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Research Output 1976 2019

2019

Blockade of the OGF-OGFr pathway in diabetic bone

Titunick, M. B., Lewis, G., Cain, J., Zagon, I. & McLaughlin, P., Jan 1 2019, In : Connective Tissue Research.

Research output: Contribution to journalArticle

Naltrexone
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Bone
Bone and Bones

Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes

McLaughlin, P., Sassani, J., Titunick, M. B. & Zagon, I., Jan 28 2019, In : BMC Ophthalmology. 19, 1, 35.

Research output: Contribution to journalArticle

Naltrexone
Type 1 Diabetes Mellitus
Safety
Ophthalmic Solutions
Tears
2018
Autoimmune Experimental Encephalomyelitis
Naltrexone
Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
1 Citation (Scopus)

Intermittent blockade of OGFr and treatment of autoimmune disorders

Zagon, I. & McLaughlin, P., Dec 1 2018, In : Experimental Biology and Medicine. 243, 17-18, p. 1323-1330 8 p.

Research output: Contribution to journalReview article

Naltrexone
Enkephalins
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
2017
5 Citations (Scopus)
Encephalomyelitis
Autoimmune Experimental Encephalomyelitis
Enkephalins
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

Ludwig, M. D., Zagon, I. & McLaughlin, P., Sep 1 2017, In : Experimental Biology and Medicine. 242, 15, p. 1524-1533 10 p.

Research output: Contribution to journalArticle

Naltrexone
Enkephalins
Multiple Sclerosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. & Neighbors, J., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

Stilbenes
Amides
Isomers
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
4 Citations (Scopus)

Topical Naltrexone is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin, P., Cain, J., Titunick, M. B., Sassani, J. & Zagon, I., Sep 1 2017, In : Advances in Wound Care. 6, 9, p. 279-288 10 p.

Research output: Contribution to journalArticle

Naltrexone
Wounds and Injuries
Diabetic Foot
Platelet-Derived Growth Factor
Mast Cells
2016
2 Citations (Scopus)

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent

Kren, N. P., Zagon, I. & McLaughlin, P., Feb 1 2016, In : Experimental Biology and Medicine. 241, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Nuclear Export Signals
Tandem Repeat Sequences
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)
Naltrexone
T-cells
Autoimmune Experimental Encephalomyelitis
Neurology
Infiltration
4 Citations (Scopus)
Naltrexone
Healthy Volunteers
Placebos
Corneal Pachymetry
Corneal Topography
2015
16 Citations (Scopus)

Duration of opioid receptor blockade determines biotherapeutic response

McLaughlin, P. & Zagon, I., Oct 1 2015, In : Biochemical Pharmacology. 97, 3, p. 236-246 11 p.

Research output: Contribution to journalComment/debate

Narcotic Antagonists
Opioid Receptors
Naltrexone
Opioid Analgesics
Opiate Alkaloids
14 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Immunization
B-Lymphocytes
Naltrexone
6 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Recurrence
12 Citations (Scopus)

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

Turel, A. P., Oh, K. H., Zagon, I. & McLaughlin, P., Jan 1 2015, In : Journal of Clinical Psychopharmacology. 35, 5, p. 609-611 3 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Naltrexone
Narcotic Antagonists
Multiple Sclerosis
Young Adult
2 Citations (Scopus)

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Kren, N. P., Zagon, I. & McLaughlin, P., Jan 1 2015, In : International Journal of Molecular Medicine. 36, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Mutation
Neoplasms
gemcitabine
2014
4 Citations (Scopus)
Triple Negative Breast Neoplasms
Ovarian Neoplasms
Opioid Analgesics
Breast Neoplasms
Neoplasms
16 Citations (Scopus)
Eye Abnormalities
Naltrexone
Narcotic Antagonists
Type 2 Diabetes Mellitus
Tears
13 Citations (Scopus)

Opioid growth factor and the treatment of human pancreatic cancer: A review

Zagon, I. & McLaughlin, P., Jan 1 2014, In : World Journal of Gastroenterology. 20, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
gemcitabine
Therapeutics
14 Citations (Scopus)

Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

Immonen, J. A., Zagon, I. & McLaughlin, P., Jan 1 2014, In : Experimental Biology and Medicine. 239, 10, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Naltrexone
Fibroblasts
Wound Healing
Narcotic Antagonists
Opioid Receptors
2013
14 Citations (Scopus)

Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Campbell, A. M., Zagon, I. & McLaughlin, P., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Astrocytes
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord
10 Citations (Scopus)

Opioid growth factor (OGF) for hepatoblastoma: A novel non-toxic treatment

Rogosnitzky, M., Finegold, M. J., McLaughlin, P. & Zagon, I., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 1066-1070 5 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Drug Therapy
Naltrexone
14 Citations (Scopus)

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer

Zagon, I., Porterfield, N. K. & McLaughlin, P., Jun 1 2013, In : Experimental Biology and Medicine. 238, 6, p. 589-599 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cells
Cell Line

Pomc-derived opioid peptides

McLaughlin, P. & Zagon, I., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1592-1595 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Opioid Peptides
1 Citation (Scopus)

