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Research Output 1992 2019

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Article
2009
48 Citations (Scopus)

Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2

Biyasheva, A., Legro, R. S., Dunaif, A. & Urbanek, M., Jul 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 7, p. 2617-2625 9 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Glucose Intolerance
Polycystic Ovary Syndrome
Medical problems
Type 2 Diabetes Mellitus
43 Citations (Scopus)
Polycystic Ovary Syndrome
Nutrition
Testosterone
Obesity
Health
18 Citations (Scopus)

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women

Chen, C., Wickenheisser, J., Ewens, K. G., Ankener, W., Legro, R. S., Dunaif, A., McAllister, J. M., Spielman, R. S. & Strauss, J. F., Jul 30 2009, In : Molecular Human Reproduction. 15, 8, p. 459-469 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Androgens
Single Nucleotide Polymorphism
Cyclic AMP
Theca Cells
2 Citations (Scopus)

Polycystic ovary syndrome and cardiovascular disease risk

Legro, R., Dec 1 2009, In : Current Cardiovascular Risk Reports. 3, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Cardiovascular Diseases
Hyperinsulinism
Dyslipidemias
Menopause
40 Citations (Scopus)

Predictors of pregnancy in women with polycystic ovary syndrome

Rausch, M. E., Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Leppert, P. C., Myers, E. R. & Coutifaris, C., Sep 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3458-3466 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Live Birth
Ovulation
Pregnancy
History
1018 Citations (Scopus)

The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E. & Witchel, S. F., Feb 1 2009, In : Fertility and sterility. 91, 2, p. 456-488 33 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Advisory Committees
Androgens
Hyperandrogenism
Consensus
12 Citations (Scopus)

The role of genetic variation in the lamin A/C gene in the etiology of polycystic ovary syndrome

Urbanek, M., Nampiaparampil, G., D'Souza, J., Sefton, E., Ackerman, C., Legro, R. S. & Dunaif, A., Jul 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 7, p. 2665-2669 5 p.

Research output: Contribution to journalArticle

Lamin Type A
Polycystic Ovary Syndrome
Lamins
Genes
Association reactions
2008
9 Citations (Scopus)
Reproduction
Clinical Trials
African Americans
Volunteers
Research
346 Citations (Scopus)

Consensus on infertility treatment related to polycystic ovary syndrome

Tarlatzis, B. C., Fauser, B. C. J. M., Legro, R. S., Norman, R. J., Hoeger, K., Pasquali, R., Franks, S., Messinis, I. E., Casper, R. F., Homburg, R., Lobo, R., Rebar, R. W., Fleming, R., Carr, B. R., Bouchard, P., Chang, J., Hugues, J. N., Azziz, R., Kolibianakis, E. M., Griesinger, G. & 11 others, Diedrich, K., Balen, A., Farquhar, C., Devroey, P., Ho, P. C., Collins, J., Goulis, D. G., Eijkemans, R., Crosignani, P. G., DeCherney, A. & Van Steirteghem, A., Mar 2008, In : Human Reproduction. 23, 3, p. 462-477 16 p.

Research output: Contribution to journalArticle

Ovulation Induction
Polycystic Ovary Syndrome
Infertility
Consensus
Clomiphene
127 Citations (Scopus)

Diminished paternity and gonadal function with increasing obesity in men

Pauli, E., Legro, R., Demers, L., Kunselman, A., Dodson, W. & Lee, P., Aug 1 2008, In : Fertility and sterility. 90, 2, p. 346-351 6 p.

Research output: Contribution to journalArticle

Paternity
Obesity
Skinfold Thickness
Body Mass Index
Semen Analysis
5 Citations (Scopus)

Does polycystic ovary syndrome increase the disparity in metabolic syndrome and cardiovascular-related health for African-American women?

Coney, P. J., Ladson, G., Sweet, S. & Legro, R., Jan 1 2008, In : Seminars in Reproductive Medicine. 26, 1, p. 35-38 4 p.

Research output: Contribution to journalArticle

Metabolic Syndrome X
Polycystic Ovary Syndrome
African Americans
Health
Cardiovascular Diseases
60 Citations (Scopus)

Effects of continuous versus cyclical oral contraception: A randomized controlled trial

Legro, R. S., Pauli, J. G., Kunselman, A. R., Meadows, J. W., Kesner, J. S., Zaino, R. J., Demers, L. M., Gnatuk, C. L. & Dodson, W. C., Feb 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 420-429 10 p.

