If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

2019
3 Citations (Scopus)

Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial

Merle, P., Blanc, J. F., Phelip, J. M., Pelletier, G., Bronowicki, J. P., Touchefeu, Y., Pageaux, G., Gerolami, R., Habersetzer, F., Nguyen-Khac, E., Casadei-Gardini, A., Borbath, I., Tran, A., Wege, H., Saad, A. S., Colombo, M., Abergel, A., Richou, C., Waked, I., Yee, N. S. & 73 others, Molé, A., Attali, P., Le Boulicaut, J., Vasseur, B., Moussata, D., Grangé, J. D., Ratziu, V., Khemissa-Akouz, F., Regnault, H., Dauvois, B., Zarski, J. P., Ollivier-Hourmand, I., Manfredi, S., Debette-Gratien, M., Gangloff, A., Fontanges, T., Baron, A., Bouattour, M., Vincent, J., Sieghart, W., Maieron, A., Peeters, M., Delwaide, J., Lasser, L., Berg, T., Schultheiß, M., Zipprich, A., Trojan, J., Ehmer, U., Luppi, G., Luca, G., Tamberi, S., Amoroso, D., Alabiso, O., Buonadonna, A., Toniutto, P., Tamburini, E., Cubillo, A., Muñoz, A., Guillén, C., Sánchez, G., Manzano, H., Navarro, V., Ales, I., Massuti, B., Dank, M., Bodoky, G., Kahan, Z., Horváth, Z., Gabrail, N., Ozer, H., Galanopoulos, C., Hauke, R., Raj, M., Harputluoglu, H., Sevinc, A., Goker, E., Coker, A., Yalcin, S., Ali, M., Ata, O., Tugba, I., ElKassas, M., Abdel, A., Wakid, I., Shamaa, S., El, N., Kohail, H., Makarem, J., Chehade, I., Farhat, F., López, C. & Marín, M., Jun 2019, In : The Lancet Gastroenterology and Hepatology. 4, 6, p. 454-465 12 p.

Research output: Contribution to journalArticle

Treatment Failure
Nanoparticles
Doxorubicin
Hepatocellular Carcinoma
Randomized Controlled Trials

Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Zhang, W. L., Hao, S. J., Yee, N. S-S. & Zheng, S., Jun 1 2019, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., p. 273-276 4 p. 8808761. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanoprobes
Vesicles
Lipids
Silica
Silicon Dioxide
1 Citation (Scopus)

Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Hao, S. J., Zhang, W. L., Yee, N. S-S. & Zheng, S., Jan 1 2019, In : Lab on a Chip. 19, 14, p. 2346-2355 10 p.

Research output: Contribution to journalArticle

Nanoprobes
Pancreatic Neoplasms
Silicon Dioxide
Lipids
Silica

Special issue: Cancer biomarkers and targets in digestive organs

Yee, N. S. & Lee, N. P., Mar 1 2019, In : Biomedicines. 7, 1, 3.

Research output: Contribution to journalEditorial

Open Access
Tumor Biomarkers
2018
1 Citation (Scopus)
Oncology
Patient Care
Health
Genetic Testing
Screening
17 Citations (Scopus)

Molecular characterization of gastric carcinoma: Therapeutic implications for biomarkers and targets

Fonkoua, L. K. & Yee, N. S., Mar 1 2018, In : Biomedicines. 6, 1, 32.

Research output: Contribution to journalReview article

Open Access
Biomarkers
Stomach
Carcinoma
Tumors
Chemotherapy
1 Citation (Scopus)

Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study

Posadas, K., Ankola, A., Yang, Z. & Yee, N. S., Jun 1 2018, In : Biomedicines. 6, 2, 46.

Research output: Contribution to journalArticle

Tumors
Hepatocellular Carcinoma
oxaliplatin
Chemotherapy
Catenins
6 Citations (Scopus)

Update in systemic and targeted therapies in gastrointestinal oncology

Yee, N. S., Mar 1 2018, In : Biomedicines. 6, 1, 34.

