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Research Output

2007

Dopamine receptor pharmacology

Mailman, R. & Huang, X., Dec 1 2007, Parkinson's Disease and Related Disorders, Part I. Aminoff, M., Michael, F., Swaab, D., Koller, W. & Melamed, E. (eds.). p. 77-105 29 p. (Handbook of Clinical Neurology; vol. 83).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Functional selectivity and classical concepts of quantitative pharmacology

Urban, J. D., Clarke, W. P., Von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M. & Mailman, R. B., Jan 5 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

789 Scopus citations

Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors

Ryman-Rasmussen, J. P., Griffith, A., Oloff, S., Vaidehi, N., Brown, J. T., Goddard, W. A. & Mailman, R. B., Feb 1 2007, In : Neuropharmacology. 52, 2, p. 562-575 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

GPCR functional selectivity has therapeutic impact

Mailman, R., Aug 1 2007, In : Trends in Pharmacological Sciences. 28, 8, p. 390-396 7 p.

Research output: Contribution to journalArticle

169 Scopus citations

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

Huang, X., Chen, H., Miller, W. C., Mailman, R., Woodard, J. L., Chen, P. C., Xiang, D., Murrow, R. W., Wang, Y. Z. & Poole, C., Feb 15 2007, In : Movement Disorders. 22, 3, p. 377-381 5 p.

Research output: Contribution to journalArticle

118 Scopus citations

Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries

Lewis, M. M., Slagle, C. G., Smith, A. B., Truong, Y., Bai, P., McKeown, M. J., Mailman, R. B., Belger, A. & Huang, X., Jun 15 2007, In : Neuroscience. 147, 1, p. 224-235 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

Toxicant-Receptor Interactions: Fundamental Principles

Mailman, R. B., Oct 23 2007, Molecular and Biochemical Toxicology, Fourth Edition. John Wiley & Sons, Inc., p. 359-388 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2006

D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinsons' disease

Lewis, M. M., Huang, X., Nichols, D. E. & Mailman, R. B., Jun 1 2006, In : CNS and Neurological Disorders - Drug Targets. 5, 3, p. 345-353 9 p.

Research output: Contribution to journalReview article

27 Scopus citations

Low affinity binding of the classical D1 antagonist SCH23390 in rodent brain: Potential interaction with A2A and D2-like receptors

Leonard, S. K., Ferry-Leeper, P. & Mailman, R. B., Oct 30 2006, In : Brain research. 1117, 1, p. 25-37 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2005

Application of validated QSAR models of D1 dopaminergic antagonists for database mining

Oloff, S., Mailman, R. & Tropsha, A., Nov 17 2005, In : Journal of Medicinal Chemistry. 48, 23, p. 7322-7332 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists

Ryman-Rasmussen, J. P., Nichols, D. E. & Mailman, R. B., Oct 1 2005, In : Molecular pharmacology. 68, 4, p. 1039-1048 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats

Padilla, S., Marshall, R. S., Hunter, D. L., Oxendine, S., Moser, V. C., Southerland, S. B. & Mailman, R. B., Nov 1 2005, In : Toxicological Sciences. 88, 1, p. 161-171 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2004

8,9-Dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms

Grubbs, R. A., Lewis, M. M., Owens-Vance, C., Gay, E. A., Jassen, A. K., Mailman, R. B. & Nichols, D. E., Mar 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 6, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: Evidence for induction of ligand-specific receptor states

Gay, E. A., Urban, J. D., Nichols, D. E., Oxford, G. S. & Mailman, R. B., Jul 1 2004, In : Molecular pharmacology. 66, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Novel mechanisms of drug action: Functional selectivity at D2 dopamine receptors (a lesson for drug discovery)

Mailman, R. B. & Gay, E. A., Nov 8 2004, In : Medicinal Chemistry Research. 13, 1-2, p. 115-126 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Synthesis and SAR exploration of dinapsoline analogues

Sit, S. Y., Xie, K., Jacutin-Porte, S., Boy, K. M., Seanz, J., Taber, M. T., Gulwadi, A. G., Korpinen, C. D., Burris, K. D., Molski, T. F., Ryan, E., Xu, C., Verdoorn, T., Johnson, G., Nichols, D. E. & Mailman, R. B., Feb 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 4, p. 715-734 20 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

Amygdaloid D1 Receptors Are Not Linked to Stimulation of Adenylate Cyclase

Leonard, S. K., Anderson, C. M., Lachowicz, J. E., Schulz, D. W., Kilts, C. D. & Mailman, R. B., Dec 15 2003, In : Synapse. 50, 4, p. 320-333 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology

Shapiro, D. A., Renock, S., Arrington, E., Chiodo, L. A., Liu, L. X., Sibley, D. R., Roth, B. L. & Mailman, R., Aug 1 2003, In : Neuropsychopharmacology. 28, 8, p. 1400-1411 12 p.

