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Research Output

2005

Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats

Padilla, S., Marshall, R. S., Hunter, D. L., Oxendine, S., Moser, V. C., Southerland, S. B. & Mailman, R. B., Nov 1 2005, In : Toxicological Sciences. 88, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2006

D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinsons' disease

Lewis, M. M., Huang, X., Nichols, D. E. & Mailman, R. B., Jun 1 2006, In : CNS and Neurological Disorders - Drug Targets. 5, 3, p. 345-353 9 p.

Research output: Contribution to journalReview article

27 Scopus citations

Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: Potential interaction with A2A and D2-like receptors

Leonard, S. K., Ferry-Leeper, P. & Mailman, R. B., Oct 30 2006, In : Brain research. 1117, 1, p. 25-37 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2007

Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways

Urban, J. D., Vargas, G. A., Von Zastrow, M. & Mailman, R. B., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia

George, M. S., Molnar, C. E., Grenesko, E. L., Anderson, B., Mu, Q., Johnson, K., Nahas, Z., Knable, M., Fernandes, P., Juncos, J., Huang, X., Nichols, D. E. & Mailman, R. B., Jul 1 2007, In : Schizophrenia Research. 93, 1-3, p. 42-50 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

Mu, Q., Johnson, K., Morgan, P. S., Grenesko, E. L., Molnar, C. E., Anderson, B., Nahas, Z., Kozel, F. A., Kose, S., Knable, M., Fernandes, P., Nichols, D. E., Mailman, R. B. & George, M. S., Aug 1 2007, In : Schizophrenia Research. 94, 1-3, p. 332-341 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Dopamine receptor pharmacology

Mailman, R. & Huang, X., Dec 1 2007, Parkinson's Disease and Related Disorders, Part I. Aminoff, M., Michael, F., Swaab, D., Koller, W. & Melamed, E. (eds.). p. 77-105 29 p. (Handbook of Clinical Neurology; vol. 83).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Functional selectivity and classical concepts of quantitative pharmacology

Urban, J. D., Clarke, W. P., Von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M. & Mailman, R. B., Jan 5 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

803 Scopus citations

Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors

Ryman-Rasmussen, J. P., Griffith, A., Oloff, S., Vaidehi, N., Brown, J. T., Goddard, W. A. & Mailman, R. B., Feb 1 2007, In : Neuropharmacology. 52, 2, p. 562-575 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

GPCR functional selectivity has therapeutic impact

Mailman, R., Aug 1 2007, In : Trends in Pharmacological Sciences. 28, 8, p. 390-396 7 p.

Research output: Contribution to journalArticle

170 Scopus citations

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Huang, X., Chen, H., Miller, W. C., Mailman, R., Woodard, J. L., Chen, P. C., Xiang, D., Murrow, R. W., Wang, Y. Z. & Poole, C., Feb 15 2007, In : Movement Disorders. 22, 3, p. 377-381 5 p.

Research output: Contribution to journalArticle

121 Scopus citations

Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries

Lewis, M. M., Slagle, C. G., Smith, A. B., Truong, Y., Bai, P., McKeown, M. J., Mailman, R. B., Belger, A. & Huang, X., Jun 15 2007, In : Neuroscience. 147, 1, p. 224-235 12 p.

Research output: Contribution to journalArticle

88 Scopus citations

Toxicant-Receptor Interactions: Fundamental Principles

Mailman, R. B., Oct 23 2007, Molecular and Biochemical Toxicology, Fourth Edition. John Wiley & Sons, Inc., p. 359-388 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2008

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia aging study

Huang, X., Abbott, R. D., Petrovitch, H., Mailman, R. B. & Ross, G. W., May 15 2008, In : Movement Disorders. 23, 7, p. 1013-1018 6 p.

Research output: Contribution to journalArticle

76 Scopus citations
2009

Asymmetrical lateral ventricular enlargement in Parkinson's disease

Lewis, M. M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. B. & Huang, X., Apr 1 2009, In : European Journal of Neurology. 16, 4, p. 475-481 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

Brown, J. T., Kant, A. & Mailman, R. B., Mar 15 2009, In : Journal of Neuroscience Methods. 177, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery

Mailman, R. & Murthy, V., Jan 1 2010, In : Neuropsychopharmacology. 35, 1, p. 345-346 2 p.

