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Research Output 1992 2019

2007
20 Citations (Scopus)

A 27-year-old woman with a diagnosis of polycystic ovary syndrome

Legro, R., Feb 7 2007, In : Journal of the American Medical Association. 297, 5, p. 509-519 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Menstruation
Weight Gain
Hirsutism
Expert Testimony
642 Citations (Scopus)

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Legro, R., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Leppert, P. C. & Myers, E. R., Feb 8 2007, In : New England Journal of Medicine. 356, 6, p. 551-566 16 p.

Research output: Contribution to journalArticle

Clomiphene
Polycystic Ovary Syndrome
Metformin
Infertility
Group Psychotherapy
17 Citations (Scopus)

Erectile dysfunction: does insulin resistance play a part?

Trussell, J. C. & Legro, R., Oct 1 2007, In : Fertility and sterility. 88, 4, p. 771-778 8 p.

Research output: Contribution to journalReview article

Erectile Dysfunction
Insulin Resistance
Nitric Oxide
MEDLINE
Type 5 Cyclic Nucleotide Phosphodiesterases
14 Citations (Scopus)

Hysterectomy and loss of fertility: Implications for women's mental health

Leppert, P. C., Legro, R. S. & Kjerulff, K. H., Sep 1 2007, In : Journal of Psychosomatic Research. 63, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

Women's Health
Hysterectomy
Fertility
Mental Health
Confusion
77 Citations (Scopus)

Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype

Urbanek, M., Sam, S., Legro, R. & Dunaif, A., Jan 1 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 11, p. 4191-4198 8 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Insulin
Phenotype
Chromosomes
Proinsulin

In reply [5]

Legro, R., Jun 20 2007, In : Journal of the American Medical Association. 297, 23, 1 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Metformin for infertility in PCOS: Going, going, gone

Legro, R., Dec 1 2007, In : Contemporary Ob/Gyn. 52, 12, p. 54-61 8 p.

Research output: Contribution to journalArticle

Clomiphene
Metformin
Infertility
Research
5 Citations (Scopus)

Phenotype and genotype in polycystic ovary syndrome

Legro, R., Jan 1 2007, Polycystic Ovary Syndrome, Second Edition. Cambridge University Press, p. 25-41 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polycystic Ovary Syndrome
Genotype
Phenotype
Oligomenorrhea
Hyperandrogenism
787 Citations (Scopus)

Polycystic ovary syndrome

Norman, R. J., Dewailly, D., Legro, R. & Hickey, T. E., Aug 25 2007, In : Lancet. 370, 9588, p. 685-697 13 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Anovulation
Hyperandrogenism
Hirsutism
Acne Vulgaris
26 Citations (Scopus)

Pregnancy considerations in women with polycystic ovary syndrome

Legro, R., Mar 1 2007, In : Clinical obstetrics and gynecology. 50, 1, p. 295-304 10 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Pregnancy
Metformin
Clomiphene
Gestational Diabetes
1 Citation (Scopus)

Should metformin be used as front-line therapy for fertility in women with PCOS?

Baillargeon, J. P. & Legro, R., May 2007, In : Sexuality, Reproduction and Menopause. 5, 2, p. 17 1 p.

Research output: Contribution to journalComment/debate

Metformin
Fertility
Therapeutics

The authors reply [5]

Legro, R. & Myers, E. R., May 10 2007, In : New England Journal of Medicine. 356, 19, p. 2000-2001 2 p.

Research output: Contribution to journalLetter

65 Citations (Scopus)
rosiglitazone
Polycystic Ovary Syndrome
Metformin
Endometrium
Ovary
6 Citations (Scopus)

Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome

McGovern, P. G., Legro, R., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C. & Giudice, L. C., Feb 1 2007, In : Fertility and sterility. 87, 2, p. 442-444 3 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Infertility
Oligospermia
Ovulation
Multicenter Studies

Views 2: Metformin does not improve live birth rates

Legro, R., May 1 2007, In : Sexuality, Reproduction and Menopause. 5, 2, p. 18-19 2 p.

