• 5303 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

2003
17 Citations (Scopus)

Isoprenoid pyrophosphate analogues regulate expression of ras-related proteins

Holstein, S. A., Wohlford-Lenane, C. L., Wiemer, D. F. & Hohl, R., Apr 22 2003, In : Biochemistry. 42, 15, p. 4384-4391 8 p.

Research output: Contribution to journalArticle

ras Proteins
Terpenes
Diphosphates
Mevalonic Acid
Proteins
36 Citations (Scopus)

Monoterpene regulation of Ras and Ras-related protein expression

Holstein, S. A. & Hohl, R. J., Jun 1 2003, In : Journal of Lipid Research. 44, 6, p. 1209-1215 7 p.

Research output: Contribution to journalArticle

ras Proteins
Monoterpenes
Signal transduction
Proteins
Signal Transduction
2002

A dose escalation study for salvage chemotherapy in patients with refractory lymphoma prior to high-dose myeloablative therapy with stem cell transplantation

Lee, C. K., de Magalhaes-Silverman, M., Hayashi, M., Schlueter, A., Strauss, R. G., Hohl, R. J. & Gingrich, R. D., Jan 1 2002, In : Bone Marrow Transplantation. 29, 8, p. 647-652 6 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Mitoxantrone
Ifosfamide
Lymphoma
Drug Therapy
76 Citations (Scopus)

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB

Holstein, S. A., Wohlford-Lenane, C. L. & Hohl, R., Mar 22 2002, In : Journal of Biological Chemistry. 277, 12, p. 10678-10682 5 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Up-Regulation
ras Proteins
Terpenes
Proteins
111 Citations (Scopus)

Cyclodextrin complexation: Influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent

Kang, J., Kumar, V., Yang, D., Chowdhury, P. R. & Hohl, R., Feb 27 2002, In : European Journal of Pharmaceutical Sciences. 15, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

Camptothecin
Cyclodextrins
Antineoplastic Agents
Solubility
Half-Life
Lovastatin
Cytarabine
Leukemia
Research
16 Citations (Scopus)

Farnesol and geranylgeraniol: Prevention and reversion of lovastatin-induced effects in NIH3T3 cells

Ownby, S. E. & Hohl, R., Jan 1 2002, In : Lipids. 37, 2, p. 185-192 8 p.

Research output: Contribution to journalArticle

Farnesol
Lovastatin
Prenylation
Mevalonic Acid
Cholesterol
61 Citations (Scopus)

Isoprenoids influence expression of Ras and Ras-related proteins

Holstein, S. A., Wohlford-Lenane, C. L. & Hohl, R., Nov 19 2002, In : Biochemistry. 41, 46, p. 13698-13704 7 p.

Research output: Contribution to journalArticle

ras Proteins
Mevalonic Acid
Terpenes
Lovastatin
Up-Regulation
5 Citations (Scopus)

Phosphonate analogues of cytosine arabinoside monophosphate

Chen, X., Jung, K. Y., Wiemer, D. F., Wiemer, A. J. & Hohl, R., Nov 14 2002, In : Phosphorus, Sulfur and Silicon and Related Elements. 177, 6-7, p. 1783-1786 4 p.

Research output: Contribution to journalArticle

Cytidine
Organophosphonates
K562 Cells
Cytarabine
Nucleosides
10 Citations (Scopus)

Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma

Lee, C. K., De Magalhaes-Silverman, M., Hohl, R. J., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jan 1 2002, In : Bone Marrow Transplantation. 29, 7, p. 615-620 6 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow Transplantation
Lymphoma
T-Lymphocytes
Survival

Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma

Lee, C. K., de Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jun 1 2002, In : Bone Marrow Transplantation. 29, 7, p. 615-620 6 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow Transplantation
Lymphoma
T-Lymphocytes
Survival
33 Citations (Scopus)

Stereoselective synthesis of the 5′-hydroxy-5′-phosphonate derivatives of cytidine and cytosine arabinoside

Chen, X., Wiemer, A. J., Hohl, R. J. & Wiemer, D. F., Dec 27 2002, In : Journal of Organic Chemistry. 67, 26, p. 9331-9339 9 p.

Research output: Contribution to journalArticle

Phosphites
Cytidine
Organophosphonates
Cytarabine
Aldehydes
2001
60 Citations (Scopus)

Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: Evidence for bone marrow as a major erythropoietin elimination pathway

Chapel, S., Veng-Pedersen, P., Hohl, R., Schmidt, R. L., Mcguire, E. M. & Widness, J. A., Aug 2 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 2, p. 820-824 5 p.