Research output: Contribution to journalArticle

730 Scopus citations

D1 dopamine receptors in the amygdala exhibit unique properties

Leonard, S. K., Petitto, J. M., Anderson, C. M., Mooney, D. H., Lachowicz, J. E., Schulz, D. W., Kilts, C. D. & Mailman, R. B., Jan 1 2003, In : Annals of the New York Academy of Sciences. 985, p. 536-539 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands

Qandil, A. M., Lewis, M. M., Jassen, A., Leonard, S. K., Mailman, R. B. & Nichols, D. E., Apr 1 2003, In : Bioorganic and Medicinal Chemistry. 11, 7, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Erratum: Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase (Journal of Pharcology and Experimental Therapeutics (2002) 301 (1166-1179))

Mottola, D. M., Kilts, J. D., Lewis, M. M., Connory, H. S., Walker, Q. D., Jones, S. R., Booth, R. G., Hyslop, D. K., Piercey, M., Wightman, R. M., Lawler, C. P., Nichols, D. E. & Mailman, R. B., Jul 4 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Erratum: Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs (Neuropsychopharmacology (2001) 27:2 (143-151) PII: S0893133X02002877)

Andersson, C., Hamer, R. M., Lawler, C. P., Mailman, R. & Lieberman, J. A., Sep 1 2002, In : Neuropsychopharmacology. 27, 3, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D 2 receptors linked to adenylate cyclase

Mottola, D. M., Kilts, J. D., Lewis, M. M., Connory, H. S., Walker, Q. D., Jones, S. R., Booth, R. G., Hyslop, D. K., Piercey, M., Wightman, R. M., Lawler, C. P., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1166-1178 13 p.

Research output: Contribution to journalArticle

102 Scopus citations

Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs

Kilts, J. D., Connery, H. S., Arrington, E. G., Lewis, M. M., Lawler, C. P., Oxford, G. S., O'Malley, K. L., Todd, R. D., Blake, B. L., Nichols, D. E. & Mailman, R. B., Jun 17 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs

Andersson, C., Hamer, R. M., Lawler, C. P., Mailman, R. & Lieberman, J. A., Jul 6 2002, In : Neuropsychopharmacology. 27, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2001

Blunted brain metabolic response to ketamine in mice lacking D1A dopamine receptors

Miyamoto, S., Mailman, R. B., Lieberman, J. A. & Duncan, G. E., Mar 16 2001, In : Brain research. 894, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

D1 dopamine receptors

Huang, X., Lawler, C. P., Lewis, M. M., Nichols, D. E. & Mailman, R. B., Jan 1 2001, In : International Review of Neurobiology. 48, p. 65-139 75 p.

Research output: Contribution to journalArticle

34 Scopus citations

Dinapsoline: Characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease

Gulwadi, A. G., Korpinen, C. D., Mailman, R. B., Nichols, D. E., Sit, S. Y. & Taber, M. T., Feb 13 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 2, p. 338-344 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Parkinson's disease and D1 dopamine receptors

Mailman, R., Huang, X. & Nichols, D. E., Dec 4 2001, In : Current Opinion in Investigational Drugs. 2, 11, p. 1582-1591 10 p.

Research output: Contribution to journalReview article

44 Scopus citations

Quantification of D1B (D5) receptors in dopamine D1A receptor-deficient mice

Montague, D. M., Striplin, C. D., Overcash, J. S., Drago, J., Lawler, C. P. & Mailman, R., Mar 15 2001, In : Synapse. 39, 4, p. 319-322 4 p.

Research output: Contribution to journalArticle

41 Scopus citations
2000

Developing novel antipsychotic drugs: Strategies and goals

Miyamoto, S., Duncan, G. E., Mailman, R. B. & Lieberman, J. A., Jan 1 2000, In : Current Opinion in Central and Peripheral Nervous System Investigational Drugs. 2, 1, p. 25-39 15 p.

Research output: Contribution to journalReview article

24 Scopus citations
1999

Developmental regulation of the dopamine D1 receptor in human caudate and putamen

Montague, D. M., Lawler, C. P., Mailman, R. B. & Gilmore, J. H., Nov 1 1999, In : Neuropsychopharmacology. 21, 5, p. 641-649 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes

Lawler, C. P., Prioleau, C., Lewis, M. M., Mak, C., Jiang, D., Schetz, J. A., Gonzalez, A. M., Sibley, D. R. & Mailman, R. B., Jun 1 1999, In : Neuropsychopharmacology. 20, 6, p. 612-627 16 p.

