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Research Output 1978 2019

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2019
3 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models
1 Citation (Scopus)
Open Access
Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Transcription Factors
Induction Chemotherapy

First-in-human phase I clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma

Allen, B. G., Bodeker, K. L., Smith, M. C., Monga, V., Sandhu, S., Hohl, R., Carlisle, T., Brown, H., Hollenbeck, N., Vollstedt, S., Greenlee, J. D., Howard, M. A., Mapuskar, K. A., Seyedin, S. N., Caster, J. M., Jones, K. A., Cullen, J. J., Berg, D., Wagner, B. A., Buettner, G. R. & 4 others, TenNapel, M. J., Smith, B. J., Spitz, D. R. & Buatti, J. M., Nov 15 2019, In : Clinical Cancer Research. 25, 22, p. 6590-6597 8 p.

Research output: Contribution to journalArticle

temozolomide
Clinical Trials, Phase I
Glioblastoma
Radiotherapy
Radiation

Increased flux through the mevalonate pathway mediates fibrotic repair without injury

Larson-Casey, J. L., Vaid, M., Gu, L., He, C., Cai, G. Q., Ding, Q., Davis, D., Berryhill, T. F., Wilson, L. S., Barnes, S., Neighbors, J. D., Hohl, R. J., Zimmerman, K. A., Yoder, B. K., Longhini, A. L. F., Hanumanthu, V. S., Surolia, R., Antony, V. B. & Brent Carter, A., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4962-4978 17 p.

Research output: Contribution to journalArticle

Mevalonic Acid
Prenylation
Idiopathic Pulmonary Fibrosis
Macrophages
Wounds and Injuries
2 Citations (Scopus)

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

Weissenrieder, J. S., Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms
Androgens
Prenylation
Open Access
decitabine
Acute Myeloid Leukemia
Therapeutics
T-Lymphocytes
DNA Methylation

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity

Kokolus, K. M., Haley, J. S., Koubek, E. J., Gowda, R., Dinavahi, S. S., Sharma, A., Claxton, D. F., Helm, K. F., Drabick, J. J., Robertson, G. P., Neighbors, J. D., Hohl, R. J. & Schell, T. D., Feb 1 2019, In : OncoImmunology. 8, 2, e1539614.

Research output: Contribution to journalArticle

Biological Products
Immunity
Melanoma
Immunotherapy
Neoplasms

The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells

Weissenrieder, J. S., Reed, J. L., Green, M. V., Moldovan, G. L., Koubek, E. J., Neighbors, J. D. & Hohl, R. J., Jan 1 2019, (Accepted/In press) In : Pharmacology.

Research output: Contribution to journalArticle

Open Access
Remoxipride
Dopamine D2 Receptors
Thioridazine
Glioblastoma
Pimozide
2018
4 Citations (Scopus)

VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML

Wang, L., Jia, B., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Mineishi, S., Naik, S., Khawaja, M. R., Sivik, J., Han, J., Hohl, R. J. & Zheng, H., Sep 2 2018, In : OncoImmunology. 7, 9, e1469594.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Myeloid-Derived Suppressor Cells
Immunoglobulin Domains
2017
12 Citations (Scopus)

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Zhu, L., Kong, Y., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., Palmisiano, N. D., Wang, M., Jia, B., Bayerl, M., Schell, T. D., Hohl, R. J., Zeng, H. & Zheng, H., Jun 19 2017, In : Journal of Hematology and Oncology. 10, 1, 124.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
B-Lymphocytes
Up-Regulation
T-Lymphocytes
Proteins
78 Citations (Scopus)

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H. & 15 others, Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Shultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G., Apr 10 2017, In : Cancer Cell. 31, 4, p. 487-500.e8

Research output: Contribution to journalArticle

Glioblastoma
Non-Small Cell Lung Carcinoma
Pharmacology
Neoplasms
Iron
1 Citation (Scopus)

PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features

Teye, E. K., Sido, A., Xin, P., Finnberg, N. K., Gokare, P., Kawasawa, Y. I., Salzberg, A. C., Shimko, S., Bayerl, M., Ehmann, W. C., Claxton, D. F., Rybka, W. B., Drabick, J. J., Wang, H. G., Abraham, T., El-Deiry, W. S., Brodsky, R. A., J.Hohl, R. & Pu, J. J., Jan 1 2017, In : Oncotarget. 8, 18, p. 29887-29905 19 p.

