• 5336 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

Review article
103 Citations (Scopus)

Anti-cancer therapy: Targeting the mevalonate pathway

Swanson, K. M. & Hohl, R. J., Feb 1 2006, In : Current Cancer Drug Targets. 6, 1, p. 15-37 23 p.

Research output: Contribution to journalReview article

Mevalonic Acid
Transferases
Post Translational Protein Processing
Neoplasms
Clinical Trials
2 Citations (Scopus)

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy
11 Citations (Scopus)

Clinical pharmacology as a foundation for translational science

Waldman, S. A., Hohl, R. J., Kearns, G. L., Swan, S. J. & Terzic, A., Jul 1 2011, In : Clinical pharmacology and therapeutics. 90, 1, p. 10-13 4 p.

Research output: Contribution to journalReview article

Translational Medical Research
Clinical Pharmacology
National Institutes of Health (U.S.)
Molecular Biology
Delivery of Health Care
13 Citations (Scopus)

Donor T-lymphocyte infusion for unrelated allogeneic bone marrow transplantation with CD3+ T-cell-depleted graft

Lee, C. K., de Magalhaes-Silverman, M., Hohl, R. J., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jan 1 2003, In : Bone Marrow Transplantation. 31, 2, p. 121-128 8 p.

Research output: Contribution to journalReview article

Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Tissue Donors
T-Lymphocytes
120 Citations (Scopus)

Isoprenoids: Remarkable diversity of form and function

Holstein, S. A. & Hohl, R. J., Apr 1 2004, In : Lipids. 39, 4, p. 293-309 17 p.

Research output: Contribution to journalReview article

Terpenes
Hydroxymethylglutaryl CoA Reductases
ras Proteins
Critical Pathways
Diterpenes
24 Citations (Scopus)

Is there a future for prenyltransferase inhibitors in cancer therapy?

Holstein, S. A. & Hohl, R., Jan 1 2012, In : Current Opinion in Pharmacology. 12, 6, p. 704-709 6 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Clinical Trials
Farnesyltranstransferase
Prenylation
Post Translational Protein Processing
20 Citations (Scopus)

Nonmalignant complications of therapy for Hodgkin's disease

Hohl, R. & Schilsky, R. L., Jan 1 1989, In : Hematology/Oncology Clinics of North America. 3, 2, p. 331-343 13 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Survivors
Therapeutics
Poisons
Virus Diseases
1 Citation (Scopus)

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J. S., Neighbors, J. & Hohl, R., Aug 1 2018, In : Lipids. 53, 8, p. 767-784 18 p.

Research output: Contribution to journalReview article

Modulators
Lipids
Neoplasms
Cells
trans-Golgi Network
54 Citations (Scopus)

The intermediate enzymes of isoprenoid metabolism as anticancer targets

Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jan 1 2009, In : Anti-Cancer Agents in Medicinal Chemistry. 9, 5, p. 526-542 17 p.

Research output: Contribution to journalReview article

Terpenes
Enzymes
mevalonate kinase
Neoplasms
Proteins
9 Citations (Scopus)

Therapeutic additions and possible deletions in oncology in 2011

Holstein, S. A. & Hohl, R., Jan 1 2012, In : Clinical pharmacology and therapeutics. 91, 1, p. 15-17 3 p.

Research output: Contribution to journalReview article

United States Food and Drug Administration
Therapeutic Uses
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Non-Hodgkin's Lymphoma
Letter
4 Citations (Scopus)
Leukemia
Bone Marrow
T-Lymphocytes

Iowa newborn hemoglobinopathy screening and comprehensive care: A model for rural states [1]

Peters, C., Miller, J., Abel, S. L., McMillan, S. K., Getchell, J. P., Giller, R. H., Hohl, R. & De Alarcon, P. A., Nov 6 1996, In : Journal of Pediatric Hematology/Oncology. 18, 4, p. 416-418 3 p.

Research output: Contribution to journalLetter

Hemoglobinopathies
Mass Screening
Rural Population
Newborn Infant
Education
20 Citations (Scopus)

Randomized, dose-escalation study of the p38α MAPK inhibitor SCIO-469 in patients with myelodysplastic syndrome

Sokol, L., Cripe, L., Kantarjian, H., Sekeres, M. A., Parmar, S., Greenberg, P., Goldberg, S. L., Bhushan, V., Shammo, J., Hohl, R., Verma, A., Garcia-Manero, G., Li, Y. P., Lowe, A., Zhu, J. & List, A. F., Apr 1 2013, In : Leukemia. 27, 4, p. 977-980 4 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Mitogen-Activated Protein Kinase 14
Indoles
Myelodysplastic Syndromes
Protein Kinase Inhibitors
Editorial
2 Citations (Scopus)

Anticoagulants: Major Advances Without Clear Consensus

Hohl, R. J., Aug 1 2016, In : Clinical pharmacology and therapeutics. p. 116-118 3 p.

