• 5336 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

Article
15 Citations (Scopus)

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Holstein, S. A., Tong, H. & Hohl, R. J., Mar 1 2010, In : Leukemia Research. 34, 3, p. 344-351 8 p.

Research output: Contribution to journalArticle

Thalidomide
Biosynthetic Pathways
Terpenes
Multiple Myeloma
Apoptosis
91 Citations (Scopus)

Differential effects of monoterpenes and lovastatin on RAS processing

Hohl, R. & Lewis, K., Jan 1 1995, In : Journal of Biological Chemistry. 270, 29, p. 17508-17512 5 p.

Research output: Contribution to journalArticle

perilla alcohol
Lovastatin
Monoterpenes
Prenylation
Methionine

Differential inhibition of farnesyl protein transferase and squalene synthase by isoprenoid phosphonic acids

Hohl, R. J., Pogatchnik, D. M., Lewis-Tibesar, K. & Wiemer, D. F., Dec 1 1997, In : Clinical pharmacology and therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Phosphorous Acids
Farnesyl-Diphosphate Farnesyltransferase
Terpenes
Transferases
Proteins
47 Citations (Scopus)

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase

Wiemer, A. J., Tong, H., Swanson, K. M. & Hohl, R. J., Feb 23 2007, In : Biochemical and Biophysical Research Communications. 353, 4, p. 921-925 5 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Terpenes
Diphosphonates
zoledronic acid
Protein Prenylation

Drug effects on glucose oxidation in human erythrocytes

Carson, P. E., Parkhurst, G. W. & Hohl, R., Jan 1 1978, In : Clinical Research. 26, 5

Research output: Contribution to journalArticle

Erythrocytes
Glucose
Pharmaceutical Preparations
20 Citations (Scopus)

Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation

Weivoda, M. M. & Hohl, R. J., Aug 1 2011, In : Endocrinology. 152, 8, p. 3113-3122 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Terpenes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oxidoreductases
Coenzyme A
120 Citations (Scopus)

Engraftment syndrome in autologous bone marrow and peripheral stem cell transplantation

Lee, C. K., Gingrich, R. D., Hohl, R. & Ajram, K. A., Jan 1 1995, In : Bone Marrow Transplantation. 16, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Bone Marrow
Exanthema
Fever
Granulocyte Colony-Stimulating Factor
1 Citation (Scopus)
Open Access
Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Transcription Factors
Induction Chemotherapy
7 Citations (Scopus)

Erythropoietin receptor signal transduction requires protein geranylgeranylation

Hamadmad, S. N., Henry, M. K. & Hohl, R. J., Jan 1 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 403-409 7 p.

Research output: Contribution to journalArticle

Protein Prenylation
Erythropoietin Receptors
Erythropoietin
Signal Transduction
Prenylation
21 Citations (Scopus)
rhoA GTP-Binding Protein
Extracellular Signal-Regulated MAP Kinases
Erythropoietin
Mitogen-Activated Protein Kinases
Cell Movement
16 Citations (Scopus)

Farnesol and geranylgeraniol: Prevention and reversion of lovastatin-induced effects in NIH3T3 cells

Ownby, S. E. & Hohl, R., Jan 1 2002, In : Lipids. 37, 2, p. 185-192 8 p.

Research output: Contribution to journalArticle

Farnesol
Lovastatin
Prenylation
Mevalonic Acid
Cholesterol
52 Citations (Scopus)

Fatal cyclophosphamide cardiomyopathy: Its clinical course and treatment

Lee, C. K., Harman, G. S., Hohl, R. & Gingrich, R. D., Sep 1 1996, In : Bone Marrow Transplantation. 18, 3, p. 573-577 5 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Cyclophosphamide
Restrictive Cardiomyopathy
Hypotension
Vascular Resistance

First-in-human phase I clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma

Allen, B. G., Bodeker, K. L., Smith, M. C., Monga, V., Sandhu, S., Hohl, R., Carlisle, T., Brown, H., Hollenbeck, N., Vollstedt, S., Greenlee, J. D., Howard, M. A., Mapuskar, K. A., Seyedin, S. N., Caster, J. M., Jones, K. A., Cullen, J. J., Berg, D., Wagner, B. A., Buettner, G. R. & 4 others, TenNapel, M. J., Smith, B. J., Spitz, D. R. & Buatti, J. M., Nov 15 2019, In : Clinical Cancer Research. 25, 22, p. 6590-6597 8 p.

