• 5262 Citations
  • 36 h-Index
1977 …2022
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Research Output 1978 2019

Article
33 Citations (Scopus)

Stereoselective synthesis of the 5′-hydroxy-5′-phosphonate derivatives of cytidine and cytosine arabinoside

Chen, X., Wiemer, A. J., Hohl, R. J. & Wiemer, D. F., Dec 27 2002, In : Journal of Organic Chemistry. 67, 26, p. 9331-9339 9 p.

Research output: Contribution to journalArticle

Phosphites
Cytidine
Organophosphonates
Cytarabine
Aldehydes
21 Citations (Scopus)

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Ulrich, N. C., Kodet, J. G., Mente, N. R., Kuder, C. H., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Bioactivity
Biological Products
Cells
2 Citations (Scopus)

Survey of muscle characteristics after statin-induced rhabdomyolysis

Phillips, P. S., Verity, M. A., Schick, B. A., Vladutiu, G. D., Laaksonen, R., Oresic, M., Hohl, R. J., Ciaraldi, T. P., Sukhatme, V. P., Lecker, S. H., Cote, H. C. F., Powell, H., Davidson, W. & Wolfson, T., Mar 9 2010, In : Clinical Lipidology. 5, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rhabdomyolysis
Muscles
coenzyme Q10
Cholesterol
63 Citations (Scopus)

Synergistic interaction of lovastatin and paclitaxel in human cancer cells

Holstein, S. A. & Hohl, R., Dec 1 2001, In : Molecular cancer therapeutics. 1, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

Lovastatin
Paclitaxel
Neoplasms
Cell Cycle
HL-60 Cells

Synergy of cytosine arabinoside and lovastatin in human leukemia cells

Hohl, R. & Holstein, S. A., 2001, In : Clinical Pharmacology and Therapeutics. 69, 2

Research output: Contribution to journalArticle

Lovastatin
Cytarabine
Leukemia
Cell Line
K562 Cells
26 Citations (Scopus)

Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues

Kim, M. K., Kleckley, T. S., Wiemer, A. J., Holstein, S. A., Hohl, R. & Wiemer, D. F., Nov 26 2004, In : Journal of Organic Chemistry. 69, 24, p. 8186-8193 8 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Farnesol
Alcohols
Metabolism
19 Citations (Scopus)

Synthesis and biological activity of a fluorescent schweinfurthin analogue

Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4718-4723 6 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Growth Inhibitors
National Cancer Institute (U.S.)
Structure-Activity Relationship
51 Citations (Scopus)

Synthesis and biological activity of isoprenoid bisphosphonates

Shull, L. W., Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jun 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 12, p. 4130-4136 7 p.

Research output: Contribution to journalArticle

Terpenes
Diphosphonates
Bioactivity
Protein Prenylation
Bone
20 Citations (Scopus)

Synthesis and biological evaluation of a series of aromatic bisphosphonates

Barney, R. J., Wasko, B. M., Dudakovic, A., Hohl, R. & Wiemer, D. F., Oct 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 20, p. 7212-7220 9 p.

Research output: Contribution to journalArticle

Diphosphonates
Terpenes
Farnesyltranstransferase
zoledronic acid
Geranyltranstransferase
23 Citations (Scopus)

Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation

Maalouf, M. A., Wiemer, A. J., Kuder, C. H., Hohl, R. J. & Wiemer, D. F., Mar 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 5, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Protein Prenylation
Terpenes
Diphosphonates
Proteins
Bone
12 Citations (Scopus)

Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

Zhou, X., Reilly, J. E., Loerch, K. A., Hohl, R. & Wiemer, D. F., Jul 18 2014, In : Beilstein Journal of Organic Chemistry. 10, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Ethers
Terpenes
Diphosphonates
Geranyltranstransferase
33 Citations (Scopus)

Synthesis of phosphonate derivatives of uridine, cytidine, and cytosine arabinoside

Jung, K. Y., Hohl, R., Wiemer, A. J. & Wiemer, D. F., Oct 1 2000, In : Bioorganic and Medicinal Chemistry. 8, 10, p. 2501-2509 9 p.