Research output: Contribution to journalEditorial

Warfarin
Anticoagulants
Heparin
Thrombosis
Therapeutics
4 Citations (Scopus)

Cancer Therapy: Shooting for the Moon

Lee, J. S. H., Blumenthal, G. M., Hohl, R. & Huang, S. M., May 1 2017, In : Clinical pharmacology and therapeutics. 101, 5, p. 552-558 7 p.

Research output: Contribution to journalEditorial

Neoplasms
Therapeutics
1 Citation (Scopus)

Clinical pharmacology: Bridging discovery and practice

Hohl, R., Jun 1 2007, In : Clinical Pharmacology and Therapeutics. 81, 6, p. 783-785 3 p.

Research output: Contribution to journalEditorial

Professional Role
Clinical Pharmacology
Biomedical Research
Drug Therapy
2 Citations (Scopus)

Drug development (and academic medicine): charting the course forward

Hohl, R., Nov 1 2014, In : Clinical Pharmacology and Therapeutics. 96, 5, p. 519-522 4 p.

Research output: Contribution to journalEditorial

Clinical Pharmacology
Industry
Economics
Medicine
Pressure
14 Citations (Scopus)

Imaging as a biomarker for therapy response: Cancer as a prototype for the creation of research resources

McLennan, G., Clarke, L. & Hohl, R., Oct 1 2008, In : Clinical pharmacology and therapeutics. 84, 4, p. 433-436 4 p.

Research output: Contribution to journalEditorial

Factual Databases
Interdisciplinary Communication
Radiology Information Systems
Program Development
National Cancer Institute (U.S.)
2 Citations (Scopus)

Oncology trial design: More accurately and efficiently advancing the field

Hohl, R., May 1 2015, In : Clinical Pharmacology and Therapeutics. 97, 5, p. 430-432 3 p.

Research output: Contribution to journalEditorial

Molecular Targeted Therapy
Off-Label Use
Medical Oncology
Evidence-Based Medicine
Antineoplastic Agents

Vascular medicine: A look forward

Holstein, S. A. & Hohl, R. J., Aug 1 2009, In : Clinical pharmacology and therapeutics. 86, 2, p. 117-119 3 p.

Research output: Contribution to journalEditorial

Coronary Restenosis
Anticholesteremic Agents
Cardiovascular Agents
Drug-Eluting Stents
Drug Design
Comment/debate

Erratum: Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies (Cancer Chemotherapy and Pharmacology 57, (155-164) DOI: 10.1007/s00280-005-0013-8)

Holstein, S. A., Knapp, H. R., Clamon, G. H., Murry, D. J. & Hohl, R., Mar 1 2007, In : Cancer Chemotherapy and Pharmacology. 59, 4, 1 p.

Research output: Contribution to journalComment/debate

15 Citations (Scopus)

Erratum: O2 ⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate (Cancer Cell (2017) 32 (2)(268) (S1535610817300624) (10.1016/j.ccell.2017.02.018))

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H. & 15 others, Kauffman, E. P. S., Schall, M. E., Hohl, R., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G., Aug 14 2017, In : Cancer Cell. 32, 2, 1 p.

Research output: Contribution to journalComment/debate

Confusion
Names
Emotions
Pharmacology
Neoplasms
Lovastatin
Cytarabine
Leukemia
Research
2 Citations (Scopus)

Modulation of RAS expression in human malignant cells by dietary supplements

Lewis, K. A. & Hohl, R., Jan 1 1997, In : Nutrition. 13, 10, p. 921-923 3 p.

Research output: Contribution to journalComment/debate

Chapter
6 Citations (Scopus)

Inhibition of Farnesyl and Geranylgeranyl Diphosphate Synthases

Holstein, S. A. & Hohl, R., Jan 1 2011, Enzymes. Academic Press, p. 301-319 19 p. (Enzymes; vol. 30).

Research output: Chapter in Book/Report/Conference proceedingChapter

Geranyltranstransferase
Farnesyltranstransferase
Protein Prenylation
Terpenes
Diphosphates

Isoprenoid regulation of the expression of ras and ras-related proteins

Holstein, S. A. & Hohl, R., Jan 1 2005, Nutrients and Cell Signaling. CRC Press, p. 439-460 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

ras Proteins
Terpenes
Proteins
Article
18 Citations (Scopus)

2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization

Cermak, D. M., Wiemer, D. F., Lewis, K. & Hohl, R., Nov 27 2000, In : Bioorganic and Medicinal Chemistry. 8, 12, p. 2729-2737 9 p.

