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Research Output 1976 2018

2018
Autoimmune Experimental Encephalomyelitis
Naltrexone
Interleukin-10
Multiple Sclerosis
Opioid Analgesics
2017
4 Citations
Encephalomyelitis
Autoimmune Experimental Encephalomyelitis
Enkephalins
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
3 Citations

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

Ludwig, M. D., Zagon, I. & McLaughlin, P., Sep 1 2017, In : Experimental Biology and Medicine. 242, 15, p. 1524-1533 10 p.

Research output: Contribution to journalArticle

Naltrexone
Enkephalins
Multiple Sclerosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. & Neighbors, J., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

Stilbenes
Amides
Isomers
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
2 Citations

Topical Naltrexone is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin, P., Cain, J., Titunick, M. B., Sassani, J. & Zagon, I., Sep 1 2017, In : Advances in Wound Care. 6, 9, p. 279-288 10 p.

Research output: Contribution to journalArticle

Naltrexone
Wounds and Injuries
Diabetic Foot
Platelet-Derived Growth Factor
Mast Cells
2016
2 Citations

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent

Kren, N. P., Zagon, I. & McLaughlin, P., Feb 1 2016, In : Experimental Biology and Medicine. 241, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Nuclear Export Signals
Tandem Repeat Sequences
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
7 Citations
Naltrexone
T-cells
Autoimmune Experimental Encephalomyelitis
Neurology
Infiltration
3 Citations
Naltrexone
Healthy Volunteers
Placebos
Corneal Pachymetry
Corneal Topography
2015
14 Citations

Duration of opioid receptor blockade determines biotherapeutic response

McLaughlin, P. & Zagon, I., Oct 1 2015, In : Biochemical Pharmacology. 97, 3, p. 236-246 11 p.

Research output: Contribution to journalReview article

Narcotic Antagonists
Opioid Receptors
Naltrexone
Opioid Analgesics
Opiate Alkaloids
12 Citations
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Immunization
B-Lymphocytes
Naltrexone
5 Citations
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Recurrence
11 Citations

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

Turel, A. P., Oh, K. H., Zagon, I. S. & McLaughlin, P. J., Jan 1 2015, In : Journal of Clinical Psychopharmacology. 35, 5, p. 609-611 3 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Naltrexone
Narcotic Antagonists
Multiple Sclerosis
Young Adult
2 Citations

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Kren, N. P., Zagon, I. & McLaughlin, P., Jan 1 2015, In : International journal of molecular medicine. 36, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Mutation
Neoplasms
gemcitabine
2014
4 Citations
Triple Negative Breast Neoplasms
Ovarian Neoplasms
Opioid Analgesics
Breast Neoplasms
Neoplasms
13 Citations
Eye Abnormalities
Naltrexone
Narcotic Antagonists
Type 2 Diabetes Mellitus
Tears
12 Citations

Opioid growth factor and the treatment of human pancreatic cancer: A review

Zagon, I. S. & McLaughlin, P. J., 2014, In : World Journal of Gastroenterology. 20, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
gemcitabine
Therapeutics
12 Citations

Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

Immonen, J. A., Zagon, I. & McLaughlin, P., Jan 1 2014, In : Experimental Biology and Medicine. 239, 10, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Naltrexone
Fibroblasts
Wound Healing
Narcotic Antagonists
Opioid Receptors
2013
13 Citations

Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Campbell, A. M., Zagon, I. & McLaughlin, P., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Astrocytes
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord
8 Citations

Opioid growth factor (OGF) for hepatoblastoma: A novel non-toxic treatment

Rogosnitzky, M., Finegold, M. J., McLaughlin, P. J. & Zagon, I. S., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 1066-1070 5 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Drug Therapy
Naltrexone
13 Citations

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer

Zagon, I., Porterfield, N. K. & McLaughlin, P., Jun 1 2013, In : Experimental Biology and Medicine. 238, 6, p. 589-599 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cells
Cell Line

Pomc-derived opioid peptides

McLaughlin, P. & Zagon, I., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1592-1595 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Opioid Peptides
1 Citations

Proenkephalin-derived peptides

McLaughlin, P., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1602-1609 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Peptides
proenkephalin
9 Citations

Targeting the opioid growth factor: Opioid growth factor receptor axis for treatment of human ovarian cancer

Zagon, I., Donahue, R. & McLaughlin, P., Aug 1 2013, In : Experimental Biology and Medicine. 238, 5, p. 579-587 9 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Therapeutics
Cells
22 Citations

Topical naltrexone accelerates full-thickness wound closure in type 1 diabetic rats by stimulating angiogenesis

McLaughlin, P., Immonen, J. A. & Zagon, I., Jul 1 2013, In : Experimental Biology and Medicine. 238, 7, p. 733-743 11 p.

