Nurgul Salli, PhD

    • 241 Citations
    • 9 h-Index
    If you made any changes in Pure, your changes will be visible here soon.

    Personal profile

    Research interests

    Dr. Nurgul Carkaci-Salli has been actively involved in numerous areas of research during her professional career.

    She is formally trained in plant pathology, with a bachelor's, master's and doctorate degrees in the field. She has worked for the Turkish Department of Agricultural and several private firms with special interests in mycology and plant disease resistance.

    Dr. Carkaci-Salli further trained in molecular biology at Auburn University. She continued her research interests at Oregon Health Sciences University, investigating disease resistance genes; the DNA fingerprint of fungi; physiological and molecular characterization of plant defense mechanisms; and physiology and molecular biology of the induced resistance in plants.

    During her time in Oregon, Dr. Carkaci-Salli developed further expertise in cell culture techniques and continued her work on the differentiation of embryonic stem cells (ESC) and induced pluripotent stem cells (iPSCs) into serotonergic neuronal cells.

    Continuing her interest in stem cell differentiation, at Penn State, she has worked extensively on neuronal differentiation of stem cells including glioblastoma cancer stem cells and mechanisms in chemoresistance development. She collaborates in the study of the potential role of stem cells for the treatment of inflammatory bowel disease and tendon dysfunction.

    In addition, since 2004, Dr. Carkaci-Salli has been exploring naturally occurring single nucleotide polymorphisms in catecholamine biosynthesis enzymes. Insight gained into their structural/functional properties in the CNS biogenic amine (dopamine, norepinephrine, epinephrine, and serotonin) biosynthetic enzymes (tyrosine hydroxylase and tryptophan hydroxylase) may result in improved drug screening methodology ultimately with clinical applications in a variety of mental health disorders.

    Fingerprint Dive into the research topics where Nurgul Salli is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 1 Similar Profiles
    Tryptophan Hydroxylase Medicine & Life Sciences
    Tyrosine 3-Monooxygenase Medicine & Life Sciences
    Serotonin Medicine & Life Sciences
    Enzymes Medicine & Life Sciences
    Catecholamines Medicine & Life Sciences
    Embryonic Stem Cells Medicine & Life Sciences
    Ventral Tegmental Area Medicine & Life Sciences
    Food Hypersensitivity Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output 2004 2016

    • 241 Citations
    • 9 h-Index
    • 10 Article
    • 2 Review article
    Tyrosine 3-Monooxygenase
    Parkinson Disease
    51 Citations (Scopus)

    Complex molecular regulation of tyrosine hydroxylase

    Tekin, I., Roskoski, R., Carkaci-Salli, N. & Vrana, K. E., Nov 22 2014, In : Journal of Neural Transmission. 121, 12, p. 1451-1481 31 p.

    Research output: Contribution to journalReview article

    Tyrosine 3-Monooxygenase
    Phosphoprotein Phosphatases
    3 Citations (Scopus)

    Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2.

    Salli, N., Salli, U., Tekin, I., Hengst, J., Zhao, M. K., Gilman, T. L., Andrews, A. M. & Vrana, K., Jan 1 2014, In : Journal of neurochemistry. 130, 6, p. 748-758 11 p.

    Research output: Contribution to journalArticle

    Tryptophan Hydroxylase
    Bipolar Disorder
    12 Citations (Scopus)

    A retrospective chart review to identify perinatal factors associated with food allergies

    Karpa, K. D., Paul, I. M., Leckie, J. A., Shung, S., Carkaci-Salli, N., Vrana, K. E., Mauger, D., Fausnight, T. & Poger, J., Oct 24 2012, In : Nutrition Journal. 11, 1, 87.

    Research output: Contribution to journalReview article

    Food Hypersensitivity
    Immunologic Factors
    Anti-Bacterial Agents

    Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice

    Carkaci-Salli, N., Battula, S., Wang, X., Connor, J. R. & Vrana, K. E., Aug 1 2012, In : Journal of Neuroscience Research. 90, 8, p. 1583-1588 6 p.

    Research output: Contribution to journalArticle

    Differentiation Antigens
    Tyrosine 3-Monooxygenase
    Knockout Mice