Research output: Contribution to journalArticle

Busulfan
Erythropoietin
Sheep
Pharmacokinetics
Bone Marrow
418 Citations (Scopus)

Clinical and biologic activity of the famesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial

Karp, J. E., Lancet, J. E., Kaufmann, S. H., End, D. W., Wright, J. J., Bol, K., Horak, I., Tidwell, M. L., Liesveld, J., Kottke, T. J., Ange, D., Buddharaju, L., Gojo, I., Edward Highsmith, W., Belly, R. T., Hohl, R., Rybak, M. E., Thibault, A. & Rosenblatt, J., Jun 1 2001, In : Blood. 97, 11, p. 3361-3369 9 p.

Research output: Contribution to journalArticle

tipifarnib
Clinical laboratories
Transferases
Refractory materials
Leukemia
20 Citations (Scopus)
oxidized cellulose
Camptothecin
Microspheres
Plasticizers
Myeloid Leukemia
54 Citations (Scopus)

Interaction of cytosine arabinoside and lovastatin in human leukemia cells

Holstein, S. A. & Hohl, R., Jun 11 2001, In : Leukemia Research. 25, 8, p. 651-660 10 p.

Research output: Contribution to journalArticle

Lovastatin
Cytarabine
Leukemia
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cell Line
63 Citations (Scopus)

Synergistic interaction of lovastatin and paclitaxel in human cancer cells

Holstein, S. A. & Hohl, R., Dec 1 2001, In : Molecular cancer therapeutics. 1, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

Lovastatin
Paclitaxel
Neoplasms
Cell Cycle
HL-60 Cells

Synergy of cytosine arabinoside and lovastatin in human leukemia cells

Hohl, R. J. & Holstein, S. A., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P46

Research output: Contribution to journalArticle

Lovastatin
Cytarabine
Leukemia
Cell Line
K562 Cells
2000
18 Citations (Scopus)

2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization

Cermak, D. M., Wiemer, D. F., Lewis, K. & Hohl, R., Nov 27 2000, In : Bioorganic and Medicinal Chemistry. 8, 12, p. 2729-2737 9 p.

Research output: Contribution to journalArticle

Organophosphonates
Diphosphates
Phosphorous Acids
Esters
Bearings (structural)

Allogeneic hematopoietic stem cell (hsct) in patients with advanced hematological diseases using a non-myeloablative conditioning regimen

Lee, C. K., Hohl, R., Masaki, H., Schlueter, A., Field, E. & Gingrich, R. D., Dec 1 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Hematologic Diseases
Hematopoietic Stem Cells
Stem cells
Transplants
Blood

A phase-I, dose escalation study for salvage chemotherapy for patients with refractory lymphoma, prior to myeloablative therapy with stem cell transplantation

Choon-Kee, L., De Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Schlueter, A. & Gingrich, R. D., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Salvaging
Transplants
Chemotherapy
Stem Cell Transplantation
Mitoxantrone
782 Citations (Scopus)

A phase II study of temozolemide vs. procarbazine in patients with glioblastoma multiforme at first relapse

Yung, W. K. A., Albright, R. E., Olson, J., Fredericks, R., Fink, K., Prados, M. D., Brada, M., Spence, A., Hohl, R., Shapiro, W., Glantz, M., Greenberg, H., Selker, R. G., Vick, N. A., Rampling, R., Friedman, H., Phillips, P., Bruner, J., Yue, N., Osoba, D. & 2 others, Zaknoen, S. & Levin, V. A., Aug 31 2000, In : British Journal of Cancer. 83, 5, p. 588-593 6 p.

Research output: Contribution to journalArticle

temozolomide
Procarbazine
Glioblastoma
Recurrence
Disease-Free Survival

Fudarabine/cyclophosphamide followed by allogeneic peripheral blood transplantation (pbct) for older patients with advanced hematological disorders

Lee, C. K., Hohl, R., Schlueter, A., Hayashi, M., Field, E. & Gingrich, R. D., Dec 1 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Transplants
Cyclophosphamide
Blood
Transplantation
Amyloid
165 Citations (Scopus)

Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and leukemia group B 9565

Venook, A. P., Egorin, M. J., Rosner, G. L., Hollis, D., Mani, S., Hawkins, M., Byrd, J., Hohl, R., Budman, D., Meropol, N. J. & Ratain, M. J., Jan 1 2000, In : Journal of Clinical Oncology. 18, 14, p. 2780-2787 8 p.

