• 7516 Citations
  • 46 h-Index
1976 …2019

Research output per year

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Research Output

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Article
2009
53 Scopus citations
13 Scopus citations
71 Scopus citations
2008

Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer

Goldenberg, D., Zagon, I., Fedok, F., Crist, H. & McLaughlin, P., Nov 1 2008, In : Thyroid. 18, 11, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function

Zagon, I. S., Donahue, R. N., Rogosnitzky, M. & McLaughlin, P. J., Aug 1 2008, In : Experimental Biology and Medicine. 233, 8, p. 968-979 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor

Zagon, I. S., Kreiner, S., Heslop, J. J., Conway, A. B., Morgan, C. R. & McLaughlin, P. J., Aug 1 2008, In : International journal of oncology. 33, 2, p. 317-323 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
18 Scopus citations

Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone

Zagon, I. S., Klocek, M. S., Griffith, J. W., Sassani, J. W., Komáromy, A. M. & McLaughlin, P. J., Apr 1 2008, In : Archives of Ophthalmology. 126, 4, p. 501-506 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
51 Scopus citations
2007
19 Scopus citations

Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells

Zagon, I. S., Rahn, K. A. & McLaughlin, P. J., Dec 1 2007, In : Neuropeptides. 41, 6, p. 441-452 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
21 Scopus citations
25 Scopus citations

The Opioid Growth Factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer

Cheng, F., Zagon, I. S., Verderame, M. F. & McLaughlin, P. J., Nov 1 2007, In : Cancer Research. 67, 21, p. 10511-10518 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Topically applied naltrexone restores corneal reepithelialization in diabetic rats

Klocek, M. S., Sassani, J., McLaughlin, P. & Zagon, I., Apr 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 2, p. 89-102 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus

Zagon, I. S., Klocek, M. S., Sassani, J. W. & McLaughlin, P. J., Aug 1 2007, In : Archives of Ophthalmology. 125, 8, p. 1082-1088 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
2006
15 Scopus citations

Corneal safety of topically applied naltrexone

Zagon, I., Klocek, M. S., Sassani, J., Mauger, D. & McLaughlin, P., Oct 1 2006, In : Journal of Ocular Pharmacology and Therapeutics. 22, 5, p. 377-387 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats

Zagon, I. S., Sassani, J. W. & McLaughlin, P. J., Jul 27 2006, In : Diabetes. 55, 4, p. 1141-1147 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
9 Scopus citations
13 Scopus citations
25 Scopus citations
2005
32 Scopus citations

Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor.

McLaughlin, P. J., Jaglowski, J. R., Verderame, M. F., Stack, B. C., Leure-Dupree, A. E. & Zagon, I. S., Mar 2005, In : International journal of oncology. 26, 3, p. 809-816 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
39 Scopus citations

Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck

Jaglowski, J. R., Zagon, I. S., Stack, B. C., Verderame, M. F., Leure-duPree, A. E., Manning, J. D. & McLaughlin, P. J., Jul 1 2005, In : Cancer Chemotherapy and Pharmacology. 56, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Opioids and differentiation in human cancer cells

Zagon, I. S. & McLaughlin, P. J., Oct 1 2005, In : Neuropeptides. 39, 5, p. 495-505 11 p.

Research output: Contribution to journalArticle

44 Scopus citations
26 Scopus citations
2004

Gene expression of OGFr in the developing and adult rat brain and cerebellum

Zagon, I. & McLaughlin, P., Mar 1 2004, In : Brain Research Bulletin. 63, 1, p. 57-63 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells.

Zagon, I. & McLaughlin, P., Jun 2004, In : International Journal of Oncology. 24, 6, p. 1443-1448 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration.

