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Research Output

Short survey

Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery

Mailman, R. & Murthy, V., Jan 1 2010, In : Neuropsychopharmacology. 35, 1, p. 345-346 2 p.

Research output: Contribution to journalShort survey

14 Scopus citations
Review article

An alternative to animal models of central nervous system disorders: Study of drug mechanisms and disease symptoms in animals

Breese, G. R., Mueller, R. A., Mailman, R., Frye, G. D. & Vogel, R. A., Jan 1 1978, In : Progress in Neuro-Psychopharmacology. 2, 3, p. 313-325 13 p.

Research output: Contribution to journalReview article

8 Scopus citations

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

2 Scopus citations

D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinsons' disease

Lewis, M. M., Huang, X., Nichols, D. E. & Mailman, R. B., Jun 1 2006, In : CNS and Neurological Disorders - Drug Targets. 5, 3, p. 345-353 9 p.

Research output: Contribution to journalReview article

27 Scopus citations

Developing novel antipsychotic drugs: Strategies and goals

Miyamoto, S., Duncan, G. E., Mailman, R. B. & Lieberman, J. A., Jan 1 2000, In : Current Opinion in Central and Peripheral Nervous System Investigational Drugs. 2, 1, p. 25-39 15 p.

Research output: Contribution to journalReview article

26 Scopus citations

Dopamine D1receptor signaling: Does GαQ-phospholipase C actually play a role?

Lee, S. M., Yang, Y. & Mailman, R. B., Oct 1 2014, In : Journal of Pharmacology and Experimental Therapeutics. 351, 1, p. 9-17 9 p.

Research output: Contribution to journalReview article

16 Scopus citations

Effects of TRH on central nervous system function.

Breese, G. R., Mueller, R. A., Mailman, R. & Frye, G. D., Dec 1 1981, In : Progress in clinical and biological research. 68, p. 99-116 18 p.

Research output: Contribution to journalReview article

20 Scopus citations

Functional selectivity and classical concepts of quantitative pharmacology

Urban, J. D., Clarke, W. P., Von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M. & Mailman, R. B., Jan 5 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

801 Scopus citations

Importance of dopaminergic pathways and other neural systems to behavior and action of psychotropic drugs

Breese, G. R., Mueller, R. A., Hollister, A. & Mailman, R., Jan 1 1978, In : Federation Proceedings. 37, 10, p. 2429-2433 5 p.

Research output: Contribution to journalReview article

13 Scopus citations

Neurotoxicants and central catecholamine systems

Mailman, R. & Lewis, M. H., Jan 1 1987, In : NeuroToxicology. 8, 1, p. 123-140 18 p.

Research output: Contribution to journalReview article

11 Scopus citations

Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

Arnsten, A. F. T., Girgis, R. R., Gray, D. L. & Mailman, R. B., Jan 1 2017, In : Biological Psychiatry. 81, 1, p. 67-77 11 p.

Research output: Contribution to journalReview article

51 Scopus citations

Parkinson's disease and D1 dopamine receptors

Mailman, R., Huang, X. & Nichols, D. E., Dec 4 2001, In : Current Opinion in Investigational Drugs. 2, 11, p. 1582-1591 10 p.

Research output: Contribution to journalReview article

45 Scopus citations

Serotonergic basis of antipsychotic drug effects in schizophrenia

Lieberman, J. A., Mailman, R., Duncan, G., Sikich, L., Chakos, M., Nichols, D. E. & Kraus, J. E., Dec 1 1998, In : Biological Psychiatry. 44, 11, p. 1099-1117 19 p.

Research output: Contribution to journalReview article

179 Scopus citations

The multiplicity of the D1 dopamine receptor.

Mailman, R., Schulz, D. W., Kilts, C. D., Lewis, M. H., Rollema, H. & Wyrick, S., Dec 1 1986, In : Advances in experimental medicine and biology. 204, p. 53-72 20 p.

Research output: Contribution to journalReview article

32 Scopus citations

Third generation antipsychotic drugs: Partial agonism or receptor functional selectivity?

Mailman, R. & Murthy, V., Mar 22 2010, In : Current Pharmaceutical Design. 16, 5, p. 488-501 14 p.

Research output: Contribution to journalReview article

159 Scopus citations
Letter

. . And more comment [3]

Mailman, R. B., Dec 1 1981, In : Chemical and Engineering News. 59, 10, 1 p.

Research output: Contribution to journalLetter

Dopamine D1 receptor agonists as antiparkinson drugs [3] (multiple letters)

Mailman, R. B., Nichols, D. E. & Williams, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 7, p. 255-256 2 p.

