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Research Output

1996

Triadimefon and triadimenol: Effects on monoamine uptake and release

Walker, Q. D. & Mailman, R. B., Aug 1996, In : Toxicology and Applied Pharmacology. 139, 2, p. 227-233 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
1995

1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and Related Derivatives as Ligands for the Neuromodulatory σ3 Receptor: Further Structure-Activity Relationships

Wyrick, S. D., Booth, R. G., Myers, A. M., Owens, C. E., Bucholtz, E. C., Hooper, P. C., Kula, N. S., Baldessarini, R. J. & Mailman, R., Sep 1 1995, In : Journal of Medicinal Chemistry. 38, 19, p. 3857-3864 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evaluation of cis- and trans-9- and 11-Hydroxy-5, 6, 6a, 7, 8, 12b-hexahydrobenzo[α]phenanthridines as Structurally Rigid, Selective D1 Dopamine Receptor Ligands

Brewster, W. K., Nichols, D. E., Watts, V. J., Riggs, R. M., Mottola, D. & Mailman, R. B., Jan 1 1995, In : Journal of Medicinal Chemistry. 38, 2, p. 318-327 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

"Full" dopamine D1 agonists in human caudate: Biochemical properties and therapeutic implications

Gilmore, J. H., Watts, V. J., Lawler, C. P., Noll, E. P., Nichols, D. E. & Mailman, R. B., May 1995, In : Neuropharmacology. 34, 5, p. 481-488 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Interhemispheric modulation of dopamine receptor interactions in unilateral 6‐OHDA rodent model

Lawler, C. P., Gilmore, J. H., Watts, V. J., Walker, Q. D., Southerland, S. B., Cook, L. L., Mathis, C. A. & Mailman, R. B., Dec 1995, In : Synapse. 21, 4, p. 299-311 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors

Watts, V. J., Mailman, R. B., Lawler, C. P., Neve, K. A. & Nichols, D. E., Apr 1 1995, In : Psychopharmacology. 118, 4, p. 401-409 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Metabolism of thioridazine by microsomal monooxygenases: Relative roles of p450 and flavin-containing monooxygenase

Blake, B. L., Rose, R. L., Mailman, R., Levi, P. E. & Hodgson, E., Jan 1 1995, In : Xenobiotica. 25, 4, p. 377-393 17 p.

Research output: Contribution to journalArticle

44 Scopus citations

Partial and full dopamine D1 agonists produce comparable increases in ventral pallidal neuronal activity: Contribution of endogenous dopamine

Heidenreich, B. A., Mailman, R., Nichols, D. E. & Napier, T. C., 1995, In : Journal of Pharmacology and Experimental Therapeutics. 273, 1, p. 516-525 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Rearing conditions alter social reactivity and D1 dopamine receptors in high- and low-aggressive mice

Gariépy, J. L., Gendreau, P. L., Mailman, R., Tancer, M. & Lewis, M. H., Aug 1995, In : Pharmacology, Biochemistry and Behavior. 51, 4, p. 767-773 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Spare receptors and intrinsic activity: Studies with D1 dopamine receptor agonists

Watts, V. J., Lawler, C. P., Gonzales, A. J., Zhou, QY. Y., Civelli, O., Nichols, D. E. & Mailman, R. B., Oct 1995, In : Synapse. 21, 2, p. 177-187 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Synthesis and Biological Evaluation of a Series of Substituted Benzo[α]phenanthridines as Agonists at D1 and D2 Dopamine Receptors

Knoerzer, T. A., Watts, V. J., Nichols, D. E. & Mailman, R. B., Aug 1 1995, In : Journal of Medicinal Chemistry. 38, 16, p. 3062-3070 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
57 Scopus citations
1994

Dopaminergic Benzo[a]phenanthridines: Resolution and Pharmacological Evaluation of the Enantiomers of Dihydrexidine, the Full Efficacy D1 Dopamine Receptor Agonist

