• 5262 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

38 Citations (Scopus)

Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207

Rosenberg, J. E., Halabi, S., Sanford, B. L., Himelstein, A. L., Atkins, J. N., Hohl, R. J., Millard, F., Bajorin, D. F. & Small, E. J., May 1 2008, In : Annals of Oncology. 19, 5, p. 946-950 5 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
Carcinoma
Confidence Intervals
Hypernatremia
Lymphopenia
74 Citations (Scopus)

Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia: A cancer and leukemia group B study

Burns, C. P., Halabi, S., Clamon, G., Kaplan, E., Hohl, R., Atkins, J. N., Schwartz, M. A., Wagner, B. A. & Paskett, E., Jul 15 2004, In : Cancer. 101, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

Cachexia
Fish Oils
Capsules
Leukemia
Neoplasms
3 Citations (Scopus)

Phase II trial of edatrexate in patients with metastatic colorectal cancer

Clamon, G. H., Riggs, C. E., Dreicer, R. & Hohl, R., Dec 1 1995, In : Investigational New Drugs. 13, 4, p. 359-361 3 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Colonic Neoplasms
Heterografts
Nude Mice
Human Activities
332 Citations (Scopus)

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer

Thibault, A., Samid, D., Tompkins, A. C., Figg, W. D., Cooper, M. R., Hohl, R., Trepel, J., Liang, B., Patronas, N., Venzon, D. J., Reed, E. & Myers, C. E., Mar 1 1996, In : Clinical Cancer Research. 2, 3, p. 483-491 9 p.

Research output: Contribution to journalArticle

Lovastatin
Mevalonic Acid
Ubiquinone
Neoplasms
Muscular Diseases
5 Citations (Scopus)

Phosphonate analogues of cytosine arabinoside monophosphate

Chen, X., Jung, K. Y., Wiemer, D. F., Wiemer, A. J. & Hohl, R., Nov 14 2002, In : Phosphorus, Sulfur and Silicon and Related Elements. 177, 6-7, p. 1783-1786 4 p.

Research output: Contribution to journalArticle

Cytidine
Organophosphonates
K562 Cells
Cytarabine
Nucleosides
91 Citations (Scopus)

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

Holstein, S. A., Cermak, D. M., Wiemer, D. F., Lewis, K. & Hohl, R., Jan 1 1998, In : Bioorganic and Medicinal Chemistry. 6, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Organophosphonates
Diphosphonates
Transferases
Bromides
citral
45 Citations (Scopus)

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

Wiemer, A. J., Yu, J. S., Shull, L. W., Barney, R. J., Wasko, B. M., Lamb, K. M., Hohl, R. & Wiemer, D. F., Apr 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 7, p. 3652-3660 9 p.

Research output: Contribution to journalArticle

Prenylation
Terpenes
Diphosphonates
Farnesyltranstransferase
Display devices
12 Citations (Scopus)

Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis

Holstein, S. A., Kuder, C. H., Tong, H. & Hohl, R., Oct 1 2011, In : Lipids. 46, 10, p. 907-921 15 p.

Research output: Contribution to journalArticle

Terpenes
Lovastatin
Homeostasis
Biosynthetic Pathways
Cells
1 Citation (Scopus)

Primary cutaneous polymorphic ebv-associated posttransplant lymphoproliferative disorder after a renal transplant and review of the literature

Ferguson, N. N., Thomas, C. P., Hohl, R., Syrbu, S. I., Stone, M. S. & Wanat, K. A., Oct 1 2015, In : American Journal of Dermatopathology. 37, 10, p. 790-794 5 p.

Research output: Contribution to journalArticle

Lymphoproliferative Disorders
Transplants
Kidney
Skin
Human Herpesvirus 4
13 Citations (Scopus)

Prophylactic reinfusion of T cells for T cell-depleted allogeneic bone marrow transplantation

Lee, C. K., Gingrich, R. D., DeMagalhaes-Silverman, M., Hohl, R., Joyce, J. K., Scott, S. D., Wen, B. C. & Schlueter, A., Jan 1 1999, In : Biology of Blood and Marrow Transplantation. 5, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Bone Marrow Transplantation
T-Lymphocytes
Transplants
Leukemia

Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma

Lee, C. K., de Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jun 1 2002, In : Bone Marrow Transplantation. 29, 7, p. 615-620 6 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow Transplantation
Lymphoma
T-Lymphocytes
Survival
10 Citations (Scopus)

Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma

Lee, C. K., De Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jan 1 2002, In : Bone Marrow Transplantation. 29, 7, p. 615-620 6 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Bone Marrow Transplantation
Lymphoma
T-Lymphocytes
Survival
6 Citations (Scopus)

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., Poyarkov, S., Nikolskaya, T., Kucaba, T., Wang, M., Abdulkawy, H., Casavant, T., Morcuende, J., Buckwalter, J., Hohl, R., Deyoung, B., Kernstine, K., Bonaldo, M. D. F., Hendrix, M. J. C., Soares, M. B. & 1 others, Soares, V. M. F. C., Mar 16 2012, In : Sarcoma. 2012, 820254.

