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Research Output 1992 2019

Article
17 Citations (Scopus)
Polycystic Ovary Syndrome
Embryo Transfer
Cryopreservation
Live Birth
Fertilization in Vitro

Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network, May 1 2019, In : Fertility and sterility. 111, 5, p. 1011-1019.e1

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Leiomyoma
Infertility
Body Mass Index
Live Birth
39 Citations (Scopus)
Caloric Restriction
Glucuronides
Menstrual Cycle
Weight Loss
Pregnanediol
5 Citations (Scopus)

Major depression, antidepressant use, and male and female fertility

Reproductive Medicine Network, May 2018, In : Fertility and sterility. 109, 5, p. 879-887 9 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Fertility
Depression
letrozole
Spontaneous Abortion
7 Citations (Scopus)

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

McGovern, P. G., Carson, S. A., Barnhart, H. X., Myers, E. R., Legro, R., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C. & Giudice, L. C., Oct 1 2008, In : Fertility and sterility. 90, 4, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

National Institute of Child Health and Human Development (U.S.)
Reproductive Medicine
Medication Adherence
Polycystic Ovary Syndrome
Metformin
21 Citations (Scopus)

Metabolic and cardiovascular genes in polycystic ovary syndrome: A candidate-wide association study (CWAS)

Jones, M. R., Chua, A. K., Mengesha, E. A., Taylor, K. D., Chen, Y. D. I., Li, X., Krauss, R. M., Rotter, J. I., Legro, R., Azziz, R. & Goodarzi, M. O., Mar 10 2012, In : Steroids. 77, 4, p. 317-322 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Medical problems
Polymorphism
Nucleotides
Genes
39 Citations (Scopus)

Metabolic phenotype in the brothers of women with polycystic ovary syndrome

Sam, S., Coviello, A. D., Sung, Y. A., Legro, R. S. & Dunaif, A., Jun 1 2008, In : Diabetes care. 31, 6, p. 1237-1241 5 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Siblings
Phenotype
Insulin Resistance
Dyslipidemias
23 Citations (Scopus)

Metabolism of dihydrotestosterone to 5α-androstane-3α,17β-diol glucuronide is greater in the peripheral compartment than in the splanchnic compartment

Duffy, D. M., Legro, R., Chang, L., Stanczyk, F. Z. & Lobo, R. A., Jan 1 1995, In : Fertility and sterility. 64, 4, p. 736-739 4 p.

Research output: Contribution to journalArticle

Androstane-3,17-diol
Viscera
Dihydrotestosterone
Serum
Cutaneous Administration
5 Citations (Scopus)

Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome

Aubuchon, M., Kunselman, A., Schlaff, W. D., Diamond, M. P., Coutifaris, C., Carson, S. A., Steinkampf, M. P., Carr, B. R., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Myers, E. R. & Legro, R., Oct 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 10

Research output: Contribution to journalArticle

Clomiphene
Polycystic Ovary Syndrome
Metformin
Liver
Kidney
1 Citation (Scopus)

Metformin for infertility in PCOS: Going, going, gone

Legro, R., Dec 1 2007, In : Contemporary Ob/Gyn. 52, 12, p. 54-61 8 p.

Research output: Contribution to journalArticle

Clomiphene
Metformin
Infertility
Research
1 Citation (Scopus)

Midluteal progesterone: A marker of treatment outcomes in couples with unexplained infertility

Hansen, K. R., Eisenberg, E., Baker, V., Hill, M. J., Chen, S., Talken, S., Diamond, M. P., Legro, R., Coutifaris, C., Alvero, R., Robinson, R. D., Casson, P., Christman, G. M., Santoro, N., Zhang, H. & Wild, R. A., Jul 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 7, p. 2743-2751 9 p.

Research output: Contribution to journalArticle

Ovulation Induction
Infertility
Progesterone
Insemination
Live Birth
6 Citations (Scopus)

Mindfulness-based stress reduction for overweight/obese women with and without polycystic ovary syndrome: Design and methods of a pilot randomized controlled trial

Raja-Khan, N., Agito, K., Shah, J., Stetter, C. M., Gustafson, T. S., Socolow, H., Kunselman, A., Reibel, D. K. & Legro, R., Mar 1 2015, In : Contemporary Clinical Trials. 41, p. 287-297 11 p.