Research output: Contribution to journalShort survey

Birth Rate
Metformin
Live Birth
2006
305 Citations (Scopus)
Polycystic Ovary Syndrome
Androgens
Insulin Resistance
Obesity
Insulin
36 Citations (Scopus)
Superovulation
Insemination
Obesity
Thinness
Gonadotropins
8 Citations (Scopus)

A twenty-first century research agenda for polycystic ovary syndrome

Legro, R., Azziz, R. & Giudice, L., Jun 1 2006, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 20, 2, p. 331-336 6 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Research
Translational Medical Research
Expert Testimony
Natural History
52 Citations (Scopus)

Brief Report: Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome

Hickey, T. E., Legro, R. & Norman, R. J., Jul 14 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 7, p. 2789-2791 3 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
X Chromosome Inactivation
X Chromosome
Chromosomes
Epigenomics
61 Citations (Scopus)

Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome

Sam, S., Legro, R., Essah, P. A., Apridonidze, T. & Dunaif, A., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7030-7035 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Mothers
Phenotype
LDL Lipoproteins
Nutrition Surveys
70 Citations (Scopus)

Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity

Stewart, D. R., Dombroski, B. A., Urbanek, M., Ankener, W., Ewens, K. G., Wood, J. R., Legro, R., Strauss, J. F., Dunaif, A. & Spielman, R. S., Jan 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 10, p. 4112-4117 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Genetic Predisposition to Disease
Chromosomes
Granulosa Cells
Alleles
6 Citations (Scopus)

Long-term, low-dose flutamide does not cause hepatotoxicity in hyperandrogenic women

Legro, R., Apr 1 2006, In : Nature Clinical Practice Endocrinology and Metabolism. 2, 4, p. 188-189 2 p.

Research output: Contribution to journalShort survey

Flutamide
Hyperandrogenism
Androgen Antagonists
Polycystic Ovary Syndrome
Liver Function Tests
89 Citations (Scopus)

Obesity and the role of gut and adipose hormones in female reproduction

Gosman, G. G., Katcher, H. I. & Legro, R., Sep 1 2006, In : Human Reproduction Update. 12, 5, p. 585-601 17 p.

Research output: Contribution to journalReview article

Reproduction
Obesity
Adipokines
Hormones
Weight Loss
80 Citations (Scopus)

Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea

Vgontzas, A., Trakada, G., Bixler, E., Lin, H. M., Pejovic, S., Zoumakis, E., Chrousos, G. P. & Legro, R., Aug 1 2006, In : Metabolism: Clinical and Experimental. 55, 8, p. 1076-1082 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Sleep Apnea Syndromes
Interleukin-6
Obesity
Insulin Resistance
1014 Citations (Scopus)

Position statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E. & Witchel, S. F., Nov 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4237-4245 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Androgens
Advisory Committees
Guidelines
Hyperandrogenism

Preface

Giudice, L. C., Legro, R. & Azziz, R., Jun 1 2006, In : Best Practice and Research: Clinical Endocrinology and Metabolism. 20, 2

Research output: Contribution to journalEditorial

441 Citations (Scopus)

Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome

Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R., Ghazzi, M. N., Aronoff, S., Bernstein, R., Bodenner, D., Braithwaite, S., Cohen, J., DePaolo, D., Einhorn, D., Hone, J., Kenshole, A., Kilo, C., Kjos, S. L., Korytkowski, M., Koster, D., Lau, R. & 13 others, Lobo, R., Lucas, J., Martin, K., Meyer, W., Pek, S., Pfeifer, S., Rebar, R., Redmond, G., Rittmaster, R., Ross, P., Schwartz, S., Wild, R. & Yen, S. S. C., Jan 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 1, p. 48-53 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Glucose
Blood pressure
troglitazone
HDL Cholesterol
79 Citations (Scopus)

The Pregnancy in Polycystic Ovary Syndrome Study: baseline characteristics of the randomized cohort including racial effects

Legro, R., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Guidice, L. C. & Leppert, P. C., Oct 1 2006, In : Fertility and sterility. 86, 4, p. 914-933 20 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Ovary
Pregnancy
Phenotype
Oligomenorrhea
69 Citations (Scopus)

The role of genes and environment in the etiology of PCOS

Diamanti-Kandarakis, E., Kandarakis, H. & Legro, R., Aug 1 2006, In : Endocrine. 30, 1, p. 19-26 8 p.