Research output: Contribution to journalArticle

Cytidine
Organophosphonates
Uridine
Cytarabine
Derivatives
9 Citations (Scopus)

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J., Tong, H., Henry, M. D. & Hohl, R., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

Prenylation
Adrenal Glands
Tumor Burden
Terpenes
Prostatic Neoplasms
5 Citations (Scopus)

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. & Hohl, R., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Burden
Farnesyltranstransferase
9 Citations (Scopus)

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

Prenylation
Oxidative stress
Pulmonary Fibrosis
Terpenes
rac1 GTP-Binding Protein
17 Citations (Scopus)

The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation

Weivoda, M. M. & Hohl, R., Jun 1 2011, In : Journal of cellular biochemistry. 112, 6, p. 1506-1513 8 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Osteoblasts
Farnesyltranstransferase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prenylation
33 Citations (Scopus)

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

Mente, N. R., Wiemer, A. J., Neighbors, J., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 4, p. 911-915 5 p.

Research output: Contribution to journalArticle

Bioactivity
Biological Products
Optical rotation
Optical Rotation
Enantiomers
42 Citations (Scopus)

Toxicology of the 8-aminoquinolines and genetic factors associated with their toxicity in man

Carson, P. E., Hohl, R., Nora, M. V., Parkhurst, G. W., Ahmad, T., Scanlan, S. & Frischer, H., 1981, In : Bulletin of the World Health Organization. 59, 3, p. 427-437 11 p.

Research output: Contribution to journalArticle

Primaquine
Toxicology
Erythrocytes
Eating
Glucose
2 Citations (Scopus)

VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML

Wang, L., Jia, B., Claxton, D., Ehmann, W. C., Rybka, W., Mineishi, S., Naik, S., Khawaja, M. R., Sivik, J., Han, J., Hohl, R. & Zheng, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1469594.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Myeloid-Derived Suppressor Cells
Immunoglobulin Domains
Chapter
6 Citations (Scopus)

Inhibition of Farnesyl and Geranylgeranyl Diphosphate Synthases

Holstein, S. A. & Hohl, R., Jan 1 2011, Enzymes. Academic Press, p. 301-319 19 p. (Enzymes; vol. 30).

Research output: Chapter in Book/Report/Conference proceedingChapter

Geranyltranstransferase
Farnesyltranstransferase
Protein Prenylation
Terpenes
Diphosphates

Isoprenoid regulation of the expression of ras and ras-related proteins

Holstein, S. A. & Hohl, R., Jan 1 2005, Nutrients and Cell Signaling. CRC Press, p. 439-460 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

ras Proteins
Terpenes
Proteins
Comment/debate

Erratum: Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies (Cancer Chemotherapy and Pharmacology 57, (155-164) DOI: 10.1007/s00280-005-0013-8)

Holstein, S. A., Knapp, H. R., Clamon, G. H., Murry, D. J. & Hohl, R., Mar 1 2007, In : Cancer Chemotherapy and Pharmacology. 59, 4, 1 p.

Research output: Contribution to journalComment/debate

Lovastatin
Cytarabine
Leukemia
Research
11 Citations (Scopus)

Erratum: O2 ⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate (Cancer Cell (2017) 32 (2)(268) (S1535610817300624) (10.1016/j.ccell.2017.02.018))

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H. & 15 others, Kauffman, E. P. S., Schall, M. E., Hohl, R., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G., Aug 14 2017, In : Cancer Cell. 32, 2, 1 p.

Research output: Contribution to journalComment/debate

Confusion
Names
Emotions
Pharmacology
Neoplasms
2 Citations (Scopus)

Modulation of RAS expression in human malignant cells by dietary supplements

Lewis, K. A. & Hohl, R., Jan 1 1997, In : Nutrition. 13, 10, p. 921-923 3 p.