Research output: Contribution to journalLetter

8 Scopus citations

Reply: Plasma cholesterol and Parkinson's disease: Is the puzzle only apparent?

Huang, X., Chen, H., Petrovitch, H., Mailman, R. & Ross, W., Jan 15 2010, In : Movement Disorders. 25, 1, 1 p.

Research output: Contribution to journalLetter

Response

Jones, B. C., Huang, X., Mailman, R., Lu, L. & Williams, R. W., 2014, In : Journal of Biochemical and Molecular Toxicology. 28, 7, p. 291 1 p.

Research output: Contribution to journalLetter

Editorial

Decline of dopamine: Effects of age and acute neuroleptic challenge

Lieberman, J. A. & Mailman, R., Jan 1 1998, In : American Journal of Psychiatry. 155, 3, p. 319-323 5 p.

Research output: Contribution to journalEditorial

6 Scopus citations
Comment/debate

Erratum: Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase (Journal of Pharcology and Experimental Therapeutics (2002) 301 (1166-1179))

Mottola, D. M., Kilts, J. D., Lewis, M. M., Connory, H. S., Walker, Q. D., Jones, S. R., Booth, R. G., Hyslop, D. K., Piercey, M., Wightman, R. M., Lawler, C. P., Nichols, D. E. & Mailman, R. B., Jul 4 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Erratum: Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs (Neuropsychopharmacology (2001) 27:2 (143-151) PII: S0893133X02002877)

Andersson, C., Hamer, R. M., Lawler, C. P., Mailman, R. & Lieberman, J. A., Sep 1 2002, In : Neuropsychopharmacology. 27, 3, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
Chapter

D1/D5 Dopamine Agonists as Pharmacotherapy for Schizophrenia

Boyd, K. N. & Mailman, R. B., Jun 24 2012, Targets and Emerging Therapies for Schizophrenia. John Wiley and Sons, p. 51-84 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Dopamine receptor pharmacology

Mailman, R. & Huang, X., Dec 1 2007, Parkinson's Disease and Related Disorders, Part I. Aminoff, M., Michael, F., Swaab, D., Koller, W. & Melamed, E. (eds.). p. 77-105 29 p. (Handbook of Clinical Neurology; vol. 83).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Dopamine receptor signaling and current and future antipsychotic drugs

Boyd, K. N. & Mailman, R. B., Dec 3 2012, Current Antipsychotics. Gross, G., Gross, G. & Geyer, M. A. (eds.). p. 53-86 34 p. (Handbook of Experimental Pharmacology; vol. 212).

Research output: Chapter in Book/Report/Conference proceedingChapter

41 Scopus citations

Toxicant-Receptor Interactions: Fundamental Principles

Mailman, R. B., Oct 23 2007, Molecular and Biochemical Toxicology, Fourth Edition. John Wiley & Sons, Inc., p. 359-388 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Article

[3H]SCH23390 has the characteristics of a dopamine receptor ligand in the rat central nervous system

Schulz, D. W., Wyrick, S. D. & Mailman, R., Oct 30 1984, In : European Journal of Pharmacology. 106, 1, p. 211-212 2 p.

Research output: Contribution to journalArticle

45 Scopus citations

1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and Related Derivatives as Ligands for the Neuromodulatory σ3 Receptor: Further Structure-Activity Relationships

Wyrick, S. D., Booth, R. G., Myers, A. M., Owens, C. E., Bucholtz, E. C., Hooper, P. C., Kula, N. S., Baldessarini, R. J. & Mailman, R., Sep 1 1995, In : Journal of Medicinal Chemistry. 38, 19, p. 3857-3864 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms

Grubbs, R. A., Lewis, M. M., Owens-Vance, C., Gay, E. A., Jassen, A. K., Mailman, R. B. & Nichols, D. E., Mar 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 6, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A potent full dopamine D1 agonist containing a rigid β-phenyldopamine pharmacophore

Ghosh, D., Snyder, S. E., Watts, V. J., Mailman, R. B. & Nichols, D. E., Jan 19 1996, In : Journal of Medicinal Chemistry. 39, 2, p. 549-555 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

A comparison of behavioral and neurochemical effects of ethanol and chlordiazepoxide.