Research output: Contribution to journalArticle

temozolomide
Clinical Trials, Phase I
Glioblastoma
Radiotherapy
Radiation
26 Citations (Scopus)

Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: Final report of Cancer and Leukemia Group B study 19901

Byrd, J. C., Peterson, B. L., Rai, K. R., Hurd, D., Hohl, R., Perry, M. C., Gockerman, J., Nattam, S. & Larson, R. A., Nov 11 2009, In : Leukemia and Lymphoma. 50, 10, p. 1589-1596 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Leukemia
Neoplasms
Cytomegalovirus Infections
alemtuzumab
10 Citations (Scopus)

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

Topczewski, J. J., Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Sep 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 18, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Poisons
Fluorescence microscopy
Fluorescence Microscopy

Fudarabine/cyclophosphamide followed by allogeneic peripheral blood transplantation (pbct) for older patients with advanced hematological disorders

Lee, C. K., Hohl, R., Schlueter, A., Hayashi, M., Field, E. & Gingrich, R. D., Dec 1 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Transplants
Cyclophosphamide
Blood
Transplantation
Amyloid
6 Citations (Scopus)

Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification

Kuder, C. H., Sheehy, R. M., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Jul 1 2012, In : Molecular pharmacology. 82, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Stilbenes
Poly(ADP-ribose) Polymerases
Caspase 9
Eukaryotic Initiation Factor-2
Apoptosis
8 Citations (Scopus)

GBM-associated mutations and altered protein expression are more common in young patients

Ferguson, S. D., Xiu, J., Weathers, S. P., Zhou, S., Kesari, S., Weiss, S. E., Verhaak, R. G., Hohl, R. J., Barger, G. R., Reddy, S. K. & Heimberger, A. B., Jan 1 2016, In : Oncotarget. 7, 43, p. 69466-69478 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Mutation
Proteins
Methylation
DNA Sequence Analysis

Geranylgeraniol restores cell growth and Ras processing in mevalonate-depleted fibroblast cells

Gao, F., Hohl, R. & Shires, T. K., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Lovastatin
Mevalonic Acid
Cell growth
Fibroblasts
NIH 3T3 Cells
20 Citations (Scopus)

Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration

Dudakovic, A., Tong, H. & Hohl, R. J., Oct 1 2011, In : Investigational New Drugs. 29, 5, p. 912-920 9 p.

Research output: Contribution to journalArticle

Cell Movement
Breast Neoplasms
Farnesyltranstransferase
Guanosine Triphosphate
geranylgeranyl pyrophosphate
34 Citations (Scopus)

Geranylgeranyl diphosphate synthase: An emerging therapeutic target

Wiemer, A. J., Wiemer, D. F. & Hohl, R., Dec 1 2011, In : Clinical pharmacology and therapeutics. 90, 6, p. 804-812 9 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Protein Prenylation
Pharmaceutical Chemistry
Therapeutics
18 Citations (Scopus)

Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiation

Weivoda, M. M. & Hohl, R., Feb 1 2012, In : Bone. 50, 2, p. 467-476 10 p.

Research output: Contribution to journalArticle

Adipogenesis
Peroxisome Proliferator-Activated Receptors
Osteoblasts
Mesenchymal Stromal Cells
geranylgeranyl pyrophosphate
20 Citations (Scopus)
oxidized cellulose
Camptothecin
Microspheres
Plasticizers
Myeloid Leukemia

Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Larson-Casey, J. L., Vaid, M., Gu, L., He, C., Cai, G. Q., Ding, Q., Davis, D., Berryhill, T. F., Wilson, L. S., Barnes, S., Neighbors, J. D., Hohl, R. J., Zimmerman, K. A., Yoder, B. K., Longhini, A. L. F., Hanumanthu, V. S., Surolia, R., Antony, V. B. & Brent Carter, A., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4962-4978 17 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Prenylation
Idiopathic Pulmonary Fibrosis
Macrophages
Wounds and Injuries
2 Citations (Scopus)

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

Weissenrieder, J. S., Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Androgens
Prenylation
38 Citations (Scopus)

Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes

Dudakovic, A., Wiemer, A. J., Lamb, K. M., Vonnahme, L. A., Dietz, S. E. & Hohl, R. J., Mar 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 324, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Terpenes
zoledronic acid
Diphosphonates
Apoptosis
18 Citations (Scopus)

Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells

Hohl, R., Larson, R. A., Mannickarottu, V. & Yachnin, S., Jan 1 1991, In : Blood. 77, 5, p. 1064-1070 7 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Coenzyme A
Oxidoreductases
DNA
54 Citations (Scopus)

Interaction of cytosine arabinoside and lovastatin in human leukemia cells

Holstein, S. A. & Hohl, R., Jun 11 2001, In : Leukemia Research. 25, 8, p. 651-660 10 p.