Research output: Contribution to journalComment/debate

Editorial
2 Citations (Scopus)

Anticoagulants: Major Advances Without Clear Consensus

Hohl, R. J., Aug 1 2016, In : Clinical pharmacology and therapeutics. p. 116-118 3 p.

Research output: Contribution to journalEditorial

Warfarin
Anticoagulants
Heparin
Thrombosis
Therapeutics
4 Citations (Scopus)

Cancer Therapy: Shooting for the Moon

Lee, J. S. H., Blumenthal, G. M., Hohl, R. & Huang, S. M., May 1 2017, In : Clinical pharmacology and therapeutics. 101, 5, p. 552-558 7 p.

Research output: Contribution to journalEditorial

Neoplasms
Therapeutics
1 Citation (Scopus)

Clinical pharmacology: Bridging discovery and practice

Hohl, R., Jun 1 2007, In : Clinical Pharmacology and Therapeutics. 81, 6, p. 783-785 3 p.

Research output: Contribution to journalEditorial

Professional Role
Clinical Pharmacology
Biomedical Research
Drug Therapy
2 Citations (Scopus)

Drug development (and academic medicine): charting the course forward

Hohl, R., Nov 1 2014, In : Clinical Pharmacology and Therapeutics. 96, 5, p. 519-522 4 p.

Research output: Contribution to journalEditorial

Clinical Pharmacology
Industry
Economics
Medicine
Pressure
14 Citations (Scopus)

Imaging as a biomarker for therapy response: Cancer as a prototype for the creation of research resources

McLennan, G., Clarke, L. & Hohl, R., Oct 1 2008, In : Clinical pharmacology and therapeutics. 84, 4, p. 433-436 4 p.

Research output: Contribution to journalEditorial

Factual Databases
Interdisciplinary Communication
Radiology Information Systems
Program Development
National Cancer Institute (U.S.)
2 Citations (Scopus)

Oncology trial design: More accurately and efficiently advancing the field

Hohl, R., May 1 2015, In : Clinical Pharmacology and Therapeutics. 97, 5, p. 430-432 3 p.

Research output: Contribution to journalEditorial

Molecular Targeted Therapy
Off-Label Use
Medical Oncology
Evidence-Based Medicine
Antineoplastic Agents

Vascular medicine: A look forward

Holstein, S. A. & Hohl, R., Aug 2009, In : Clinical Pharmacology and Therapeutics. 86, 2, p. 117-119 3 p.

Research output: Contribution to journalEditorial

Coronary Restenosis
Anticholesteremic Agents
Cardiovascular Agents
Drug-Eluting Stents
Drug Design
Letter
3 Citations (Scopus)
Leukemia
Bone Marrow
T-Lymphocytes

Iowa newborn hemoglobinopathy screening and comprehensive care: A model for rural states [1]

Peters, C., Miller, J., Abel, S. L., McMillan, S. K., Getchell, J. P., Giller, R. H., Hohl, R. & De Alarcon, P. A., Nov 6 1996, In : Journal of Pediatric Hematology/Oncology. 18, 4, p. 416-418 3 p.

Research output: Contribution to journalLetter

Hemoglobinopathies
Mass Screening
Rural Population
Newborn Infant
Education
20 Citations (Scopus)

Randomized, dose-escalation study of the p38α MAPK inhibitor SCIO-469 in patients with myelodysplastic syndrome

Sokol, L., Cripe, L., Kantarjian, H., Sekeres, M. A., Parmar, S., Greenberg, P., Goldberg, S. L., Bhushan, V., Shammo, J., Hohl, R., Verma, A., Garcia-Manero, G., Li, Y. P., Lowe, A., Zhu, J. & List, A. F., Apr 1 2013, In : Leukemia. 27, 4, p. 977-980 4 p.