Research output: Contribution to journalArticle

Contraception
Randomized Controlled Trials
Ultrasonics
Ethinyl Estradiol
Hemorrhage
38 Citations (Scopus)

Evidence for pancreatic β-cell dysfunction in brothers of women with polycystic ovary syndrome

Sam, S., Sung, Y. A., Legro, R. & Dunaif, A., Jan 1 2008, In : Metabolism: Clinical and Experimental. 57, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Siblings
Insulin Resistance
Glucose Tolerance Test
Type 2 Diabetes Mellitus
10 Citations (Scopus)

Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome

Cataldo, N. A., Barnhart, H. X., Legro, R. S., Myers, E. R., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Gosman, G., Nestler, J. E. & Giudice, L. C., Aug 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 8, p. 3124-3127 4 p.

Research output: Contribution to journalArticle

Clomiphene
Polycystic Ovary Syndrome
Metformin
Ovulation
National Institute of Child Health and Human Development (U.S.)
51 Citations (Scopus)
Hyperandrogenism
Polycystic Ovary Syndrome
Hyperinsulinism
Insulin
Puberty
7 Citations (Scopus)

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

McGovern, P. G., Carson, S. A., Barnhart, H. X., Myers, E. R., Legro, R. S., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C. & Giudice, L. C., Oct 1 2008, In : Fertility and sterility. 90, 4, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

National Institute of Child Health and Human Development (U.S.)
Reproductive Medicine
Medication Adherence
Polycystic Ovary Syndrome
Metformin
39 Citations (Scopus)

Metabolic phenotype in the brothers of women with polycystic ovary syndrome

Sam, S., Coviello, A. D., Sung, Y. A., Legro, R. S. & Dunaif, A., Jun 1 2008, In : Diabetes care. 31, 6, p. 1237-1241 5 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Siblings
Phenotype
Insulin Resistance
Dyslipidemias
80 Citations (Scopus)

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene

Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Ewens, K. G., Spielman, R. S., Leppert, P. C. & Myers, E. R., Mar 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 3, p. 792-800 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Metformin
Polymorphism
Ovulation
Body Mass Index
212 Citations (Scopus)

The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome

Katcher, H. I., Legro, R. S., Kunselman, A. R., Gillies, P. J., Demers, L. M., Bagshaw, D. M. & Kris-Etherton, P. M., Jan 1 2008, In : American Journal of Clinical Nutrition. 87, 1, p. 79-90 12 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Diet
Reducing Diet
Adipose Tissue
Weight Loss
2007
20 Citations (Scopus)

A 27-year-old woman with a diagnosis of polycystic ovary syndrome

Legro, R., Feb 7 2007, In : Journal of the American Medical Association. 297, 5, p. 509-519 11 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Menstruation
Weight Gain
Hirsutism
Expert Testimony
654 Citations (Scopus)

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Leppert, P. C. & Myers, E. R., Feb 8 2007, In : New England Journal of Medicine. 356, 6, p. 551-566 16 p.

Research output: Contribution to journalArticle

Clomiphene
Polycystic Ovary Syndrome
Metformin
Infertility
Group Psychotherapy
16 Citations (Scopus)

Hysterectomy and loss of fertility: Implications for women's mental health

Leppert, P. C., Legro, R. S. & Kjerulff, K. H., Sep 1 2007, In : Journal of Psychosomatic Research. 63, 3, p. 269-274 6 p.

Research output: Contribution to journalArticle

Women's Health
Hysterectomy
Fertility
Mental Health
Confusion
79 Citations (Scopus)

Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype

Urbanek, M., Sam, S., Legro, R. S. & Dunaif, A., Nov 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 11, p. 4191-4198 8 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Insulin
Phenotype
Chromosomes
Proinsulin
1 Citation (Scopus)

Metformin for infertility in PCOS: Going, going, gone

Legro, R., Dec 1 2007, In : Contemporary Ob/Gyn. 52, 12, p. 54-61 8 p.