Research output: Contribution to journalArticle

Genomic Instability
Acute Myeloid Leukemia
Gene Expression
Protein Deficiency
M Phase Cell Cycle Checkpoints
8 Citations (Scopus)

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Burden
Farnesyltranstransferase
2016
8 Citations (Scopus)

GBM-associated mutations and altered protein expression are more common in young patients

Ferguson, S. D., Xiu, J., Weathers, S. P., Zhou, S., Kesari, S., Weiss, S. E., Verhaak, R. G., Hohl, R. J., Barger, G. R., Reddy, S. K. & Heimberger, A. B., Jan 1 2016, In : Oncotarget. 7, 43, p. 69466-69478 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Mutation
Proteins
Methylation
DNA Sequence Analysis
7 Citations (Scopus)

Phase 1 study of tabalumab, a human anti-B-cell activating factor antibody, and bortezomib in patients with relapsed/refractory multiple myeloma

Raje, N. S., Faber, E. A., Richardson, P. G., Schiller, G., Hohl, R. J., Cohen, A. D., Forero, A., Carpenter, S., Nguyen, T. S., Conti, I., Kaiser, C. J., Cronier, D. M., Wooldridge, J. E. & Anderson, K. C., Dec 1 2016, In : Clinical Cancer Research. 22, 23, p. 5688-5695 8 p.

Research output: Contribution to journalArticle

B-Cell Activating Factor
Multiple Myeloma
Antibodies
Peripheral Nervous System Diseases
Neutropenia
2015
4 Citations (Scopus)

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Kuder, C. H., Weivoda, M. M., Zhang, Y., Zhu, J., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Dec 1 2015, In : Lipids. 50, 12, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

Cultured Cells
Cholesterol
Cells
Cell Line
Liver
6 Citations (Scopus)

Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil

Sheehy, R. M., Kuder, C. H., Bachman, Z. & Hohl, R. J., Jan 1 2015, In : Cancer Biology and Therapy. 16, 8, p. 1259-1268 10 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Verapamil
Calcium
Cholesterol
Rhodamine 123
1 Citation (Scopus)

In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors

Reilly, J. E., Zhou, X., Tong, H., Kuder, C. H., Wiemer, D. F. & Hohl, R., Jun 11 2015, In : Biochemical Pharmacology. 96, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Myeloid Leukemia
Terpenes
Cells
Diphosphonates
5 Citations (Scopus)

Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors

Holstein, S. A., Bigelow, J. C., Olson, R. D., Vestal, R. E., Walsh, G. M. & Hohl, R., Jun 22 2015, In : Investigational New Drugs. 33, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Anthracyclines
Pharmacokinetics
Neoplasms
Maximum Tolerated Dose
Neutropenia
1 Citation (Scopus)

Primary cutaneous polymorphic ebv-associated posttransplant lymphoproliferative disorder after a renal transplant and review of the literature

Ferguson, N. N., Thomas, C. P., Hohl, R., Syrbu, S. I., Stone, M. S. & Wanat, K. A., Oct 1 2015, In : American Journal of Dermatopathology. 37, 10, p. 790-794 5 p.

