• 7553 Citations
  • 46 h-Index
1976 …2019

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Research Output

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2019

Blockade of the OGF-OGFr pathway in diabetic bone

Titunick, M. B., Lewis, G. S., Cain, J. D., Zagon, I. S. & McLaughlin, P. J., Jan 1 2019, In : Connective Tissue Research. 60, 6, p. 521-529 9 p.

Research output: Contribution to journalArticle

Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes

McLaughlin, P. J., Sassani, J. W., Titunick, M. B. & Zagon, I. S., Jan 28 2019, In : BMC Ophthalmology. 19, 1, 35.

Research output: Contribution to journalArticle

1 Scopus citations
2018
3 Scopus citations
2017
8 Scopus citations
14 Scopus citations

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. J. & Neighbors, J. D., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Topical Naltrexone is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin, P. J., Cain, J. D., Titunick, M. B., Sassani, J. W. & Zagon, I. S., Sep 2017, In : Advances in Wound Care. 6, 9, p. 279-288 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent

Kren, N. P., Zagon, I. & McLaughlin, P., Feb 1 2016, In : Experimental Biology and Medicine. 241, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
11 Scopus citations
9 Scopus citations
2015
20 Scopus citations
8 Scopus citations

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Kren, N. P., Zagon, I. S. & McLaughlin, P. J., Jul 1 2015, In : International journal of molecular medicine. 36, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014
21 Scopus citations

Opioid growth factor and the treatment of human pancreatic cancer: A review

Zagon, I. & McLaughlin, P., Jan 1 2014, In : World journal of gastroenterology. 20, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

Immonen, J. A., Zagon, I. S. & McLaughlin, P. J., Jan 1 2014, In : Experimental Biology and Medicine. 239, 10, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Campbell, A. M., Zagon, I. S. & McLaughlin, P. J., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Opioid growth factor (OGF) for hepatoblastoma: A novel non-toxic treatment

Rogosnitzky, M., Finegold, M. J., McLaughlin, P. J. & Zagon, I. S., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 1066-1070 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer

Zagon, I., Porterfield, N. K. & McLaughlin, P., Jun 1 2013, In : Experimental Biology and Medicine. 238, 6, p. 589-599 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
13 Scopus citations
24 Scopus citations
15 Scopus citations

Treatment of a relapse-remitting model of multiple sclerosis with opioid growth factor

Hammer, L. A., Zagon, I. S. & McLaughlin, P. J., Sep 1 2013, In : Brain Research Bulletin. 98, p. 122-131 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer

Fanning, J., Hossler, C. A., Kesterson, J. P., Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Gynecologic Oncology. 124, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
13 Scopus citations
22 Scopus citations

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
10 Scopus citations
4 Scopus citations

Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer

Donahue, R. N., Mclaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Experimental Biology and Medicine. 237, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011
34 Scopus citations

Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Jul 1 2011, In : Experimental Biology and Medicine. 236, 7, p. 883-895 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
34 Scopus citations
31 Scopus citations

The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Aug 1 2011, In : Gynecologic Oncology. 122, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
36 Scopus citations

Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats

McLaughlin, P. J., Pothering, C. A., Immonen, J. A. & Zagon, I. S., Oct 1 2011, In : Experimental Biology and Medicine. 236, 10, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors

McLaughlin, P. J., Rogosnitzky, M. & Zagon, I. S., Nov 1 2010, In : Experimental Biology and Medicine. 235, 11, p. 1292-1299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
13 Scopus citations

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Zagon, I., Rahn, K. A., Bonneau, R. H., Turel, A. P. & McLaughlin, P., Jan 15 2010, In : Brain research. 1310, p. 154-161 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
18 Scopus citations
4 Scopus citations

The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer

Avella, D. M., Kimchi, E. T., Donahue, R. N., Tagaram, H. R. S., McLaughlin, P. J., Zagon, I. S. & Staveley-O'Carroll, K. F., Feb 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 2, p. R459-R466

Research output: Contribution to journalArticle

31 Scopus citations

Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits

Zagon, I. S., Sassani, J. W., Carroll, M. A. & McLaughlin, P. J., Feb 15 2010, In : Brain Research Bulletin. 81, 2-3, p. 248-255 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009
55 Scopus citations
29 Scopus citations

Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus

Zagon, I. S., Klocek, M. S., Sassani, J. W. & McLaughlin, P. J., Nov 1 2009, In : Archives of Ophthalmology. 127, 11, p. 1468-1473 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
30 Scopus citations
13 Scopus citations
19 Scopus citations