• 5303 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

2011
12 Citations (Scopus)

Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis

Holstein, S. A., Kuder, C. H., Tong, H. & Hohl, R., Oct 1 2011, In : Lipids. 46, 10, p. 907-921 15 p.

Research output: Contribution to journalArticle

Terpenes
Lovastatin
Homeostasis
Biosynthetic Pathways
Cells
18 Citations (Scopus)

The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation

Weivoda, M. M. & Hohl, R., Jun 1 2011, In : Journal of cellular biochemistry. 112, 6, p. 1506-1513 8 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Osteoblasts
Farnesyltranstransferase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prenylation
2010
9 Citations (Scopus)

Biologically active biotin derivatives of schweinfurthin F

Ulrich, N. C., Kuder, C. H., Hohl, R. & Wiemer, D. F., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6716-6720 5 p.

Research output: Contribution to journalArticle

Biotin
Amides
Carrier Proteins
Esters
Derivatives
15 Citations (Scopus)

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Holstein, S. A., Tong, H. & Hohl, R. J., Mar 1 2010, In : Leukemia Research. 34, 3, p. 344-351 8 p.

Research output: Contribution to journalArticle

Thalidomide
Biosynthetic Pathways
Terpenes
Multiple Myeloma
Apoptosis
10 Citations (Scopus)

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

Topczewski, J. J., Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Sep 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 18, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Poisons
Fluorescence microscopy
Fluorescence Microscopy
21 Citations (Scopus)

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Ulrich, N. C., Kodet, J. G., Mente, N. R., Kuder, C. H., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Bioactivity
Biological Products
Cells
2 Citations (Scopus)

Survey of muscle characteristics after statin-induced rhabdomyolysis

Phillips, P. S., Verity, M. A., Schick, B. A., Vladutiu, G. D., Laaksonen, R., Oresic, M., Hohl, R. J., Ciaraldi, T. P., Sukhatme, V. P., Lecker, S. H., Cote, H. C. F., Powell, H., Davidson, W. & Wolfson, T., Mar 9 2010, In : Clinical Lipidology. 5, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rhabdomyolysis
Muscles
coenzyme Q10
Cholesterol
20 Citations (Scopus)

Synthesis and biological evaluation of a series of aromatic bisphosphonates

Barney, R. J., Wasko, B. M., Dudakovic, A., Hohl, R. & Wiemer, D. F., Oct 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 20, p. 7212-7220 9 p.

Research output: Contribution to journalArticle

Diphosphonates
Terpenes
Farnesyltranstransferase
zoledronic acid
Geranyltranstransferase
2009
26 Citations (Scopus)

Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: Final report of Cancer and Leukemia Group B study 19901

Byrd, J. C., Peterson, B. L., Rai, K. R., Hurd, D., Hohl, R., Perry, M. C., Gockerman, J., Nattam, S. & Larson, R. A., Nov 11 2009, In : Leukemia and Lymphoma. 50, 10, p. 1589-1596 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Leukemia
Neoplasms
Cytomegalovirus Infections
alemtuzumab
153 Citations (Scopus)

Phase i and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301

Miller, A. A., Murry, D. J., Owzar, K., Hollis, D. R., Kennedy, E. B., Abou-Alfa, G., Desai, A., Hwang, J., Villalona-Calero, M. A., Dees, E. C., Lewis, L. D., Fakih, M. G., Edelman, M. J., Millard, F., Frank, R. C., Hohl, R. J. & Ratain, M. J., Apr 10 2009, In : Journal of Clinical Oncology. 27, 11, p. 1800-1805 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Bilirubin
Kidney
Liver
Creatinine
50 Citations (Scopus)

Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma

Chanan-Khan, A., Niesvizky, R., Hohl, R., Zimmerman, T. M., Christiansen, N. P., Schiller, G. J., Callander, N., Lister, J., Oken, M. & Jagannath, S., Aug 17 2009, In : Leukemia and Lymphoma. 50, 4, p. 559-565 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Myeloma Proteins
Antisense Oligonucleotides
Cytotoxins
8 Citations (Scopus)

Quantitative determination of geranyl diphosphate levels in cultured human cells

Holstein, S. A., Tong, H., Kuder, C. H. & Hohl, R., Nov 1 2009, In : Lipids. 44, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Terpenes
Cultured Cells
Cells
zoledronic acid
Biosynthetic Pathways
23 Citations (Scopus)

Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia

Holstein, S. A., Stokes, J. B. & Hohl, R., Feb 1 2009, In : Leukemia Research. 33, 2, p. 344-347 4 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Renal Insufficiency
Phosphotransferases
Kidney
Protein-Tyrosine Kinases
19 Citations (Scopus)

Synthesis and biological activity of a fluorescent schweinfurthin analogue

Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4718-4723 6 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Growth Inhibitors
National Cancer Institute (U.S.)
Structure-Activity Relationship
54 Citations (Scopus)

The intermediate enzymes of isoprenoid metabolism as anticancer targets

Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jan 1 2009, In : Anti-Cancer Agents in Medicinal Chemistry. 9, 5, p. 526-542 17 p.

