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Research Output 1986 2019

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15 Citations (Scopus)

Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: Required for cancer cell invasion and implicated in tumor growth and metastasis

Yee, N. S., Kazi, A. A., Li, Q., Yang, Z., Berg, A. & Yee, R. K., Jan 1 2015, In : Biology Open. 4, 4, p. 507-514 8 p.

Research output: Contribution to journalArticle

pancreatic neoplasms
cell invasion
ion channels
Pancreatic Neoplasms
Ion Channels
91 Citations (Scopus)
Proto-Oncogene Proteins c-kit
Cell Degranulation
Mast Cells
Protein Kinase C
Carrier Proteins
25 Citations (Scopus)

Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome

Yee, N. S., Furth, E. E. & Pack, M., Jan 1 2003, In : Cancer Biology and Therapy. 2, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Peutz-Jeghers Syndrome
Pancreatic Neoplasms
Molecular Biology
Adenocarcinoma
Hereditary Neoplastic Syndromes

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

Willumsen, N., Ali, S. M., Leitzel, K., Drabick, J. J., Yee, N., Polimera, H. V., Nagabhairu, V., Krecko, L., Ali, A., Maddukuri, A., Moku, P., Ali, A., Poulose, J., Menon, H., Pancholy, N., Costa, L., Karsdal, M. A. & Lipton, A., Dec 1 2019, In : Scientific reports. 9, 1, 19761.

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Adenocarcinoma
Collagen
Survival
Serum
51 Citations (Scopus)

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 1328-1339 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pancreatic Neoplasms
gemcitabine
Cell Cycle Checkpoints
Adenocarcinoma

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 19-30 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pancreatic Neoplasms
gemcitabine
Cell Cycle Checkpoints
Adenocarcinoma
16 Citations (Scopus)

Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options

Ang, C., Miura, J. T., Clark Gamblin, T., He, R., Xiu, J., Millis, S. Z., Gatalica, Z., Reddy, S. K., Yee, N. S. & Abou-Alfa, G. K., Jan 1 2016, In : Journal of Surgical Oncology. 113, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Biomarkers
Neoplasms
Therapeutics
Biological Science Disciplines
5 Citations (Scopus)

Current systemic treatment and emerging therapeutic strategies in pancreatic adenocarcinoma

Yee, N. S., Kazi, A. A. & Yee, R. K., Jan 1 2015, In : Current Clinical Pharmacology. 10, 4, p. 256-266 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Pancreatic Neoplasms
Therapeutics
Cellular Microenvironment
58 Citations (Scopus)

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas

Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S-S., Pack, M. A. & Leach, S. D., Jun 15 2004, In : Developmental biology. 270, 2, p. 474-486 13 p.

Research output: Contribution to journalArticle

Zebrafish
Pancreas
Exocrine Pancreas
Population
Basic Helix-Loop-Helix Transcription Factors
193 Citations (Scopus)

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells

Serve, H., Yee, N. S., Stella, G., Sepp-Lorenzino, L., Tan, J. C. & Besmer, P., Jan 1 1995, In : EMBO Journal. 14, 3, p. 473-483 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell adhesion
Mast Cells
Cell Adhesion
Tyrosine
4 Citations (Scopus)

Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial

Merle, P., Blanc, J. F., Phelip, J. M., Pelletier, G., Bronowicki, J. P., Touchefeu, Y., Pageaux, G., Gerolami, R., Habersetzer, F., Nguyen-Khac, E., Casadei-Gardini, A., Borbath, I., Tran, A., Wege, H., Saad, A. S., Colombo, M., Abergel, A., Richou, C., Waked, I., Yee, N. S. & 73 others, Molé, A., Attali, P., Le Boulicaut, J., Vasseur, B., Moussata, D., Grangé, J. D., Ratziu, V., Khemissa-Akouz, F., Regnault, H., Dauvois, B., Zarski, J. P., Ollivier-Hourmand, I., Manfredi, S., Debette-Gratien, M., Gangloff, A., Fontanges, T., Baron, A., Bouattour, M., Vincent, J., Sieghart, W., Maieron, A., Peeters, M., Delwaide, J., Lasser, L., Berg, T., Schultheiß, M., Zipprich, A., Trojan, J., Ehmer, U., Luppi, G., Luca, G., Tamberi, S., Amoroso, D., Alabiso, O., Buonadonna, A., Toniutto, P., Tamburini, E., Cubillo, A., Muñoz, A., Guillén, C., Sánchez, G., Manzano, H., Navarro, V., Ales, I., Massuti, B., Dank, M., Bodoky, G., Kahan, Z., Horváth, Z., Gabrail, N., Ozer, H., Galanopoulos, C., Hauke, R., Raj, M., Harputluoglu, H., Sevinc, A., Goker, E., Coker, A., Yalcin, S., Ali, M., Ata, O., Tugba, I., ElKassas, M., Abdel, A., Wakid, I., Shamaa, S., El, N., Kohail, H., Makarem, J., Chehade, I., Farhat, F., López, C. & Marín, M., Jun 2019, In : The Lancet Gastroenterology and Hepatology. 4, 6, p. 454-465 12 p.

