Richard Mailman

2019

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journal › Article

5 Scopus citations

Cancer and the dopamine D₂ receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journal › Review article

2 Scopus citations

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Kong, L., Yanosky, J. D., Mailman, R. B. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

Research output: Contribution to journal › Article

1 Scopus citations

2018

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R., Hyman, D. L., Carter, L. P. & Janowsky, A., Aug 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journal › Article

16 Scopus citations

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R. B., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journal › Article

2 Scopus citations

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

Research output: Contribution to journal › Article

15 Scopus citations

Effect of manganese on neural endocrine hormones in serum of welders and smelters

Ou, S. Y., Luo, H. L., Mailman, R., Li, Z. C., Zhang, Y. W., Cai, M., Huang, X. W., Li, S. J. & Jiang, Y. M., Dec 2018, In : Journal of Trace Elements in Medicine and Biology. 50, p. 1-7 7 p.

Research output: Contribution to journal › Article

3 Scopus citations

Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

Rossi, A., Berger, K., Chen, H., Leslie, D., Mailman, R. & Huang, X., Jan 2018, In : Movement Disorders. 33, 1, p. 156-159 4 p.

Research output: Contribution to journal › Article

22 Scopus citations

Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze

Yang, Y. & Mailman, R. B., May 2 2018, In : Behavioural Brain Research. 343, p. 50-60 11 p.

Research output: Contribution to journal › Article

5 Scopus citations

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

Research output: Contribution to journal › Article

14 Scopus citations

Welding-related brain and functional changes in welders with chronic and low-level exposure

Lee, E. Y., Flynn, M. R., Lewis, M. M., Mailman, R. B. & Huang, X., Jan 2018, In : NeuroToxicology. 64, p. 50-59 10 p.

Research output: Contribution to journal › Article

6 Scopus citations

2017

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Eslinger, P. J., Flynn, M. R., Wagner, D., Du, G., Lewis, M. M., Kong, L., Mailman, R. B. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

Research output: Contribution to journal › Article

7 Scopus citations

Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M. M., Yao, T., Mailman, R. B., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

Research output: Contribution to journal › Article

5 Scopus citations

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

Research output: Contribution to journal › Article

3 Scopus citations

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Arnsten, A. F. T., Girgis, R. R., Gray, D. L. & Mailman, R. B., Jan 1 2017, In : Biological Psychiatry. 81, 1, p. 67-77 11 p.

Research output: Contribution to journal › Review article

51 Scopus citations

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Liu, G., Sterling, N. W., Kong, L., Lewis, M. M., Mailman, R. B., Chen, H., Leslie, D. & Huang, X., Jun 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

Research output: Contribution to journal › Article

23 Scopus citations

2016

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

Research output: Contribution to journal › Article

11 Scopus citations

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journal › Article

6 Scopus citations

Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

Research output: Contribution to journal › Article

9 Scopus citations

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M. M., Kong, L., Wang, Y., Connor, J., Mailman, R. B. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journal › Article

73 Scopus citations

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

Lewis, M. M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P. J., Mailman, R. B. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

Research output: Contribution to journal › Article

22 Scopus citations

The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease

Tekin, I., Carkaci-Salli, N., Lewis, M. M., Mailman, R. B., Huang, X. & Vrana, K. E., Jan 1 2016, In : Parkinsonism and Related Disorders. 23, p. 86-90 5 p.

Research output: Contribution to journal › Article

1 Scopus citations

2015

Effects of the D₁ dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder

Rosell, D. R., Zaluda, L. C., McClure, M. M., Perez-Rodriguez, M. M., Strike, K. S., Barch, D. M., Harvey, P. D., Girgis, R. R., Hazlett, E. A., Mailman, R. B., Abi-Dargham, A., Lieberman, J. A. & Siever, L. J., Jan 1 2015, In : Neuropsychopharmacology. 40, 2, p. 446-453 8 p.

Research output: Contribution to journal › Article

48 Scopus citations

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

Huang, X., Alonso, A., Guo, X., Umbach, D. M., Lichtenstein, M. L., Ballantyne, C. M., Mailman, R. B., Mosley, T. H. & Chen, H., Apr 1 2015, In : Movement Disorders. 30, 4, p. 552-559 8 p.

Research output: Contribution to journal › Article

64 Scopus citations

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. B. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journal › Article

23 Scopus citations

2014

A novel role of CDX1 in embryonic epicardial development

Chu, M., Wang, L., Wang, H., Shen, T., Yang, Y., Sun, Y., Tang, N., Ni, T., Zhu, J., Mailman, R. B. & Wang, Y., Jul 28 2014, In : PloS one. 9, 7, e103271.

Research output: Contribution to journal › Article

5 Scopus citations

Dopamine D₁receptor signaling: Does Gα_Q-phospholipase C actually play a role?

Lee, S. M., Yang, Y. & Mailman, R. B., Oct 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 1, p. 9-17 9 p.

Research output: Contribution to journal › Review article

16 Scopus citations

Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

Research output: Contribution to journal › Article

13 Scopus citations

Response

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 7, p. 291 1 p.

Research output: Contribution to journal › Letter

SKF-83959 is not a highly-biased functionally selective D₁ dopamine receptor ligand with activity at phospholipase C

Lee, S. M., Kant, A., Blake, D., Murthy, V., Boyd, K., Wyrick, S. J. & Mailman, R. B., Nov 2014, In : Neuropharmacology. 86, p. 145-154 10 p.

Research output: Contribution to journal › Article

20 Scopus citations

The perplexing paradox of paraquat: The case for host-based susceptibility and postulated neurodegenerative effects

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., May 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 5, p. 191-197 7 p.