Research output: Contribution to journalArticle

Organophosphonates
Diphosphates
Phosphorous Acids
Esters
Bearings (structural)
4 Citations (Scopus)

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Kuder, C. H., Weivoda, M. M., Zhang, Y., Zhu, J., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Dec 1 2015, In : Lipids. 50, 12, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

Cultured Cells
Cholesterol
Cells
Cell Line
Liver
10 Citations (Scopus)

A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep

Veng-Pedersen, P., Chapel, S., Al-Huniti, N. H., Schmidt, R. L., Sedars, E. M., Hohl, R. J. & Widness, J. A., Aug 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 2, p. 532-537 6 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Sheep
Pharmacokinetics
Bone Marrow
Erythroid Precursor Cells

A dose escalation study for salvage chemotherapy in patients with refractory lymphoma prior to high-dose myeloablative therapy with stem cell transplantation

Lee, C. K., de Magalhaes-Silverman, M., Hayashi, M., Schlueter, A., Strauss, R. G., Hohl, R. J. & Gingrich, R. D., Jan 1 2002, In : Bone Marrow Transplantation. 29, 8, p. 647-652 6 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Mitoxantrone
Ifosfamide
Lymphoma
Drug Therapy

Allogeneic hematopoietic stem cell (hsct) in patients with advanced hematological diseases using a non-myeloablative conditioning regimen

Lee, C. K., Hohl, R., Masaki, H., Schlueter, A., Field, E. & Gingrich, R. D., Dec 1 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Hematologic Diseases
Hematopoietic Stem Cells
Stem cells
Transplants
Blood
9 Citations (Scopus)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro

Wasko, B. M., Smits, J. P., Shull, L. W., Wiemer, D. F. & Hohl, R. J., Nov 1 2011, In : Journal of Lipid Research. 52, 11, p. 1957-1964 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Farnesyl-Diphosphate Farnesyltransferase
Protein Prenylation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lovastatin
1 Citation (Scopus)

A novel four-drug ablative regimen with hemopoietic stem cell rescue for patients with breast cancer: A phase II study

Gingrich, R. D., Lee, C. K., Hohl, R., Joyce, J., Burns, L. J., Tamaki, K., Wen, B. C. & Scott, S., Jan 1 1999, In : Biology of Blood and Marrow Transplantation. 5, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Stem Cells
Breast Neoplasms
Stem Cell Transplantation
Pharmaceutical Preparations
Disease-Free Survival
43 Citations (Scopus)

A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients

Messing, E., Gee, J. R., Saltzstein, D. R., Kim, K. M., DiSant'Agnese, A., Kolesar, J., Harris, L., Faerber, A., Havighurst, T., Young, J. M., Efros, M., Getzenberg, R. H., Wheeler, M. A., Tangrea, J., Parnes, H., House, M., Busby, J. E., Hohl, R. & Bailey, H., Apr 1 2012, In : Cancer Prevention Research. 5, 4, p. 621-630 10 p.

Research output: Contribution to journalArticle

Isoflavones
Genistein
Chemoprevention
Tumor Biomarkers
Urinary Bladder Neoplasms

A phase-I, dose escalation study for salvage chemotherapy for patients with refractory lymphoma, prior to myeloablative therapy with stem cell transplantation

Choon-Kee, L., De Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Schlueter, A. & Gingrich, R. D., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Salvaging
Transplants
Chemotherapy
Stem Cell Transplantation
Mitoxantrone
71 Citations (Scopus)

A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863

Venook, A. P., Klein, C. E., Fleming, G., Hollis, D., Leichman, C. G., Hohl, R., Byrd, J., Budman, D., Villalona, M., Marshall, J., Rosner, G. L., Ramirez, J., Kastrissios, H. & Ratain, M. J., Dec 1 2003, In : Annals of Oncology. 14, 12, p. 1783-1790 8 p.

Research output: Contribution to journalArticle

irinotecan
Pharmacokinetics
Radiation
Kidney
Liver
783 Citations (Scopus)

A phase II study of temozolemide vs. procarbazine in patients with glioblastoma multiforme at first relapse

Yung, W. K. A., Albright, R. E., Olson, J., Fredericks, R., Fink, K., Prados, M. D., Brada, M., Spence, A., Hohl, R., Shapiro, W., Glantz, M., Greenberg, H., Selker, R. G., Vick, N. A., Rampling, R., Friedman, H., Phillips, P., Bruner, J., Yue, N., Osoba, D. & 2 others, Zaknoen, S. & Levin, V. A., Aug 31 2000, In : British Journal of Cancer. 83, 5, p. 588-593 6 p.