Research output: Contribution to journalArticle

Lymphoproliferative Disorders
Transplants
Kidney
Skin
Human Herpesvirus 4
11 Citations (Scopus)

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J., Tong, H., Henry, M. D. & Hohl, R., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

Prenylation
Adrenal Glands
Tumor Burden
Terpenes
Prostatic Neoplasms
10 Citations (Scopus)

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J. D., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

Prenylation
Oxidative stress
Pulmonary Fibrosis
Terpenes
rac1 GTP-Binding Protein
2014
12 Citations (Scopus)

Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

Zhou, X., Reilly, J. E., Loerch, K. A., Hohl, R. J. & Wiemer, D. F., Jul 18 2014, In : Beilstein Journal of Organic Chemistry. 10, p. 1645-1650 6 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Ethers
Terpenes
Diphosphonates
Geranyltranstransferase
2013
1 Citation (Scopus)

Personalized medicine: Through the looking glass of functional imaging

Hohl, R. J., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4024-4026 3 p.

Research output: Contribution to journalArticle

Precision Medicine
Glass
Pharmaceutical Preparations
Drug Therapy
Neoplasms
4 Citations (Scopus)

Quantitative determination of isopentenyl diphosphate in cultured mammalian cells

Tong, H., Kuder, C. H., Wasko, B. M. & Hohl, R., Feb 1 2013, In : Analytical Biochemistry. 433, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Cultured Cells
Cells
zoledronic acid
Lovastatin
Biosynthetic Pathways
2012
43 Citations (Scopus)

A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients

Messing, E., Gee, J. R., Saltzstein, D. R., Kim, K. M., DiSant'Agnese, A., Kolesar, J., Harris, L., Faerber, A., Havighurst, T., Young, J. M., Efros, M., Getzenberg, R. H., Wheeler, M. A., Tangrea, J., Parnes, H., House, M., Busby, J. E., Hohl, R. & Bailey, H., Apr 1 2012, In : Cancer Prevention Research. 5, 4, p. 621-630 10 p.

Research output: Contribution to journalArticle

Isoflavones
Genistein
Chemoprevention
Tumor Biomarkers
Urinary Bladder Neoplasms
6 Citations (Scopus)

Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification

Kuder, C. H., Sheehy, R. M., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Jul 1 2012, In : Molecular pharmacology. 82, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Stilbenes
Poly(ADP-ribose) Polymerases
Caspase 9
Eukaryotic Initiation Factor-2
Apoptosis
18 Citations (Scopus)

Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiation

Weivoda, M. M. & Hohl, R., Feb 1 2012, In : Bone. 50, 2, p. 467-476 10 p.

Research output: Contribution to journalArticle

Adipogenesis
Peroxisome Proliferator-Activated Receptors
Osteoblasts
Mesenchymal Stromal Cells
geranylgeranyl pyrophosphate
109 Citations (Scopus)

Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma

Gronchi, A., Bui, B. N., Bonvalot, S., Pilotti, S., Ferrari, S., Hohenberger, P., Hohl, R. J., Demetri, G. D., Le cesne, A., Lardelli, P., Pérez, I., Nieto, A., Tercero, J. C., Alfaro, V., Tamborini, E. & Blay, J. Y., Mar 1 2012, In : Annals of Oncology. 23, 3, p. 771-776 6 p.

Research output: Contribution to journalArticle

trabectedin
Myxoid Liposarcoma
Phase II Clinical Trials
Liposarcoma
Confidence Intervals
7 Citations (Scopus)

Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma

Malchenko, S., Seftor, E. A., Nikolsky, Y., Hasegawa, S. L., Kuo, S., Stevens, J. W., Poyarkov, S., Nikolskaya, T., Kucaba, T., Wang, M., Abdulkawy, H., Casavant, T., Morcuende, J., Buckwalter, J., Hohl, R., Deyoung, B., Kernstine, K., Bonaldo, M. D. F., Hendrix, M. J. C., Soares, M. B. & 1 others, Soares, V. M. F. C., Mar 16 2012, In : Sarcoma. 2012, 820254.