Research output: Contribution to journalArticle

Clomiphene
Metformin
Infertility
Research
26 Citations (Scopus)

Pregnancy considerations in women with polycystic ovary syndrome

Legro, R., Mar 1 2007, In : Clinical obstetrics and gynecology. 50, 1, p. 295-304 10 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Pregnancy
Metformin
Clomiphene
Gestational Diabetes
67 Citations (Scopus)
rosiglitazone
Polycystic Ovary Syndrome
Metformin
Endometrium
Ovary
8 Citations (Scopus)

Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome

McGovern, P. G., Legro, R., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C. & Giudice, L. C., Feb 1 2007, In : Fertility and sterility. 87, 2, p. 442-444 3 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Infertility
Oligospermia
Ovulation
Multicenter Studies
2006
305 Citations (Scopus)
Polycystic Ovary Syndrome
Androgens
Insulin Resistance
Obesity
Insulin
36 Citations (Scopus)
Superovulation
Insemination
Obesity
Thinness
Gonadotropins
54 Citations (Scopus)

Brief Report: Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome

Hickey, T. E., Legro, R. & Norman, R. J., Jul 14 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 7, p. 2789-2791 3 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
X Chromosome Inactivation
X Chromosome
Chromosomes
Epigenomics
63 Citations (Scopus)

Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome

Sam, S., Legro, R. S., Essah, P. A., Apridonidze, T. & Dunaif, A., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7030-7035 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Mothers
Phenotype
LDL Lipoproteins
Nutrition Surveys
71 Citations (Scopus)

Fine mapping of genetic susceptibility to polycystic ovary syndrome on chromosome 19p13.2 and tests for regulatory activity

Stewart, D. R., Dombroski, B. A., Urbanek, M., Ankener, W., Ewens, K. G., Wood, J. R., Legro, R. S., Strauss, J. F., Dunaif, A. & Spielman, R. S., Oct 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 10, p. 4112-4117 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Genetic Predisposition to Disease
Chromosomes
Granulosa Cells
Alleles
83 Citations (Scopus)

Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea

Vgontzas, A., Trakada, G., Bixler, E., Lin, H. M., Pejovic, S., Zoumakis, E., Chrousos, G. P. & Legro, R., Aug 1 2006, In : Metabolism: Clinical and Experimental. 55, 8, p. 1076-1082 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Sleep Apnea Syndromes
Interleukin-6
Obesity
Insulin Resistance
1038 Citations (Scopus)

Position statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E. & Witchel, S. F., Nov 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 11, p. 4237-4245 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Androgens
Advisory Committees
Guidelines
Hyperandrogenism
445 Citations (Scopus)

Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome

Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., Ghazzi, M. N., Aronoff, S., Bernstein, R., Bodenner, D., Braithwaite, S., Cohen, J., DePaolo, D., Einhorn, D., Hone, J., Kenshole, A., Kilo, C., Kjos, S. L., Korytkowski, M., Koster, D., Lau, R. & 13 others, Lobo, R., Lucas, J., Martin, K., Meyer, W., Pek, S., Pfeifer, S., Rebar, R., Redmond, G., Rittmaster, R., Ross, P., Schwartz, S., Wild, R. & Yen, S. S. C., Jan 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 1, p. 48-53 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Glucose
Blood pressure
troglitazone
HDL Cholesterol
80 Citations (Scopus)

The Pregnancy in Polycystic Ovary Syndrome Study: baseline characteristics of the randomized cohort including racial effects

Legro, R., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Guidice, L. C. & Leppert, P. C., Oct 1 2006, In : Fertility and sterility. 86, 4, p. 914-933 20 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Ovary
Pregnancy
Phenotype
Oligomenorrhea
16 Citations (Scopus)

Type 2 diabetes and polycystic ovary syndrome

Legro, R., Jul 1 2006, In : Fertility and sterility. 86, SUPPL. 1

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Type 2 Diabetes Mellitus
Obesity
Anovulation
Glucose Intolerance
2005
105 Citations (Scopus)

Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome

Nelson-Degrave, V. L., Wickenheisser, J. K., Hendricks, K. L., Asano, T., Fujishiro, M., Legro, R. S., Kimball, S. R., Strauss, J. F. & McAllister, J. M., Feb 1 2005, In : Molecular Endocrinology. 19, 2, p. 379-390 12 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Mitogen-Activated Protein Kinase Kinases
Steroid 17-alpha-Hydroxylase
Androgens
110 Citations (Scopus)