Research output: Contribution to journalArticle

Chondrosarcoma
Neoplasm Metastasis
Lung
Gene Expression Profiling
Transcriptome
33 Citations (Scopus)

Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue

Tong, H., Wiemer, A. J., Neighbors, J. D. & Hohl, R. J., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Tissue
Terpenes
Biosynthesis
Transferases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
8 Citations (Scopus)

Quantitative determination of geranyl diphosphate levels in cultured human cells

Holstein, S. A., Tong, H., Kuder, C. H. & Hohl, R., Nov 1 2009, In : Lipids. 44, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Terpenes
Cultured Cells
Cells
zoledronic acid
Biosynthetic Pathways
4 Citations (Scopus)

Quantitative determination of isopentenyl diphosphate in cultured mammalian cells

Tong, H., Kuder, C. H., Wasko, B. M. & Hohl, R., Feb 1 2013, In : Analytical Biochemistry. 433, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Cultured Cells
Cells
zoledronic acid
Lovastatin
Biosynthetic Pathways
20 Citations (Scopus)

Randomized, dose-escalation study of the p38α MAPK inhibitor SCIO-469 in patients with myelodysplastic syndrome

Sokol, L., Cripe, L., Kantarjian, H., Sekeres, M. A., Parmar, S., Greenberg, P., Goldberg, S. L., Bhushan, V., Shammo, J., Hohl, R., Verma, A., Garcia-Manero, G., Li, Y. P., Lowe, A., Zhu, J. & List, A. F., Apr 1 2013, In : Leukemia. 27, 4, p. 977-980 4 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Mitogen-Activated Protein Kinase 14
Indoles
Myelodysplastic Syndromes
Protein Kinase Inhibitors
28 Citations (Scopus)

Regulation of fatty acid synthesis by farnesyl pyrophosphate

Murthy, S., Tong, H. & Hohl, R. J., Dec 23 2005, In : Journal of Biological Chemistry. 280, 51, p. 41793-41804 12 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Fatty Acids
Terpenes
Biosynthesis
Liver
22 Citations (Scopus)

Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia

Holstein, S. A., Stokes, J. B. & Hohl, R., Feb 1 2009, In : Leukemia Research. 33, 2, p. 344-347 4 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Renal Insufficiency
Phosphotransferases
Kidney
Protein-Tyrosine Kinases

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D., Helm, K., Drabick, J., Robertson, G., Neighbors, J., Hohl, R. & Schell, T., Feb 1 2019, In : OncoImmunology. 8, 2, e1539614.

Research output: Contribution to journalArticle

Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms
1 Citation (Scopus)

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J. S., Neighbors, J. & Hohl, R., Aug 1 2018, In : Lipids. 53, 8, p. 767-784 18 p.

Research output: Contribution to journalReview article

Modulators
Lipids
Neoplasms
Cells
trans-Golgi Network
65 Citations (Scopus)

Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells

Tong, H., Holstein, S. A. & Hohl, R., Jan 1 2005, In : Analytical Biochemistry. 336, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Cultured Cells
Cells
Transferases
Peptides
Recombinant proteins
28 Citations (Scopus)

Stereochemistry-dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

Hohl, R., Lewis, K. A., Cermak, D. M. & Wiemer, D. F., Mar 9 1998, In : Lipids. 33, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

Phosphorous Acids
Prenylation
Stereochemistry
Terpenes
Farnesyl-Diphosphate Farnesyltransferase
33 Citations (Scopus)

Stereoselective synthesis of the 5′-hydroxy-5′-phosphonate derivatives of cytidine and cytosine arabinoside

Chen, X., Wiemer, A. J., Hohl, R. J. & Wiemer, D. F., Dec 27 2002, In : Journal of Organic Chemistry. 67, 26, p. 9331-9339 9 p.

Research output: Contribution to journalArticle

Phosphites
Cytidine
Organophosphonates
Cytarabine
Aldehydes
21 Citations (Scopus)

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Ulrich, N. C., Kodet, J. G., Mente, N. R., Kuder, C. H., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Bioactivity
Biological Products
Cells
2 Citations (Scopus)

Survey of muscle characteristics after statin-induced rhabdomyolysis

Phillips, P. S., Verity, M. A., Schick, B. A., Vladutiu, G. D., Laaksonen, R., Oresic, M., Hohl, R. J., Ciaraldi, T. P., Sukhatme, V. P., Lecker, S. H., Cote, H. C. F., Powell, H., Davidson, W. & Wolfson, T., Mar 9 2010, In : Clinical Lipidology. 5, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rhabdomyolysis
Muscles
coenzyme Q10
Cholesterol
63 Citations (Scopus)

Synergistic interaction of lovastatin and paclitaxel in human cancer cells

Holstein, S. A. & Hohl, R., Dec 1 2001, In : Molecular cancer therapeutics. 1, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

Lovastatin
Paclitaxel
Neoplasms
Cell Cycle
HL-60 Cells

Synergy of cytosine arabinoside and lovastatin in human leukemia cells

Hohl, R. & Holstein, S. A., 2001, In : Clinical Pharmacology and Therapeutics. 69, 2