Research output: Contribution to journalArticle

temozolomide
Procarbazine
Glioblastoma
Recurrence
Disease-Free Survival
22 Citations (Scopus)

A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days

Bailey, H. H., Wilding, G., Tutsch, K. D., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Simon, K., Marnocha, R., Holstein, S. A., Stewart, J., Lewis, K. A. & Hohl, R., Oct 1 2004, In : Cancer Chemotherapy and Pharmacology. 54, 4, p. 368-376 9 p.

Research output: Contribution to journalArticle

perilla alcohol
Transforming Growth Factors
Pharmacokinetics
Toxicity
Plasmas
9 Citations (Scopus)

Biologically active biotin derivatives of schweinfurthin F

Ulrich, N. C., Kuder, C. H., Hohl, R. & Wiemer, D. F., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6716-6720 5 p.

Research output: Contribution to journalArticle

Biotin
Amides
Carrier Proteins
Esters
Derivatives
44 Citations (Scopus)

Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate

Wasko, B. M., Dudakovic, A. & Hohl, R. J., May 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 337, 2, p. 540-546 7 p.

Research output: Contribution to journalArticle

Autophagy
Diphosphonates
zoledronic acid
Terpenes
Prenylation
12 Citations (Scopus)

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Zhu, L., Kong, Y., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Palmisiano, N. D., Wang, M., Jia, B., Bayerl, M., Schell, T. D., Hohl, R. J., Zeng, H. & Zheng, H., Jun 19 2017, In : Journal of Hematology and Oncology. 10, 1, 124.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
B-Lymphocytes
Up-Regulation
T-Lymphocytes
Proteins
3 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models
6 Citations (Scopus)

Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil

Sheehy, R. M., Kuder, C. H., Bachman, Z. & Hohl, R. J., Jan 1 2015, In : Cancer Biology and Therapy. 16, 8, p. 1259-1268 10 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Verapamil
Calcium
Cholesterol
Rhodamine 123
18 Citations (Scopus)

Change in erythropoietin pharmacokinetics following hematopoietic transplantation

Widness, J. A., Schmidt, R. L., Hohl, R. J., Goldman, F. D., Al-Huniti, N. H., Freise, K. J. & Veng-Pedersen, P., Jun 1 2007, In : Clinical pharmacology and therapeutics. 81, 6, p. 873-879 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Pharmacokinetics
Transplantation
Bone Marrow
Transplants
61 Citations (Scopus)

Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: Evidence for bone marrow as a major erythropoietin elimination pathway

Chapel, S., Veng-Pedersen, P., Hohl, R., Schmidt, R. L., Mcguire, E. M. & Widness, J. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 820-824 5 p.

Research output: Contribution to journalArticle

Busulfan
Erythropoietin
Sheep
Pharmacokinetics
Bone Marrow
418 Citations (Scopus)

Clinical and biologic activity of the famesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial

Karp, J. E., Lancet, J. E., Kaufmann, S. H., End, D. W., Wright, J. J., Bol, K., Horak, I., Tidwell, M. L., Liesveld, J., Kottke, T. J., Ange, D., Buddharaju, L., Gojo, I., Edward Highsmith, W., Belly, R. T., Hohl, R. J., Rybak, M. E., Thibault, A. & Rosenblatt, J., Jun 1 2001, In : Blood. 97, 11, p. 3361-3369 9 p.

Research output: Contribution to journalArticle

tipifarnib
Clinical laboratories
Transferases
Refractory materials
Leukemia
76 Citations (Scopus)

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB

Holstein, S. A., Wohlford-Lenane, C. L. & Hohl, R., Mar 22 2002, In : Journal of Biological Chemistry. 277, 12, p. 10678-10682 5 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Up-Regulation
ras Proteins
Terpenes
Proteins
113 Citations (Scopus)

Cyclodextrin complexation: Influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent

Kang, J., Kumar, V., Yang, D., Chowdhury, P. R. & Hohl, R., Feb 27 2002, In : European Journal of Pharmaceutical Sciences. 15, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Camptothecin
Cyclodextrins
Antineoplastic Agents
Solubility
Half-Life
13 Citations (Scopus)

Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells

Henry, M. K., Nimbalkar, D., Hohl, R. & Quelle, F. W., Sep 10 2004, In : Experimental Cell Research. 299, 1, p. 257-266 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Cytokines
S Phase
Phosphorylation
Cell Proliferation
11 Citations (Scopus)
Decarboxylation
Glutathione Disulfide
Glutathione Reductase
Erythrocytes
Chemical activation