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Research Output 1971 2019

2019
2 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Kong, L., Yanosky, J., Mailman, R. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

Research output: Contribution to journalArticle

Manganese
Alzheimer Disease
Hippocampus
Brain
Diffusion tensor imaging
2018
11 Citations (Scopus)

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R., Hyman, D. L., Carter, L. P. & Janowsky, A., Aug 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journalArticle

Dopamine Uptake Inhibitors
Narcolepsy
Obstructive Sleep Apnea
Inhibitory Concentration 50
Norepinephrine
1 Citation (Scopus)

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Arrestin
Prefrontal Cortex
Short-Term Memory
Dopamine
Adenylyl Cyclases
11 Citations (Scopus)

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

Research output: Contribution to journalArticle

Substantia Nigra
Control Groups
Parkinson Disease
Longitudinal Studies
Pars Reticulata
3 Citations (Scopus)

Effect of manganese on neural endocrine hormones in serum of welders and smelters

Ou, S. Y., Luo, H. L., Mailman, R., Li, Z. C., Zhang, Y. W., Cai, M., Huang, X. W., Li, S. J. & Jiang, Y. M., Dec 1 2018, In : Journal of Trace Elements in Medicine and Biology. 50, p. 1-7 7 p.

Research output: Contribution to journalArticle

Manganese
Hormones
Serum
Occupational Exposure
Erythrocytes
17 Citations (Scopus)

Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

Rossi, A., Berger, K., Chen, H., Leslie, D., Mailman, R. & Huang, X., Jan 1 2018, In : Movement Disorders. 33, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Smoking
Resource Allocation
Censuses
Population
2 Citations (Scopus)

Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze

Yang, Y. & Mailman, R., May 2 2018, In : Behavioural Brain Research. 343, p. 50-60 11 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Short-Term Memory
Neurons
Social Adjustment
Task Performance and Analysis
11 Citations (Scopus)

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

Synucleins
Parkinsonian Disorders
Substantia Nigra
Pathology
Iron
1 Citation (Scopus)

Welding-related brain and functional changes in welders with chronic and low-level exposure

Lee, E. Y., Flynn, M. R., Lewis, M., Mailman, R. & Huang, X., Jan 1 2018, In : NeuroToxicology. 64, p. 50-59 10 p.

Research output: Contribution to journalArticle

Welding
Manganese
Brain
Basal Ganglia
Magnetic resonance imaging
2017
6 Citations (Scopus)

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Eslinger, P., Flynn, M. R., Wagner, D., Du, G., Lewis, M., Kong, L., Mailman, R. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Brain
Neuropsychological Tests
2 Citations (Scopus)

Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M., Yao, T., Mailman, R., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
LDL Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Propensity Score
2 Citations (Scopus)

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Diffusion tensor imaging
Basal Ganglia
Pesticides
Corpus Striatum
Globus Pallidus
39 Citations (Scopus)

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Arnsten, A. F. T., Girgis, R. R., Gray, D. L. & Mailman, R., Jan 1 2017, In : Biological Psychiatry. 81, 1, p. 67-77 11 p.

Research output: Contribution to journalReview article

Prefrontal Cortex
Dopamine
Schizophrenia
Short-Term Memory
Therapeutics
18 Citations (Scopus)

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Liu, G., Sterling, N. W., Kong, L., Lewis, M., Mailman, R., Chen, H., Leslie, D. & Huang, X., Jun 1 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Parkinson Disease
Databases
Odds Ratio
Prescriptions
2016
10 Citations (Scopus)

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A., Connor, J., Yang, Q., Mailman, R. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood
6 Citations (Scopus)

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journalArticle

Welding
Blood
Globus Pallidus
Biomarkers
Brain
7 Citations (Scopus)

Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

Research output: Contribution to journalArticle

Welding
Globus Pallidus
Anisotropy
Manganese
Basal Ganglia
66 Citations (Scopus)

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M., Kong, L., Wang, Y., Connor, J., Mailman, R. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

Mesencephalon
Parkinson Disease
Iron
Levodopa
Magnetic Resonance Imaging
18 Citations (Scopus)

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

Lewis, M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P., Mailman, R. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Atrophy
Parkinson Disease
Corpus Striatum
Putamen
Gray Matter
Tyrosine 3-Monooxygenase
Gait
Freezing
Parkinson Disease
Catecholamines
2015
42 Citations (Scopus)

Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder

Rosell, D. R., Zaluda, L. C., McClure, M. M., Perez-Rodriguez, M. M., Strike, K. S., Barch, D. M., Harvey, P. D., Girgis, R. R., Hazlett, E. A., Mailman, R., Abi-Dargham, A., Lieberman, J. A. & Siever, L. J., Jan 1 2015, In : Neuropsychopharmacology. 40, 2, p. 446-453 8 p.

