If you made any changes in Pure, your changes will be visible here soon.

Research Output 1976 2019

Filter
Article
2019

Blockade of the OGF-OGFr pathway in diabetic bone

Titunick, M. B., Lewis, G. S., Cain, J. D., Zagon, I. S. & McLaughlin, P. J., Jan 1 2019, In : Connective Tissue Research. 60, 6, p. 521-529 9 p.

Research output: Contribution to journalArticle

Naltrexone
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Bone
Bone and Bones
1 Citation (Scopus)

Efficacy and safety of a novel naltrexone treatment for dry eye in type 1 diabetes

McLaughlin, P. J., Sassani, J. W., Titunick, M. B. & Zagon, I. S., Jan 28 2019, In : BMC Ophthalmology. 19, 1, 35.

Research output: Contribution to journalArticle

Naltrexone
Type 1 Diabetes Mellitus
Safety
Ophthalmic Solutions
Tears
2018
3 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Naltrexone
Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
2017
8 Citations (Scopus)
Encephalomyelitis
Autoimmune Experimental Encephalomyelitis
Enkephalins
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
12 Citations (Scopus)
Naltrexone
Enkephalins
Multiple Sclerosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
1 Citation (Scopus)

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. J. & Neighbors, J. D., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

Stilbenes
Amides
Isomers
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
7 Citations (Scopus)

Topical Naltrexone is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin, P. J., Cain, J. D., Titunick, M. B., Sassani, J. W. & Zagon, I. S., Sep 2017, In : Advances in Wound Care. 6, 9, p. 279-288 10 p.

Research output: Contribution to journalArticle

Naltrexone
Wounds and Injuries
Diabetic Foot
Platelet-Derived Growth Factor
Mast Cells
2016
2 Citations (Scopus)

Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent

Kren, N. P., Zagon, I. & McLaughlin, P., Feb 1 2016, In : Experimental Biology and Medicine. 241, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Nuclear Export Signals
Tandem Repeat Sequences
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
11 Citations (Scopus)
Naltrexone
T-cells
Autoimmune Experimental Encephalomyelitis
Neurology
Infiltration
7 Citations (Scopus)
Naltrexone
Healthy Volunteers
Placebos
Corneal Pachymetry
Corneal Topography
2015
19 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Immunization
B-Lymphocytes
Naltrexone
7 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Recurrence
3 Citations (Scopus)

Mutations in the opioid growth factor receptor in human cancers alter receptor function

Kren, N. P., Zagon, I. S. & McLaughlin, P. J., Jul 1 2015, In : International journal of molecular medicine. 36, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Mutation
Neoplasms
gemcitabine
2014
20 Citations (Scopus)
Eye Abnormalities
Naltrexone
Narcotic Antagonists
Type 2 Diabetes Mellitus
Tears
15 Citations (Scopus)

Opioid growth factor and the treatment of human pancreatic cancer: A review

Zagon, I. & McLaughlin, P., Jan 1 2014, In : World journal of gastroenterology. 20, 9, p. 2218-2223 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
gemcitabine
Therapeutics
16 Citations (Scopus)

Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

Immonen, J. A., Zagon, I. & McLaughlin, P., Jan 1 2014, In : Experimental Biology and Medicine. 239, 10, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Naltrexone
Fibroblasts
Wound Healing
Narcotic Antagonists
Opioid Receptors
2013
15 Citations (Scopus)

Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis

Campbell, A. M., Zagon, I. S. & McLaughlin, P. J., Jan 1 2013, In : Brain Research Bulletin. 90, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Astrocytes
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord
13 Citations (Scopus)

Opioid growth factor (OGF) for hepatoblastoma: A novel non-toxic treatment

Rogosnitzky, M., Finegold, M. J., McLaughlin, P. J. & Zagon, I. S., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 1066-1070 5 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Drug Therapy
Naltrexone
18 Citations (Scopus)

Opioid growth factor - opioid growth factor receptor axis inhibits proliferation of triple negative breast cancer

Zagon, I., Porterfield, N. K. & McLaughlin, P., Jun 1 2013, In : Experimental Biology and Medicine. 238, 6, p. 589-599 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cells
Cell Line
12 Citations (Scopus)
Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Therapeutics
Cells
24 Citations (Scopus)
Naltrexone
Rats
Wound Healing
Granulation
Wounds and Injuries
15 Citations (Scopus)
Naltrexone
Narcotic Antagonists
Wound Healing
Rats
Skin
11 Citations (Scopus)

Treatment of a relapse-remitting model of multiple sclerosis with opioid growth factor

Hammer, L. A., Zagon, I. & McLaughlin, P., Sep 1 2013, In : Brain Research Bulletin. 98, p. 122-131 10 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Multiple Sclerosis
Intercellular Signaling Peptides and Proteins
Autoimmune Experimental Encephalomyelitis
Recurrence
2012
10 Citations (Scopus)

Expression of the opioid growth factor-opioid growth factor receptor axis in human ovarian cancer