Research output: Contribution to journalArticle

gemcitabine
Kidney Neoplasms
Leukemia
Pharmacokinetics
Liver
33 Citations (Scopus)

Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside

Jung, K. Y., Hohl, R. J., Wiemer, A. J. & Wiemer, D. F., Oct 1 2000, In : Bioorganic and Medicinal Chemistry. 8, 10, p. 2501-2509 9 p.

Research output: Contribution to journalArticle

Cytidine
Organophosphonates
Uridine
Cytarabine
Derivatives
1999
1 Citation (Scopus)

A novel four-drug ablative regimen with hemopoietic stem cell rescue for patients with breast cancer: A phase II study

Gingrich, R. D., Lee, C. K., Hohl, R., Joyce, J., Burns, L. J., Tamaki, K., Wen, B. C. & Scott, S., Jan 1 1999, In : Biology of Blood and Marrow Transplantation. 5, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Stem Cells
Breast Neoplasms
Stem Cell Transplantation
Pharmaceutical Preparations
Disease-Free Survival
82 Citations (Scopus)

Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: Cancer and leukemia group B study 9473

Burns, C. P., Halabi, S., Clamon, G. H., Hars, V., Wagner, B. A., Hohl, R., Lester, E., Kirshner, J. J., Vinciguerra, V. & Paskett, E., Dec 1999, In : Clinical Cancer Research. 5, 12, p. 3942-3947 6 p.

Research output: Contribution to journalArticle

Cachexia
Fish Oils
Capsules
Leukemia
Fatty Acids
13 Citations (Scopus)

Prophylactic reinfusion of T cells for T cell-depleted allogeneic bone marrow transplantation

Lee, C. K., Gingrich, R. D., DeMagalhaes-Silverman, M., Hohl, R., Joyce, J. K., Scott, S. D., Wen, B. C. & Schlueter, A., Jan 1 1999, In : Biology of Blood and Marrow Transplantation. 5, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Bone Marrow Transplantation
T-Lymphocytes
Transplants
Leukemia
1998

Geranylgeraniol restores cell growth and Ras processing in mevalonate-depleted fibroblast cells

Gao, F., Hohl, R. & Shires, T. K., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Lovastatin
Mevalonic Acid
Cell growth
Fibroblasts
NIH 3T3 Cells
22 Citations (Scopus)

Low pulse oximeter-measured hemoglobin oxygen saturations with hemoglobin Cheverly

Hohl, R., Sherburne, A. R., Feeley, J. E., Huisman, T. H. J. & Burns, C. P., Nov 1 1998, In : American Journal of Hematology. 59, 3, p. 181-184 4 p.

Research output: Contribution to journalArticle

Pulse
Hemoglobins
Oxygen
phenylalanylserine
Mutation
101 Citations (Scopus)

Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and leukemia group B 9264

Venook, A. P., Egorin, M. J., Rosner, G. L., Brown, T. D., Jahan, T. M., Batist, G., Hohl, R., Budman, D., Ratain, M. J., Kearns, C. M. & Schilsky, R. L., Jan 1 1998, In : Journal of Clinical Oncology. 16, 5, p. 1811-1819 9 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Paclitaxel
Leukemia
Pharmacokinetics
Bilirubin
93 Citations (Scopus)

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

Holstein, S. A., Cermak, D. M., Wiemer, D. F., Lewis, K. & Hohl, R., Jan 1 1998, In : Bioorganic and Medicinal Chemistry. 6, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Organophosphonates
Diphosphonates
Transferases
Bromides
citral
28 Citations (Scopus)

Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

Hohl, R. J., Lewis, K. A., Cermak, D. M. & Wiemer, D. F., Mar 9 1998, In : Lipids. 33, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Phosphorous Acids
Prenylation
Stereochemistry
Terpenes
Farnesyl-Diphosphate Farnesyltransferase
1997

Differential inhibition of farnesyl protein transferase and squalene synthase by isoprenoid phosphonic acids

Hohl, R. J., Pogatchnik, D. M., Lewis-Tibesar, K. & Wiemer, D. F., Dec 1 1997, In : Clinical pharmacology and therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

Phosphorous Acids
Farnesyl-Diphosphate Farnesyltransferase
Terpenes
Transferases
Proteins
2 Citations (Scopus)

Modulation of RAS expression in human malignant cells by dietary supplements

Lewis, K. A. & Hohl, R., Jan 1 1997, In : Nutrition. 13, 10, p. 921-923 3 p.

