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Research Output

  • 3360 Citations
  • 24 h-Index
  • 40 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
2017

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

Nguyen, J. Q. & Irby, R. B., Jan 2 2017, In : Cancer Biology and Therapy. 18, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Intra-cellular tyrosine kinase

Irby, R. & Yeatman, T. J., Jan 1 2015, Molecular Oncology: Causes of Cancer and Targets for Treatment. Cambridge University Press, p. 231-242 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Par-4 as a potential target for cancer therapy

Irby, R. & Kline, C. L., Jan 1 2013, In : Expert Opinion on Therapeutic Targets. 17, 1, p. 77-87 11 p.

Research output: Contribution to journalReview article

11 Scopus citations

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Allen, J. E., Gallant, J. N., Dicker, D. T., Amin, S., Irby, R. B., Sharma, A. K. & El-Deiry, W. S., Mar 12 2013, In : PloS one. 8, 3, e59380.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study

Nyland, S. B., Krissinger, D. J., Clemente, M. J., Irby, R. B., Baab, K. T., Jarbadan, N. R., Sokol, L., Schaefer, E., Liao, J., Cuthbertson, D., Epling-Burnette, P., Paquette, R., List, A. F., Maciejewski, J. P. & Loughran, T. P., May 1 2012, In : Leukemia Research. 36, 5, p. 581-587 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Gowda, K., Prakasha Gowda, A. S., Tagaram, H. R. S., Carroll, K. F. S. O., Irby, R., Sharma, A. & Amin, S., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6006-6014 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
24 Scopus citations

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Kline, C. L. B. & Irby, R. B., Dec 1 2011, In : Apoptosis. 16, 12, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tyrosine kinase update: Role and response in cancer therapy

Irby, R. B. & Jiang, Y., May 1 2011, In : Current Cancer Therapy Reviews. 7, 2, p. 155-166 12 p.

Research output: Contribution to journalArticle

2010

Epidermal growth factor receptor revisited: Prognostic marker or target for therapy?

Irby, R. B., Sep 1 2010, In : Cancer Biology and Therapy. 10, 5, p. 422-424 3 p.

Research output: Contribution to journalComment/debate

Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway

Yang, J., Liu, X., Nyland, S. B., Zhang, R., Ryland, L. K., Broeg, K., Baab, K. T., Jarbadan, N. R., Irby, R. & Loughran, T. P., Jan 7 2010, In : Blood. 115, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Primary cell lines: False representation or model system? A comparison of four human colorectal tumors and their coordinately established cell lines

Pastor, D. M., Poritz, L., Olson, T. L., Kline, C. L., Harris, L. R., Koltun, W., Chinchilli, V. & Irby, R., Mar 9 2010, In : International Journal of Clinical and Experimental Medicine. 3, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Wang, B. D., Kline, C. L. B., Pastor, D. M., Olson, T. L., Frank, B., Luu, T., Sharma, A. K., Robertson, G., Weirauch, M. T., Patierno, S. R., Stuart, J. M., Irby, R. B. & Lee, N. H., Apr 30 2010, In : Molecular Cancer. 9, 98.

Research output: Contribution to journalArticle

37 Scopus citations

Tumor necrosis factor α induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines

Pastor, D. M., Irby, R. & Poritz, L., Mar 1 2010, In : Diseases of the colon and rectum. 53, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

House, C. D., Vaske, C. J., Schwartz, A. M., Obias, V., Frank, B., Luu, T., Sarvazyan, N., Irby, R., Strausberg, R. L., Hales, T. G., Stuart, J. M. & Lee, N. H., Sep 1 2010, In : Cancer Research. 70, 17, p. 6957-6967 11 p.

Research output: Contribution to journalArticle

136 Scopus citations
2009

Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU

Kline, C. L., Shanmugavelandy, S. S., Kester, M. & Irby, R., Oct 10 2009, In : Cancer Biology and Therapy. 8, 19, p. 1831-1837 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Src activity alters α3 integrin expression in colon tumor cells

Kline, C. L. B., Olson, T. L. & Irby, R., Feb 1 2009, In : Clinical and Experimental Metastasis. 26, 2, p. 77-87 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

Shah, M. V., Zhang, R., Irby, R., Kothapalli, R., Liu, X., Arrington, T., Frank, B., Lee, N. H. & Loughran, T. P., Aug 1 2008, In : Blood. 112, 3, p. 770-781 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

Src kinase induces tumor formation in the c-SRC C57BL/6 mouse

Kline, C. L. B., Jackson, R., Engelman, R., Pledger, W. J., Yeatman, T. J. & Irby, R. B., Jun 15 2008, In : International Journal of Cancer. 122, 12, p. 2665-2673 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2005

Iterative microarray and RNA interference-based interrogation of the Src-induced invasive phenotype

Irby, R. B., Malek, R. L., Bloom, G., Tsai, J., Letwin, N., Frank, B. C., Verratti, K., Yeatman, T. J. & Lee, N. H., Mar 1 2005, In : Cancer Research. 65, 5, p. 1814-1821 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression

Cook, A. C., Tuck, A. B., McCarthy, S., Turner, J. G., Irby, R., Bloom, G. C., Yeatman, T. J. & Chambers, A. F., Aug 1 2005, In : Molecular Carcinogenesis. 43, 4, p. 225-236 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Role of Stat3 in regulating p53 expression and function

Niu, G., Wright, K. L., Ma, Y., Wright, G. M., Huang, M., Irby, R., Briggs, J., Karras, J., Cress, W. D., Pardoll, D., Jove, R., Chen, J. & Yu, H., Sep 1 2005, In : Molecular and cellular biology. 25, 17, p. 7432-7440 9 p.

