• 7516 Citations
  • 46 h-Index
1976 …2019

Research output per year

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Research Output

2019

Blockade of the OGF-OGFr pathway in diabetic bone

Titunick, M. B., Lewis, G. S., Cain, J. D., Zagon, I. S. & McLaughlin, P. J., Jan 1 2019, In : Connective Tissue Research. 60, 6, p. 521-529 9 p.

Research output: Contribution to journalArticle

Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes

McLaughlin, P. J., Sassani, J. W., Titunick, M. B. & Zagon, I. S., Jan 28 2019, In : BMC Ophthalmology. 19, 1, 35.

Research output: Contribution to journalArticle

1 Scopus citations
2018
3 Scopus citations

Intermittent blockade of OGFr and treatment of autoimmune disorders

Zagon, I. S. & McLaughlin, P. J., Dec 1 2018, In : Experimental Biology and Medicine. 243, 17-18, p. 1323-1330 8 p.

Research output: Contribution to journalReview article

1 Scopus citations
2017
8 Scopus citations
13 Scopus citations

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. J. & Neighbors, J. D., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Topical Naltrexone is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin, P. J., Cain, J. D., Titunick, M. B., Sassani, J. W. & Zagon, I. S., Sep 2017, In : Advances in Wound Care. 6, 9, p. 279-288 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent

Kren, N. P., Zagon, I. & McLaughlin, P., Feb 1 2016, In : Experimental Biology and Medicine. 241, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
11 Scopus citations
8 Scopus citations
2015

Duration of opioid receptor blockade determines biotherapeutic response

McLaughlin, P. J. & Zagon, I. S., Oct 1 2015, In : Biochemical Pharmacology. 97, 3, p. 236-246 11 p.

Research output: Contribution to journalComment/debate

17 Scopus citations
19 Scopus citations
8 Scopus citations

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

Turel, A. P., Oh, K. H., Zagon, I. S. & McLaughlin, P. J., Oct 12 2015, In : Journal of Clinical Psychopharmacology. 35, 5, p. 609-611 3 p.

Research output: Contribution to journalLetter

13 Scopus citations

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Kren, N. P., Zagon, I. S. & McLaughlin, P. J., Jul 1 2015, In : International journal of molecular medicine. 36, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014
4 Scopus citations
20 Scopus citations

Opioid growth factor and the treatment of human pancreatic cancer: A review

Zagon, I. & McLaughlin, P., Jan 1 2014, In : World journal of gastroenterology. 20, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

Immonen, J. A., Zagon, I. S. & McLaughlin, P. J., Jan 1 2014, In : Experimental Biology and Medicine. 239, 10, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Campbell, A. M., Zagon, I. S. & McLaughlin, P. J., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Opioid growth factor (OGF) for hepatoblastoma: A novel non-toxic treatment

Rogosnitzky, M., Finegold, M. J., McLaughlin, P. J. & Zagon, I. S., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 1066-1070 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer

Zagon, I., Porterfield, N. K. & McLaughlin, P., Jun 1 2013, In : Experimental Biology and Medicine. 238, 6, p. 589-599 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pomc-derived opioid peptides

McLaughlin, P. & Zagon, I., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1592-1595 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Proenkephalin-derived peptides

McLaughlin, P., Aug 29 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1602-1609 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
13 Scopus citations
24 Scopus citations
15 Scopus citations

Treatment of a relapse-remitting model of multiple sclerosis with opioid growth factor

Hammer, L. A., Zagon, I. S. & McLaughlin, P. J., Sep 1 2013, In : Brain Research Bulletin. 98, p. 122-131 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer

Fanning, J., Hossler, C. A., Kesterson, J. P., Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Gynecologic Oncology. 124, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
13 Scopus citations
20 Scopus citations

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
10 Scopus citations
4 Scopus citations
6 Scopus citations
40 Scopus citations

Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer

Donahue, R. N., Mclaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Experimental Biology and Medicine. 237, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011
34 Scopus citations

Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Jul 1 2011, In : Experimental Biology and Medicine. 236, 7, p. 883-895 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
33 Scopus citations
31 Scopus citations

Targeting opioid signaling in Crohns disease: New therapeutic pathways

Zagon, I. S. & McLaughlin, P. J., Oct 1 2011, In : Expert Review of Gastroenterology and Hepatology. 5, 5, p. 555-558 4 p.

Research output: Contribution to journalReview article

8 Scopus citations

The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Aug 1 2011, In : Gynecologic Oncology. 122, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
36 Scopus citations

Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats

McLaughlin, P. J., Pothering, C. A., Immonen, J. A. & Zagon, I. S., Oct 1 2011, In : Experimental Biology and Medicine. 236, 10, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010
33 Scopus citations

Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors

McLaughlin, P. J., Rogosnitzky, M. & Zagon, I. S., Nov 1 2010, In : Experimental Biology and Medicine. 235, 11, p. 1292-1299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
13 Scopus citations

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Zagon, I., Rahn, K. A., Bonneau, R. H., Turel, A. P. & McLaughlin, P., Jan 15 2010, In : Brain research. 1310, p. 154-161 8 p.

Research output: Contribution to journalArticle

21 Scopus citations