Research output: Contribution to journalArticle

Open Access
Oncology
oxaliplatin
irinotecan
docetaxel
gemcitabine
2017
4 Citations (Scopus)

Locally advanced unresectable pancreatic cancer: American Society of clinical oncology clinical practice guideline summary

Balaban, E., Mangu, P. B. & Yee, N. S-S., Apr 1 2017, In : Journal of Oncology Practice. 13, 4, p. 265-269 5 p.

Research output: Contribution to journalReview article

Medical Oncology
Pancreatic Neoplasms
Practice Guidelines
12 Citations (Scopus)

Role of TRPM7 in cancer: Potential as molecular biomarker and therapeutic target

Yee, N. S., Apr 5 2017, In : Pharmaceuticals. 10, 2, 39.

Research output: Contribution to journalReview article

Biomarkers
Phosphotransferases
Neoplasms
Epithelial-Mesenchymal Transition
Therapeutics
2016
16 Citations (Scopus)

Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options

Ang, C., Miura, J. T., Clark Gamblin, T., He, R., Xiu, J., Millis, S. Z., Gatalica, Z., Reddy, S. K., Yee, N. S. & Abou-Alfa, G. K., Jan 1 2016, In : Journal of Surgical Oncology. 113, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Biomarkers
Neoplasms
Therapeutics
Biological Science Disciplines
3 Citations (Scopus)

Immunotherapeutic approaches in pancreatic adenocarcinoma: Current status and future perspectives

Yee, N. S., Aug 1 2016, In : Current Molecular Pharmacology. 9, 3, p. 231-241 11 p.

Research output: Contribution to journalReview article

Adenocarcinoma
Pancreatic Neoplasms
Immunotherapy
Cytokines
Therapeutics
119 Citations (Scopus)

Locally advanced, unresectable pancreatic cancer: American society of clinical oncology clinical practice guideline

Balaban, E. P., Mangu, P. B., Khorana, A. A., Shah, M. A., Mukherjee, S., Crane, C. H., Javle, M. M., Eads, J. R., Allen, P., Ko, A. H., Engebretson, A., Herman, J. M., Strickler, J. H., Benson, A. B., Urba, S. & Yee, N. S., Aug 1 2016, In : Journal of Clinical Oncology. 34, 22, p. 2654-2667 14 p.

Research output: Contribution to journalArticle

Medical Oncology
Pancreatic Neoplasms
Practice Guidelines
Comorbidity
irinotecan
31 Citations (Scopus)

Molecular genetics and targeted therapeutics in biliary tract carcinoma

Marks, E. I. & Yee, N. S., Jan 28 2016, In : World journal of gastroenterology. 22, 4, p. 1335-1347 13 p.

Research output: Contribution to journalReview article

Biliary Tract
Molecular Biology
Biliary Tract Neoplasms
Carcinoma
Neoplasm Invasiveness
11 Citations (Scopus)

Molecular genetics and targeted therapy in hepatocellular carcinoma

Marks, E. I. & Yee, N. S-S., Jan 1 2016, In : Current Cancer Drug Targets. 16, 1, p. 53-70 18 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Genetic Therapy
Molecular Biology
Hepatocellular Carcinoma
Therapeutics
8 Citations (Scopus)

TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer

Yee, N. S., Jan 1 2016, Advances in Protein Chemistry and Structural Biology. Donev, R. (ed.). Academic Press Inc., p. 127-155 29 p. (Advances in Protein Chemistry and Structural Biology; vol. 104).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor Biomarkers
Pancreatic Neoplasms
Ion Channels
Neoplasms
Adenocarcinoma
2015
15 Citations (Scopus)

Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: Required for cancer cell invasion and implicated in tumor growth and metastasis

Yee, N. S., Kazi, A. A., Li, Q., Yang, Z., Berg, A. & Yee, R. K., Jan 1 2015, In : Biology Open. 4, 4, p. 507-514 8 p.