Research output: Contribution to journalReview article

Terpenes
Enzymes
mevalonate kinase
Neoplasms
Proteins

Vascular medicine: A look forward

Holstein, S. A. & Hohl, R. J., Aug 1 2009, In : Clinical pharmacology and therapeutics. 86, 2, p. 117-119 3 p.

Research output: Contribution to journalEditorial

Coronary Restenosis
Anticholesteremic Agents
Cardiovascular Agents
Drug-Eluting Stents
Drug Design
2008
21 Citations (Scopus)
rhoA GTP-Binding Protein
Extracellular Signal-Regulated MAP Kinases
Erythropoietin
Mitogen-Activated Protein Kinases
Cell Movement
14 Citations (Scopus)

Imaging as a biomarker for therapy response: Cancer as a prototype for the creation of research resources

McLennan, G., Clarke, L. & Hohl, R., Oct 1 2008, In : Clinical pharmacology and therapeutics. 84, 4, p. 433-436 4 p.

Research output: Contribution to journalEditorial

Factual Databases
Interdisciplinary Communication
Radiology Information Systems
Program Development
National Cancer Institute (U.S.)
37 Citations (Scopus)

Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes

Dudakovic, A., Wiemer, A. J., Lamb, K. M., Vonnahme, L. A., Dietz, S. E. & Hohl, R. J., Mar 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 324, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Terpenes
zoledronic acid
Diphosphonates
Apoptosis
33 Citations (Scopus)

Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

Wiemer, A. J., Yu, J. S., Lamb, K. M., Hohl, R. & Wiemer, D. F., Jan 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 1, p. 390-399 10 p.

Research output: Contribution to journalArticle

Protein Prenylation
Farnesyltranstransferase
Terpenes
Diphosphonates
Proteins
38 Citations (Scopus)

Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207

Rosenberg, J. E., Halabi, S., Sanford, B. L., Himelstein, A. L., Atkins, J. N., Hohl, R. J., Millard, F., Bajorin, D. F. & Small, E. J., May 1 2008, In : Annals of Oncology. 19, 5, p. 946-950 5 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
Carcinoma
Confidence Intervals
Hypernatremia
Lymphopenia
45 Citations (Scopus)

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

Wiemer, A. J., Yu, J. S., Shull, L. W., Barney, R. J., Wasko, B. M., Lamb, K. M., Hohl, R. J. & Wiemer, D. F., Apr 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 7, p. 3652-3660 9 p.

Research output: Contribution to journalArticle

Prenylation
Terpenes
Diphosphonates
Farnesyltranstransferase
Display devices
33 Citations (Scopus)

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue

Tong, H., Wiemer, A. J., Neighbors, J. D. & Hohl, R. J., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Tissue
Terpenes
Biosynthesis
Transferases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
2007
17 Citations (Scopus)

Change in erythropoietin pharmacokinetics following hematopoietic transplantation

Widness, J. A., Schmidt, R. L., Hohl, R. J., Goldman, F. D., Al-Huniti, N. H., Freise, K. J. & Veng-Pedersen, P., Jun 1 2007, In : Clinical pharmacology and therapeutics. 81, 6, p. 873-879 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Pharmacokinetics
Transplantation
Bone Marrow
Transplants
1 Citation (Scopus)

Clinical pharmacology: Bridging discovery and practice

Hohl, R., Jun 1 2007, In : Clinical Pharmacology and Therapeutics. 81, 6, p. 783-785 3 p.

Research output: Contribution to journalEditorial

Professional Role
Clinical Pharmacology
Biomedical Research
Drug Therapy
47 Citations (Scopus)

Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase

Wiemer, A. J., Tong, H., Swanson, K. M. & Hohl, R. J., Feb 23 2007, In : Biochemical and Biophysical Research Communications. 353, 4, p. 921-925 5 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Terpenes
Diphosphonates
zoledronic acid
Protein Prenylation

Erratum: Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies (Cancer Chemotherapy and Pharmacology 57, (155-164) DOI: 10.1007/s00280-005-0013-8)

Holstein, S. A., Knapp, H. R., Clamon, G. H., Murry, D. J. & Hohl, R., Mar 1 2007, In : Cancer Chemotherapy and Pharmacology. 59, 4, 1 p.