Research output: Contribution to journalArticle

Mindfulness
Polycystic Ovary Syndrome
Randomized Controlled Trials
Blood Glucose
Ovary
6 Citations (Scopus)

Mindfulness-Based Stress Reduction in Women with Overweight or Obesity: A Randomized Clinical Trial

Raja-Khan, N., Agito, K., Shah, J., Stetter, C. M., Gustafson, T. S., Socolow, H., Kunselman, A., Reibel, D. K. & Legro, R., Aug 1 2017, In : Obesity. 25, 8, p. 1349-1359 11 p.

Research output: Contribution to journalArticle

Mindfulness
Randomized Controlled Trials
Obesity
Health Education
Glucose
41 Citations (Scopus)

Minimal Response of Circulating Lipids in Women with Polycystic Ovary Syndrome to Improvement in Insulin Sensitivity with Troglitazone

Legro, R., Azziz, R., Ehrmann, D., Fereshetian, A. G., O'Keefe, M. & Ghazzi, M. N., Nov 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 11, p. 5137-5144 8 p.

Research output: Contribution to journalArticle

troglitazone
Polycystic Ovary Syndrome
Insulin Resistance
Insulin
Lipids
120 Citations (Scopus)

Molecular progress in infertility: Polycystic ovary syndrome

Legro, R. & Strauss, J. F., Jan 1 2002, In : Fertility and Sterility. 78, 3, p. 569-576 8 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Infertility
Genes
Insulin Receptor
Phenotype
17 Citations (Scopus)

Multiple implantation after oocyte donation: A frequent but inefficient event

Legro, R., Wong, I. L., Paulson, R. J., Lobo, R. A. & Sauer, M. V., Jan 1 1995, In : Fertility and sterility. 63, 4, p. 849-853 5 p.

Research output: Contribution to journalArticle

Oocyte Donation
Oocytes
Pregnancy
Tissue Donors
Gestational Sac
94 Citations (Scopus)

Nonsurgical management of placenta percreta: A case report

Legro, R., Price, F. V., Hill, L. M. & Caritis, S. N., Jan 1 1994, In : Obstetrics and Gynecology. 83, 5, p. 847-849 3 p.

Research output: Contribution to journalArticle

Placenta Accreta
Placenta
Hemorrhage
Hysteroscopy
Hysterectomy
6 Citations (Scopus)

Normal pubertal development in daughters of women with PCOS: A controlled study

Legro, R. S., Kunselman, A. R., Stetter, C. M., Gnatuk, C. L., Estes, S. J., Brindle, E., Vesper, H. W., Botelho, J. C., Lee, P. A. & Dodson, W. C., Jan 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 1, p. 122-131 10 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Nuclear Family
Gonadotropins
Insulin
Steroids
74 Citations (Scopus)

Obesity and PCOS: Implications for diagnosis and treatment

Legro, R. S., Oct 22 2012, In : Seminars in reproductive medicine. 30, 6, p. 496-506 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Obesity
Phenotype
Weight Loss
Therapeutics
14 Citations (Scopus)

Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial

Zhang, B., Wei, D., Legro, R., Shi, Y., Li, J., Zhang, L., Hong, Y., Sun, G., Zhang, T., Li, W. & Chen, Z. J., Feb 1 2018, In : Fertility and sterility. 109, 2, p. 324-329 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Embryo Transfer
Obstetrics
Gestational Age
Twin Pregnancy
3 Citations (Scopus)

Oocyte donors as gynecologic teaching associates

Legro, R., Gnatuk, C., Kunselman, A. & Cain, J., Jan 1 1999, In : Obstetrics and Gynecology. 93, 1, p. 147-150 4 p.

Research output: Contribution to journalArticle

Oocytes
Teaching
Tissue Donors
Students
Gynecological Examination
31 Citations (Scopus)

Oral contraceptive use by teenage women does not affect body composition

Lloyd, T., Lin, H. M., Matthews, A. E., Bentley, C. M. & Legro, R., Aug 23 2002, In : Obstetrics and Gynecology. 100, 2, p. 235-239 5 p.

Research output: Contribution to journalArticle

Oral Contraceptives
Body Composition
Adipose Tissue
Serum
Cholesterol
53 Citations (Scopus)

Oral contraceptive use by teenage women does not affect peak bone mass: A longitudinal study

Lloyd, T., Taylor, D. S., Lin, H. M., Matthews, A. E., Eggli, D. F. & Legro, R., Oct 1 2000, In : Fertility and Sterility. 74, 4, p. 734-738 5 p.