Knoerzer, T. A., Nichols, D. E., Brewster, W. K., Watts, V. J., Mottola, D. & Mailman, R. B., Jul 1 1994, In : Journal of Medicinal Chemistry. 37, 15, p. 2453-2460 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Heterotypic sprouting of serotonergic forebrain fibers in the brindled mottled mutant mouse

Martin, P., Ohno, M., Southerland, S. B., Mailman, R. B. & Suzuki, K., Feb 18 1994, In : Developmental Brain Research. 77, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia

Tancer, M. E., Mailman, R. B., Stein, M. B., Mason, G. A., Carson, S. W. & Golden, R. N., 1994, In : Anxiety. 1, 5, p. 216-223 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Novel (4-Phenylpiperidinyl)- and (4-Phenylpiperazinyl)alkyl-Spaced Esters of 1-Phenylcyclopentanecarboxylic Acids as Potent σ-Selective Compounds

Hudkins, R. L., Mailman, R. B. & DeHaven-Hudkins, D. L., Jun 1 1994, In : Journal of Medicinal Chemistry. 37, 13, p. 1964-1970 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

RLH-033, a novel, potent and selective ligand for the σ1 recognition site

Hudkins, R. L., Mailman, R. B. & DeHaven-Hudkins, D. L., Dec 12 1994, In : European Journal of Pharmacology. 271, 1, p. 235-236 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Social reactivity and D1 dopamine receptors: Studies in mice selectively bred for high and low levels of aggression

Lewis, M. H., Gariépy, J. L., Gendreau, P., Nichols, D. E. & Mailman, R. B., Apr 1994, In : Neuropsychopharmacology. 10, 2, p. 115-122 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Synthesis and Molecular Modeling of 1-Phenyl-1,2,3,4-tetrahydroisoquinolines and Related 5,6,8,9-Tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 Dopamine Antagonists

Minor, D. L., Wyrick, S. D., Charifson, P. S., Watts, V. J., Mailman, R. B. & Mailman, R. B., Dec 1 1994, In : Journal of Medicinal Chemistry. 37, 25, p. 4317-4328 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Synthesis of [N‐C3H3]‐trans‐(1R,3S)‐(−)‐1‐Phenyl‐3‐N,N‐dimethylamino‐1,2,3,4‐tetrahydronaphthalene (H2‐PAT)

Wyrick, S. D., Myers, A. M., Booth, R. G., Kula, N. S., Baldessarini, R. J. & Mailman, R. B., Feb 1994, In : Journal of Labelled Compounds and Radiopharmaceuticals. 34, 2, p. 131-134 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
1993

A rapid and efficient method for the radiosynthesis and purification of [125I]SCH23982

Lawler, C. P., Gilmore, J. H., Mooney, D. H., Mayleben, M. A., Atashi, J. R., Mileson, B. E., Wyrick, S. D. & Mailman, R. B., Aug 1993, In : Journal of Neuroscience Methods. 49, 1-2, p. 141-153 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents

Watts, V. J., Lawler, C. P., Gilmore, J. H., Southerland, S. B., Nichols, D. E. & Mailman, R. B., Sep 28 1993, In : European Journal of Pharmacology. 242, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands

Watts, V. J., Lawler, C. P., Knoerzer, T., Mayleben, M. A., Neve, K. A., Nichols, D. E. & Mailman, R. B., Aug 3 1993, In : European Journal of Pharmacology. 239, 1-3, p. 271-273 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

New σ-like receptor recognized by novel phenylaminotetralins: Ligand binding and functional studies

Booth, R. G., Wyrick, S. D., Baldessarini, R. J., Kula, N. S., Myers, A. M. & Mailman, R., Dec 1 1993, In : Molecular pharmacology. 44, 6, p. 1232-1239 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Postmortem stability of dopamine D1 receptor mRNA and D1 receptors

Gilmore, J. H., Lawler, C. P., Eaton, A. M. & Mailman, R., Jan 1 1993, In : Molecular Brain Research. 18, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for a Novel Receptor with σ-like Neuromodulatory Activity

Wyrick, S. D., Booth, R. G., Myers, A. M., Owens, C. E., Kula, N. S., Baldessarini, R. J., McPhail, A. T. & Mailman, R. B., Jan 1 1993, In : Journal of Medicinal Chemistry. 36, 17, p. 2542-2551 10 p.