Research output: Contribution to journalArticle

Lovastatin
Cytarabine
Leukemia
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cell Line
1 Citation (Scopus)

In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors

Reilly, J. E., Zhou, X., Tong, H., Kuder, C. H., Wiemer, D. F. & Hohl, R., Jun 11 2015, In : Biochemical Pharmacology. 96, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Myeloid Leukemia
Terpenes
Cells
Diphosphonates
10 Citations (Scopus)

Isoprenoid Alcohols Restore Protein Isoprenylation in a Time-Dependent Manner Independent of Protein Synthesis

Ownby, S. E. & Hohl, R., Jul 1 2003, In : Lipids. 38, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prenylation
Lovastatin
Terpenes
Alcohols
27 Citations (Scopus)
Unfolded Protein Response
Biosynthetic Pathways
Terpenes
Multiple Myeloma
Proteins
17 Citations (Scopus)

Isoprenoid pyrophosphate analogues regulate expression of ras-related proteins

Holstein, S. A., Wohlford-Lenane, C. L., Wiemer, D. F. & Hohl, R., Apr 22 2003, In : Biochemistry. 42, 15, p. 4384-4391 8 p.

Research output: Contribution to journalArticle

ras Proteins
Terpenes
Diphosphates
Mevalonic Acid
Proteins
61 Citations (Scopus)

Isoprenoids influence expression of Ras and Ras-related proteins

Holstein, S. A., Wohlford-Lenane, C. L. & Hohl, R. J., Nov 19 2002, In : Biochemistry. 41, 46, p. 13698-13704 7 p.

Research output: Contribution to journalArticle

ras Proteins
Mevalonic Acid
Terpenes
Lovastatin
Up-Regulation
4 Citations (Scopus)

Lack of effect of casopitant on the pharmacokinetics of docetaxel in patients with cancer

Dandamudi, U. B., Adams, L. M., Johnson, B., Bauman, J., Morris, S., Murray, S., Webb, R. T., Gartner, E., Hohl, R. & Lewis, L. D., Apr 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 4, p. 783-790 8 p.

Research output: Contribution to journalArticle

docetaxel
Pharmacokinetics
Neoplasms
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
32 Citations (Scopus)

Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo

Lewis, K. A., Holstein, S. A. & Hohl, R., Jan 1 2005, In : Leukemia Research. 29, 5, p. 527-533 7 p.

Research output: Contribution to journalArticle

Lovastatin
Biosynthetic Pathways
Terpenes
Acute Myeloid Leukemia
Leukemia
32 Citations (Scopus)

Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras

Goldman, F., Hohl, R. J., Crabtree, J., Lewis-Tibesar, K. & Koretzky, G., Dec 15 1996, In : Blood. 88, 12, p. 4611-4619 9 p.

Research output: Contribution to journalArticle

Lovastatin
T-Cell Antigen Receptor
Signal transduction
Phosphorylation
Inositol Phosphates
9 Citations (Scopus)

Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity

Xing, D., Murry, D. J., Schmidt, M. S., Hohl, R. & Martins, J. B., May 1 2007, In : Heart Rhythm. 4, 5, p. 629-637 9 p.

Research output: Contribution to journalArticle

Lovastatin
Ventricular Tachycardia
Action Potentials
Mevalonic Acid
Dogs
15 Citations (Scopus)

Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation

Hamadmad, S. N. & Hohl, R. J., Aug 15 2007, In : Biochemical Pharmacology. 74, 4, p. 590-600 11 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Prenylation
Glycosylation
Lovastatin
Erythropoietin
22 Citations (Scopus)

Low pulse oximeter-measured hemoglobin oxygen saturations with hemoglobin Cheverly

Hohl, R., Sherburne, A. R., Feeley, J. E., Huisman, T. H. J. & Burns, C. P., Nov 1 1998, In : American Journal of Hematology. 59, 3, p. 181-184 4 p.

Research output: Contribution to journalArticle

Pulse
Hemoglobins
Oxygen
phenylalanylserine
Mutation
33 Citations (Scopus)

Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

Wiemer, A. J., Yu, J. S., Lamb, K. M., Hohl, R. & Wiemer, D. F., Jan 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 1, p. 390-399 10 p.