Research output: Contribution to journalArticle

Oral Contraceptives
Longitudinal Studies
Bone and Bones
Body Composition
Pelvic Bones
87 Citations (Scopus)

Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

McAllister, J. M., Modi, B., Miller, B. A., Biegler, J., Bruggeman, R., Legro, R. S. & Strauss, J. F., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. E1519-E1527

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Protein Isoforms
Theca Cells
Phenotype
Cholesterol Side-Chain Cleavage Enzyme
80 Citations (Scopus)

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene

Legro, R., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Ewens, K. G., Spielman, R. S., Leppert, P. C. & Myers, E. R., Jan 1 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Metformin
Polymorphism
Ovulation
Body Mass Index
9 Citations (Scopus)

Parent-of-origin effects on glucose homeostasis in polycystic ovary syndrome

Kobaly, K., Vellanki, P., Sisk, R. K., Armstrong, L., Lee, J. Y., Lee, J., Hayes, M. G., Urbanek, M., Legro, R. S. & Dunaif, A., Aug 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 8, p. 2961-2966 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Fasting
Homeostasis
Mothers
Glucose
15 Citations (Scopus)

Pathogenic anti-Müllerian hormone variants in polycystic ovary syndrome

Gorsic, L. K., Kosova, G., Werstein, B., Sisk, R., Legro, R., Hayes, M. G., Teixeira, J. M., Dunaif, A. & Urbanek, M., Aug 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 8, p. 2862-2872 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Hormones
Steroid 17-alpha-Hydroxylase
Biosynthesis
Androgens
18 Citations (Scopus)

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women

Chen, C., Wickenheisser, J., Ewens, K. G., Ankener, W., Legro, R., Dunaif, A., McAllister, J., Spielman, R. S. & Strauss, J. F., Jul 30 2009, In : Molecular Human Reproduction. 15, 8, p. 459-469 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Androgens
Single Nucleotide Polymorphism
Cyclic AMP
Theca Cells
16 Citations (Scopus)

Peripubertal estrogen levels and physical activity affect femur geometry in young adult women

Devlin, M. J., Stetter, C. M., Lin, H. M., Beck, T. J., Legro, R. S., Petit, M. A., Lieberman, D. E. & Lloyd, T., Apr 1 2010, In : Osteoporosis International. 21, 4, p. 609-617 9 p.

Research output: Contribution to journalArticle

Femur
Young Adult
Estrogens
Exercise
Menarche

Pharmacologic Treatment of Polycystic Ovary Syndrome: Alternate and Future Paths

Duguech, L. M. M. & Legro, R., Jul 1 2017, In : Seminars in Reproductive Medicine. 35, 4, p. 326-343 18 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Therapeutics
Drug Repositioning
Anovulation
Secretory Pathway
116 Citations (Scopus)

Phenotype and Genotype in Polycystic Ovary Syndrome

Legro, R. S., Spielman, R., Urbanek, M., Driscoll, D., Strauss, J. F. & Dunaif, A., Dec 1 1998, In : Recent Progress in Hormone Research. 53, p. 217-256 40 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Genotype
Phenotype
Glucose Intolerance
Siblings
80 Citations (Scopus)

Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea

Vgontzas, A., Trakada, G., Bixler, E., Lin, H. M., Pejovic, S., Zoumakis, E., Chrousos, G. P. & Legro, R., Aug 1 2006, In : Metabolism: Clinical and Experimental. 55, 8, p. 1076-1082 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Sleep Apnea Syndromes
Interleukin-6
Obesity
Insulin Resistance
87 Citations (Scopus)
Anovulation
Polycystic Ovary Syndrome
Ovary
Phenotype
Insulin
56 Citations (Scopus)

Polycystic ovary syndrome: The new millenium

Legro, R. S., Nov 26 2001, In : Molecular and Cellular Endocrinology. 184, 1-2, p. 87-93 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Insulin
Insulin Resistance
Hyperandrogenism
Gonadotropins
9 Citations (Scopus)

Polycystic ovary syndrome: Current infertility management

Aubuchon, M. & Legro, R., Dec 1 2011, In : Clinical obstetrics and gynecology. 54, 4, p. 675-684 10 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Infertility
Therapeutics
9 Citations (Scopus)