Research output: Contribution to journalArticle

44 Scopus citations
1992

Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist

Mottola, D. M., Brewster, W. K., Cook, L. L., Nichols, D. E. & Mailman, R. B., Jan 1 1992, In : Journal of Pharmacology and Experimental Therapeutics. 262, 1, p. 383-393 11 p.

Research output: Contribution to journalArticle

92 Scopus citations
1991

Behavioral effects in the rat of dihydrexidine, a high-potency, full-efficacy D1 dopamine receptor agonist

Darney, K. J., Lewis, M. H., Brewster, W. K., Nichols, D. E. & Mailman, R. B., Jan 1 1991, In : Neuropsychopharmacology. 5, 3, p. 187-195 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey

Elsworth, J. D., Lawrence, M. S., Roth, R. H., Taylor, J. R., Mailman, R., Nichols, D. E., Lewis, M. H. & Redmond, D. E., Dec 1 1991, In : Journal of Pharmacology and Experimental Therapeutics. 259, 2, p. 595-600 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

D1 Dopamine Receptors of NS20Y Neuroblastoma Cells Are Functionally Similar to Rat Striatal D1 Receptors

Lovenberg, T. W., Roth, R. H., Nichols, D. E. & Mailman, R. B., Nov 1991, In : Journal of neurochemistry. 57, 5, p. 1563-1569 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-ioduced parkinsonism in monkeys

Taylor, J. R., Lawrence, M. S., Redmond, D. E., Elsworth, J. D., Roth, R. H., Nichols, D. E. & Mailman, R. B., Jul 9 1991, In : European Journal of Pharmacology. 199, 3, p. 389-391 3 p.

Research output: Contribution to journalArticle

139 Scopus citations

Dopamine receptor 'supersensitivity' occurring without receptor up-regulation

Mileson, B. E., Lewis, M. H. & Mailman, R. B., Oct 4 1991, In : Brain research. 561, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors

Lovenberg, T. W., Nichols, D. E., Nestler, E. J., Roth, R. H. & Mailman, R. B., Aug 9 1991, In : Brain research. 556, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Neurochemical and immunocytochemical studies of catecholamine system in the brindled mouse

Satoh, J., Irino, M., Martin, P. M., Mailman, R. B. & Suzuki, K., Nov 1991, In : Journal of neuropathology and experimental neurology. 50, 6, p. 793-808 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis and evaluation of (S)-5-[125I]iodo-2,3-methylenedioxybenzamide

Mathis, C. A., Gerdes, J. M., Shulgin, A. T., Hanrahan, S., Faggin, B. & Mailman, R., Apr 5 1991, In : Journal of Labelled Compounds and Radiopharmaceuticals. 30, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and in Vitro Evaluation of 2,3-Dimethoxy-5-(fluoroalkyl)-Substituted Benzamides: High-Affinity Ligands for CNS Dopamine D2 Receptors

Bishop, J. E., Mathis, C. A., Gerdes, J. M., Whitney, J. M., Eaton, A. M. & Mailman, R. B., May 1 1991, In : Journal of Medicinal Chemistry. 34, 5, p. 1612-1624 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Synthesis of aryl-substituted 5-[18F]fluoroalkylbenzamides: High affinity ligands for dopamine D-2 studies

Mathis, C. A., Bishop, J. E., Gerdes, J. M., Faggin, B. & Mailman, R., Apr 5 1991, In : Journal of Labelled Compounds and Radiopharmaceuticals. 30, p. 357-359 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