Research output: Contribution to journalReview article

Genes
Insulin Receptor
Follistatin
Phenotype
Obesity
16 Citations (Scopus)

Type 2 diabetes and polycystic ovary syndrome

Legro, R., Jul 1 2006, In : Fertility and sterility. 86, SUPPL. 1

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Type 2 Diabetes Mellitus
Obesity
Anovulation
Glucose Intolerance
2005
102 Citations (Scopus)

Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome

Nelson-Degrave, V. L., Wickenheisser, J. K., Hendricks, K. L., Asano, T., Fujishiro, M., Legro, R., Kimball, S., Strauss, J. F. & McAllister, J., Feb 1 2005, In : Molecular Endocrinology. 19, 2, p. 379-390 12 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Mitogen-Activated Protein Kinase Kinases
Steroid 17-alpha-Hydroxylase
Androgens
109 Citations (Scopus)

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2

Urbanek, M., Woodroffe, A., Ewens, K. G., Diamanti-Kandarakis, E., Legro, R., Strauss, J. F., Dunaif, A. & Spielman, R. S., Dec 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 12, p. 6623-6629 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Chromosomes
Drawing (graphics)
Genes
DNA sequences
211 Citations (Scopus)
Polycystic Ovary Syndrome
Glucose Intolerance
Glucose
Medical problems
Type 2 Diabetes Mellitus
4 Citations (Scopus)

Diagnosis and management of polycystic ovary syndrome

Raja-Khan, N. & Legro, R., Apr 2005, In : Journal of Clinical Outcomes Management. 12, 4, p. 218-226 9 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Metformin
Ovulation
Insulin Resistance
Hirsutism
72 Citations (Scopus)

Dyslipidemia and metabolic syndrome in the sisters of women with polycystic ovary syndrome

Sam, S., Legro, R. S., Bentley-Lewis, R. & Dunaif, A., Aug 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4797-4802 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Dyslipidemias
Siblings
Lipids
LDL Lipoproteins
120 Citations (Scopus)

Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome

Ehrmann, D. A., Kasza, K., Azziz, R., Legro, R. & Ghazzi, M. N., Jan 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Women's Rights
Polycystic Ovary Syndrome
Medical problems
Type 2 Diabetes Mellitus
Glucose Intolerance
18 Citations (Scopus)

Estimating live birth rates after ovulation induction in polycystic ovary syndrome: Sample size calculations for the pregnancy in polycystic ovary syndrome trial

Myers, E. R., Silva, S. G., Hafley, G., Kunselman, A., Nestler, J. E. & Legro, R., Jun 1 2005, In : Contemporary Clinical Trials. 26, 3, p. 271-280 10 p.

Research output: Contribution to journalArticle

Ovulation Induction
Polycystic Ovary Syndrome
Birth Rate
Live Birth
Sample Size
18 Citations (Scopus)

Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells

Ho, C. K. M., Wood, J. R., Stewart, D. R., Ewens, K., Ankener, W., Wickenheisser, J., Nelson-Degrave, V., Zhang, Z., Legro, R., Dunaif, A., McAllister, J., Spielman, R. & Strauss, J. F., Dec 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 12, p. 6596-6602 7 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Transcription
Genes
RNA

Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype

Legro, R., Chiu, P., Kunselman, A., Bentley, C. M., Dodson, W. & Dunaif, A., Dec 1 2005, In : Obstetrical and Gynecological Survey. 60, 12, p. 802-803 2 p.