Fanning, J., Hossler, C. A., Kesterson, J. P., Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Gynecologic Oncology. 124, 2, p. 319-324 6 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Ovarian Cysts
Epithelial Cells
13 Citations (Scopus)
Methionine Enkephalin
imiquimod
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Naltrexone
20 Citations (Scopus)
Autoimmune Experimental Encephalomyelitis
Spinal Cord Diseases
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Pathology
1 Citation (Scopus)

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
encephalitis
Disease Outbreaks
Clostridium difficile
Fecal Impaction
10 Citations (Scopus)
Tears
Naltrexone
Methionine Enkephalin
Ophthalmic Solutions
Opioid Receptors
4 Citations (Scopus)
Transgenic Mice
Epithelium
Cell Proliferation
Wounds and Injuries
Cornea
7 Citations (Scopus)

Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer

Donahue, R. N., Mclaughlin, P. J. & Zagon, I. S., Feb 1 2012, In : Experimental Biology and Medicine. 237, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Tumors
Tumor Burden
Opioid Analgesics
Cells
2011
34 Citations (Scopus)
Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
B-Lymphocytes
Cell Count
26 Citations (Scopus)

Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Jul 1 2011, In : Experimental Biology and Medicine. 236, 7, p. 883-895 13 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Cisplatin
Paclitaxel
Tissue culture
33 Citations (Scopus)
Tissue culture
Naltrexone
Cell proliferation
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
31 Citations (Scopus)
Myelin-Oligodendrocyte Glycoprotein
Naltrexone
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
26 Citations (Scopus)

The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice

Donahue, R. N., McLaughlin, P. J. & Zagon, I. S., Aug 1 2011, In : Gynecologic Oncology. 122, 2, p. 382-388 7 p.

Research output: Contribution to journalArticle

Naltrexone
Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Opioid Receptors
36 Citations (Scopus)
Enkephalins
Opioid Analgesics
Autoimmune Diseases
Intercellular Signaling Peptides and Proteins
T-Lymphocytes
16 Citations (Scopus)

Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats

McLaughlin, P. J., Pothering, C. A., Immonen, J. A. & Zagon, I. S., Oct 1 2011, In : Experimental Biology and Medicine. 236, 10, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

Naltrexone
Narcotic Antagonists
Medical problems
Rats
Type 1 Diabetes Mellitus
2010
6 Citations (Scopus)

Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors

McLaughlin, P. J., Rogosnitzky, M. & Zagon, I. S., Nov 1 2010, In : Experimental Biology and Medicine. 235, 11, p. 1292-1299 8 p.

Research output: Contribution to journalArticle

imiquimod
Opioid Receptors
Epidermis
DNA
Immune system
13 Citations (Scopus)
Clathrin
Enkephalins
Endocytosis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
21 Citations (Scopus)

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Zagon, I., Rahn, K. A., Bonneau, R. H., Turel, A. P. & McLaughlin, P., Jan 15 2010, In : Brain research. 1310, p. 154-161 8 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Spinal Cord
18 Citations (Scopus)
Karyopherins
Cell proliferation
Cell Proliferation
Cell Nucleus Active Transport
Nuclear Envelope
4 Citations (Scopus)
Tenon Capsule
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Fibroblasts
Cell Proliferation
31 Citations (Scopus)

The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer

Avella, D. M., Kimchi, E. T., Donahue, R. N., Tagaram, H. R. S., McLaughlin, P. J., Zagon, I. S. & Staveley-O'Carroll, K. F., Feb 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 2, p. R459-R466

Research output: Contribution to journalArticle

Liver Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Hepatocellular Carcinoma
20 Citations (Scopus)

Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits

Zagon, I. S., Sassani, J. W., Carroll, M. A. & McLaughlin, P. J., Feb 15 2010, In : Brain Research Bulletin. 81, 2-3, p. 248-255 8 p.

Research output: Contribution to journalArticle

Naltrexone
Cornea
Rabbits
Alloxan
Narcotic Antagonists
2009
54 Citations (Scopus)
Ovarian Neoplasms
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Cell Line
29 Citations (Scopus)
Nuclear Localization Signals
Cell proliferation
Cell Proliferation
Mutation
Bromodeoxyuridine
33 Citations (Scopus)

Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus

Zagon, I. S., Klocek, M. S., Sassani, J. W. & McLaughlin, P. J., Nov 1 2009, In : Archives of Ophthalmology. 127, 11, p. 1468-1473 6 p.

Research output: Contribution to journalArticle

Naltrexone
Tears
Diabetes Mellitus
Ophthalmic Solutions
Insulin
30 Citations (Scopus)
Naltrexone
Autoimmune Experimental Encephalomyelitis
Opioid Analgesics
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
12 Citations (Scopus)
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
Growth
Neoplasms
Thyroid Epithelial Cells
18 Citations (Scopus)
Naltrexone
Insulin
Re-Epithelialization
Wounds and Injuries
Cornea