Research output: Contribution to journalArticle

pancreatic neoplasms
cell invasion
ion channels
Pancreatic Neoplasms
Ion Channels

Advances in pharmacological treatment of cancer in digestive organs

Yee, N. S-S., Jan 1 2015, In : Current Clinical Pharmacology. 10, 4, p. 254-255 2 p.

Research output: Contribution to journalEditorial

Digestive System Neoplasms
Molecular Targeted Therapy
Antineoplastic Agents
Pharmacology
Neoplasms
5 Citations (Scopus)

Current systemic treatment and emerging therapeutic strategies in pancreatic adenocarcinoma

Yee, N. S., Kazi, A. A. & Yee, R. K., Jan 1 2015, In : Current Clinical Pharmacology. 10, 4, p. 256-266 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Pancreatic Neoplasms
Therapeutics
Cellular Microenvironment
2 Citations (Scopus)

Immunotherapy in gastric carcinoma: Current status and future perspectives

Fonkoua, L. K. & Yee, N. S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

Immunotherapy
Stomach
Carcinoma
Neoplasms
Vascular Endothelial Growth Factor Receptor-2
33 Citations (Scopus)

Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites

El-Deiry, W. S., Vijayvergia, N., Xiu, J., Scicchitano, A., Lim, B., Yee, N. S., Harvey, H. A., Gatalica, Z. & Reddy, S., Dec 2 2015, In : Cancer Biology and Therapy. 16, 12, p. 1726-1737 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
temozolomide
irinotecan
gemcitabine
Neoplasm Metastasis
27 Citations (Scopus)

Roles of TRPM8 ion channels in cancer: Proliferation, survival, and invasion

Yee, N. S., Jan 1 2015, In : Cancers. 7, 4, p. 2134-2146 13 p., A13.

Research output: Contribution to journalReview article

Ion Channels
Neoplasms
Cell Proliferation
Precision Medicine
Translational Medical Research
4 Citations (Scopus)

Systemic treatment of advanced biliary tract Carcinoma: Emerging roles of targeted therapy and molecular profiling

Wyluda, E. & Yee, N. S-S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 80-86 7 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Biliary Tract
Carcinoma
Therapeutics
Neoplasms
2013
3 Citations (Scopus)

Ion channels as novel pancreatic cancer biomarkers and targets

Yee, N. S-S. & Yee, R. K., Nov 1 2013, New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. Humana Press Inc., p. 75-84 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transient Receptor Potential Channels
Tumor Biomarkers
Pancreatic Neoplasms
Ion Channels
Biomarkers
119 Citations (Scopus)

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase i clinical trial

Welsh, J. L., Wagner, B. A., Van'T Erve, T. J., Zehr, P. S., Berg, D. J., Halfdanarson, T. R., Yee, N. S., Bodeker, K. L., Du, J., Roberts, L. J., Drisko, J., Levine, M., Buettner, G. R. & Cullen, J. J., Mar 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 3, p. 765-775 11 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Clinical Trials
Pharmacology
Ascorbic Acid
13 Citations (Scopus)

Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype

Yee, N. S-S., Feb 15 2013, Impact of Genetic Targets on Cancer Therapy. El-Deiry, W. (ed.). p. 91-143 53 p. (Advances in Experimental Medicine and Biology; vol. 779).

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers
Pancreatic Neoplasms
Tumors
Phenotype
Therapeutics
4 Citations (Scopus)

Translating discovery in zebrafish pancreatic development to human pancreatic cancer: Biomarkers, targets, pathogenesis, and therapeutics

Yee, N. S-S., Kazi, A. & Yee, R. K., Jun 1 2013, In : Zebrafish. 10, 2, p. 132-146 15 p.

Research output: Contribution to journalReview article

pancreatic neoplasms
Human Development
Zebrafish
Tumor Biomarkers
Pancreatic Neoplasms
2012
29 Citations (Scopus)

Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W., Lee, M. & Yee, R. K., May 1 2012, In : Cancer Letters. 318, 1, p. 99-105 7 p.