Research output: Contribution to journalArticle

Lovastatin
Cytarabine
Leukemia
Cell Line
K562 Cells
26 Citations (Scopus)

Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues

Kim, M. K., Kleckley, T. S., Wiemer, A. J., Holstein, S. A., Hohl, R. & Wiemer, D. F., Nov 26 2004, In : Journal of Organic Chemistry. 69, 24, p. 8186-8193 8 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Farnesol
Alcohols
Metabolism
19 Citations (Scopus)

Synthesis and biological activity of a fluorescent schweinfurthin analogue

Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4718-4723 6 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Growth Inhibitors
National Cancer Institute (U.S.)
Structure-Activity Relationship
51 Citations (Scopus)

Synthesis and biological activity of isoprenoid bisphosphonates

Shull, L. W., Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jun 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 12, p. 4130-4136 7 p.

Research output: Contribution to journalArticle

Terpenes
Diphosphonates
Bioactivity
Protein Prenylation
Bone
20 Citations (Scopus)

Synthesis and biological evaluation of a series of aromatic bisphosphonates

Barney, R. J., Wasko, B. M., Dudakovic, A., Hohl, R. & Wiemer, D. F., Oct 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 20, p. 7212-7220 9 p.

Research output: Contribution to journalArticle

Diphosphonates
Terpenes
Farnesyltranstransferase
zoledronic acid
Geranyltranstransferase
23 Citations (Scopus)

Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation

Maalouf, M. A., Wiemer, A. J., Kuder, C. H., Hohl, R. J. & Wiemer, D. F., Mar 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 5, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Protein Prenylation
Terpenes
Diphosphonates
Proteins
Bone
12 Citations (Scopus)

Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

Zhou, X., Reilly, J. E., Loerch, K. A., Hohl, R. & Wiemer, D. F., Jul 18 2014, In : Beilstein Journal of Organic Chemistry. 10, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Ethers
Terpenes
Diphosphonates
Geranyltranstransferase
33 Citations (Scopus)

Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside

Jung, K. Y., Hohl, R., Wiemer, A. J. & Wiemer, D. F., Oct 1 2000, In : Bioorganic and Medicinal Chemistry. 8, 10, p. 2501-2509 9 p.

Research output: Contribution to journalArticle

Cytidine
Organophosphonates
Uridine
Cytarabine
Derivatives
9 Citations (Scopus)

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J., Tong, H., Henry, M. D. & Hohl, R., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

Prenylation
Adrenal Glands
Tumor Burden
Terpenes
Prostatic Neoplasms
5 Citations (Scopus)

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. & Hohl, R., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Burden
Farnesyltranstransferase
9 Citations (Scopus)

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

Prenylation
Oxidative stress
Pulmonary Fibrosis
Terpenes
rac1 GTP-Binding Protein
17 Citations (Scopus)

The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation

Weivoda, M. M. & Hohl, R., Jun 1 2011, In : Journal of cellular biochemistry. 112, 6, p. 1506-1513 8 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Osteoblasts
Farnesyltranstransferase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prenylation
54 Citations (Scopus)

The intermediate enzymes of isoprenoid metabolism as anticancer targets

Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jan 1 2009, In : Anti-Cancer Agents in Medicinal Chemistry. 9, 5, p. 526-542 17 p.

Research output: Contribution to journalReview article

Terpenes
Enzymes
mevalonate kinase
Neoplasms
Proteins
9 Citations (Scopus)

Therapeutic additions and possible deletions in oncology in 2011

Holstein, S. A. & Hohl, R., Jan 1 2012, In : Clinical pharmacology and therapeutics. 91, 1, p. 15-17 3 p.

Research output: Contribution to journalReview article

United States Food and Drug Administration
Therapeutic Uses
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Non-Hodgkin's Lymphoma
33 Citations (Scopus)

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Mente, N. R., Wiemer, A. J., Neighbors, J., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 4, p. 911-915 5 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Optical rotation
Optical Rotation
Enantiomers
42 Citations (Scopus)

Toxicology of the 8-aminoquinolines and genetic factors associated with their toxicity in man

Carson, P. E., Hohl, R., Nora, M. V., Parkhurst, G. W., Ahmad, T., Scanlan, S. & Frischer, H., 1981, In : Bulletin of the World Health Organization. 59, 3, p. 427-437 11 p.

Research output: Contribution to journalArticle

Primaquine
Toxicology
Erythrocytes
Eating
Glucose

Vascular medicine: A look forward

Holstein, S. A. & Hohl, R., Aug 2009, In : Clinical Pharmacology and Therapeutics. 86, 2, p. 117-119 3 p.

Research output: Contribution to journalEditorial

Coronary Restenosis
Anticholesteremic Agents
Cardiovascular Agents
Drug-Eluting Stents
Drug Design
2 Citations (Scopus)

VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML

Wang, L., Jia, B., Claxton, D., Ehmann, W. C., Rybka, W., Mineishi, S., Naik, S., Khawaja, M. R., Sivik, J., Han, J., Hohl, R. & Zheng, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1469594.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Myeloid-Derived Suppressor Cells
Immunoglobulin Domains