The female brindled mouse as a model of menkes’ disease: The relationship of fur pattern to behavioral and neurochemical abnormalities

Martin, P. M., Irino, M., Suzuki, K., Lewis, M. H. & Mailman, R. B., Jan 1 1991, In : Developmental Neuroscience. 13, 3, p. 121-129 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1990

Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge

Lewis, M. H., Gluck, J. P., Beauchamp, A. J., Keresztury, M. F. & Mailman, R. B., Apr 9 1990, In : Brain research. 513, 1, p. 67-73 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

trau5-10,11-Dihydroxy-5,6,6a,7,8,12b-Hexahydrobenzo[a]Phenanthridine: A Highly Potent Selective Dopamine D1 Full Agonist

Brewster, W. K., Nichols, D. E., Riggs, R. M., Mottola, D. M., Lovenberg, T. W., Lewis, M. H. & Mailman, R. B., Jan 1 1990, In : Journal of Medicinal Chemistry. 33, 6, p. 1756-1764 9 p.

Research output: Contribution to journalArticle

176 Scopus citations

Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats

Walker, Q. D., Lewis, M. H., Crofton, K. M. & Mailman, R. B., Mar 1 1990, In : Toxicology and Applied Pharmacology. 102, 3, p. 474-485 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
1989

Blockade of only spinal α1 adrenoceptors is insufficient to attenuate DDT-induced alterations in motor function

Herr, D. W., Mailman, R. B. & Tilson, H. A., Oct 1989, In : Toxicology and Applied Pharmacology. 101, 1, p. 11-26 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Buffer effects on high affinity [3H]-prazosin binding in brain and spinal cord

Herr, D. W. & Mailman, R. B., Mar 1989, In : Pharmacology, Biochemistry and Behavior. 32, 3, p. 831-834 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Comparative anticholinergic properties of thioridazine, mesoridazine and sulforidazine

Niedzwiecki, D. M., Cubeddu, L. X. & Mailman, R., 1989, In : Journal of Pharmacology and Experimental Therapeutics. 250, 1, p. 126-133 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum

Niedzwiecki, D. N., Cubeddu, L. X. & Mailman, R. B., Jan 1 1989, In : Journal of Pharmacology and Experimental Therapeutics. 250, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Conformational Analysis and Molecular Modeling of 1-Phenyl-, 4-Phenyl-, and l-Benzyl-l,2,3,4-tetrahydroisoquinolines as D1Dopamine Receptor Ligands

Charifson, P. S., Bowen, J. P., Wyrick, S. D., Hoffman, A. J., Cory, M., McPhail, A. T. & Mailman, R., Sep 1 1989, In : Journal of Medicinal Chemistry. 32, 9, p. 2050-2058 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat

Jimmerson, V. R., Tsung-Ming, S., Maxwell, D. M. & Mailman, R., Jan 1 1989, In : Toxicology Letters. 48, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist

Lovenberg, T. W., Brewster, W. K., Mottola, D. M., Lee, R. C., Riggs, R. M., Nichols, D. E., Lewis, M. H. & Mailman, R. B., Jul 4 1989, In : European Journal of Pharmacology. 166, 1, p. 111-113 3 p.

Research output: Contribution to journalArticle

96 Scopus citations

The effect of 2-(o-Cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide on tissue cholinesterase and carboxylesterase activities of the rat

Jimmerson, V. R., Shih, T. M., Maxwell, D. M., Kaminskis, A. & Mailman, R. B., Oct 1 1989, In : Toxicological Sciences. 13, 3, p. 568-575 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effect of 2-(o-Cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide on tissue cholinesterase and carboxylesterase activities of the rat

Jimmerson, V. R., Shih, T. M., Maxwell, D. M., Kaminskis, A. & Mailman, R., Oct 1 1989, In : Toxicological Sciences. 13, 3, p. 568-575 8 p.

Research output: Contribution to journalArticle