Research output: Contribution to journalShort survey

14 Scopus citations

Reply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?

Huang, X., Chen, H., Petrovitch, H., Mailman, R. & Ross, W., Jan 15 2010, In : Movement Disorders. 25, 1, 1 p.

Research output: Contribution to journalLetter

Smoking duration, intensity, and risk of Parkinson disease

Chen, H., Huang, X., Guo, X., Mailman, R. B., Park, Y., Kamel, F., Umbach, D. M., Xu, Q., Hollenbeck, A., Schatzkin, A. & Blair, A., Mar 16 2010, In : Neurology. 74, 11, p. 878-884 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Third generation antipsychotic drugs: Partial agonism or receptor functional selectivity?

Mailman, R. & Murthy, V., Mar 22 2010, In : Current Pharmaceutical Design. 16, 5, p. 488-501 14 p.

Research output: Contribution to journalReview article

160 Scopus citations
2011

Apolipoprotein E genotypes and the risk of Parkinson disease

Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Nov 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

Research output: Contribution to journalArticle

26 Scopus citations

Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease

Lewis, M. M., Du, G., Sen, S., Kawaguchi, A., Truong, Y., Lee, S., Mailman, R. B. & Huang, X., Mar 17 2011, In : Neuroscience. 177, p. 230-239 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Serum cholesterol and the progression of parkinson's disease: Results from DATATOP

Huang, X., Auinger, P., Eberly, S., Oakes, D., Schwarzschild, M., Ascherio, A., Mailman, R. & Chen, H., Aug 18 2011, In : PloS one. 6, 8, e22854.

Research output: Contribution to journalArticle

32 Scopus citations
2012

D1/D5 Dopamine Agonists as Pharmacotherapy for Schizophrenia

Boyd, K. N. & Mailman, R. B., Jun 24 2012, Targets and Emerging Therapies for Schizophrenia. John Wiley and Sons, p. 51-84 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Dopamine receptor signaling and current and future antipsychotic drugs

Boyd, K. N. & Mailman, R. B., Dec 3 2012, Current Antipsychotics. Gross, G., Gross, G. & Geyer, M. A. (eds.). p. 53-86 34 p. (Handbook of Experimental Pharmacology; vol. 212).

Research output: Chapter in Book/Report/Conference proceedingChapter

42 Scopus citations

Receptor conformations involved in dopamine D 2L receptor functional selectivity induced by selected transmembrane-5 serine mutations

Fowler, J. C., Bhattacharya, S., Urban, J. D., Vaidehi, N. & Mailman, R. B., Jun 1 2012, In : Molecular pharmacology. 81, 6, p. 820-831 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M. M., Shaffer, M. L., Chen, H., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Higher iron in the red nucleus marks Parkinson's dyskinesia

Lewis, M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. & Huang, X., May 1 2013, In : Neurobiology of Aging. 34, 5, p. 1497-1503 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

A novel role of CDX1 in embryonic epicardial development

Chu, M., Wang, L., Wang, H., Shen, T., Yang, Y., Sun, Y., Tang, N., Ni, T., Zhu, J., Mailman, R. B. & Wang, Y., Jul 28 2014, In : PloS one. 9, 7, e103271.

Research output: Contribution to journalArticle

5 Scopus citations

Dopamine D1receptor signaling: Does GαQ-phospholipase C actually play a role?

Lee, S. M., Yang, Y. & Mailman, R. B., Oct 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 1, p. 9-17 9 p.

Research output: Contribution to journalReview article

16 Scopus citations

Microstructural changes in the substantia nigra of asymptomatic agricultural workers

Du, G., Lewis, M., Sterling, N. W., Kong, L., Chen, H., Mailman, R. & Huang, X., Jan 1 2014, In : Neurotoxicology and Teratology. 41, p. 60-64 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Response

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 7, p. 291 1 p.

