Richard Mailman, PhD &ndash; Research Output

2019

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journal › Article

Parkinson Disease

Cholesterol

Brain

Odds Ratio

Logistic Models

Cancer and the dopamine D₂ receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journal › Review article

Dopamine D2 Receptors

Pharmacology

Neoplasms

Ligands

Drug Therapy

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Kong, L., Yanosky, J., Mailman, R. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

Research output: Contribution to journal › Article

Manganese

Alzheimer Disease

Hippocampus

Brain

Diffusion tensor imaging

2018

11 Citations (Scopus)

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R., Hyman, D. L., Carter, L. P. & Janowsky, A., Aug 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journal › Article

Dopamine Uptake Inhibitors

Narcolepsy

Obstructive Sleep Apnea

Inhibitory Concentration 50

Norepinephrine

1 Citation (Scopus)

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journal › Article

Arrestin

Prefrontal Cortex

Short-Term Memory

Dopamine

Adenylyl Cyclases

11 Citations (Scopus)

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients

Du, G., Lewis, M., Sica, C., He, L., Connor, J., Kong, L., Mailman, R. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1423-1431 9 p.

Research output: Contribution to journal › Article

Substantia Nigra

Control Groups

Parkinson Disease

Longitudinal Studies

Pars Reticulata

3 Citations (Scopus)

Effect of manganese on neural endocrine hormones in serum of welders and smelters

Ou, S. Y., Luo, H. L., Mailman, R., Li, Z. C., Zhang, Y. W., Cai, M., Huang, X. W., Li, S. J. & Jiang, Y. M., Dec 1 2018, In : Journal of Trace Elements in Medicine and Biology. 50, p. 1-7 7 p.

Research output: Contribution to journal › Article

Manganese

Hormones

Serum

Occupational Exposure

Erythrocytes

17 Citations (Scopus)

Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

Rossi, A., Berger, K., Chen, H., Leslie, D., Mailman, R. & Huang, X., Jan 1 2018, In : Movement Disorders. 33, 1, p. 156-159 4 p.

Research output: Contribution to journal › Article

Parkinson Disease

Smoking

Resource Allocation

Censuses

Population

2 Citations (Scopus)

Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze

Yang, Y. & Mailman, R., May 2 2018, In : Behavioural Brain Research. 343, p. 50-60 11 p.

Research output: Contribution to journal › Article

Prefrontal Cortex

Short-Term Memory

Neurons

Social Adjustment

Task Performance and Analysis

11 Citations (Scopus)

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 1 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

Research output: Contribution to journal › Article

Synucleins

Parkinsonian Disorders

Substantia Nigra

Pathology

Iron

1 Citation (Scopus)

Welding-related brain and functional changes in welders with chronic and low-level exposure

Lee, E. Y., Flynn, M. R., Lewis, M., Mailman, R. & Huang, X., Jan 1 2018, In : NeuroToxicology. 64, p. 50-59 10 p.

Research output: Contribution to journal › Article

Welding

Manganese

Brain

Basal Ganglia

Magnetic resonance imaging

2017

6 Citations (Scopus)

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Eslinger, P., Flynn, M. R., Wagner, D., Du, G., Lewis, M., Kong, L., Mailman, R. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

Research output: Contribution to journal › Article

Welding

Caudate Nucleus

Manganese

Brain

Neuropsychological Tests

2 Citations (Scopus)

Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M., Yao, T., Mailman, R., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

Research output: Contribution to journal › Article

Parkinson Disease

Cholesterol

LDL Cholesterol

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Propensity Score

2 Citations (Scopus)

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

Research output: Contribution to journal › Article

Diffusion tensor imaging

Basal Ganglia

Pesticides

Corpus Striatum

Globus Pallidus

39 Citations (Scopus)

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Arnsten, A. F. T., Girgis, R. R., Gray, D. L. & Mailman, R., Jan 1 2017, In : Biological Psychiatry. 81, 1, p. 67-77 11 p.