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2

Urbanek, M., Woodroffe, A., Ewens, K. G., Diamanti-Kandarakis, E., Legro, R., Strauss, J. F., Dunaif, A. & Spielman, R. S., Dec 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 12, p. 6623-6629 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Chromosomes
Drawing (graphics)
Genes
DNA sequences
215 Citations (Scopus)
Polycystic Ovary Syndrome
Glucose Intolerance
Glucose
Medical problems
Type 2 Diabetes Mellitus
75 Citations (Scopus)

Dyslipidemia and metabolic syndrome in the sisters of women with polycystic ovary syndrome

Sam, S., Legro, R. S., Bentley-Lewis, R. & Dunaif, A., Aug 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4797-4802 6 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Dyslipidemias
Siblings
Lipids
LDL Lipoproteins
121 Citations (Scopus)

Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome

Ehrmann, D. A., Kasza, K., Azziz, R., Legro, R. & Ghazzi, M. N., Jan 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Women's Rights
Polycystic Ovary Syndrome
Medical problems
Type 2 Diabetes Mellitus
Glucose Intolerance
18 Citations (Scopus)

Estimating live birth rates after ovulation induction in polycystic ovary syndrome: Sample size calculations for the pregnancy in polycystic ovary syndrome trial

Myers, E. R., Silva, S. G., Hafley, G., Kunselman, A., Nestler, J. E. & Legro, R., Jun 1 2005, In : Contemporary Clinical Trials. 26, 3, p. 271-280 10 p.

Research output: Contribution to journalArticle

Ovulation Induction
Polycystic Ovary Syndrome
Birth Rate
Live Birth
Sample Size
18 Citations (Scopus)

Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells

Ho, C. K. M., Wood, J. R., Stewart, D. R., Ewens, K., Ankener, W., Wickenheisser, J., Nelson-Degrave, V., Zhang, Z., Legro, R. S., Dunaif, A., McAllister, J. M., Spielman, R. & Strauss, J. F., Dec 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 12, p. 6596-6602 7 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Transcription
Genes
RNA
87 Citations (Scopus)
Anovulation
Polycystic Ovary Syndrome
Ovary
Phenotype
Insulin
50 Citations (Scopus)

Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome

Wickenheisser, J. K., Nelson-DeGrave, V. L., Hendricks, K. L., Legro, R. S., Strauss, J. F. & McAllister, J. M., Aug 1 2005, In : Journal of Clinical Endocrinology and Metabolism. 90, 8, p. 4858-4865 8 p.

Research output: Contribution to journalArticle

Theca Cells
Polycystic Ovary Syndrome
Biosynthesis
Retinoids
Tretinoin
2004
34 Citations (Scopus)

Absence of secretory endometrium after false-positive home urine luteinizing hormone testing

McGovern, P. G., Myers, E. R., Silva, S., Coutifaris, C., Carson, S. A., Legro, R., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Giudice, L. C., Leppert, P. C. & Diamond, M. P., Jan 1 2004, In : Fertility and sterility. 82, 5, p. 1273-1277 5 p.

Research output: Contribution to journalArticle

Luteinizing Hormone
Endometrium
Urine
Biopsy
Luteal Phase
159 Citations (Scopus)

A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome

Stamets, K., Taylor, D. S., Kunselman, A., Demers, L. M., Pelkman, C. L. & Legro, R. S., Mar 1 2004, In : Fertility and sterility. 81, 3, p. 630-637 8 p.

Research output: Contribution to journalArticle

Reducing Diet
Polycystic Ovary Syndrome
Diet
Weight Loss
Fats
102 Citations (Scopus)

Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: The Penn State Young Women's Health Study

Petit, M. A., Beck, T. J., Lin, H. M., Bentley, C., Legro, R. S. & Lloyd, T., Sep 1 2004, In : Bone. 35, 3, p. 750-759 10 p.

Research output: Contribution to journalArticle

Women's Health
Thigh
Steroids
Bone and Bones
Neck
205 Citations (Scopus)

Histological dating of timed endometrial biopsy tissue is not related to fertility status

Coutifaris, C., Myers, E. R., Guzick, D. S., Diamond, M. P., Carson, S. A., Legro, R., McGovern, P. G., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Silva, S., Vogel, D. L. & Leppert, P. C., Jan 1 2004, In : Fertility and sterility. 82, 5, p. 1264-1272 9 p.

Research output: Contribution to journalArticle

Fertility
Biopsy
Infertility
Luteal Phase
Endometrium