• 1046 Citations
  • 18 h-Index
1983 …2019
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Research Output 1994 2019

  • 1046 Citations
  • 18 h-Index
  • 39 Article
  • 1 Chapter
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Article
2019
Dihydroxyacetone Phosphate
Quinolinic Acid
X ray crystallography
X Ray Crystallography
Phosphates

Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α2-gliadin (57-89) at physiological conditions

Van Buiten, C. B., Yennawar, N., Pacheco, C. N., Hatzakis, E. & Elias, R., May 1 2019, In : Food and Function. 10, 5, p. 2997-3007 11 p.

Research output: Contribution to journalArticle

Gliadin
epigallocatechin
gliadin
abdomen
Abdomen
1 Citation (Scopus)

Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis

Rose, H. R., Maggiolo, A. O., McBride, M. J., Palowitch, G. M., Pandelia, M. E., Davis, K. M., Yennawar, N. & Boal, A. K., Apr 9 2019, In : Biochemistry. 58, 14, p. 1845-1860 16 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Biosynthesis
Flavobacterium
Catalytic Domain
Actinobacillus
2018
3 Citations (Scopus)

Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms

Leamy, K. A., Yennawar, N. & Bevilacqua, P. C., May 22 2018, In : Biochemistry. 57, 20, p. 2994-3002 9 p.

Research output: Contribution to journalArticle

RNA, Transfer, Phe
Base Pairing
RNA
Temperature
Entropy
14 Citations (Scopus)

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

McBrayer, S. K., Mayers, J. R., DiNatale, G. J., Shi, D. D., Khanal, J., Chakraborty, A. A., Sarosiek, K. A., Briggs, K. J., Robbins, A. K., Sewastianik, T., Shareef, S. J., Olenchock, B. A., Parker, S. J., Tateishi, K., Spinelli, J. B., Islam, M., Haigis, M. C., Looper, R. E., Ligon, K. L., Bernstein, B. E. & 7 others, Carrasco, R. D., Cahill, D. P., Asara, J. M., Metallo, C. M., Yennawar, N., Vander Heiden, M. G. & Kaelin, W. G., Sep 20 2018, In : Cell. 175, 1, p. 101-116.e25

Research output: Contribution to journalArticle

Glutaminase
Biosynthesis
Transaminases
Glioma
Oxidation-Reduction
2017
15 Citations (Scopus)
RNA Folding
Stabilization
RNA
Transfer RNA
Nucleotides
3 Citations (Scopus)

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

DiMarzio, M., Rusconi, B., Yennawar, N., Eppinger, M., Patterson, A. D. & Dudley, E. G., Sep 1 2017, In : PloS one. 12, 9, e0183564.

Research output: Contribution to journalArticle

choloylglycine hydrolase
Lactobacillus johnsonii
beta acids
antagonists
receptors
18 Citations (Scopus)

Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies

Glisan, S. L., Grove, K. A., Yennawar, N. & Lambert, J. D., Feb 1 2017, In : Food Chemistry. 216, p. 296-300 5 p.

Research output: Contribution to journalArticle

theaflavins
enzymology
black tea
Tea
Lipase
20 Citations (Scopus)

The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme

Bingaman, J. L., Zhang, S., Stevens, D. R., Yennawar, N., Hammes-Schiffer, S. & Bevilacqua, P. C., Apr 1 2017, In : Nature Chemical Biology. 13, 4, p. 439-445 7 p.

Research output: Contribution to journalArticle

Catalytic RNA
Metals
RNA
Ions
Enzymes
2016
5 Citations (Scopus)
Enzymes and Coenzymes
Methanosarcina
Glutaredoxins
Mesna
Disulfides
8 Citations (Scopus)

Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid

Esakova, O. A., Silakov, A., Grove, T. L., Saunders, A. H., McLaughlin, M. I., Yennawar, N. & Booker, S. J., Jun 15 2016, In : Journal of the American Chemical Society. 138, 23, p. 7224-7227 4 p.

Research output: Contribution to journalArticle

Pyrococcus horikoshii
Quinolinic Acid
Acids
Amino acids
Hydroxyl Radical
2015
5 Citations (Scopus)

Conformational ensemble of the poliovirus 3CD precursor observed by MD simulations and confirmed by SAXS: A strategy to expand the viral proteome?

Moustafa, I., Gohara, D. W., Uchida, A., Yennawar, N. & Cameron, C. E., Nov 23 2015, In : Viruses. 7, 11, p. 5962-5986 25 p.