Research output: Contribution to journal › Article

10 Scopus citations

Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells

Zhang, X., Li, B., Li, W., Ma, L., Zheng, D., Li, L., Yang, W., Chu, M., Chen, W., Mailman, R. B., Zhu, J., Fan, G., Archer, T. K. & Wang, Y., Sep 9 2014, In : Stem Cell Reports. 3, 3, p. 460-474 15 p.

Research output: Contribution to journal › Article

34 Scopus citations

2013

Higher iron in the red nucleus marks Parkinson's dyskinesia

Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

Research output: Contribution to journal › Article

29 Scopus citations

2012

D₁/D₅ Dopamine Agonists as Pharmacotherapy for Schizophrenia

Boyd, K. N. & Mailman, R. B., Jun 24 2012, Targets and Emerging Therapies for Schizophrenia. John Wiley and Sons, p. 51-84 34 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Dopamine receptor signaling and current and future antipsychotic drugs

Boyd, K. N. & Mailman, R. B., Dec 3 2012, Current Antipsychotics. Gross, G., Gross, G. & Geyer, M. A. (eds.). p. 53-86 34 p. (Handbook of Experimental Pharmacology; vol. 212).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

41 Scopus citations

Receptor conformations involved in dopamine D _2L receptor functional selectivity induced by selected transmembrane-5 serine mutations

Fowler, J. C., Bhattacharya, S., Urban, J. D., Vaidehi, N. & Mailman, R. B., Jun 1 2012, In : Molecular pharmacology. 81, 6, p. 820-831 12 p.

Research output: Contribution to journal › Article

20 Scopus citations

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M. M., Shaffer, M. L., Chen, H., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journal › Article

11 Scopus citations

2011

Apolipoprotein E genotypes and the risk of Parkinson disease

Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Nov 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

Research output: Contribution to journal › Article

26 Scopus citations

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Lewis, M. M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. B. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

Research output: Contribution to journal › Article

82 Scopus citations

Serum cholesterol and the progression of parkinson's disease: Results from DATATOP

Huang, X., Auinger, P., Eberly, S., Oakes, D., Schwarzschild, M., Ascherio, A., Mailman, R. & Chen, H., Aug 18 2011, In : PloS one. 6, 8, e22854.

Research output: Contribution to journal › Article

31 Scopus citations

2010

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery

Mailman, R. & Murthy, V., Jan 1 2010, In : Neuropsychopharmacology. 35, 1, p. 345-346 2 p.

Research output: Contribution to journal › Short survey

14 Scopus citations

Reply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?

Huang, X., Chen, H., Petrovitch, H., Mailman, R. & Ross, W., Jan 15 2010, In : Movement Disorders. 25, 1, 1 p.

Research output: Contribution to journal › Letter

Smoking duration, intensity, and risk of Parkinson disease

Chen, H., Huang, X., Guo, X., Mailman, R. B., Park, Y., Kamel, F., Umbach, D. M., Xu, Q., Hollenbeck, A., Schatzkin, A. & Blair, A., Mar 16 2010, In : Neurology. 74, 11, p. 878-884 7 p.

Research output: Contribution to journal › Article

136 Scopus citations

Third generation antipsychotic drugs: Partial agonism or receptor functional selectivity?

Mailman, R. & Murthy, V., Mar 22 2010, In : Current Pharmaceutical Design. 16, 5, p. 488-501 14 p.

Research output: Contribution to journal › Review article

159 Scopus citations

2009

Asymmetrical lateral ventricular enlargement in Parkinson's disease

Lewis, M. M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. B. & Huang, X., Apr 1 2009, In : European Journal of Neurology. 16, 4, p. 475-481 7 p.

Research output: Contribution to journal › Article

33 Scopus citations

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

Brown, J. T., Kant, A. & Mailman, R. B., Mar 15 2009, In : Journal of Neuroscience Methods. 177, 2, p. 261-266 6 p.

Research output: Contribution to journal › Article

3 Scopus citations

2008

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia aging study

Huang, X., Abbott, R. D., Petrovitch, H., Mailman, R. B. & Ross, G. W., May 15 2008, In : Movement Disorders. 23, 7, p. 1013-1018 6 p.

Research output: Contribution to journal › Article

74 Scopus citations

2007

Aripiprazole has functionally selective actions at dopamine D₂ receptor-mediated signaling pathways

Urban, J. D., Vargas, G. A., Von Zastrow, M. & Mailman, R. B., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 67-77 11 p.

Research output: Contribution to journal › Article

158 Scopus citations

A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D₁ agonist, is safe and tolerated in patients with schizophrenia

George, M. S., Molnar, C. E., Grenesko, E. L., Anderson, B., Mu, Q., Johnson, K., Nahas, Z., Knable, M., Fernandes, P., Juncos, J., Huang, X., Nichols, D. E. & Mailman, R. B., Jul 1 2007, In : Schizophrenia Research. 93, 1-3, p. 42-50 9 p.

Research output: Contribution to journal › Article

72 Scopus citations

A single 20 mg dose of the full D₁ dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Mu, Q., Johnson, K., Morgan, P. S., Grenesko, E. L., Molnar, C. E., Anderson, B., Nahas, Z., Kozel, F. A., Kose, S., Knable, M., Fernandes, P., Nichols, D. E., Mailman, R. B. & George, M. S., Aug 1 2007, In : Schizophrenia Research. 94, 1-3, p. 332-341 10 p.

Research output: Contribution to journal › Article

66 Scopus citations

Richard Mailman, PhD