Research output: Contribution to journalComment/debate

Anovulation
Ovary
Phenotype
85 Citations (Scopus)
Anovulation
Polycystic Ovary Syndrome
Ovary
Phenotype
Insulin
50 Citations (Scopus)

Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome

Wickenheisser, J. K., Nelson-DeGrave, V. L., Hendricks, K. L., Legro, R., Strauss, J. F. & McAllister, J., Aug 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4858-4865 8 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Biosynthesis
Retinoids
Tretinoin
2004
34 Citations (Scopus)

Absence of secretory endometrium after false-positive home urine luteinizing hormone testing

McGovern, P. G., Myers, E. R., Silva, S., Coutifaris, C., Carson, S. A., Legro, R., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Giudice, L. C., Leppert, P. C. & Diamond, M. P., Jan 1 2004, In : Fertility and sterility. 82, 5, p. 1273-1277 5 p.

Research output: Contribution to journalArticle

Luteinizing Hormone
Endometrium
Urine
Biopsy
Luteal Phase
156 Citations (Scopus)

A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome

Stamets, K., Taylor, D. S., Kunselman, A., Demers, L., Pelkman, C. L. & Legro, R., Mar 1 2004, In : Fertility and Sterility. 81, 3, p. 630-637 8 p.

Research output: Contribution to journalArticle

Reducing Diet
Polycystic Ovary Syndrome
Diet
Weight Loss
Fats
274 Citations (Scopus)

Detecting Insulin Resistance in Polycystic Ovary Syndrome: Purposes and Pitfalls

Legro, R., Castracane, V. D. & Kauffman, R. P., Feb 1 2004, In : Obstetrical and Gynecological Survey. 59, 2, p. 141-154 14 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Insulin Resistance
Glucose Intolerance
Glucose Tolerance Test
Dyslipidemias
102 Citations (Scopus)

Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: The Penn State Young Women's Health Study

Petit, M. A., Beck, T. J., Lin, H. M., Bentley, C., Legro, R. & Lloyd, T., Sep 1 2004, In : Bone. 35, 3, p. 750-759 10 p.

Research output: Contribution to journalArticle

Women's Health
Thigh
Steroids
Bone and Bones
Neck
204 Citations (Scopus)

Histological dating of timed endometrial biopsy tissue is not related to fertility status

Coutifaris, C., Myers, E. R., Guzick, D. S., Diamond, M. P., Carson, S. A., Legro, R., McGovern, P. G., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Silva, S., Vogel, D. L. & Leppert, P. C., Jan 1 2004, In : Fertility and sterility. 82, 5, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

Fertility
Biopsy
Infertility
Luteal Phase
Endometrium
2 Citations (Scopus)

Polycystic Ovarian Syndrome

Legro, R., Jan 1 2004, The Ovary: Second Edition. Elsevier Inc., p. 489-512 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polycystic Ovary Syndrome
Hirsutism
Uterine Diseases
Anovulation
Christianity
34 Citations (Scopus)

Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome?

Legro, R. & Myers, E., Jan 1 2004, In : Human Reproduction. 19, 8, p. 1697-1704 8 p.

Research output: Contribution to journalReview article

Polycystic Ovary Syndrome
Biomarkers
Clinical Trials
Ovulation
Pregnancy
120 Citations (Scopus)

Valproate Potentiates Androgen Biosynthesis in Human Ovarian Theca Cells

Nelson-DeGrave, V. L., Wickenheisser, J. K., Cockrell, J. E., Wood, J. R., Legro, R. S., Strauss, J. F. & McAllister, J. M., Feb 1 2004, In : Endocrinology. 145, 2, p. 799-808 10 p.

Research output: Contribution to journalArticle

Theca Cells
Valproic Acid
Androgens
Acetylation
Dehydroepiandrosterone
2003
3 Citations (Scopus)
Chromatography
Hydrocortisone