Research output: Contribution to journalArticle

Schizotypal Personality Disorder
Dopamine Agonists
Short-Term Memory
Schizophrenia
Placebos
57 Citations (Scopus)

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

Huang, X., Alonso, A., Guo, X., Umbach, D. M., Lichtenstein, M. L., Ballantyne, C. M., Mailman, R., Mosley, T. H. & Chen, H., Apr 1 2015, In : Movement Disorders. 30, 4, p. 552-559 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Parkinson Disease
Cholesterol
Prospective Studies
Lipids
22 Citations (Scopus)

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Manganese
Brain
Tissue
Welding
Globus Pallidus
2014
5 Citations (Scopus)

A novel role of CDX1 in embryonic epicardial development

Chu, M., Wang, L., Wang, H., Shen, T., Yang, Y., Sun, Y., Tang, N., Ni, T., Zhu, J., Mailman, R. & Wang, Y., Jul 28 2014, In : PloS one. 9, 7, e103271.

Research output: Contribution to journalArticle

pericardium
Epithelial-Mesenchymal Transition
Pericardium
smooth muscle
Embryonic Development
16 Citations (Scopus)

Dopamine D1receptor signaling: Does GαQ-phospholipase C actually play a role?

Lee, S. M., Yang, Y. & Mailman, R., Oct 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 1, p. 9-17 9 p.

Research output: Contribution to journalReview article

Type C Phospholipases
Dopamine
Adenylyl Cyclases
Azepines
Benzazepines
13 Citations (Scopus)

Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

Research output: Contribution to journalArticle

Substantia Nigra
Pesticides
Parkinson Disease
Anisotropy
Magnetic resonance

Response

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 7, p. 291 1 p.

Research output: Contribution to journalLetter

Neurotoxicity Syndromes
Gene-Environment Interaction
Environmental Pollutants
Paraquat
Herbicides
18 Citations (Scopus)

SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C

Lee, S. M., Kant, A., Blake, D., Murthy, V., Boyd, K., Wyrick, S. J. & Mailman, R., Jan 1 2014, In : Neuropharmacology. 86, p. 145-154 10 p.

Research output: Contribution to journalArticle

Dopamine D1 Receptors
Type C Phospholipases
Ligands
Adenylyl Cyclases
Primate Diseases
10 Citations (Scopus)

The perplexing paradox of paraquat: The case for host-based susceptibility and postulated neurodegenerative effects

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., Jan 1 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 5, p. 191-197 7 p.

Research output: Contribution to journalArticle

Paraquat
Gene-Environment Interaction
Herbicides
Biomarkers
Agriculture
33 Citations (Scopus)

Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells

Zhang, X., Li, B., Li, W., Ma, L., Zheng, D., Li, L., Yang, W., Chu, M., Chen, W., Mailman, R., Zhu, J., Fan, G., Archer, T. K. & Wang, Y., Sep 9 2014, In : Stem Cell Reports. 3, 3, p. 460-474 15 p.

Research output: Contribution to journalArticle

Stem cells
Genes
Acetylation
Chromatin
Specifications
2013
27 Citations (Scopus)

Higher iron in the red nucleus marks Parkinson's dyskinesia

Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

Research output: Contribution to journalArticle

Red Nucleus
Dyskinesias
Parkinson Disease
Iron
Levodopa
2012
2 Citations (Scopus)

D1/D5 Dopamine Agonists as Pharmacotherapy for Schizophrenia

Boyd, K. N. & Mailman, R. B., Jun 24 2012, Targets and Emerging Therapies for Schizophrenia. John Wiley and Sons, p. 51-84 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drug therapy
Dopamine Agonists
37 Citations (Scopus)

Dopamine receptor signaling and current and future antipsychotic drugs

Boyd, K. N. & Mailman, R., 2012, Current Antipsychotics. Vol. 212. p. 53-86 34 p. (Handbook of Experimental Pharmacology; vol. 212).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dopamine Receptors
Antipsychotic Agents
Dopamine D1 Receptors
Dopamine D2 Receptors
Pharmaceutical Preparations
16 Citations (Scopus)

Receptor conformations involved in dopamine D 2L receptor functional selectivity induced by selected transmembrane-5 serine mutations

Fowler, J. C., Bhattacharya, S., Urban, J. D., Vaidehi, N. & Mailman, R., Jun 1 2012, In : Molecular Pharmacology. 81, 6, p. 820-831 12 p.