Frye, G. D., Vogel, R. A., Mailman, R. B., Ondrusek, M. G., Wilson, J. H., Mueller, P. A. & Breese, G. R., Jan 1 1980, In : Advances in experimental medicine and biology. 132, p. 729-737 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

A computer-supported method for analyzing behavioral observations: Studies with stereotypy

Lewis, M. H., Baumeister, A. A., McCorkle, D. L. & Mailman, R. B., Feb 1 1985, In : Psychopharmacology. 85, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat

Walsh, T. J., Tilson, H. A., DeHaven, D. L., Mailman, R. B., Fisher, A. & Hanin, I., Oct 29 1984, In : Brain research. 321, 1, p. 91-102 12 p.

Research output: Contribution to journalArticle

184 Scopus citations

Amygdaloid D1 Receptors Are Not Linked to Stimulation of Adenylate Cyclase

Leonard, S. K., Anderson, C. M., Lachowicz, J. E., Schulz, D. W., Kilts, C. D. & Mailman, R. B., Dec 15 2003, In : Synapse. 50, 4, p. 320-333 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Analytical considerations for quantitative determination of serotonin and its metabolically related products in biological matrices

Mailman, R. & Kilts, C. D., Jan 1 1985, In : Clinical chemistry. 31, 11, p. 1849-1854 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
41 Scopus citations

An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function

Frye, G. D., Breese, G. R., Mailman, R., Vogel, R. A., Gene Ondrusek, M. & Mueller, R. A., Jul 1 1980, In : Psychopharmacology. 69, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Animal models related to developmental disorders: Theoretical and pharmacological analyses

Mailman, R. B., Lewis, M. H. & Kilts, C. D., 1981, In : Applied Research In Mental Retardation. 2, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

An Improved, Automated Adenylate Cyclase Assay Utilizing Preparative HPLC: Effects of Phosphodiesterase Inhibitors

Schulz, D. W. & Mailman, R. B., Mar 1984, In : Journal of neurochemistry. 42, 3, p. 764-774 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Anorectic and other behavioral effects of centrally administered calcitonins

Cooper, C. W., Twery, M. J., Lewis, M. H. & Mailman, R., 1984, In : Psychopharmacology Bulletin. 20, 3, p. 451-455 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

A novel role of CDX1 in embryonic epicardial development

Chu, M., Wang, L., Wang, H., Shen, T., Yang, Y., Sun, Y., Tang, N., Ni, T., Zhu, J., Mailman, R. B. & Wang, Y., Jul 28 2014, In : PloS one. 9, 7, e103271.

Research output: Contribution to journalArticle

5 Scopus citations

Antagonism of the ethanol-induced fall in cerebellar guanosine cyclic-3',5'-monophosphate by thyrotropin-releasing hormone

Frye, G. D., Mailman, R. B., Mueller, R. A. & Breese, G. R., Jan 1 1977, In : Pharmacologist. 19, 2, p. No. 066

Research output: Contribution to journalArticle

Antagonistic behavioral effects of calcitonin and amphetamine in the rat

Twery, M. J., Kirkpatrick, B., Lewis, M. H., Mailman, R. B. & Cooper, C. W., May 1986, In : Pharmacology, Biochemistry and Behavior. 24, 5, p. 1203-1207 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Anti-dopaminergic activity of N-oxides of several neuroleptics

Lewis, M. H., Mailman, R. B. & Kilts, C. D., Jan 1 1981, In : Federation Proceedings. 40, 3 I, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Apolipoprotein E genotypes and the risk of Parkinson disease

Gao, J., Huang, X., Park, Y., Liu, R., Hollenbeck, A., Schatzkin, A., Mailman, R. & Chen, H., Nov 2011, In : Neurobiology of Aging. 32, 11, p. 2106.e1-2106.e6

Research output: Contribution to journalArticle

26 Scopus citations

Application of validated QSAR models of D1 dopaminergic antagonists for database mining

Oloff, S., Mailman, R. & Tropsha, A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7322-7332 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

A rapid and efficient method for the radiosynthesis and purification of [125I]SCH23982

Lawler, C. P., Gilmore, J. H., Mooney, D. H., Mayleben, M. A., Atashi, J. R., Mileson, B. E., Wyrick, S. D. & Mailman, R. B., Aug 1993, In : Journal of Neuroscience Methods. 49, 1-2, p. 141-153 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology

Shapiro, D. A., Renock, S., Arrington, E., Chiodo, L. A., Liu, L. X., Sibley, D. R., Roth, B. L. & Mailman, R., Aug 1 2003, In : Neuropsychopharmacology. 28, 8, p. 1400-1411 12 p.

Research output: Contribution to journalArticle

735 Scopus citations

Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways

Urban, J. D., Vargas, G. A., Von Zastrow, M. & Mailman, R. B., Jan 1 2007, In : Neuropsychopharmacology. 32, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

158 Scopus citations