Research output: Contribution to journalComment/debate

1996
52 Citations (Scopus)

Fatal cyclophosphamide cardiomyopathy: Its clinical course and treatment

Lee, C. K., Harman, G. S., Hohl, R. & Gingrich, R. D., Sep 1 1996, In : Bone Marrow Transplantation. 18, 3, p. 573-577 5 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Cyclophosphamide
Restrictive Cardiomyopathy
Hypotension
Vascular Resistance

Iowa newborn hemoglobinopathy screening and comprehensive care: A model for rural states [1]

Peters, C., Miller, J., Abel, S. L., McMillan, S. K., Getchell, J. P., Giller, R. H., Hohl, R. & De Alarcon, P. A., Nov 6 1996, In : Journal of Pediatric Hematology/Oncology. 18, 4, p. 416-418 3 p.

Research output: Contribution to journalLetter

Hemoglobinopathies
Mass Screening
Rural Population
Newborn Infant
Education
32 Citations (Scopus)

Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras

Goldman, F., Hohl, R. J., Crabtree, J., Lewis-Tibesar, K. & Koretzky, G., Dec 15 1996, In : Blood. 88, 12, p. 4611-4619 9 p.

Research output: Contribution to journalArticle

Lovastatin
T-Cell Antigen Receptor
Signal transduction
Phosphorylation
Inositol Phosphates
34 Citations (Scopus)

Monoterpenes as regulators of malignant cell proliferation

Hohl, R., 1996, In : Advances in Experimental Medicine and Biology. 401, p. 137-146 10 p.

Research output: Contribution to journalArticle

Monoterpenes
perilla alcohol
Cell proliferation
Cell Proliferation
Prenylation
333 Citations (Scopus)

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer

Thibault, A., Samid, D., Tompkins, A. C., Figg, W. D., Cooper, M. R., Hohl, R., Trepel, J., Liang, B., Patronas, N., Venzon, D. J., Reed, E. & Myers, C. E., Mar 1 1996, In : Clinical Cancer Research. 2, 3, p. 483-491 9 p.

Research output: Contribution to journalArticle

Lovastatin
Mevalonic Acid
Ubiquinone
Neoplasms
Muscular Diseases
1995
91 Citations (Scopus)

Differential effects of monoterpenes and lovastatin on RAS processing

Hohl, R. & Lewis, K., Jan 1 1995, In : Journal of Biological Chemistry. 270, 29, p. 17508-17512 5 p.

Research output: Contribution to journalArticle

perilla alcohol
Lovastatin
Monoterpenes
Prenylation
Methionine
120 Citations (Scopus)

Engraftment syndrome in autologous bone marrow and peripheral stem cell transplantation

Lee, C. K., Gingrich, R. D., Hohl, R. & Ajram, K. A., Jan 1 1995, In : Bone Marrow Transplantation. 16, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Bone Marrow
Exanthema
Fever
Granulocyte Colony-Stimulating Factor
3 Citations (Scopus)

Phase II trial of edatrexate in patients with metastatic colorectal cancer

Clamon, G. H., Riggs, C. E., Dreicer, R. & Hohl, R., Dec 1 1995, In : Investigational New Drugs. 13, 4, p. 359-361 3 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Colonic Neoplasms
Heterografts
Nude Mice
Human Activities
1991
11 Citations (Scopus)
Decarboxylation
Glutathione Disulfide
Glutathione Reductase
Erythrocytes
Chemical activation
18 Citations (Scopus)

Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells

Hohl, R., Larson, R. A., Mannickarottu, V. & Yachnin, S., Jan 1 1991, In : Blood. 77, 5, p. 1064-1070 7 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Coenzyme A
Oxidoreductases
DNA
1989
20 Citations (Scopus)

Nonmalignant complications of therapy for Hodgkin's disease

Hohl, R. & Schilsky, R. L., Jan 1 1989, In : Hematology/Oncology Clinics of North America. 3, 2, p. 331-343 13 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Survivors
Therapeutics
Poisons
Virus Diseases
1981
43 Citations (Scopus)

Toxicology of the 8-aminoquinolines and genetic factors associated with their toxicity in man

Carson, P. E., Hohl, R., Nora, M. V., Parkhurst, G. W., Ahmad, T., Scanlan, S. & Frischer, H., 1981, In : Bulletin of the World Health Organization. 59, 3, p. 427-437 11 p.

Research output: Contribution to journalArticle

Primaquine
Toxicology
Erythrocytes
Eating
Glucose
1978

Drug effects on glucose oxidation in human erythrocytes

Carson, P. E., Parkhurst, G. W. & Hohl, R., Jan 1 1978, In : Clinical Research. 26, 5

Research output: Contribution to journalArticle

Erythrocytes
Glucose
Pharmaceutical Preparations