Research output: Contribution to journal › Review article

Prefrontal Cortex

Dopamine

Schizophrenia

Short-Term Memory

Therapeutics

18 Citations (Scopus)

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Liu, G., Sterling, N. W., Kong, L., Lewis, M., Mailman, R., Chen, H., Leslie, D. & Huang, X., Jun 1 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

Research output: Contribution to journal › Article

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Parkinson Disease

Databases

Odds Ratio

Prescriptions

2016

10 Citations (Scopus)

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A., Connor, J., Yang, Q., Mailman, R. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

Research output: Contribution to journal › Article

Welding

Caudate Nucleus

Manganese

Basal Ganglia

Blood

6 Citations (Scopus)

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journal › Article

Welding

Blood

Globus Pallidus

Biomarkers

Brain

7 Citations (Scopus)

Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

Research output: Contribution to journal › Article

Welding

Globus Pallidus

Anisotropy

Manganese

Basal Ganglia

66 Citations (Scopus)

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M., Kong, L., Wang, Y., Connor, J., Mailman, R. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journal › Article

Mesencephalon

Parkinson Disease

Iron

Levodopa

Magnetic Resonance Imaging

18 Citations (Scopus)

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

Lewis, M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P., Mailman, R. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

Research output: Contribution to journal › Article

Atrophy

Parkinson Disease

Corpus Striatum

Putamen

Gray Matter

The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease

Tekin, I., Salli, N., Lewis, M., Mailman, R., Huang, X. & Vrana, K., Jan 1 2016, In : Parkinsonism and Related Disorders. 23, p. 86-90 5 p.

Research output: Contribution to journal › Article

Tyrosine 3-Monooxygenase

Gait

Freezing

Parkinson Disease

Catecholamines

2015

42 Citations (Scopus)

Effects of the D₁ dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder

Rosell, D. R., Zaluda, L. C., McClure, M. M., Perez-Rodriguez, M. M., Strike, K. S., Barch, D. M., Harvey, P. D., Girgis, R. R., Hazlett, E. A., Mailman, R., Abi-Dargham, A., Lieberman, J. A. & Siever, L. J., Jan 1 2015, In : Neuropsychopharmacology. 40, 2, p. 446-453 8 p.

Research output: Contribution to journal › Article

Schizotypal Personality Disorder

Dopamine Agonists

Short-Term Memory

Schizophrenia

Placebos

57 Citations (Scopus)

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

Huang, X., Alonso, A., Guo, X., Umbach, D. M., Lichtenstein, M. L., Ballantyne, C. M., Mailman, R., Mosley, T. H. & Chen, H., Apr 1 2015, In : Movement Disorders. 30, 4, p. 552-559 8 p.

Research output: Contribution to journal › Article

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Parkinson Disease

Cholesterol

Prospective Studies

Lipids

22 Citations (Scopus)

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journal › Article

Manganese

Brain

Tissue

Welding

Globus Pallidus

2014

5 Citations (Scopus)

A novel role of CDX1 in embryonic epicardial development

Chu, M., Wang, L., Wang, H., Shen, T., Yang, Y., Sun, Y., Tang, N., Ni, T., Zhu, J., Mailman, R. & Wang, Y., Jul 28 2014, In : PloS one. 9, 7, e103271.

Research output: Contribution to journal › Article

pericardium

Epithelial-Mesenchymal Transition

Pericardium

smooth muscle

Embryonic Development

16 Citations (Scopus)

Dopamine D₁receptor signaling: Does Gα_Q-phospholipase C actually play a role?

Lee, S. M., Yang, Y. & Mailman, R., Oct 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 1, p. 9-17 9 p.

Research output: Contribution to journal › Review article

Type C Phospholipases

Dopamine

Adenylyl Cyclases

Azepines

Benzazepines

13 Citations (Scopus)

Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

Research output: Contribution to journal › Article

Substantia Nigra

Pesticides

Parkinson Disease

Anisotropy

Magnetic resonance

Response

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 7, p. 291 1 p.