Research output: Contribution to journalArticle

Poliovirus
Proteome
Molecular Dynamics Simulation
X-Rays
RNA Replicase
27 Citations (Scopus)

Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves

Guo, F., Zhou, W., Li, P., Mao, Z., Yennawar, N., French, J. B. & Huang, T. J., Jun 1 2015, In : Small. 11, 23, p. 2733-2737 5 p.

Research output: Contribution to journalArticle

Crystallography
Surface waves
Acoustic waves
Proteins
Crystals
10 Citations (Scopus)

Structural and biochemical characterization of a ferredoxin: Thioredoxin reductase-like enzyme from methanosarcina acetivorans

Kumar, A. K., Kumar, R. S. S., Yennawar, N., Yennawar, H. P. & Ferry, J. G., May 19 2015, In : Biochemistry. 54, 19, p. 3122-3128 7 p.

Research output: Contribution to journalArticle

Methanosarcina
Disulfides
Ferredoxins
Enzymes
Methane
4 Citations (Scopus)

Structural models of mammalian mitochondrial transcription factor B2

Moustafa, I., Uchida, A., Wang, Y., Yennawar, N. & Cameron, C. E., Aug 1 2015, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1849, 8, p. 987-1002 16 p.

Research output: Contribution to journalArticle

Structural Models
Transcription Factors
Transcription
Mitochondrial DNA
Nucleic Acids
2014
3 Citations (Scopus)

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain

Wang, X., Yennawar, N. & Giblin, P. H., Apr 16 2014, In : Cell Communication and Signaling. 12, 1, 28.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Chemical activation
Tyrosine
Phosphorylation
Molecular modeling
2013
1 Citation (Scopus)
adenosine diphosphate
adenosine triphosphate
X ray analysis
Transcription
Crystallization
30 Citations (Scopus)

Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions

Strulson, C. A., Yennawar, N., Rambo, R. P. & Bevilacqua, P. C., Nov 19 2013, In : Biochemistry. 52, 46, p. 8187-8197 11 p.

Research output: Contribution to journalArticle

Catalytic RNA
Crowding
RNA Folding
RNA
Urea
18 Citations (Scopus)

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

Wörsdörfer, B., Lingaraju, M., Yennawar, N., Boal, A. K., Krebs, C., Bollinger, Jr., J. M. & Pandelia, M. E., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18874-18879 6 p.

Research output: Contribution to journalArticle

Inositol Oxygenase
Organophosphonates
Oxygenases
X Ray Crystallography
Phosphoric Monoester Hydrolases
2012
4 Citations (Scopus)
Secretory Phospholipase A2
Proanthocyanidins
phospholipase A2
Phospholipases A2
proanthocyanidins
80 Citations (Scopus)
Entropy
Cellulose
Oligosaccharides
Ligands
Cellulases
116 Citations (Scopus)

Structural basis for methyl transfer by a radical SAM enzyme

Boal, A. K., Grove, T. L., McLaughlin, M. I., Yennawar, N., Booker, S. J. & Rosenzweig, A. C., May 27 2011, In : Science. 332, 6033, p. 1089-1092 4 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Enzymes
23S Ribosomal RNA
Adenosine
Methylation
11 Citations (Scopus)

X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase

Yennawar, H. P., Mller, M., Gillilan, R. & Yennawar, N., May 1 2011, In : Acta Crystallographica Section D: Biological Crystallography. 67, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

L-Iditol 2-Dehydrogenase
Sheep
X-Rays
Liver
Catalytic Domain
2010
11 Citations (Scopus)

Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae

Lee, J., Yennawar, N., Gam, J. & Benkovic, S., Jan 12 2010, In : Biochemistry. 49, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Streptococcus pneumoniae
Kinetics
Trimethoprim
Escherichia coli
9 Citations (Scopus)
Crystallization
dehydrogenases
L-Iditol 2-Dehydrogenase
Screening
Lasers
2007
1 Citation (Scopus)
Clostridium
Exotoxins
Clostridium perfringens
Crystallization
Synchrotrons
2006
151 Citations (Scopus)

Crystal structure and activities of EXPB1 (Zea m 1), a β-expansin and group-1 pollen allergen from maize

Yennawar, N., Li, A. C., Dudzinski, D. M., Tabuchi, A. & Cosgrove, D. J., Oct 3 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14664-14671 8 p.