Research output: Contribution to journalArticle

Chondrosarcoma
Neoplasm Metastasis
Lung
Gene Expression Profiling
Transcriptome
2011
9 Citations (Scopus)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro

Wasko, B. M., Smits, J. P., Shull, L. W., Wiemer, D. F. & Hohl, R. J., Nov 1 2011, In : Journal of Lipid Research. 52, 11, p. 1957-1964 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Farnesyl-Diphosphate Farnesyltransferase
Protein Prenylation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lovastatin
44 Citations (Scopus)

Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate

Wasko, B. M., Dudakovic, A. & Hohl, R. J., May 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 337, 2, p. 540-546 7 p.

Research output: Contribution to journalArticle

Autophagy
Diphosphonates
zoledronic acid
Terpenes
Prenylation
20 Citations (Scopus)

Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation

Weivoda, M. M. & Hohl, R. J., Aug 1 2011, In : Endocrinology. 152, 8, p. 3113-3122 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Terpenes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Oxidoreductases
Coenzyme A
20 Citations (Scopus)

Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration

Dudakovic, A., Tong, H. & Hohl, R. J., Oct 1 2011, In : Investigational New Drugs. 29, 5, p. 912-920 9 p.

Research output: Contribution to journalArticle

Cell Movement
Breast Neoplasms
Farnesyltranstransferase
Guanosine Triphosphate
geranylgeranyl pyrophosphate
34 Citations (Scopus)

Geranylgeranyl diphosphate synthase: An emerging therapeutic target

Wiemer, A. J., Wiemer, D. F. & Hohl, R., Dec 1 2011, In : Clinical pharmacology and therapeutics. 90, 6, p. 804-812 9 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Protein Prenylation
Pharmaceutical Chemistry
Therapeutics
27 Citations (Scopus)
Unfolded Protein Response
Biosynthetic Pathways
Terpenes
Multiple Myeloma
Proteins
4 Citations (Scopus)

Lack of effect of casopitant on the pharmacokinetics of docetaxel in patients with cancer

Dandamudi, U. B., Adams, L. M., Johnson, B., Bauman, J., Morris, S., Murray, S., Webb, R. T., Gartner, E., Hohl, R. & Lewis, L. D., Apr 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 4, p. 783-790 8 p.

Research output: Contribution to journalArticle

docetaxel
Pharmacokinetics
Neoplasms
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
30 Citations (Scopus)

Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas

Witzig, T. E., Tang, H., Micallef, I. N. M., Ansell, S. M., Link, B. K., Inwards, D. J., Porrata, L. F., Johnston, P. B., Colgan, J. P., Markovic, S. N., Nowakowski, G. S., Thompson, C. A., Allmer, C., Maurer, M. J., Gupta, M., Weiner, G., Hohl, R., Kurtin, P. J., Ding, H., Loegering, D. & 4 others, Schneider, P., Peterson, K., Habermann, T. M. & Kaufmann, S. H., Nov 3 2011, In : Blood. 118, 18, p. 4882-4889 8 p.

Research output: Contribution to journalArticle

tipifarnib
Farnesyltranstransferase
Refractory materials
Non-Hodgkin's Lymphoma
Lymphoma
13 Citations (Scopus)

Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis

Holstein, S. A., Kuder, C. H., Tong, H. & Hohl, R., Oct 1 2011, In : Lipids. 46, 10, p. 907-921 15 p.

Research output: Contribution to journalArticle

Terpenes
Lovastatin
Homeostasis
Biosynthetic Pathways
Cells
18 Citations (Scopus)

The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation

Weivoda, M. M. & Hohl, R., Jun 1 2011, In : Journal of cellular biochemistry. 112, 6, p. 1506-1513 8 p.

Research output: Contribution to journalArticle

Geranylgeranyl-Diphosphate Geranylgeranyltransferase
Osteoblasts
Farnesyltranstransferase
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prenylation
2010
9 Citations (Scopus)

Biologically active biotin derivatives of schweinfurthin F

Ulrich, N. C., Kuder, C. H., Hohl, R. & Wiemer, D. F., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6716-6720 5 p.

