long enough?

Kelly, R. B., Porter, P. A., Meier, A. H., Myers, J. & Thomas, N., Sep 1 2005, In : ASAIO Journal. 51, 5, p. 665-667 3 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: A randomized controlled trial

Willson, D. F., Thomas, N. J., Markovitz, B. P., Bauman, L. A., DiCarlo, J. V., Pon, S., Jacobs, B. R., Jefferson, L. S., Conaway, M. R. & Egan, E. A., Jan 26 2005, In : Journal of the American Medical Association. 293, 4, p. 470-476 7 p.

Research output: Contribution to journalArticle

305 Scopus citations
27 Scopus citations
14 Scopus citations

Idiopathic thrombocytopenic purpura complicated by an intracranial hemorrhage secondary to an arteriovenous malformation

Downs, L. A., Thomas, N. J., Comito, M. A., Meier, A. H. & Dias, M. S., May 1 2005, In : Pediatric Emergency Care. 21, 5, p. 309-311 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Jading [1] (multiple letters)

Graham, R. J., Levi, B. H., Thomas, N. J., Green, M. J., Rentmeester, C. A. & Ceneviva, G. D., Jan 2005, In : Pediatric Critical Care Medicine. 6, 1, 1 p.

Research output: Contribution to journalLetter

Myocardial calcification caused by secondary hyperparathyroidism due to dietary deficiency of calcium and vitamin D

Zaidi, A. N., Ceneviva, G. D., Phipps, L. M., Dettorre, M. D., Mart, C. R. & Thomas, N. J., Aug 1 2005, In : Pediatric cardiology. 26, 4, p. 460-463 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Prospective assessment of guidelines for determining appropriate depth of endotracheal tube placement in children

Phipps, L. M., Thomas, N. J., Gilmore, R. K., Raymond, J. A., Bittner, T. R., Orr, R. A. & Robertson, C. L., Sep 2005, In : Pediatric Critical Care Medicine. 6, 5, p. 519-522 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Surfactant and pediatric acute lung injury [2] (multiple letters)

Hunt, E. A., Schwartz, J. M. E., Fackler, J. C., Willson, D. F., Egan, E. A., Thomas, N. J., DiCarlo, J. V., Pon, S., Jefferson, L. & Jacobs, B., Aug 24 2005, In : Journal of the American Medical Association. 294, 8, p. 898-899 2 p.

Research output: Contribution to journalLetter

2 Scopus citations
2004

Amantadine penetration into cerebrospinal fluid of a child with influenza A encephalitis

Geskey, J. M. & Thomas, N. J., Mar 1 2004, In : Pediatric Infectious Disease Journal. 23, 3, p. 270-272 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: Insight into the timing and severity of injury in child abuse

Berger, R. P., Heyes, M. P., Wisniewski, S. R., Adelson, P. D., Thomas, N. & Kochanek, P. M., Sep 1 2004, In : Journal of Neurotrauma. 21, 9, p. 1123-1130 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Continuous versus intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: Effect on biochemical markers

Shore, P. M., Thomas, N. J., Clark, R. S. B., Adelson, P. D., Wisniewski, S. R., Janesko, K. L., Bayir, H., Jackson, E. K. & Kochanek, P. M., Sep 1 2004, In : Journal of Neurotrauma. 21, 9, p. 1113-1122 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Decreasing unplanned extubations: Utilization of the Penn State Children's Hospital Sedation Algorithm

Popernack, M. L., Thomas, N. J. & Lucking, S. E., Dec 1 2004, In : Pediatric Critical Care Medicine. 5, 1, p. 58-62 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients

Temple, A. M. M. & Thomas, N. J., Jul 1 2004, In : Pediatric Emergency Care. 20, 7, p. 457-459 3 p.

Research output: Contribution to journalArticle

10 Scopus citations
16 Scopus citations
2003

F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children

Varma, S., Janesko, K. L., Wisniewski, S. R., Bayir, H., Adelson, P. D., Thomas, N. J. & Kochanek, P. M., Aug 1 2003, In : Journal of Neurotrauma. 20, 8, p. 781-786 6 p.

Research output: Contribution to journalArticle

68 Scopus citations

Isabel

Thomas, N. J., Feb 1 2003, In : Critical Care. 7, 1, p. 99-100 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations
25 Scopus citations

Theophylline for acute renal vasoconstriction associated with tacrolimus: A new indication for an old therapeutic agent?

Thomas, N. J. & Carcillo, J. A., Dec 1 2003, In : Pediatric Critical Care Medicine. 4, 3, p. 392-393 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats

Thomas, N. J., Carcillo, J. A., Herzer, W. A., Mi, Z., Tofovic, S. P. & Jackson, E. K., Mar 28 2003, In : European Journal of Pharmacology. 465, 1-2, p. 133-139 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2002

Plasma concentrations of defensins and lactoferrin in children with severe sepsis

Thomas, N. J., Carcillo, J. A., Doughty, L. A., Sasser, H. & Heine, R. P., Jan 29 2002, In : Pediatric Infectious Disease Journal. 21, 1, p. 34-38 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pro/con clinical debate: Do colloids have advantages over crystalloids in paediatric sepsis?

Khandelwal, P., Bohn, D., Carcillo, J. A. & Thomas, N. J., Aug 21 2002, In : Critical Care. 6, 4, p. 286-288 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
2001
9 Scopus citations
1999

Cardiac contractility in endotoxemic rats treated with catecholamines is improved by high dose type IV phosphodiesterase (PDE4) inhibition with Ro 20-1724

Thomas, N. J., Carcillo, J. A., Herzer, W. A., Mi, Z. & Jackson, E. K., 1999, In : Critical Care Medicine. 27, 1 SUPPL.

Research output: Contribution to journalArticle

Systemic and local surfactant protein a is altered in a model of multiple organ dysfunction syndrome (MODS)

Thomas, N. J., Umstead, T. M., Hayden, C. J. & Phelps, D. S., Dec 1 1999, In : Critical care medicine. 27, 12 SUPPL.

Research output: Contribution to journalArticle

1998

Effect of the type IV phosphodiesterase inhibitor Ro 20-1724 on catecholamine-induced alterations in regional vascular resistance and regional blood flow

Thomas, N. J., Herzer, W. A., Carcillo, J. A. & Jackson, E. K., Jun 1 1998, In : Journal of Cardiovascular Pharmacology. 31, 6, p. 840-853 14 p.

Research output: Contribution to journalArticle

Effects of type IV phosphodiesterase inhibition on cardiac function in the presence and absence of catecholamines

Herzer, W. A., Thomas, N. J., Carcillo, J. A., Tofovic, S. P. & Jackson, E. K., Nov 1 1998, In : Journal of Cardiovascular Pharmacology. 32, 5, p. 769-776 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Hypovolemic shock in pediatric patients

Thomas, N. J. & Carcillo, J. A., Jun 30 1998, In : New Horizons: Science and Practice of Acute Medicine. 6, 2, p. 120-129 10 p.

Research output: Contribution to journalReview article

21 Scopus citations