Research output: Contribution to journalArticle

Naltrexone
Rats
Wound Healing
Granulation
Wounds and Injuries
14 Citations
Naltrexone
Narcotic Antagonists
Wound Healing
Rats
Skin
10 Citations

Treatment of a relapse-remitting model of multiple sclerosis with opioid growth factor

Hammer, L. A., Zagon, I. & McLaughlin, P., Sep 1 2013, In : Brain Research Bulletin. 98, p. 122-131 10 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Autoimmune Experimental Encephalomyelitis
Recurrence
2012
8 Citations

Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer

Fanning, J., Hossler, C., Kesterson, J., Donahue, R. N., McLaughlin, P. & Zagon, I., Feb 1 2012, In : Gynecologic Oncology. 124, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Ovarian Cysts
Epithelial Cells
12 Citations
Methionine Enkephalin
imiquimod
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Naltrexone
18 Citations
Autoimmune Experimental Encephalomyelitis
Spinal Cord Diseases
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Pathology

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
encephalitis
Disease Outbreaks
Clostridium difficile
Fecal Impaction
9 Citations
Tears
Naltrexone
Methionine Enkephalin
Ophthalmic Solutions
Opioid Receptors
4 Citations
Transgenic Mice
Epithelium
Cell Proliferation
Wounds and Injuries
Cornea
5 Citations
Antineoplastic Combined Chemotherapy Protocols
Methionine Enkephalin
Opioid Receptors
Pancreatic Neoplasms
Antineoplastic Agents
33 Citations
Cell proliferation
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Naltrexone
Cell Proliferation
5 Citations

Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer

Donahue, R. N., McLaughlin, P. & Zagon, I., Feb 1 2012, In : Experimental Biology and Medicine. 237, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Tumors
Tumor Burden
Opioid Analgesics
Cells
2011
31 Citations

B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases

Zagon, I., Donahue, R. N., Bonneau, R. H. & McLaughlin, P., Jan 1 2011, In : Immunobiology. 216, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
B-Lymphocytes
Cell Count
23 Citations

Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Donahue, R. N., McLaughlin, P. & Zagon, I., Jul 1 2011, In : Experimental Biology and Medicine. 236, 7, p. 883-895 13 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Cisplatin
Paclitaxel
Tissue culture
26 Citations
Tissue culture
Naltrexone
Cell proliferation
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
28 Citations
Myelin-Oligodendrocyte Glycoprotein
Naltrexone
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
8 Citations

Targeting opioid signaling in Crohns disease: New therapeutic pathways

Zagon, I. & McLaughlin, P., Oct 1 2011, In : Expert Review of Gastroenterology and Hepatology. 5, 5, p. 555-558 4 p.

Research output: Contribution to journalReview article

Naltrexone
Narcotic Antagonists
Opioid Receptors
Inflammatory Bowel Diseases
Crohn Disease
21 Citations

The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice

Donahue, R. N., McLaughlin, P. & Zagon, I., Aug 1 2011, In : Gynecologic Oncology. 122, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Opioid Receptors
32 Citations
Enkephalins
Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
T-Lymphocytes
15 Citations

Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats

McLaughlin, P., Pothering, C. A., Immonen, J. A. & Zagon, I., Oct 1 2011, In : Experimental Biology and Medicine. 236, 10, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Medical problems
Rats
Type 1 Diabetes Mellitus
2010
29 Citations
Naltrexone
Re-Epithelialization
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Topical Administration
5 Citations

Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors

McLaughlin, P., Rogosnitzky, M. & Zagon, I., Nov 1 2010, In : Experimental Biology and Medicine. 235, 11, p. 1292-1299 8 p.

Research output: Contribution to journalArticle

imiquimod
Opioid Receptors
Epidermis
DNA
Immune system
11 Citations
Clathrin
Enkephalins
Endocytosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
20 Citations

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Zagon, I., Rahn, K. A., Bonneau, R. H., Turel, A. P. & McLaughlin, P., Jan 15 2010, In : Brain research. 1310, p. 154-161 8 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord
16 Citations
beta Karyopherins
Cell proliferation
Karyopherins
Cell Proliferation
Cell Nucleus Active Transport
3 Citations
Tenon Capsule
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Fibroblasts
Cell Proliferation
29 Citations

The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer

Avella, D. M., Kimchi, E. T., Donahue, R. N., Tagaram, H. R. S., McLaughlin, P. J., Zagon, I. S. & Staveley-O'Carroll, K. F., Feb 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 2

Research output: Contribution to journalArticle

Liver Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Hepatocellular Carcinoma