Research output: Contribution to journalArticle

Pollen
Allergens
Cell Wall
Zea mays
Polysaccharides
25 Citations (Scopus)

Human mitochondrial branched chain aminotransferase isozyme: Structural role of the CXXC center in catalysis

Yennawar, N., Islam, M. M., Conway, M., Wallin, R. & Hutson, S. M., Dec 22 2006, In : Journal of Biological Chemistry. 281, 51, p. 39660-39671 12 p.

Research output: Contribution to journalArticle

Catalysis
Isoenzymes
Pyridoxamine
Substrates
Enzymes
2005
45 Citations (Scopus)

Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

Goto, M., Miyahara, I., Hirotsu, K., Conway, M., Yennawar, N., Islam, M. M. & Hutson, S. M., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 37246-37256 11 p.

Research output: Contribution to journalArticle

Anticonvulsants
Isoenzymes
Leucine
Catalytic Domain
Oxidation
2003
24 Citations (Scopus)

Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines

Conway, M. E., Yennawar, N., Wallin, R., Poole, L. B. & Hutson, S. M., Apr 11 2003, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1647, 1-2, p. 61-65 5 p.

Research output: Contribution to journalArticle

Substrate Specificity
Oxidation-Reduction
Cysteine
Amino Acids
Reaction intermediates
2002
30 Citations (Scopus)

Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: Ketimine and pyridoxamine phosphate forms

Yennawar, N., Conway, M. E., Yennawar, H. P., Farber, G. K. & Hutson, S. M., Oct 1 2002, In : Biochemistry. 41, 39, p. 11592-11601 10 p.

Research output: Contribution to journalArticle

Reaction intermediates
Pyridoxal Phosphate
Isoleucine
Catalytic Domain
Hydrogen bonds
31 Citations (Scopus)

Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase

Conway, M. E., Yennawar, N., Wallin, R., Poole, L. B. & Hutson, S. M., Jul 23 2002, In : Biochemistry. 41, 29, p. 9070-9078 9 p.

Research output: Contribution to journalArticle

Peroxides
Isoenzymes
Oxidation-Reduction
Switches
Disulfides
45 Citations (Scopus)
Adenosine Triphosphatases
Oligomerization
Conformations
Bearings (structural)
Sinorhizobium meliloti
2001
30 Citations (Scopus)

A dimeric two-component receiver domain inhibits the sigma54-dependent ATPase in DctD.

Meyer, M. G., Park, S., Zeringue, L., Staley, M., McKinstry, M., Kaufman, R. I., Zhang, H., Yan, D., Yennawar, N., Yennawar, H. P., Farber, G. K. & Nixon, B. T., Jan 1 2001, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15, 7, p. 1326-1328 3 p.

Research output: Contribution to journalArticle

protein tertiary structure
sigma factors
bacterial proteins
DNA-binding proteins
dimerization
36 Citations (Scopus)

The structure of human mitochondrial branched-chain aminotransferase

Yennawar, N., Dunbar, J., Conway, M., Hutson, S. & Farber, G., Apr 25 2001, In : Acta Crystallographica Section D: Biological Crystallography. 57, 4, p. 506-515 10 p.

Research output: Contribution to journalArticle

Pyridoxal Phosphate
Lysine
Catalytic Domain
Tromethamine
Enzymes
1995
7 Citations (Scopus)

A structural explanation for enzyme memory in nonaqueous solvents

Yennawar, H. P., Yennawar, N. & Farber, G. K., Jan 18 1995, In : Journal of the American Chemical Society. 117, 2

Research output: Contribution to journalArticle

2-Propanol
Propanol
Enzymes
Data storage equipment
Chymotrypsin
60 Citations (Scopus)

A Structural Explanation for Enzyme Memory in Nonaqueous Solvents

Yennawar, H. P., Yennawar, N. & Farber, G. K., Jan 1 1995, In : Journal of the American Chemical Society. 117, 2, p. 577-585 9 p.

Research output: Contribution to journalArticle

2-Propanol
Propanol
Enzymes
Data storage equipment
Chymotrypsin
1994
140 Citations (Scopus)

X-ray Crystal Structure of γ-Chymotrypsin in Hexane

Yennawar, N., Yennawar, H. P. & Farber, G. K., Jun 1 1994, In : Biochemistry. 33, 23, p. 7326-7336 11 p.

Research output: Contribution to journalArticle

Chymotrypsin
Hexanes
Crystal structure
X-Rays
X rays