Research output: Contribution to journalArticle

Treatment Failure
Nanoparticles
Doxorubicin
Hepatocellular Carcinoma
Randomized Controlled Trials
34 Citations (Scopus)

Ectopic expression of a c-kit(W42) minigene in transgenic mice: Recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors

Ray, P., Higgins, K. M., Tan, J. C., Chu, T. Y., Yee, N. S., Nguyen, H., Lacy, E. & Besmer, P., Jan 1 1991, In : Genes and Development. 5, 12 A, p. 2265-2273 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Transgenes
Phenotype
Mutation
Proto-Oncogene Proteins c-kit
11 Citations (Scopus)

Effect of cimetidine or ranitidine pretreatment on hepatic mixed function oxidase activity in the rat

Yee, N. S-S. & Shargel, L., Dec 1 1986, In : Drug Metabolism and Disposition. 14, 5, p. 580-584 5 p.

Research output: Contribution to journalArticle

Aminopyrine N-Demethylase
Ranitidine
Cimetidine
Mixed Function Oxygenases
Hexobarbital
1 Citation (Scopus)

Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Hao, S. J., Zhang, W. L., Yee, N. S-S. & Zheng, S., Jan 1 2019, In : Lab on a Chip. 19, 14, p. 2346-2355 10 p.

Research output: Contribution to journalArticle

Nanoprobes
Pancreatic Neoplasms
Silicon Dioxide
Lipids
Silica
85 Citations (Scopus)

Exocrine pancreas development in zebrafish

Yee, N. S., Lorent, K. & Pack, M., Aug 1 2005, In : Developmental biology. 284, 1, p. 84-101 18 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Zebrafish
Morphogenesis
Larva
Bombs
1 Citation (Scopus)
Oncology
Patient Care
Health
Genetic Testing
Screening
22 Citations (Scopus)

Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer

Zhou, W., Liang, I. C. & Yee, N. S., Apr 1 2011, In : Cancer Biology and Therapy. 11, 7, p. 659-670 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Exocrine Pancreas
Histone Deacetylases
Pancreatic Neoplasms
Zebrafish
2 Citations (Scopus)

Immunotherapy in gastric carcinoma: Current status and future perspectives

Fonkoua, L. K. & Yee, N. S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

Immunotherapy
Stomach
Carcinoma
Neoplasms
Vascular Endothelial Growth Factor Receptor-2
122 Citations (Scopus)

Locally advanced, unresectable pancreatic cancer: American society of clinical oncology clinical practice guideline

Balaban, E. P., Mangu, P. B., Khorana, A. A., Shah, M. A., Mukherjee, S., Crane, C. H., Javle, M. M., Eads, J. R., Allen, P., Ko, A. H., Engebretson, A., Herman, J. M., Strickler, J. H., Benson, A. B., Urba, S. & Yee, N. S., Aug 1 2016, In : Journal of Clinical Oncology. 34, 22, p. 2654-2667 14 p.

Research output: Contribution to journalArticle

Medical Oncology
Pancreatic Neoplasms
Practice Guidelines
Comorbidity
irinotecan
41 Citations (Scopus)

Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3

Durand, B., Migliaccio, G., Yee, N. S-S., Eddleman, K., Huima-Byron, T., Migliaccio, A. R. & Adamson, J. W., Dec 1 1994, In : Blood. 84, 11, p. 3667-3674 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Interleukin-3
Fetal Blood
Cell culture
Mast Cells
128 Citations (Scopus)

Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C

Yee, N. S., Hsiau, C. W. M., Serve, H., Vosseller, K. & Besmer, P., Jan 1 1994, In : Journal of Biological Chemistry. 269, 50, p. 31991-31998 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-kit
Stem Cell Factor
Receptor Protein-Tyrosine Kinases
Protein Kinase C
101 Citations (Scopus)

Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells

Yee, N. S-S., Langen, H. & Besmer, P., Jul 5 1993, In : Journal of Biological Chemistry. 268, 19, p. 14189-14201 13 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-kit
Stem Cell Factor
Phorbol Esters
Mast Cells
Down-Regulation
12 Citations (Scopus)

Molecular genetics and targeted therapy in hepatocellular carcinoma

Marks, E. I. & Yee, N. S-S., Jan 1 2016, In : Current Cancer Drug Targets. 16, 1, p. 53-70 18 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Genetic Therapy
Molecular Biology
Hepatocellular Carcinoma
Therapeutics
35 Citations (Scopus)

Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites

El-Deiry, W. S., Vijayvergia, N., Xiu, J., Scicchitano, A., Lim, B., Yee, N. S., Harvey, H. A., Gatalica, Z. & Reddy, S., Dec 2 2015, In : Cancer Biology and Therapy. 16, 12, p. 1726-1737 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
temozolomide
irinotecan
gemcitabine
Neoplasm Metastasis
45 Citations (Scopus)

Mutation of RNA Pol III subunit rpc2/polr3b leads to deficiency of subunit Rpc11 and disrupts zebrafish digestive development

Yee, N. S., Gong, W., Huang, Y., Lorent, K., Dolan, A. C., Maraia, R. J. & Pack, M., Nov 1 2007, In : PLoS biology. 5, 11, p. 2484-2492 9 p.