McLaughlin, P., Stack, B. C., Braine, K. M., Ruda, J. D. & Zagon, I., Jan 1 2004, In : International Journal of Oncology. 24, 1, p. 227-232 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Treatment of advanced pancreatic cancer with opioid growth factor: Phase I

Smith, J. P., Conter, R. L., Bingaman, S. I., Harvey, H., Mauger, D., Ahmad, M., Demers, L., Stanley, W. B., McLaughlin, P. & Zagon, I., Mar 1 2004, In : Anti-Cancer Drugs. 15, 3, p. 203-209 7 p.

Research output: Contribution to journalArticle

52 Scopus citations
2003

Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck

McLaughlin, P., Stack, B. C., Levin, R. J., Fedok, F. & Zagon, I., Apr 1 2003, In : Cancer. 97, 7, p. 1701-1710 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea

Zagon, I. S., Ruth, T. B., Leure-DuPree, A. E., Sassani, J. W. & McLaughlin, P. J., Mar 28 2003, In : Brain research. 967, 1-2, p. 37-47 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
26 Scopus citations

Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery

Zagon, I. S., Essis, F. M., Verderame, M. F., Healy, D. A., Atnip, R. G. & McLaughlin, P. J., Mar 1 2003, In : Journal of Vascular Surgery. 37, 3, p. 636-643 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Opioids and the apoptotic pathway in human cancer cells

Zagon, I. S. & McLaughlin, P. J., Apr 2003, In : Neuropeptides. 37, 2, p. 79-88 10 p.

Research output: Contribution to journalArticle

75 Scopus citations
11 Scopus citations
2002

Characterization of the CCK-C (cancer) receptor in human pancreatic cancer.

Smith, J. P., Verderame, M., McLaughlin, P., Sasso, M., Ballard, E. & Zagon, I., Jan 1 2002, In : International Journal of Molecular Medicine. 10, 6, p. 689-694 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: Maternal and preweaning effects

McLaughlin, P., Wylie, J. D., Bloom, G., Griffith, J. W. & Zagon, I., Jan 2 2002, In : Pharmacology Biochemistry and Behavior. 71, 1-2, p. 171-181 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Differential effects of vascular growth factors on arterial and venous angiogenesis

Blebea, J., Vu, J. H., Assadnia, S., McLaughlin, P. J., Atnip, R. G. & Zagon, I. S., Mar 2002, In : Journal of Vascular Surgery. 35, 3, p. 532-538 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Exposure to the opioid antagonist naltrexone throughout gestation alters postnatal heart development

McLaughlin, P., Nov 23 2002, In : Biology of the Neonate. 82, 3, p. 207-216 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat

Zagon, I. S., Jenkins, J. B., Sassani, J. W., Wylie, J. D., Ruth, T. B., Fry, J. L., Max Lang, C. & McLaughlin, P. J., Oct 1 2002, In : Diabetes. 51, 10, p. 3055-3062 8 p.

Research output: Contribution to journalArticle

59 Scopus citations
2001

Epithelial adhesion complexes and organ culture of the human cornea

Zagon, I. S., Sassani, J. W., Ruth, T. B. & McLaughlin, P. J., May 11 2001, In : Brain research. 900, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Transplacental transfer of the opioid growth factor, [Met5]-enkephalin, in rats

Zagon, I., Wylie, J. D., Hurst, W. J. & McLaughlin, P., Aug 20 2001, In : Brain Research Bulletin. 55, 3, p. 341-346 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
2000

Cellular dynamics of corneal wound re-epithelialization in the rat III. Mitotic activity

Zagon, I. S., Sassani, J. W., Ruth, T. B. & McLaughlin, P. J., Nov 3 2000, In : Brain research. 882, 1-2, p. 169-179 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
50 Scopus citations

Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancer

Smith, J. P., Conter, R. L., Demers, L., McLaughlin, P. & Zagon, I., Aug 21 2000, In : Pancreas. 21, 2, p. 158-164 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identification and characterization of opioid growth factor receptor in human pancreatic adenocarcinoma.

Zagon, I. S., Smith, J. P., Conter, R. & McLaughlin, P. J., Jan 2000, In : International journal of molecular medicine. 5, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

29 Scopus citations