Research output: Contribution to journal › Letter

Neurotoxicity Syndromes

Gene-Environment Interaction

Environmental Pollutants

Paraquat

Herbicides

18 Citations (Scopus)

SKF-83959 is not a highly-biased functionally selective D₁ dopamine receptor ligand with activity at phospholipase C

Lee, S. M., Kant, A., Blake, D., Murthy, V., Boyd, K., Wyrick, S. J. & Mailman, R., Jan 1 2014, In : Neuropharmacology. 86, p. 145-154 10 p.

Research output: Contribution to journal › Article

Dopamine D1 Receptors

Type C Phospholipases

Ligands

Adenylyl Cyclases

Primate Diseases

10 Citations (Scopus)

The perplexing paradox of paraquat: The case for host-based susceptibility and postulated neurodegenerative effects

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., Jan 1 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 5, p. 191-197 7 p.

Research output: Contribution to journal › Article

Paraquat

Gene-Environment Interaction

Herbicides

Biomarkers

Agriculture

33 Citations (Scopus)

Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells

Zhang, X., Li, B., Li, W., Ma, L., Zheng, D., Li, L., Yang, W., Chu, M., Chen, W., Mailman, R., Zhu, J., Fan, G., Archer, T. K. & Wang, Y., Sep 9 2014, In : Stem Cell Reports. 3, 3, p. 460-474 15 p.

Research output: Contribution to journal › Article

Stem cells

Genes

Acetylation

Chromatin

Specifications

2013

27 Citations (Scopus)

Higher iron in the red nucleus marks Parkinson's dyskinesia

Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

Research output: Contribution to journal › Article

Red Nucleus

Dyskinesias

Parkinson Disease

Iron

Levodopa

2012

2 Citations (Scopus)

D₁/D₅ Dopamine Agonists as Pharmacotherapy for Schizophrenia

Boyd, K. N. & Mailman, R. B., Jun 24 2012, Targets and Emerging Therapies for Schizophrenia. John Wiley and Sons, p. 51-84 34 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Drug therapy

Dopamine Agonists

37 Citations (Scopus)

Dopamine receptor signaling and current and future antipsychotic drugs

Boyd, K. N. & Mailman, R., 2012, Current Antipsychotics. Vol. 212. p. 53-86 34 p. (Handbook of Experimental Pharmacology; vol. 212).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Dopamine Receptors

Antipsychotic Agents

Dopamine D1 Receptors

Dopamine D2 Receptors

Pharmaceutical Preparations

16 Citations (Scopus)

Receptor conformations involved in dopamine D _2L receptor functional selectivity induced by selected transmembrane-5 serine mutations

Fowler, J. C., Bhattacharya, S., Urban, J. D., Vaidehi, N. & Mailman, R., Jun 1 2012, In : Molecular Pharmacology. 81, 6, p. 820-831 12 p.

Research output: Contribution to journal › Article

Serine

Dopamine

Ligands

Mutation

Quinpirole

9 Citations (Scopus)

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M., Shaffer, M. L., Chen, H., Yang, Q., Mailman, R. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journal › Article

Parkinson disease

Parkinson Disease

Cholesterol

cholesterol

Iron

2011

25 Citations (Scopus)

Apolipoprotein E genotypes and the risk of Parkinson disease

Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Jan 1 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

Research output: Contribution to journal › Article

Apolipoproteins E

Parkinson Disease

Odds Ratio

Genotype

Confidence Intervals

78 Citations (Scopus)

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Lewis, M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

Research output: Contribution to journal › Article

Tremor

Parkinson Disease

Corpus Striatum

Hypokinesia

Basal Ganglia Diseases

28 Citations (Scopus)

Serum cholesterol and the progression of parkinson's disease: Results from DATATOP

Huang, X., Auinger, P., Eberly, S., Oakes, D., Schwarzschild, M., Ascherio, A., Mailman, R. & Chen, H., Aug 18 2011, In : PloS one. 6, 8, e22854.

Research output: Contribution to journal › Article

Selegiline

Tocopherols

Parkinson disease

Parkinsonian Disorders

tocopherols

2010

14 Citations (Scopus)

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery

Mailman, R. & Murthy, V., Jan 1 2010, In : Neuropsychopharmacology. 35, 1, p. 345-346 2 p.