Research output: Contribution to journalComment/debate

9 Citations (Scopus)

Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity

Xing, D., Murry, D. J., Schmidt, M. S., Hohl, R. & Martins, J. B., May 1 2007, In : Heart Rhythm. 4, 5, p. 629-637 9 p.

Research output: Contribution to journalArticle

Lovastatin
Ventricular Tachycardia
Action Potentials
Mevalonic Acid
Dogs
15 Citations (Scopus)

Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation

Hamadmad, S. N. & Hohl, R. J., Aug 15 2007, In : Biochemical Pharmacology. 74, 4, p. 590-600 11 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Prenylation
Glycosylation
Lovastatin
Erythropoietin
61 Citations (Scopus)

Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101

Miller, A. A., Murry, D. J., Owzar, K., Hollis, D. R., Lewis, L. D., Kindler, H. L., Marshall, J. L., Villalona-Calero, M. A., Edelman, M. J., Hohl, R. J., Lichtman, S. M. & Ratain, M. J., Jul 20 2007, In : Journal of Clinical Oncology. 25, 21, p. 3055-3060 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Kidney
Liver
Neoplasms
Erlotinib Hydrochloride
24 Citations (Scopus)

Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation

Maalouf, M. A., Wiemer, A. J., Kuder, C. H., Hohl, R. J. & Wiemer, D. F., Mar 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 5, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Protein Prenylation
Terpenes
Diphosphonates
Proteins
Bone
33 Citations (Scopus)

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Mente, N. R., Wiemer, A. J., Neighbors, J. D., Beutler, J. A., Hohl, R. J. & Wiemer, D. F., Feb 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 4, p. 911-915 5 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Optical rotation
Optical Rotation
Enantiomers
2006
102 Citations (Scopus)

Anti-cancer therapy: Targeting the mevalonate pathway

Swanson, K. M. & Hohl, R., Feb 1 2006, In : Current Cancer Drug Targets. 6, 1, p. 15-37 23 p.

Research output: Contribution to journalReview article

Mevalonic Acid
Transferases
Post Translational Protein Processing
Neoplasms
Clinical Trials
7 Citations (Scopus)

Erythropoietin receptor signal transduction requires protein geranylgeranylation

Hamadmad, S. N., Henry, M. K. & Hohl, R. J., Jan 1 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 403-409 7 p.

Research output: Contribution to journalArticle

Protein Prenylation
Erythropoietin Receptors
Erythropoietin
Signal Transduction
Prenylation
62 Citations (Scopus)

Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies

Holstein, S. A., Knapp, H. R., Clamon, G. H., Murry, D. J. & Hohl, R., Jan 1 2006, In : Cancer Chemotherapy and Pharmacology. 57, 2, p. 155-164 10 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Lovastatin
Bioactivity
Neoplasms
Cholesterol
53 Citations (Scopus)

Synthesis and biological activity of isoprenoid bisphosphonates

Shull, L. W., Wiemer, A. J., Hohl, R. J. & Wiemer, D. F., Jun 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 12, p. 4130-4136 7 p.

Research output: Contribution to journalArticle

Terpenes
Diphosphonates
Bioactivity
Protein Prenylation
Bone
2005

Isoprenoid regulation of the expression of ras and ras-related proteins

Holstein, S. A. & Hohl, R., Jan 1 2005, Nutrients and Cell Signaling. CRC Press, p. 439-460 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

ras Proteins
Terpenes
Proteins
32 Citations (Scopus)

Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo

Lewis, K. A., Holstein, S. A. & Hohl, R., Jan 1 2005, In : Leukemia Research. 29, 5, p. 527-533 7 p.

