• 894 Citations
  • 17 h-Index
20102019
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Personal profile

Research interests

Nearly 80 percent of adults in the United States with an alcohol use disorder also use nicotine in various forms. The lab of Dr. Patrick Randall focuses on gaining a better understanding of the underlying neurobiology that leads to and maintains nicotine and alcohol co-use.

Of particular interest is the role that the neuroimmune system plays in co-use. Dr. Randall and his colleagues have previously demonstrated that a single immune challenge produces both rapid and lasting changes to not only markers of immune function but also changes in brain regions related to drug-seeking behavior and corresponding increases in alcohol self-administration.

Dr. Randall has also previously shown through drug discrimination models that, when nicotine and alcohol are used in combination, they are perceived differently from either drug on its own, suggesting that the experience of using both is unique and an important factor in understanding co-use.

The Randall lab uses a variety of techniques, including comprehensive behavioral models and viral techniques, to probe the role of specific brain circuitry in addiction.

Education/Academic qualification

Research Associate, Bowles Center for Alcohol Studies

Oct 2017May 2019

Postdoctoral Fellowship, Bowles Center for Alcohol Studies

Oct 2013Oct 2017

Psychology - Behavioral Neuroscience, PhD, University of Connecticut

May 2008Oct 2013

Fingerprint Dive into the research topics where Patrick Arthur Randall is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Corpus Striatum Medicine & Life Sciences

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Research Output 2010 2019

  • 894 Citations
  • 17 h-Index
  • 26 Article
  • 1 Chapter
  • 1 Review article

Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats

Randall, P. A., Fortino, B., Huynh, Y. W., Thompson, B. M., Larsen, C. E., Callen, M. P., Barrett, S. T., Murray, J. E., Bevins, R. A. & Besheer, J., Apr 1 2019, In : Pharmacology Biochemistry and Behavior. 179, p. 1-8 8 p.

Research output: Contribution to journalArticle

Self Administration
Methamphetamine
Nicotine
Rats
History

Role of mPFC and nucleus accumbens circuitry in modulation of a nicotine plus alcohol compound drug state

Randall, P. A., McElligott, Z. A. & Besheer, J., Jan 1 2019, (Accepted/In press) In : Addiction Biology. e12782.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nicotine
Cues
Designer Drugs
Alcohols
2 Citations (Scopus)
Toll-Like Receptor 3
Poly I-C
Self Administration
Gene expression
Rats
12 Citations (Scopus)

Functional role for cortical-striatal circuitry in modulating alcohol self-administration

Jaramillo, A. A., Randall, P. A., Stewart, S., Fortino, B., Van Voorhies, K. & Besheer, J., Mar 1 2018, In : Neuropharmacology. 130, p. 42-53 12 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self Administration
Alcohols
Prefrontal Cortex
Cerebral Cortex
6 Citations (Scopus)

Silencing the insular-striatal circuit decreases alcohol self-administration and increases sensitivity to alcohol

Jaramillo, A. A., Van Voorhies, K., Randall, P. A. & Besheer, J., Aug 1 2018, In : Behavioural Brain Research. 348, p. 74-81 8 p.

Research output: Contribution to journalArticle

Corpus Striatum
Self Administration
Alcohols
Cerebral Cortex
Alcohol Drinking