Research output: Contribution to journalLetter

Drug Dose Response Relationship
Mitogen-Activated Protein Kinase 14
Indoles
Myelodysplastic Syndromes
Protein Kinase Inhibitors
Review article
100 Citations (Scopus)

Anti-cancer therapy: Targeting the mevalonate pathway

Swanson, K. M. & Hohl, R., Feb 1 2006, In : Current Cancer Drug Targets. 6, 1, p. 15-37 23 p.

Research output: Contribution to journalReview article

Mevalonic Acid
Transferases
Post Translational Protein Processing
Neoplasms
Clinical Trials
1 Citation (Scopus)

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy
11 Citations (Scopus)

Clinical pharmacology as a foundation for translational science

Waldman, S. A., Hohl, R. J., Kearns, G. L., Swan, S. J. & Terzic, A., Jul 1 2011, In : Clinical pharmacology and therapeutics. 90, 1, p. 10-13 4 p.

Research output: Contribution to journalReview article

Translational Medical Research
Clinical Pharmacology
National Institutes of Health (U.S.)
Molecular Biology
Delivery of Health Care
13 Citations (Scopus)

Donor T-lymphocyte infusion for unrelated allogeneic bone marrow transplantation with CD3+ T-cell-depleted graft

Lee, C. K., de Magalhaes-Silverman, M., Hohl, R., Hayashi, M., Buatti, J., Wen, B. C., Schlueter, A., Strauss, R. G. & Gingrich, R. D., Jan 1 2003, In : Bone Marrow Transplantation. 31, 2, p. 121-128 8 p.

Research output: Contribution to journalReview article

Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Tissue Donors
T-Lymphocytes
118 Citations (Scopus)

Isoprenoids: Remarkable diversity of form and function

Holstein, S. A. & Hohl, R. J., Apr 1 2004, In : Lipids. 39, 4, p. 293-309 17 p.

Research output: Contribution to journalReview article

Terpenes
Hydroxymethylglutaryl CoA Reductases
ras Proteins
Critical Pathways
Diterpenes
24 Citations (Scopus)

Is there a future for prenyltransferase inhibitors in cancer therapy?

Holstein, S. A. & Hohl, R., Jan 1 2012, In : Current Opinion in Pharmacology. 12, 6, p. 704-709 6 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Clinical Trials
Farnesyltranstransferase
Prenylation
Post Translational Protein Processing
20 Citations (Scopus)

Nonmalignant complications of therapy for Hodgkin's disease

Hohl, R. & Schilsky, R. L., Jan 1 1989, In : Hematology/Oncology Clinics of North America. 3, 2, p. 331-343 13 p.

Research output: Contribution to journalReview article

Hodgkin Disease
Survivors
Therapeutics
Poisons
Virus Diseases
1 Citation (Scopus)

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity

Koubek, E. J., Weissenrieder, J. S., Neighbors, J. & Hohl, R., Aug 1 2018, In : Lipids. 53, 8, p. 767-784 18 p.

Research output: Contribution to journalReview article

Modulators
Lipids
Neoplasms
Cells
trans-Golgi Network
54 Citations (Scopus)

The intermediate enzymes of isoprenoid metabolism as anticancer targets

Wiemer, A. J., Hohl, R. & Wiemer, D. F., Jan 1 2009, In : Anti-Cancer Agents in Medicinal Chemistry. 9, 5, p. 526-542 17 p.

Research output: Contribution to journalReview article

Terpenes
Enzymes
mevalonate kinase
Neoplasms
Proteins
9 Citations (Scopus)

Therapeutic additions and possible deletions in oncology in 2011

Holstein, S. A. & Hohl, R., Jan 1 2012, In : Clinical pharmacology and therapeutics. 91, 1, p. 15-17 3 p.

Research output: Contribution to journalReview article

United States Food and Drug Administration
Therapeutic Uses
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Non-Hodgkin's Lymphoma