Research output: Contribution to journalArticle

Protein Prenylation
Farnesyltranstransferase
Terpenes
Diphosphonates
Proteins
36 Citations (Scopus)

Monoterpene regulation of Ras and Ras-related protein expression

Holstein, S. A. & Hohl, R. J., Jun 1 2003, In : Journal of Lipid Research. 44, 6, p. 1209-1215 7 p.

Research output: Contribution to journalArticle

ras Proteins
Monoterpenes
Signal transduction
Proteins
Signal Transduction
34 Citations (Scopus)

Monoterpenes as regulators of malignant cell proliferation

Hohl, R., 1996, In : Advances in Experimental Medicine and Biology. 401, p. 137-146 10 p.

Research output: Contribution to journalArticle

Monoterpenes
perilla alcohol
Cell proliferation
Cell Proliferation
Prenylation
Open Access
decitabine
Acute Myeloid Leukemia
Therapeutics
T-Lymphocytes
DNA Methylation
30 Citations (Scopus)

Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas

Witzig, T. E., Tang, H., Micallef, I. N. M., Ansell, S. M., Link, B. K., Inwards, D. J., Porrata, L. F., Johnston, P. B., Colgan, J. P., Markovic, S. N., Nowakowski, G. S., Thompson, C. A., Allmer, C., Maurer, M. J., Gupta, M., Weiner, G., Hohl, R., Kurtin, P. J., Ding, H., Loegering, D. & 4 others, Schneider, P., Peterson, K., Habermann, T. M. & Kaufmann, S. H., Nov 3 2011, In : Blood. 118, 18, p. 4882-4889 8 p.

Research output: Contribution to journalArticle

tipifarnib
Farnesyltranstransferase
Refractory materials
Non-Hodgkin's Lymphoma
Lymphoma
78 Citations (Scopus)

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H. & 15 others, Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G., Apr 10 2017, In : Cancer Cell. 31, 4, p. 487-500.e8

Research output: Contribution to journalArticle

Glioblastoma
Non-Small Cell Lung Carcinoma
Pharmacology
Neoplasms
Iron
1 Citation (Scopus)

Personalized medicine: Through the looking glass of functional imaging

Hohl, R. J., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4024-4026 3 p.

Research output: Contribution to journalArticle

Precision Medicine
Glass
Pharmaceutical Preparations
Drug Therapy
Neoplasms
62 Citations (Scopus)

Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies

Holstein, S. A., Knapp, H. R., Clamon, G. H., Murry, D. J. & Hohl, R., Jan 1 2006, In : Cancer Chemotherapy and Pharmacology. 57, 2, p. 155-164 10 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Lovastatin
Bioactivity
Neoplasms
Cholesterol
22 Citations (Scopus)

Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phylebotomy-induced anemia and bone marrow ablation

Veng-Pedersen, P., Chapel, S., Al-Huniti, N. H., Schimdt, R. L., Sedars, E. M., Hohl, R. J. & Widness, J. A., May 1 2004, In : Biopharmaceutics and Drug Disposition. 25, 4, p. 149-156 8 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Phlebotomy
Anemia
Pharmacokinetics
Bone Marrow
7 Citations (Scopus)

Phase 1 study of tabalumab, a human anti-B-cell activating factor antibody, and bortezomib in patients with relapsed/refractory multiple myeloma

Raje, N. S., Faber, E. A., Richardson, P. G., Schiller, G., Hohl, R. J., Cohen, A. D., Forero, A., Carpenter, S., Nguyen, T. S., Conti, I., Kaiser, C. J., Cronier, D. M., Wooldridge, J. E. & Anderson, K. C., Dec 1 2016, In : Clinical Cancer Research. 22, 23, p. 5688-5695 8 p.

Research output: Contribution to journalArticle

B-Cell Activating Factor
Multiple Myeloma
Antibodies
Peripheral Nervous System Diseases
Neutropenia
61 Citations (Scopus)

Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101

Miller, A. A., Murry, D. J., Owzar, K., Hollis, D. R., Lewis, L. D., Kindler, H. L., Marshall, J. L., Villalona-Calero, M. A., Edelman, M. J., Hohl, R. J., Lichtman, S. M. & Ratain, M. J., Jul 20 2007, In : Journal of Clinical Oncology. 25, 21, p. 3055-3060 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Kidney
Liver
Neoplasms
Erlotinib Hydrochloride