Research output: Contribution to journalArticle

Biotin
Amides
Carrier Proteins
Esters
Derivatives
15 Citations (Scopus)

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Holstein, S. A., Tong, H. & Hohl, R. J., Mar 1 2010, In : Leukemia Research. 34, 3, p. 344-351 8 p.

Research output: Contribution to journalArticle

Thalidomide
Biosynthetic Pathways
Terpenes
Multiple Myeloma
Apoptosis
10 Citations (Scopus)

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

Topczewski, J. J., Kuder, C. H., Neighbors, J., Hohl, R. & Wiemer, D. F., Sep 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 18, p. 6734-6741 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Poisons
Fluorescence microscopy
Fluorescence Microscopy
21 Citations (Scopus)

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

Ulrich, N. C., Kodet, J. G., Mente, N. R., Kuder, C. H., Beutler, J. A., Hohl, R. & Wiemer, D. F., Feb 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 4, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Growth Inhibitors
National Cancer Institute (U.S.)
Bioactivity
Biological Products
Cells
2 Citations (Scopus)

Survey of muscle characteristics after statin-induced rhabdomyolysis

Phillips, P. S., Verity, M. A., Schick, B. A., Vladutiu, G. D., Laaksonen, R., Oresic, M., Hohl, R. J., Ciaraldi, T. P., Sukhatme, V. P., Lecker, S. H., Cote, H. C. F., Powell, H., Davidson, W. & Wolfson, T., Mar 9 2010, In : Clinical Lipidology. 5, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rhabdomyolysis
Muscles
coenzyme Q10
Cholesterol
20 Citations (Scopus)

Synthesis and biological evaluation of a series of aromatic bisphosphonates

Barney, R. J., Wasko, B. M., Dudakovic, A., Hohl, R. & Wiemer, D. F., Oct 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 20, p. 7212-7220 9 p.

Research output: Contribution to journalArticle

Diphosphonates
Terpenes
Farnesyltranstransferase
zoledronic acid
Geranyltranstransferase
2009
26 Citations (Scopus)

Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: Final report of Cancer and Leukemia Group B study 19901

Byrd, J. C., Peterson, B. L., Rai, K. R., Hurd, D., Hohl, R., Perry, M. C., Gockerman, J., Nattam, S. & Larson, R. A., Nov 11 2009, In : Leukemia and Lymphoma. 50, 10, p. 1589-1596 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Leukemia
Neoplasms
Cytomegalovirus Infections
alemtuzumab
153 Citations (Scopus)

Phase i and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301

Miller, A. A., Murry, D. J., Owzar, K., Hollis, D. R., Kennedy, E. B., Abou-Alfa, G., Desai, A., Hwang, J., Villalona-Calero, M. A., Dees, E. C., Lewis, L. D., Fakih, M. G., Edelman, M. J., Millard, F., Frank, R. C., Hohl, R. J. & Ratain, M. J., Apr 10 2009, In : Journal of Clinical Oncology. 27, 11, p. 1800-1805 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Bilirubin
Kidney
Liver
Creatinine
50 Citations (Scopus)

Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma

Chanan-Khan, A., Niesvizky, R., Hohl, R., Zimmerman, T. M., Christiansen, N. P., Schiller, G. J., Callander, N., Lister, J., Oken, M. & Jagannath, S., Aug 17 2009, In : Leukemia and Lymphoma. 50, 4, p. 559-565 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Myeloma Proteins
Antisense Oligonucleotides
Cytotoxins
8 Citations (Scopus)

Quantitative determination of geranyl diphosphate levels in cultured human cells

Holstein, S. A., Tong, H., Kuder, C. H. & Hohl, R., Nov 1 2009, In : Lipids. 44, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Terpenes
Cultured Cells
Cells
zoledronic acid
Biosynthetic Pathways