Research output: Contribution to journalArticle

Serine
Dopamine
Ligands
Mutation
Quinpirole
9 Citations (Scopus)

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M., Shaffer, M. L., Chen, H., Yang, Q., Mailman, R. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journalArticle

Parkinson disease
Parkinson Disease
Cholesterol
cholesterol
Iron
2011
25 Citations (Scopus)

Apolipoprotein E genotypes and the risk of Parkinson disease

Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Jan 1 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

Research output: Contribution to journalArticle

Apolipoproteins E
Parkinson Disease
Odds Ratio
Genotype
Confidence Intervals
78 Citations (Scopus)

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Lewis, M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

Research output: Contribution to journalArticle

Tremor
Parkinson Disease
Corpus Striatum
Hypokinesia
Basal Ganglia Diseases
28 Citations (Scopus)

Serum cholesterol and the progression of parkinson's disease: Results from DATATOP

Huang, X., Auinger, P., Eberly, S., Oakes, D., Schwarzschild, M., Ascherio, A., Mailman, R. & Chen, H., Aug 18 2011, In : PloS one. 6, 8, e22854.

Research output: Contribution to journalArticle

Selegiline
Tocopherols
Parkinson disease
Parkinsonian Disorders
tocopherols
2010
14 Citations (Scopus)

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery

Mailman, R. & Murthy, V., Jan 1 2010, In : Neuropsychopharmacology. 35, 1, p. 345-346 2 p.

Research output: Contribution to journalShort survey

Receptor, Serotonin, 5-HT2B
Competitive Binding
Dopamine D2 Receptors
Psychotropic Drugs
Drug Discovery

Reply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?

Huang, X., Chen, H., Petrovitch, H., Mailman, R. & Ross, W., Jan 15 2010, In : Movement Disorders. 25, 1, 1 p.

Research output: Contribution to journalLetter

Parkinson Disease
Cholesterol
125 Citations (Scopus)

Smoking duration, intensity, and risk of Parkinson disease

Chen, H., Huang, X., Guo, X., Mailman, R., Park, Y., Kamel, F., Umbach, D. M., Xu, Q., Hollenbeck, A., Schatzkin, A. & Blair, A., Mar 16 2010, In : Neurology. 74, 11, p. 878-884 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Smoking
Tobacco Products
Logistic Models
Odds Ratio
145 Citations (Scopus)

Third generation antipsychotic drugs: Partial agonism or receptor functional selectivity?

Mailman, R. & Murthy, V., Mar 22 2010, In : Current Pharmaceutical Design. 16, 5, p. 488-501 14 p.

Research output: Contribution to journalReview article

Drug Partial Agonism
Drug Receptors
Antipsychotic Agents
olanzapine
Pharmaceutical Preparations
2009
32 Citations (Scopus)

Asymmetrical lateral ventricular enlargement in Parkinson's disease

Lewis, M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. & Huang, X., Apr 1 2009, In : European Journal of Neurology. 16, 4, p. 475-481 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Lateral Ventricles
Disease Progression
Healthy Volunteers
Hand
2 Citations (Scopus)

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

Brown, J. T., Kant, A. & Mailman, R., Mar 15 2009, In : Journal of Neuroscience Methods. 177, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Cyclic AMP
Radioimmunoassay
Costs and Cost Analysis
Antibodies
2008
67 Citations (Scopus)

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia aging study

Huang, X., Abbott, R. D., Petrovitch, H., Mailman, R. & Ross, G. W., May 15 2008, In : Movement Disorders. 23, 7, p. 1013-1018 6 p.

Research output: Contribution to journalArticle

LDL Cholesterol
Parkinson Disease
Coffee
Fasting
Smoking
2007
152 Citations (Scopus)

Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways

Urban, J. D., Vargas, G. A., Von Zastrow, M. & Mailman, R., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Mitogen-Activated Protein Kinases
Arachidonic Acid
Guanosine Triphosphate
G Protein-Coupled Inwardly-Rectifying Potassium Channels
71 Citations (Scopus)

A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia

George, M. S., Molnar, C. E., Grenesko, E. L., Anderson, B., Mu, Q., Johnson, K., Nahas, Z., Knable, M., Fernandes, P., Juncos, J., Huang, X., Nichols, D. E. & Mailman, R., Jul 1 2007, In : Schizophrenia Research. 93, 1-3, p. 42-50 9 p.

Research output: Contribution to journalArticle

Dopamine Agonists
Schizophrenia
Short-Term Memory
Perfusion
Magnetic Resonance Imaging
63 Citations (Scopus)

A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Mu, Q., Johnson, K., Morgan, P. S., Grenesko, E. L., Molnar, C. E., Anderson, B., Nahas, Z., Kozel, F. A., Kose, S., Knable, M., Fernandes, P., Nichols, D. E., Mailman, R. & George, M. S., Aug 1 2007, In : Schizophrenia Research. 94, 1-3, p. 332-341 10 p.

Research output: Contribution to journalArticle

Dopamine Agonists
Schizophrenia
Perfusion
Primates
Dopamine