Research output: Contribution to journal › Short survey

Receptor, Serotonin, 5-HT2B

Competitive Binding

Dopamine D2 Receptors

Psychotropic Drugs

Drug Discovery

Reply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?

Huang, X., Chen, H., Petrovitch, H., Mailman, R. & Ross, W., Jan 15 2010, In : Movement Disorders. 25, 1, 1 p.

Research output: Contribution to journal › Letter

Parkinson Disease

Cholesterol

125 Citations (Scopus)

Smoking duration, intensity, and risk of Parkinson disease

Chen, H., Huang, X., Guo, X., Mailman, R., Park, Y., Kamel, F., Umbach, D. M., Xu, Q., Hollenbeck, A., Schatzkin, A. & Blair, A., Mar 16 2010, In : Neurology. 74, 11, p. 878-884 7 p.

Research output: Contribution to journal › Article

Parkinson Disease

Smoking

Tobacco Products

Logistic Models

Odds Ratio

145 Citations (Scopus)

Third generation antipsychotic drugs: Partial agonism or receptor functional selectivity?

Mailman, R. & Murthy, V., Mar 22 2010, In : Current Pharmaceutical Design. 16, 5, p. 488-501 14 p.

Research output: Contribution to journal › Review article

Drug Partial Agonism

Drug Receptors

Antipsychotic Agents

olanzapine

Pharmaceutical Preparations

2009

32 Citations (Scopus)

Asymmetrical lateral ventricular enlargement in Parkinson's disease

Lewis, M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. & Huang, X., Apr 1 2009, In : European Journal of Neurology. 16, 4, p. 475-481 7 p.

Research output: Contribution to journal › Article

Parkinson Disease

Lateral Ventricles

Disease Progression

Healthy Volunteers

Hand

2 Citations (Scopus)

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

Brown, J. T., Kant, A. & Mailman, R., Mar 15 2009, In : Journal of Neuroscience Methods. 177, 2, p. 261-266 6 p.

Research output: Contribution to journal › Article

Adenylyl Cyclases

Cyclic AMP

Radioimmunoassay

Costs and Cost Analysis

Antibodies

2008

67 Citations (Scopus)

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia aging study

Huang, X., Abbott, R. D., Petrovitch, H., Mailman, R. & Ross, G. W., May 15 2008, In : Movement Disorders. 23, 7, p. 1013-1018 6 p.

Research output: Contribution to journal › Article

LDL Cholesterol

Parkinson Disease

Coffee

Fasting

Smoking

2007

152 Citations (Scopus)

Aripiprazole has functionally selective actions at dopamine D₂ receptor-mediated signaling pathways

Urban, J. D., Vargas, G. A., Von Zastrow, M. & Mailman, R., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 67-77 11 p.

Research output: Contribution to journal › Article

Dopamine D2 Receptors

Mitogen-Activated Protein Kinases

Arachidonic Acid

Guanosine Triphosphate

G Protein-Coupled Inwardly-Rectifying Potassium Channels

71 Citations (Scopus)

A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D₁ agonist, is safe and tolerated in patients with schizophrenia

George, M. S., Molnar, C. E., Grenesko, E. L., Anderson, B., Mu, Q., Johnson, K., Nahas, Z., Knable, M., Fernandes, P., Juncos, J., Huang, X., Nichols, D. E. & Mailman, R., Jul 1 2007, In : Schizophrenia Research. 93, 1-3, p. 42-50 9 p.

Research output: Contribution to journal › Article

Dopamine Agonists

Schizophrenia

Short-Term Memory

Perfusion

Magnetic Resonance Imaging

63 Citations (Scopus)

A single 20 mg dose of the full D₁ dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Mu, Q., Johnson, K., Morgan, P. S., Grenesko, E. L., Molnar, C. E., Anderson, B., Nahas, Z., Kozel, F. A., Kose, S., Knable, M., Fernandes, P., Nichols, D. E., Mailman, R. & George, M. S., Aug 1 2007, In : Schizophrenia Research. 94, 1-3, p. 332-341 10 p.

Research output: Contribution to journal › Article

Dopamine Agonists

Schizophrenia

Perfusion

Primates

Dopamine