Research output: Contribution to journalArticle

Lovastatin
Biosynthetic Pathways
Terpenes
Acute Myeloid Leukemia
Leukemia
28 Citations (Scopus)

Regulation of fatty acid synthesis by farnesyl pyrophosphate

Murthy, S., Tong, H. & Hohl, R. J., Dec 23 2005, In : Journal of Biological Chemistry. 280, 51, p. 41793-41804 12 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Fatty Acids
Terpenes
Biosynthesis
Liver
65 Citations (Scopus)

Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells

Tong, H., Holstein, S. A. & Hohl, R. J., Jan 1 2005, In : Analytical Biochemistry. 336, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Cultured Cells
Cells
Transferases
Peptides
Recombinant proteins
2004
22 Citations (Scopus)

A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days

Bailey, H. H., Wilding, G., Tutsch, K. D., Arzoomanian, R. Z., Alberti, D., Feierabend, C., Simon, K., Marnocha, R., Holstein, S. A., Stewart, J., Lewis, K. A. & Hohl, R., Oct 1 2004, In : Cancer Chemotherapy and Pharmacology. 54, 4, p. 368-376 9 p.

Research output: Contribution to journalArticle

perilla alcohol
Transforming Growth Factors
Pharmacokinetics
Toxicity
Plasmas
13 Citations (Scopus)

Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells

Henry, M. K., Nimbalkar, D., Hohl, R. & Quelle, F. W., Sep 10 2004, In : Experimental Cell Research. 299, 1, p. 257-266 10 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Cytokines
S Phase
Phosphorylation
Cell Proliferation
119 Citations (Scopus)

Isoprenoids: Remarkable diversity of form and function

Holstein, S. A. & Hohl, R. J., Apr 1 2004, In : Lipids. 39, 4, p. 293-309 17 p.

Research output: Contribution to journalReview article

Terpenes
Hydroxymethylglutaryl CoA Reductases
ras Proteins
Critical Pathways
Diterpenes
22 Citations (Scopus)

Pharmacokinetic tracer kinetics analysis of changes in erythropoietin receptor population in phylebotomy-induced anemia and bone marrow ablation

Veng-Pedersen, P., Chapel, S., Al-Huniti, N. H., Schimdt, R. L., Sedars, E. M., Hohl, R. J. & Widness, J. A., May 1 2004, In : Biopharmaceutics and Drug Disposition. 25, 4, p. 149-156 8 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Phlebotomy
Anemia
Pharmacokinetics
Bone Marrow
74 Citations (Scopus)

Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia: A cancer and leukemia group B study

Burns, C. P., Halabi, S., Clamon, G., Kaplan, E., Hohl, R., Atkins, J. N., Schwartz, M. A., Wagner, B. A. & Paskett, E., Jul 15 2004, In : Cancer. 101, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

Cachexia
Fish Oils
Capsules
Leukemia
Neoplasms
26 Citations (Scopus)

Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues

Kim, M. K., Kleckley, T. S., Wiemer, A. J., Holstein, S. A., Hohl, R. & Wiemer, D. F., Nov 26 2004, In : Journal of Organic Chemistry. 69, 24, p. 8186-8193 8 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Farnesol
Alcohols
Metabolism
2003
10 Citations (Scopus)

A differential pharmacokinetic analysis of the erythropoietin receptor population in newborn and adult sheep

Veng-Pedersen, P., Chapel, S., Al-Huniti, N. H., Schmidt, R. L., Sedars, E. M., Hohl, R. J. & Widness, J. A., Aug 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 2, p. 532-537 6 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Sheep
Pharmacokinetics
Bone Marrow
Erythroid Precursor Cells
70 Citations (Scopus)

A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863

Venook, A. P., Klein, C. E., Fleming, G., Hollis, D., Leichman, C. G., Hohl, R., Byrd, J., Budman, D., Villalona, M., Marshall, J., Rosner, G. L., Ramirez, J., Kastrissios, H. & Ratain, M. J., Dec 1 2003, In : Annals of Oncology. 14, 12, p. 1783-1790 8 p.

Research output: Contribution to journalArticle

irinotecan
Pharmacokinetics
Radiation
Kidney
Liver
13 Citations (Scopus)

Donor T-lymphocyte infusion for unrelated allogeneic bone marrow transplantation with CD3+ T-cell-depleted graft

Lee, C. K., de Magalhaes-Silverman, M., Hohl, R. J., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jan 1 2003, In : Bone Marrow Transplantation. 31, 2, p. 121-128 8 p.

Research output: Contribution to journalReview article

Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Tissue Donors
T-Lymphocytes
10 Citations (Scopus)

Isoprenoid Alcohols Restore Protein Isoprenylation in a Time-Dependent Manner Independent of Protein Synthesis

Ownby, S. E. & Hohl, R., Jul 1 2003, In : Lipids. 38, 7, p. 751-759 9 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prenylation
Lovastatin
Terpenes
Alcohols