Research output: Contribution to journalLetter

SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C

Lee, S. M., Kant, A., Blake, D., Murthy, V., Boyd, K., Wyrick, S. J. & Mailman, R. B., Nov 2014, In : Neuropharmacology. 86, p. 145-154 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

The perplexing paradox of paraquat: The case for host-based susceptibility and postulated neurodegenerative effects

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., May 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 5, p. 191-197 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells

Zhang, X., Li, B., Li, W., Ma, L., Zheng, D., Li, L., Yang, W., Chu, M., Chen, W., Mailman, R. B., Zhu, J., Fan, G., Archer, T. K. & Wang, Y., Sep 9 2014, In : Stem Cell Reports. 3, 3, p. 460-474 15 p.

Research output: Contribution to journalArticle

35 Scopus citations
2015

Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder

Rosell, D. R., Zaluda, L. C., McClure, M. M., Perez-Rodriguez, M. M., Strike, K. S., Barch, D. M., Harvey, P. D., Girgis, R. R., Hazlett, E. A., Mailman, R. B., Abi-Dargham, A., Lieberman, J. A. & Siever, L. J., Jan 1 2015, In : Neuropsychopharmacology. 40, 2, p. 446-453 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

Huang, X., Alonso, A., Guo, X., Umbach, D. M., Lichtenstein, M. L., Ballantyne, C. M., Mailman, R. B., Mosley, T. H. & Chen, H., Apr 1 2015, In : Movement Disorders. 30, 4, p. 552-559 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. B. & Huang, X., Aug 1 2015, In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331.

Research output: Contribution to journalArticle

12 Scopus citations

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lower fractional anisotropy in the globus pallidus of asymptomatic welders, a marker for long-term welding exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Herring, A. H., Van Buren, E., Van Buren, S., Kong, L., Mailman, R. & Huang, X., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 165-173 9 p., kfw116.

Research output: Contribution to journalArticle

9 Scopus citations

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M. M., Kong, L., Wang, Y., Connor, J., Mailman, R. B. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

The pattern of gray matter atrophy in Parkinson’s disease differs in cortical and subcortical regions

Lewis, M. M., Du, G., Lee, E. Y., Nasralah, Z., Sterling, N. W., Zhang, L., Wagner, D., Kong, L., Tröster, A. I., Styner, M., Eslinger, P. J., Mailman, R. B. & Huang, X., Jan 1 2016, In : Journal of Neurology. 263, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
1 Scopus citations
2017

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Eslinger, P. J., Flynn, M. R., Wagner, D., Du, G., Lewis, M. M., Kong, L., Mailman, R. B. & Huang, X., Jan 1 2017, In : NeuroToxicology. 58, p. 66-74 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Circulating cholesterol levels may link to the factors influencing Parkinson's Risk

Zhang, L., Wang, X., Wang, M., Sterling, N. W., Du, G., Lewis, M. M., Yao, T., Mailman, R. B., Li, R. & Huang, X., Sep 27 2017, In : Frontiers in Neurology. 8, SEP, 501.

Research output: Contribution to journalArticle

5 Scopus citations

Lateralized basal ganglia vulnerability to pesticide exposure in asymptomatic agricultural workers

Lewis, M., Sterling, N. W., Du, G., Lee, E. Y., Shyu, G., Goldenberg, M., Allen, T., Stetter, C., Kong, L., Snipes, S. A., Jones, B. C., Chen, H., Mailman, R. & Huang, X., Jan 1 2017, In : Toxicological Sciences. 159, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Arnsten, A. F. T., Girgis, R. R., Gray, D. L. & Mailman, R. B., Jan 1 2017, In : Biological Psychiatry. 81, 1, p. 67-77 11 p.

Research output: Contribution to journalReview article

52 Scopus citations

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Liu, G., Sterling, N. W., Kong, L., Lewis, M. M., Mailman, R. B., Chen, H., Leslie, D. & Huang, X., Jun 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

Research output: Contribution to journalArticle

23 Scopus citations
2018

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R., Hyman, D. L., Carter, L. P. & Janowsky, A., Aug 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journalArticle

17 Scopus citations