• 1961 Citations
  • 23 h-Index
1986 …2019

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Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: Required for cancer cell invasion and implicated in tumor growth and metastasis

Yee, N. S., Kazi, A. A., Li, Q., Yang, Z., Berg, A. & Yee, R. K., Jan 1 2015, In : Biology Open. 4, 4, p. 507-514 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
91 Scopus citations

Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome

Yee, N. S., Furth, E. E. & Pack, M., Jan 1 2003, In : Cancer Biology and Therapy. 2, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

Willumsen, N., Ali, S. M., Leitzel, K., Drabick, J. J., Yee, N., Polimera, H. V., Nagabhairu, V., Krecko, L., Ali, A., Maddukuri, A., Moku, P., Ali, A., Poulose, J., Menon, H., Pancholy, N., Costa, L., Karsdal, M. A. & Lipton, A., Dec 1 2019, In : Scientific reports. 9, 1, 19761.

Research output: Contribution to journalArticle

Open Access

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 19-30 12 p.

Research output: Contribution to journalArticle

Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer

Chun, S. G., Zhou, W. & Yee, N. S., Jul 15 2009, In : Cancer Biology and Therapy. 8, 14, p. 1328-1339 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options

Ang, C., Miura, J. T., Clark Gamblin, T., He, R., Xiu, J., Millis, S. Z., Gatalica, Z., Reddy, S. K., Yee, N. S. & Abou-Alfa, G. K., Jan 1 2016, In : Journal of Surgical Oncology. 113, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Current systemic treatment and emerging therapeutic strategies in pancreatic adenocarcinoma

Yee, N. S., Kazi, A. A. & Yee, R. K., Jan 1 2015, In : Current Clinical Pharmacology. 10, 4, p. 256-266 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas

Lin, J. W., Biankin, A. V., Horb, M. E., Ghosh, B., Prasad, N. B., Yee, N. S., Pack, M. A. & Leach, S. D., Jun 15 2004, In : Developmental biology. 270, 2, p. 474-486 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells

Serve, H., Yee, N. S., Stella, G., Sepp-Lorenzino, L., Tan, J. C. & Besmer, P., Jan 1 1995, In : EMBO Journal. 14, 3, p. 473-483 11 p.

Research output: Contribution to journalArticle

193 Scopus citations

Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial

Merle, P., Blanc, J. F., Phelip, J. M., Pelletier, G., Bronowicki, J. P., Touchefeu, Y., Pageaux, G., Gerolami, R., Habersetzer, F., Nguyen-Khac, E., Casadei-Gardini, A., Borbath, I., Tran, A., Wege, H., Saad, A. S., Colombo, M., Abergel, A., Richou, C., Waked, I., Yee, N. S. & 73 others, Molé, A., Attali, P., Le Boulicaut, J., Vasseur, B., Moussata, D., Grangé, J. D., Ratziu, V., Khemissa-Akouz, F., Regnault, H., Dauvois, B., Zarski, J. P., Ollivier-Hourmand, I., Manfredi, S., Debette-Gratien, M., Gangloff, A., Fontanges, T., Baron, A., Bouattour, M., Vincent, J., Sieghart, W., Maieron, A., Peeters, M., Delwaide, J., Lasser, L., Berg, T., Schultheiß, M., Zipprich, A., Trojan, J., Ehmer, U., Luppi, G., Luca, G., Tamberi, S., Amoroso, D., Alabiso, O., Buonadonna, A., Toniutto, P., Tamburini, E., Cubillo, A., Muñoz, A., Guillén, C., Sánchez, G., Manzano, H., Navarro, V., Ales, I., Massuti, B., Dank, M., Bodoky, G., Kahan, Z., Horváth, Z., Gabrail, N., Ozer, H., Galanopoulos, C., Hauke, R., Raj, M., Harputluoglu, H., Sevinc, A., Goker, E., Coker, A., Yalcin, S., Ali, M., Ata, O., Tugba, I., ElKassas, M., Abdel, A., Wakid, I., Shamaa, S., El, N., Kohail, H., Makarem, J., Chehade, I., Farhat, F., López, C. & Marín, M., Jun 2019, In : The Lancet Gastroenterology and Hepatology. 4, 6, p. 454-465 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ectopic expression of a c-kit(W42) minigene in transgenic mice: Recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors

Ray, P., Higgins, K. M., Tan, J. C., Chu, T. Y., Yee, N. S., Nguyen, H., Lacy, E. & Besmer, P., Jan 1 1991, In : Genes and Development. 5, 12 A, p. 2265-2273 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Effect of cimetidine or ranitidine pretreatment on hepatic mixed function oxidase activity in the rat

Yee, N. S-S. & Shargel, L., Dec 1 1986, In : Drug Metabolism and Disposition. 14, 5, p. 580-584 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Hao, S. J., Zhang, W. L., Yee, N. S. & Zheng, S. Y., Jan 1 2019, In : Lab on a Chip. 19, 14, p. 2346-2355 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Exocrine pancreas development in zebrafish

Yee, N. S., Lorent, K. & Pack, M., Aug 1 2005, In : Developmental biology. 284, 1, p. 84-101 18 p.