Proenkephalin-derived peptides

McLaughlin, P., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1602-1609 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peptides
proenkephalin
10 Citations (Scopus)

Targeting the opioid growth factor: Opioid growth factor receptor axis for treatment of human ovarian cancer

Zagon, I., Donahue, R. & McLaughlin, P., Aug 1 2013, In : Experimental Biology and Medicine. 238, 5, p. 579-587 9 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Therapeutics
Cells
23 Citations (Scopus)

Topical naltrexone accelerates full-thickness wound closure in type 1 diabetic rats by stimulating angiogenesis

McLaughlin, P., Immonen, J. A. & Zagon, I., Jul 1 2013, In : Experimental Biology and Medicine. 238, 7, p. 733-743 11 p.

Research output: Contribution to journalArticle

Naltrexone
Rats
Wound Healing
Granulation
Wounds and Injuries
15 Citations (Scopus)
Naltrexone
Narcotic Antagonists
Wound Healing
Rats
Skin
11 Citations (Scopus)

Treatment of a relapse-remitting model of multiple sclerosis with opioid growth factor

Hammer, L. A., Zagon, I. & McLaughlin, P., Sep 1 2013, In : Brain Research Bulletin. 98, p. 122-131 10 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Autoimmune Experimental Encephalomyelitis
Recurrence
2012
9 Citations (Scopus)

Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer

Fanning, J., Hossler, C., Kesterson, J., Donahue, R. N., McLaughlin, P. & Zagon, I., Feb 1 2012, In : Gynecologic Oncology. 124, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Ovarian Cysts
Epithelial Cells
12 Citations (Scopus)
Methionine Enkephalin
imiquimod
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Naltrexone
19 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Spinal Cord Diseases
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Pathology
1 Citation (Scopus)

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
encephalitis
Disease Outbreaks
Clostridium difficile
Fecal Impaction
10 Citations (Scopus)
Tears
Naltrexone
Methionine Enkephalin
Ophthalmic Solutions
Opioid Receptors
4 Citations (Scopus)
Transgenic Mice
Epithelium
Cell Proliferation
Wounds and Injuries
Cornea
6 Citations (Scopus)
Antineoplastic Combined Chemotherapy Protocols
Methionine Enkephalin
Opioid Receptors
Pancreatic Neoplasms
Antineoplastic Agents
35 Citations (Scopus)
Cell proliferation
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Naltrexone
Cell Proliferation
5 Citations (Scopus)

Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer

Donahue, R. N., McLaughlin, P. & Zagon, I., Feb 1 2012, In : Experimental Biology and Medicine. 237, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Tumors
Tumor Burden
Opioid Analgesics
Cells
2011
32 Citations (Scopus)

B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases

Zagon, I., Donahue, R. N., Bonneau, R. H. & McLaughlin, P., Jan 1 2011, In : Immunobiology. 216, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
B-Lymphocytes
Cell Count
23 Citations (Scopus)

Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Donahue, R. N., McLaughlin, P. & Zagon, I., Jul 1 2011, In : Experimental Biology and Medicine. 236, 7, p. 883-895 13 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Cisplatin
Paclitaxel
Tissue culture
27 Citations (Scopus)
Tissue culture
Naltrexone
Cell proliferation
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
30 Citations (Scopus)
Myelin-Oligodendrocyte Glycoprotein
Naltrexone
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
8 Citations (Scopus)

Targeting opioid signaling in Crohns disease: New therapeutic pathways

Zagon, I. & McLaughlin, P., Oct 1 2011, In : Expert Review of Gastroenterology and Hepatology. 5, 5, p. 555-558 4 p.

Research output: Contribution to journalReview article

Naltrexone
Narcotic Antagonists
Opioid Receptors
Inflammatory Bowel Diseases
Crohn Disease
22 Citations (Scopus)

The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice

Donahue, R. N., McLaughlin, P. & Zagon, I., Aug 1 2011, In : Gynecologic Oncology. 122, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Opioid Receptors
33 Citations (Scopus)
Enkephalins
Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
T-Lymphocytes
16 Citations (Scopus)

Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats

McLaughlin, P., Pothering, C. A., Immonen, J. A. & Zagon, I., Oct 1 2011, In : Experimental Biology and Medicine. 236, 10, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Medical problems
Rats
Type 1 Diabetes Mellitus
2010
29 Citations (Scopus)
Naltrexone
Re-Epithelialization
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Topical Administration
6 Citations (Scopus)

Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors

McLaughlin, P., Rogosnitzky, M. & Zagon, I., Nov 1 2010, In : Experimental Biology and Medicine. 235, 11, p. 1292-1299 8 p.

Research output: Contribution to journalArticle

imiquimod
Opioid Receptors
Epidermis
DNA
Immune system
11 Citations (Scopus)
Clathrin
Enkephalins
Endocytosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
21 Citations (Scopus)

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Zagon, I., Rahn, K. A., Bonneau, R. H., Turel, A. P. & McLaughlin, P., Jan 15 2010, In : Brain research. 1310, p. 154-161 8 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord