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Research Output

Article

New σ-like receptor recognized by novel phenylaminotetralins: Ligand binding and functional studies

Booth, R. G., Wyrick, S. D., Baldessarini, R. J., Kula, N. S., Myers, A. M. & Mailman, R., Dec 1 1993, In : Molecular pharmacology. 44, 6, p. 1232-1239 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Noradrenergic hyperinnervation reduces the density of β-adrenergic receptors in rat cerebellum

Kendall Harden, T., Mailman, R. B., Mueller, R. A. & Breese, G. R., Apr 20 1979, In : Brain research. 166, 1, p. 194-198 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Novel (4-Phenylpiperidinyl)- and (4-Phenylpiperazinyl)alkyl-Spaced Esters of 1-Phenylcyclopentanecarboxylic Acids as Potent σ-Selective Compounds

Hudkins, R. L., Mailman, R. B. & DeHaven-Hudkins, D. L., Jun 1 1994, In : Journal of Medicinal Chemistry. 37, 13, p. 1964-1970 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Novel mechanisms of drug action: Functional selectivity at D2 dopamine receptors (a lesson for drug discovery)

Mailman, R. B. & Gay, E. A., Nov 8 2004, In : Medicinal Chemistry Research. 13, 1-2, p. 115-126 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

N-oxides of phenothiazine antipsychotics: Effects on in vivo and in vitro estimates of dopaminergic function

Lewis, M. H., Widerlov, E., Knight, D. L., Kilts, C. D. & Mailman, R., Sep 1 1983, In : Journal of Pharmacology and Experimental Therapeutics. 225, 3, p. 539-545 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Partial and full dopamine D1 agonists produce comparable increases in ventral pallidal neuronal activity: Contribution of endogenous dopamine

Heidenreich, B. A., Mailman, R., Nichols, D. E. & Napier, T. C., 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 1, p. 516-525 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Placebo, Double-Blind Evaluation of Long-Term Naltrexone Treatment Effects for Adults with Mental Retardation and Self-Injury

Bodfish, J. W., McCuller, W. R., Madison, J. M., Register, M., Mailman, R. B. & Lewis, M. H., Jan 1 1997, In : Journal of Developmental and Physical Disabilities. 9, 2, p. 135-152 18 p.

Research output: Contribution to journalArticle

18 Scopus citations

Postmortem stability of dopamine D1 receptor mRNA and D1 receptors

Gilmore, J. H., Lawler, C. P., Eaton, A. M. & Mailman, R., Jan 1 1993, In : Molecular Brain Research. 18, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Projection of the prevalence of Parkinson's disease in the coming decades: Revisited

Rossi, A., Berger, K., Chen, H., Leslie, D., Mailman, R. & Huang, X., Jan 2018, In : Movement Disorders. 33, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pyrethroid insecticides and radioligand displacement from the gaba receptor chloride ionophore complex

Crofton, K. M., Reiter, L. W. & Mailman, R., Jan 1 1987, In : Toxicology Letters. 35, 2-3, p. 183-190 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quantification of D1B (D5) receptors in dopamine D1A receptor-deficient mice

Montague, D. M., Striplin, C. D., Overcash, J. S., Drago, J., Lawler, C. P. & Mailman, R., Mar 15 2001, In : Synapse. 39, 4, p. 319-322 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Quantitative structure-activity relationship modeling of dopamine D1 antagonists using comparative molecular field analysis, genetic algorithms- partial least-squares, and K nearest neighbor methods

Hoffman, B., Cho, S. J., Zheng, W., Wyrick, S., Nichols, D. E., Mailman, R. B. & Tropsha, A., Aug 26 1999, In : Journal of Medicinal Chemistry. 42, 17, p. 3217-3226 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

Du, G., Liu, T., Lewis, M. M., Kong, L., Wang, Y., Connor, J., Mailman, R. B. & Huang, X., Mar 1 2016, In : Movement Disorders. 31, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays

Brown, J. T., Kant, A. & Mailman, R. B., Mar 15 2009, In : Journal of Neuroscience Methods. 177, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Rearing conditions alter social reactivity and D1 dopamine receptors in high- and low-aggressive mice

Gariépy, J. L., Gendreau, P. L., Mailman, R., Tancer, M. & Lewis, M. H., Aug 1995, In : Pharmacology, Biochemistry and Behavior. 51, 4, p. 767-773 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Receptor conformations involved in dopamine D 2L receptor functional selectivity induced by selected transmembrane-5 serine mutations

Fowler, J. C., Bhattacharya, S., Urban, J. D., Vaidehi, N. & Mailman, R. B., Jun 1 2012, In : Molecular pharmacology. 81, 6, p. 820-831 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain

Bunin, M. A., Prioleau, C., Mailman, R. & Wightman, R. M., Mar 1 1998, In : Journal of neurochemistry. 70, 3, p. 1077-1087 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Responses of dopaminergic and serotonergic systems to triethyllead intoxication

DeHaven-Hudkins, D. L., Schulz, D. W., Walsh, T. J. & Mailman, R., Jan 1 1988, In : Neurotoxicology and Teratology. 10, 4, p. 279-285 7 p.

Research output: Contribution to journalArticle

Reversal of neuroleptic actions with scopolamine: Restoration of function without changing spiroperidol binding

Ondrusek, M. G., Frye, G. D. & Mailman, R., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

RLH-033, a novel, potent and selective ligand for the σ1 recognition site

Hudkins, R. L., Mailman, R. B. & DeHaven-Hudkins, D. L., Dec 12 1994, In : European Journal of Pharmacology. 271, 1, p. 235-236 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

S(-)DP-5,6-ADTN as an in vivo dopamine receptor ligand: Relation between displacement by dopamine agonists and their pharmacological effects

Rollema, H., Feenstra, M. G. P., Grol, C. J., Lewis, M. H., Staples, L. & Mailman, R. B., Apr 1 1986, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 332, 4, p. 338-345 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

SCH-23390: A selective D1 dopamine antagonist with potent D2 behavioral actions

Mailman, R., Schulz, D. W., Lewis, M. H., Staples, L., Rollema, H. & Dehaven, D. L., May 18 1984, In : European Journal of Pharmacology. 101, 1-2, p. 159-160 2 p.

Research output: Contribution to journalArticle

145 Scopus citations

SCH23390 causes persistent antidopaminergic effects in vivo: Evidence for longterm occupation of receptors

Schulz, D. W., Staples, L. & Mailman, R. B., May 20 1985, In : Life Sciences. 36, 20, p. 1941-1948 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons

Napier, T. C., Givens, B. S., Schulz, D. W., Bunney, B. S., Breese, G. R. & Mailman, R. B., Aug 13 1986, In : Journal of Pharmacology and Experimental Therapeutics. 236, 3, p. 838-845 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease

Du, G., Lewis, M. M., Shaffer, M. L., Chen, H., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 17 2012, In : PloS one. 7, 4, e35397.

Research output: Contribution to journalArticle

11 Scopus citations

Serum cholesterol and the progression of parkinson's disease: Results from DATATOP

Huang, X., Auinger, P., Eberly, S., Oakes, D., Schwarzschild, M., Ascherio, A., Mailman, R. & Chen, H., Aug 18 2011, In : PloS one. 6, 8, e22854.

Research output: Contribution to journalArticle

32 Scopus citations

Serum concentrations of thioridazine, its major metabolites and serum neuroleptic‐like activities in schizophrenics with and without tardive dyskinesia

Widerlöv, E., Häggström, J. E., Kilts, C. D., Andersson, U., Breese, G. R. & Mailman, R. B., Oct 1982, In : Acta Psychiatrica Scandinavica. 66, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Serum effects confound the neuroleptic radioreceptor assay

Mailman, R. B., DeHaven, D. L., Halperin, E. A. & Lewis, M. H., Mar 12 1984, In : Life Sciences. 34, 11, p. 1057-1064 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
18 Scopus citations

Simultaneous determination of thioridazine and its sulfoxidized metabolites by HPLC: Use in clinical and preclinical metabolic studies

Kilts, C. D., Mailman, R., Hodgson, E. & Breese, G. R., Jan 1 1981, In : Federation Proceedings. 40, 3 I, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations
176 Scopus citations

SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C

Lee, S. M., Kant, A., Blake, D., Murthy, V., Boyd, K., Wyrick, S. J. & Mailman, R. B., Nov 2014, In : Neuropharmacology. 86, p. 145-154 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Smoking duration, intensity, and risk of Parkinson disease

Chen, H., Huang, X., Guo, X., Mailman, R. B., Park, Y., Kamel, F., Umbach, D. M., Xu, Q., Hollenbeck, A., Schatzkin, A. & Blair, A., Mar 16 2010, In : Neurology. 74, 11, p. 878-884 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Social reactivity and D1 dopamine receptors: Studies in mice selectively bred for high and low levels of aggression

Lewis, M. H., Gariépy, J. L., Gendreau, P., Nichols, D. E. & Mailman, R. B., Apr 1994, In : Neuropsychopharmacology. 10, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Spare receptors and intrinsic activity: Studies with D1 dopamine receptor agonists

Watts, V. J., Lawler, C. P., Gonzales, A. J., Zhou, QY. Y., Civelli, O., Nichols, D. E. & Mailman, R. B., Oct 1995, In : Synapse. 21, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

Huang, X., Alonso, A., Guo, X., Umbach, D. M., Lichtenstein, M. L., Ballantyne, C. M., Mailman, R. B., Mosley, T. H. & Chen, H., Apr 1 2015, In : Movement Disorders. 30, 4, p. 552-559 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

Liu, G., Sterling, N. W., Kong, L., Lewis, M. M., Mailman, R. B., Chen, H., Leslie, D. & Huang, X., Jun 2017, In : Movement Disorders. 32, 6, p. 913-917 5 p.

Research output: Contribution to journalArticle

23 Scopus citations
5 Scopus citations

Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs

Andersson, C., Hamer, R. M., Lawler, C. P., Mailman, R. & Lieberman, J. A., Jul 6 2002, In : Neuropsychopharmacology. 27, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Substituted naphthofurans as hallucinogenic phenethylamine -Ergoline hybrid molecules with unexpected muscarinic antagonist activity

Monte, A. P., Marona-Lewicka, D., Lewis, M. M., Mailman, R. B., Wainscott, D. B., Nelson, D. L. & Nichols, D. E., Jun 4 1998, In : Journal of Medicinal Chemistry. 41, 12, p. 2134-2145 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2 Scopus citations

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes

Lewis, M., Du, G., Baccon, J., Snyder, A., Murie, B., Cooper, F., Stetter, C., Kong, L., Sica, C., Mailman, R., Connor, J. & Huang, X., Sep 2018, In : Movement Disorders. 33, 9, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synthesis and Biological Evaluation of a Series of Substituted Benzo[α]phenanthridines as Agonists at D1 and D2 Dopamine Receptors

Knoerzer, T. A., Watts, V. J., Nichols, D. E. & Mailman, R. B., Aug 1 1995, In : Journal of Medicinal Chemistry. 38, 16, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane

Doll, M. K. H., Nichols, D. E., Kilts, J. D., Prioleau, C., Lawler, C. P., Lewis, M. M. & Mailman, R. B., Mar 11 1999, In : Journal of Medicinal Chemistry. 42, 5, p. 935-940 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Synthesis and evaluation of (S)-5-[125I]iodo-2,3-methylenedioxybenzamide

Mathis, C. A., Gerdes, J. M., Shulgin, A. T., Hanrahan, S., Faggin, B. & Mailman, R., Apr 5 1991, In : Journal of Labelled Compounds and Radiopharmaceuticals. 30, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations
59 Scopus citations

Synthesis and in Vitro Evaluation of 2,3-Dimethoxy-5-(fluoroalkyl)-Substituted Benzamides: High-Affinity Ligands for CNS Dopamine D2 Receptors

Bishop, J. E., Mathis, C. A., Gerdes, J. M., Whitney, J. M., Eaton, A. M. & Mailman, R. B., May 1 1991, In : Journal of Medicinal Chemistry. 34, 5, p. 1612-1624 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Synthesis and Molecular Modeling of 1-Phenyl-1,2,3,4-tetrahydroisoquinolines and Related 5,6,8,9-Tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 Dopamine Antagonists

Minor, D. L., Wyrick, S. D., Charifson, P. S., Watts, V. J., Mailman, R. B. & Mailman, R. B., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 25, p. 4317-4328 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1, 2, 3, 4-tetrahydroisoquinolines as dopamine receptor ligands

Charifson, P. S., Wyrick, S. D., Phillip Bowen, J., McDougald, D. L., Hoffman, A. J., Ademe Simmons, R. M. & Mailman, R., Feb 1 1988, In : Journal of Medicinal Chemistry. 31, 10, p. 1941-1946 6 p.

Research output: Contribution to journalArticle

42 Scopus citations