Research output: Contribution to journalArticle

86 Scopus citations
1 Scopus citations

Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer

Zhou, W., Liang, I. C. & Yee, N. S., Apr 1 2011, In : Cancer Biology and Therapy. 11, 7, p. 659-670 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Immunotherapy in gastric carcinoma: Current status and future perspectives

Fonkoua, L. K. & Yee, N. S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Locally advanced, unresectable pancreatic cancer: American society of clinical oncology clinical practice guideline

Balaban, E. P., Mangu, P. B., Khorana, A. A., Shah, M. A., Mukherjee, S., Crane, C. H., Javle, M. M., Eads, J. R., Allen, P., Ko, A. H., Engebretson, A., Herman, J. M., Strickler, J. H., Benson, A. B., Urba, S. & Yee, N. S., Aug 1 2016, In : Journal of Clinical Oncology. 34, 22, p. 2654-2667 14 p.

Research output: Contribution to journalArticle

131 Scopus citations

Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3

Durand, B., Migliaccio, G., Yee, N. S-S., Eddleman, K., Huima-Byron, T., Migliaccio, A. R. & Adamson, J. W., Dec 1 1994, In : Blood. 84, 11, p. 3667-3674 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C

Yee, N. S., Hsiau, C. W. M., Serve, H., Vosseller, K. & Besmer, P., Jan 1 1994, In : Journal of Biological Chemistry. 269, 50, p. 31991-31998 8 p.

Research output: Contribution to journalArticle

128 Scopus citations

Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells

Yee, N. S-S., Langen, H. & Besmer, P., Jul 5 1993, In : Journal of Biological Chemistry. 268, 19, p. 14189-14201 13 p.

Research output: Contribution to journalArticle

101 Scopus citations

Molecular genetics and targeted therapy in hepatocellular carcinoma

Marks, E. I. & Yee, N. S-S., Jan 1 2016, In : Current Cancer Drug Targets. 16, 1, p. 53-70 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites

El-Deiry, W. S., Vijayvergia, N., Xiu, J., Scicchitano, A., Lim, B., Yee, N. S., Harvey, H. A., Gatalica, Z. & Reddy, S., Dec 2 2015, In : Cancer Biology and Therapy. 16, 12, p. 1726-1737 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mutation of RNA Pol III subunit rpc2/polr3b leads to deficiency of subunit Rpc11 and disrupts zebrafish digestive development

Yee, N. S., Gong, W., Huang, Y., Lorent, K., Dolan, A. C., Maraia, R. J. & Pack, M., Nov 1 2007, In : PLoS biology. 5, 11, p. 2484-2492 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Pancreatic adenocarcinoma associated with Werner's syndrome (adult-onset progeria)

Chun, S. G., Yee, N. S-S., Holland, J. M., Shohet, R. V., Palalay, M. P. & Bryant-Greenwood, P. K., Jan 1 2011, In : Gastrointestinal Cancer Research. 4, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase i clinical trial

Welsh, J. L., Wagner, B. A., Van'T Erve, T. J., Zehr, P. S., Berg, D. J., Halfdanarson, T. R., Yee, N. S., Bodeker, K. L., Du, J., Roberts, L. J., Drisko, J., Levine, M., Buettner, G. R. & Cullen, J. J., Mar 1 2013, In : Cancer Chemotherapy and Pharmacology. 71, 3, p. 765-775 11 p.

Research output: Contribution to journalArticle

124 Scopus citations
143 Scopus citations

Systemic treatment of advanced biliary tract Carcinoma: Emerging roles of targeted therapy and molecular profiling

Wyluda, E. & Yee, N. S-S., Dec 1 2015, In : Clinical Cancer Drugs. 2, 2, p. 80-86 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W., Lee, M. & Yee, R. K., May 1 2012, In : Cancer Letters. 318, 1, p. 99-105 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer

Yee, N. S., Zhou, W., Chun, S. G., Liang, I. C. & Yee, R. K., Apr 15 2012, In : Biology Open. 1, 4, p. 295-307 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

Yee, N. S-S., Zhou, W. & Lee, M., Nov 1 2010, In : Cancer Letters. 297, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
66 Scopus citations

TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target

Yee, N. S., Brown, R. D., Lee, M. S. U., Zhou, W., Jensen, C., Gerke, H. & Yee, R. K., Jun 1 2012, In : Cancer Biology and Therapy. 13, 8, p. 592-599 8 p.

Research output: Contribution to journalArticle

Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study

Posadas, K., Ankola, A., Yang, Z. & Yee, N. S., Jun 1 2018, In : Biomedicines. 6, 2, 46.

Research output: Contribution to journalArticle

1 Scopus citations

Update in systemic and targeted therapies in gastrointestinal oncology

Yee, N. S., Mar 1 2018, In : Biomedicines. 6, 1, 34.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
14 Scopus citations

Zebrafish as a model for pancreatic cancer research.

Yee, N. S-S. & Pack, M., Jan 1 2005, In : Methods in molecular medicine. 103, p. 273-298 26 p.

Research output: Contribution to journalArticle

20 Scopus citations
74 Scopus citations