Research output: Contribution to journalArticle

377 Scopus citations

Quantitative structure-activity relationship modeling of dopamine D1 antagonists using comparative molecular field analysis, genetic algorithms- partial least-squares, and K nearest neighbor methods

Hoffman, B., Cho, S. J., Zheng, W., Wyrick, S., Nichols, D. E., Mailman, R. B. & Tropsha, A., Aug 26 1999, In : Journal of Medicinal Chemistry. 42, 17, p. 3217-3226 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane

Doll, M. K. H., Nichols, D. E., Kilts, J. D., Prioleau, C., Lawler, C. P., Lewis, M. M. & Mailman, R. B., Mar 11 1999, In : Journal of Medicinal Chemistry. 42, 5, p. 935-940 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
1998

Behavioural assessment of mice lacking D(1A) dopamine receptors

Smith, D. R., Striplin, C. D., Geller, A. M., Mailman, R. B., Drago, J., Lawler, C. P. & Gallagher, M., May 21 1998, In : Neuroscience. 86, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Decline of dopamine: Effects of age and acute neuroleptic challenge

Lieberman, J. A. & Mailman, R., Jan 1 1998, In : American Journal of Psychiatry. 155, 3, p. 319-323 5 p.

Research output: Contribution to journalEditorial

6 Scopus citations

Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation

Duncan, G. E., Leipzig, J. N., Mailman, R. B. & Lieberman, J. A., Nov 23 1998, In : Brain research. 812, 1-2, p. 65-75 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Dopamine D1 receptor agonists as antiparkinson drugs [3] (multiple letters)

Mailman, R. B., Nichols, D. E. & Williams, M., Jan 1 1998, In : Trends in Pharmacological Sciences. 19, 7, p. 255-256 2 p.

Research output: Contribution to journalLetter

8 Scopus citations

Emerging roles for novel antipsychotic medications in the treatment of schizophrenia

Anderson, C., Chakos, M., Mailman, R. & Lieberman, J., Jan 1 1998, In : Psychiatric Clinics of North America. 21, 1, p. 151-179 29 p.

Research output: Contribution to journalArticle

24 Scopus citations
70 Scopus citations

Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain

Bunin, M. A., Prioleau, C., Mailman, R. & Wightman, R. M., Mar 1 1998, In : Journal of neurochemistry. 70, 3, p. 1077-1087 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Serotonergic basis of antipsychotic drug effects in schizophrenia

Lieberman, J. A., Mailman, R., Duncan, G., Sikich, L., Chakos, M., Nichols, D. E. & Kraus, J. E., Dec 1 1998, In : Biological Psychiatry. 44, 11, p. 1099-1117 19 p.

Research output: Contribution to journalReview article

179 Scopus citations

Substituted naphthofurans as hallucinogenic phenethylamine -Ergoline hybrid molecules with unexpected muscarinic antagonist activity

Monte, A. P., Marona-Lewicka, D., Lewis, M. M., Mailman, R. B., Wainscott, D. B., Nelson, D. L. & Nichols, D. E., Jun 4 1998, In : Journal of Medicinal Chemistry. 41, 12, p. 2134-2145 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
1997
11 Scopus citations

Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist

Smith, H. P., Nichols, D. E., Mailman, R. B. & Lawler, C. P., Mar 26 1997, In : European Journal of Pharmacology. 323, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Placebo, Double-Blind Evaluation of Long-Term Naltrexone Treatment Effects for Adults with Mental Retardation and Self-Injury

Bodfish, J. W., McCuller, W. R., Madison, J. M., Register, M., Mailman, R. B. & Lewis, M. H., Jan 1 1997, In : Journal of Developmental and Physical Disabilities. 9, 2, p. 135-152 18 p.

Research output: Contribution to journalArticle

18 Scopus citations
1996

8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A potent full dopamine D1 agonist containing a rigid β-phenyldopamine pharmacophore

Ghosh, D., Snyder, S. E., Watts, V. J., Mailman, R. B. & Nichols, D. E., Jan 19 1996, In : Journal of Medicinal Chemistry. 39, 2, p. 549-555 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Conformational analysis of D1 dopamine receptor agonists: Pharmacophore assessment and receptor mapping

Mottola, D. M., Laiter, S., Watts, V. J., Tropsha, A., Wyrick, S. D., Nichols, D. E. & Mailman, R. B., Jan 5 1996, In : Journal of Medicinal Chemistry. 39, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

56 Scopus citations