Research output: Contribution to journalArticle

gemcitabine
Cell Aging
Pancreatic Neoplasms
Ion Channels
Adenocarcinoma
8 Citations (Scopus)

Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer

Yee, N. S., Zhou, W., Chun, S. G., Liang, I. C. & Yee, R. K., Apr 15 2012, In : Biology Open. 1, 4, p. 295-307 13 p.

Research output: Contribution to journalArticle

pancreatic neoplasms
Exocrine Pancreas
Histone Deacetylases
Zebrafish
Pancreatic Neoplasms
3 Citations (Scopus)

The epigenetics of gastrointestinal malignancies

Hasanali, Z., Stuart, A., Yee, N. S-S., Sharma, K. & Epner, E., Dec 1 2012, In : Current Colorectal Cancer Reports. 8, 4, p. 254-262 9 p.

Research output: Contribution to journalReview article

Epigenomics
Neoplasms
Inborn Genetic Diseases
Sequence Deletion
Esophageal Neoplasms

TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target

Yee, N. S., Brown, R. D., Lee, M. S. U., Zhou, W., Jensen, C., Gerke, H. & Yee, R. K., Jun 1 2012, In : Cancer Biology and Therapy. 13, 8, p. 592-599 8 p.

Research output: Contribution to journalArticle

Cell Aging
Ion Channels
Adenocarcinoma
Biomarkers
Carcinogenesis
23 Citations (Scopus)

TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: Potential role of TRPM8 as a biomarker and target

Yee, N. S-S., Brown, R. D., Lee, M. S., Zhou, W., Jensen, C., Gerke, H. & Yee, R. K., Jan 1 2012, In : Cancer Biology and Therapy. 13, 8, p. 592-599 8 p.

Research output: Contribution to journalReview article

Cell Aging
Ion Channels
Adenocarcinoma
Biomarkers
Carcinogenesis
2011
3 Citations (Scopus)

Brca2 deficiency and Trp53 deregulation in pancreatic cancer: Implications for therapeutic targeting

Yee, N. S-S., Jun 1 2011, In : Cancer Biology and Therapy. 11, 11, p. 969-973 5 p.

Research output: Contribution to journalComment/debate

BRCA2 Protein
Pancreatic Ductal Carcinoma
Tumor Suppressor Protein p53
Poly(ADP-ribose) Polymerases
Genetic Association Studies
22 Citations (Scopus)

Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer

Zhou, W., Liang, I. C. & Yee, N. S., Apr 1 2011, In : Cancer Biology and Therapy. 11, 7, p. 659-670 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Exocrine Pancreas
Histone Deacetylases
Pancreatic Neoplasms
Zebrafish
3 Citations (Scopus)

Pancreatic adenocarcinoma associated with Werner's syndrome (adult-onset progeria)

Chun, S. G., Yee, N. S-S., Holland, J. M., Shohet, R. V., Palalay, M. P. & Bryant-Greenwood, P. K., Jan 1 2011, In : Gastrointestinal Cancer Research. 4, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

Werner Syndrome
Adenocarcinoma
62 Citations (Scopus)
Transient Receptor Potential Channels
Ion Channels
Cell Cycle
Cytokines
Growth
2010
59 Citations (Scopus)

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W. & Lee, M., Nov 1 2010, In : Cancer Letters. 297, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Adenocarcinoma
Cell Proliferation
Cyclin-Dependent Kinases
Pancreatic Neoplasms
14 Citations (Scopus)
Werner Syndrome
Pancreatic Neoplasms
Carcinogenesis
Adenocarcinoma
Molecular Biology
11 Citations (Scopus)

Zebrafish as a biological system for identifying and validating therapeutic targets and compounds

Yee, N. S-S., Dec 1 2010, Drug Discovery in Pancreatic Cancer: Models and Techniques. Springer New York, p. 95-112 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zebrafish
Pancreatic Neoplasms
Therapeutics
Pharmaceutical Preparations
Genetic Transformation
2009
8 Citations (Scopus)