Research output: Contribution to journalArticle

RNA Polymerase III
Zebrafish
DNA-directed RNA polymerase
Danio rerio
Yeast
3 Citations (Scopus)

Pancreatic adenocarcinoma associated with Werner's syndrome (adult-onset progeria)

Chun, S. G., Yee, N. S-S., Holland, J. M., Shohet, R. V., Palalay, M. P. & Bryant-Greenwood, P. K., Jan 1 2011, In : Gastrointestinal Cancer Research. 4, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

Werner Syndrome
Adenocarcinoma
120 Citations (Scopus)

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase i clinical trial

Welsh, J. L., Wagner, B. A., Van'T Erve, T. J., Zehr, P. S., Berg, D. J., Halfdanarson, T. R., Yee, N. S., Bodeker, K. L., Du, J., Roberts, L. J., Drisko, J., Levine, M., Buettner, G. R. & Cullen, J. J., Mar 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 3, p. 765-775 11 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Clinical Trials
Pharmacology
Ascorbic Acid
143 Citations (Scopus)
Metrorrhagia
Stem Cell Factor
Steel
Radiation Tolerance
Mast Cells
4 Citations (Scopus)

Systemic treatment of advanced biliary tract Carcinoma: Emerging roles of targeted therapy and molecular profiling

Wyluda, E. & Yee, N. S-S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 80-86 7 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Biliary Tract
Carcinoma
Therapeutics
Neoplasms
29 Citations (Scopus)

Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W., Lee, M. & Yee, R. K., May 1 2012, In : Cancer Letters. 318, 1, p. 99-105 7 p.

Research output: Contribution to journalArticle

gemcitabine
Cell Aging
Pancreatic Neoplasms
Ion Channels
Adenocarcinoma
8 Citations (Scopus)

Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer

Yee, N. S., Zhou, W., Chun, S. G., Liang, I. C. & Yee, R. K., Apr 15 2012, In : Biology Open. 1, 4, p. 295-307 13 p.

Research output: Contribution to journalArticle

pancreatic neoplasms
Exocrine Pancreas
Histone Deacetylases
Zebrafish
Pancreatic Neoplasms
60 Citations (Scopus)

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W. & Lee, M., Nov 1 2010, In : Cancer Letters. 297, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Adenocarcinoma
Cell Proliferation
Cyclin-Dependent Kinases
Pancreatic Neoplasms
63 Citations (Scopus)
Transient Receptor Potential Channels
Ion Channels
Cell Cycle
Cytokines
Growth

TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target

Yee, N. S., Brown, R. D., Lee, M. S. U., Zhou, W., Jensen, C., Gerke, H. & Yee, R. K., Jun 1 2012, In : Cancer Biology and Therapy. 13, 8, p. 592-599 8 p.

Research output: Contribution to journalArticle

Cell Aging
Ion Channels
Adenocarcinoma
Biomarkers
Carcinogenesis
1 Citation (Scopus)

Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study

Posadas, K., Ankola, A., Yang, Z. & Yee, N. S., Jun 1 2018, In : Biomedicines. 6, 2, 46.

Research output: Contribution to journalArticle

Tumors
Hepatocellular Carcinoma
oxaliplatin
Chemotherapy
Catenins
6 Citations (Scopus)

Update in systemic and targeted therapies in gastrointestinal oncology

Yee, N. S., Mar 1 2018, In : Biomedicines. 6, 1, 34.

Research output: Contribution to journalArticle

Open Access
Oncology
oxaliplatin
irinotecan
docetaxel
gemcitabine
14 Citations (Scopus)
Werner Syndrome
Pancreatic Neoplasms
Carcinogenesis
Adenocarcinoma
Molecular Biology
20 Citations (Scopus)

Zebrafish as a model for pancreatic cancer research.

Yee, N. S-S. & Pack, M., Jan 1 2005, In : Methods in molecular medicine. 103, p. 273-298 26 p.

Research output: Contribution to journalArticle

Zebrafish
Pancreatic Neoplasms
Research
Vertebrates
Organogenesis
74 Citations (Scopus)
Digestive System Abnormalities
Developmental Gene Expression Regulation
Zebrafish Proteins
Homeodomain Proteins
Trans-Activators