Polycystic ovary syndrome: The new millenium

Legro, R., Jan 25 2002, In : Molecular and Cellular Endocrinology. 186, 2, p. 219-225 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Insulin
Insulin Resistance
Hyperandrogenism
Gonadotropins
39 Citations (Scopus)

Polycystic ovary syndrome: Phenotype to genotype

Legro, R., Jan 1 1999, In : Endocrinology and Metabolism Clinics of North America. 28, 2, p. 379-396 18 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Genotype
Phenotype
Pedigree
Cluster Analysis
31 Citations (Scopus)

Polycystic ovary syndrome: Current and future treatment paradigms

Legro, R., Dec 1 1998, In : American journal of obstetrics and gynecology. 179, 6 II

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Glucose Intolerance
Insulin
Therapeutics
Insulin Resistance
2 Citations (Scopus)

Polycystic ovary syndrome and cardiovascular disease risk

Legro, R., Dec 1 2009, In : Current Cardiovascular Risk Reports. 3, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Cardiovascular Diseases
Hyperinsulinism
Dyslipidemias
Menopause
275 Citations (Scopus)

Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: Role of insulin resistance

Vgontzas, A., Legro, R., Bixler, E., Grayev, A., Kales, A. & Chrousos, G. P., Mar 22 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 2, p. 517-520 4 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Obstructive Sleep Apnea
Insulin Resistance
Insulin
Sleep Apnea Syndromes
36 Citations (Scopus)

Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome

Wickham, E. P., Ewens, K. G., Legro, R. S., Dunaif, A., Nestler, J. E. & Strauss, J. F., Apr 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 4, p. E719-E727

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Genes
1034 Citations (Scopus)

Position statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E. & Witchel, S. F., Nov 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4237-4245 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Androgens
Advisory Committees
Guidelines
Hyperandrogenism
3 Citations (Scopus)

Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women

Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network, Nov 1 2017, In : Fertility and sterility. 108, 5, p. 843-850 8 p.

Research output: Contribution to journalArticle

Birth Rate
Live Birth
Thyrotropin
Peroxidase
Spontaneous Abortion
2 Citations (Scopus)

Predictors of participant retention in infertility treatment trials

Kuang, H., Jin, S., Thomas, T., Engmann, L., Hansen, K. R., Coutifaris, C., Casson, P., Christman, G., Alvero, R., Santoro, N., Eisenberg, E., Diamond, M. P., Legro, R. & Zhang, H., Nov 1 2015, In : Fertility and sterility. 104, 5, p. 1236-1243.e2

Research output: Contribution to journalArticle

Infertility
Randomized Controlled Trials
Insurance Coverage
letrozole
Alcohols
19 Citations (Scopus)

Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine insemination

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network, Jun 1 2016, In : Fertility and sterility. 105, 6, p. 1575-1583.e2

Research output: Contribution to journalArticle

Insemination
Live Birth
Infertility
Ovulation Induction
Pregnancy
39 Citations (Scopus)

Predictors of pregnancy in women with polycystic ovary syndrome

Rausch, M. E., Legro, R., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Leppert, P. C., Myers, E. R. & Coutifaris, C., Jan 1 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3458-3466 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Live Birth
Ovulation
Pregnancy
History
92 Citations (Scopus)

Pregnancy: Premature luteinization as detected by elevated serum progesterone is associated with a higher pregnancy rate in donor oocyte in-vitro fertilization

Legro, R., Ary, B. A., Paulson, R. J., Stanczyk, F. Z. & Sauer, M. V., Jan 1 1993, In : Human Reproduction. 8, 9, p. 1506-1511 6 p.

Research output: Contribution to journalArticle

Luteinization
Pregnancy Rate
Fertilization in Vitro
Oocytes
Progesterone
26 Citations (Scopus)

Pregnancy considerations in women with polycystic ovary syndrome

Legro, R., Mar 1 2007, In : Clinical obstetrics and gynecology. 50, 1, p. 295-304 10 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Pregnancy
Metformin
Clomiphene
Gestational Diabetes
Polycystic Ovary Syndrome
Publications
Clinical Trials
Pregnancy
Multicenter Studies
379 Citations (Scopus)

Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome

Legro, R., Kunselman, A. & Dunaif, A., Dec 1 2001, In : American Journal of Medicine. 111, 8, p. 607-613 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Dyslipidemias
LDL Cholesterol
Confidence Intervals
HDL Cholesterol