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 19-30 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pancreatic Neoplasms
gemcitabine
Cell Cycle Checkpoints
Adenocarcinoma
50 Citations (Scopus)

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S-S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 1328-1339 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pancreatic Neoplasms
gemcitabine
Cell Cycle Checkpoints
Adenocarcinoma
2007
45 Citations (Scopus)

Mutation of RNA Pol III subunit rpc2/polr3b leads to deficiency of subunit Rpc11 and disrupts zebrafish digestive development

Yee, N. S., Gong, W., Huang, Y., Lorent, K., Dolan, A. C., Maraia, R. J. & Pack, M., Nov 1 2007, In : PLoS biology. 5, 11, p. 2484-2492 9 p.

Research output: Contribution to journalArticle

RNA Polymerase III
Zebrafish
DNA-directed RNA polymerase
Danio rerio
Yeast
2006
6 Citations (Scopus)

Clinical remission of acquired thrombasthenia with low-dose methotrexate in a patient with systemic lupus erythematosus [2]

Yee, N. S-S. & Schuster, S. J., Jan 1 2006, In : Mayo Clinic Proceedings. 81, 4, p. 566-567 2 p.

Research output: Contribution to journalLetter

Thrombasthenia
Methotrexate
Systemic Lupus Erythematosus
2005
85 Citations (Scopus)

Exocrine pancreas development in zebrafish

Yee, N. S., Lorent, K. & Pack, M., Aug 1 2005, In : Developmental biology. 284, 1, p. 84-101 18 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Zebrafish
Morphogenesis
Larva
Bombs
20 Citations (Scopus)

Zebrafish as a model for pancreatic cancer research.

Yee, N. S-S. & Pack, M., Jan 1 2005, In : Methods in molecular medicine. 103, p. 273-298 26 p.

Research output: Contribution to journalArticle

Zebrafish
Pancreatic Neoplasms
Research
Vertebrates
Organogenesis
2004
58 Citations (Scopus)

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas

Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S-S., Pack, M. A. & Leach, S. D., Jun 15 2004, In : Developmental biology. 270, 2, p. 474-486 13 p.

Research output: Contribution to journalArticle

Zebrafish
Pancreas
Exocrine Pancreas
Population
Basic Helix-Loop-Helix Transcription Factors
55 Citations (Scopus)

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S., Pack, M. A. & Leach, S. D., Oct 15 2004, In : Developmental biology. 274, 2, p. 491-503 13 p.

Research output: Contribution to journalComment/debate

Zebrafish
Pancreas
Exocrine Pancreas
Population
Basic Helix-Loop-Helix Transcription Factors
1 Citation (Scopus)

Erratum: Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas (Developmental Biology (2004) 270 (474-486) DOI: 10.1016/j.ydbio.2004.02.023)

Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S-S., Pack, M. A. & Leach, S. D., Oct 15 2004, In : Developmental Biology. 274, 2, 1 p.

Research output: Contribution to journalComment/debate

Developmental Biology
Zebrafish
Pancreas
2003
25 Citations (Scopus)

Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome

Yee, N. S-S., Furth, E. E. & Pack, M., Jan 1 2003, In : Cancer Biology and Therapy. 2, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

Peutz-Jeghers Syndrome
Pancreatic Neoplasms
Molecular Biology
Adenocarcinoma
Hereditary Neoplastic Syndromes
2002
2 Citations (Scopus)

Ischemic colitis associated with anti-β2 glycoprotein-I antibody [6]

Yee, N. S-S., Schuster, S. J. & Lichtenstein, G. R., Aug 20 2002, In : Annals of internal medicine. 137, 4, 1 p.

Research output: Contribution to journalLetter

Contraceptives, Oral, Hormonal
beta 2-Glycoprotein I
Ischemic Colitis
Membrane Glycoproteins
Immunoglobulin M