Research output: Contribution to journalArticle

227 Scopus citations
2004

Osteopontin regulates multiple functions contributing to human colon cancer development and progression

Irby, R. B., McCarthy, S. M. & Yeatman, T. J., Oct 1 2004, In : Clinical and Experimental Metastasis. 21, 6, p. 515-523 9 p.

Research output: Contribution to journalArticle

62 Scopus citations
2003

Osteopontin identified as colon cancer tumor progression marker

Agrawal, D., Chen, T., Irby, R., Quackenbush, J., Chambers, A. F., Szabo, M., Cantor, A., Coppola, D. & Yeatman, T. J., Jan 1 2003, In : Comptes Rendus - Biologies. 326, 10-11, p. 1041-1043 3 p.

Research output: Contribution to journalArticle

43 Scopus citations
15 Scopus citations

Regulation of caspase expression and apoptosis by adenomatous polyposis coli

Chen, T., Yang, I., Irby, R., Shain, K. H., Wang, H-G., Quackenbush, J., Coppola, D., Cheng, J. Q. & Yeatman, T. J., Aug 1 2003, In : Cancer Research. 63, 15, p. 4368-4374 7 p.

Research output: Contribution to journalArticle

78 Scopus citations
2002

Identification of Src transformation fingerprint in human colon cancer

Malek, R. L., Irby, R. B., Guo, Q. M., Lee, K., Wong, S., He, M., Tsai, J., Frank, B., Liu, E. T., Quackenbush, J., Jove, R., Yeatman, T. J. & Lee, N. H., Jan 1 2002, In : Oncogene. 21, 47, p. 7256-7265 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells

Irby, R. & Yeatman, T. J., May 1 2002, In : Cancer Research. 62, 9, p. 2669-2674 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling

Agrawal, D., Chen, T., Irby, R., Quackenbush, J., Chambers, A. F., Szabo, M., Cantor, A., Coppola, D. & Yeatman, T. J., Apr 3 2002, In : Journal of the National Cancer Institute. 94, 7, p. 513-521 9 p.

Research output: Contribution to journalArticle

350 Scopus citations
2001

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A. & Jove, R., Jun 19 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 13, p. 7319-7324 6 p.

Research output: Contribution to journalArticle

370 Scopus citations

v-Src transformation is mediated through farnesylated proteins

Teng, S., Sun, J., Irby, R., Hamilton, A. D., Sebti, S. & Yeatman, T. J., Jan 1 2001, In : Journal of Surgical Research. 99, 2, p. 343-346 4 p.

Research output: Contribution to journalArticle

2000

Role of Src expression and activation in human cancer

Irby, R. B. & Yeatman, T. J., Nov 20 2000, In : Oncogene. 19, 49, p. 5636-5642 7 p.

Research output: Contribution to journalReview article

572 Scopus citations
1999

Activating SRC mutation in a subset of advanced human colon cancers

Irby, R., Mao, W., Coppola, D., Kang, J., Loubeau, J. M., Trudeau, W., Karl, R., Fujita, D. J., Jove, R. & Yeatman, T. J., Feb 1 1999, In : Nature Genetics. 21, 2, p. 187-190 4 p.

Research output: Contribution to journalArticle

417 Scopus citations
1998

Analysis of colorectal cancer by comparative genomic hybridization: Evidence for induction of the metastatic phenotype by loss of tumor suppressor genes

Paredes-Zaglul, A., Kang, J. J., Essig, Y. P., Mao, W., Irby, R., Wloch, M. & Yeatman, T. J., Apr 1 1998, In : Clinical Cancer Research. 4, 4, p. 879-886 8 p.

Research output: Contribution to journalArticle

70 Scopus citations
1997

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

Mao, W., Irby, R., Coppola, D., Fu, L., Wloch, M., Turner, J., Yu, H., Garcia, R., Jove, R. & Yeatman, T. J., Dec 18 1997, In : Oncogene. 15, 25, p. 3083-3090 8 p.

Research output: Contribution to journalArticle

173 Scopus citations

Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential

Irby, R., Mao, W., Coppola, D., Jove, R., Gamero, A., Cuthbertson, D., Fujita, D. J. & Yeatman, T. J., Dec 1 1997, In : Cell Growth and Differentiation. 8, 12, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
1996

Altered ovarian sterol carrier protein expression in the pregnant streptozotocintreated diabetic rat

McLean, M. P., Warden, K. J., Sandhoff, T. W., Irby, R. B. & Hales, D. B., Jul 1996, In : Biology of reproduction. 55, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Rat sterol carrier protein-X expression is induced by a peroxisome proliferator-activated receptor

Irby, R. B. & McLean, M. P., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1380

Research output: Contribution to journalArticle

1995

Differential expression of hepatic sterol carrier proteins in the streptozotocin-treated diabetic rat

Mc Lean, M. P., Billheimer, J. T., Warden, K. J. & Irby, R. B., Aug 1995, In : Endocrinology. 136, 8, p. 3360-3368 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Prostaglandin f2α mediates ovarian sterol carrier protein-2 expression during luteolysis

Mc lean, M. P., Billheimer, J. T., Warden, K. J. & Irby, R. B., Nov 1995, In : Endocrinology. 136, 11, p. 4963-4972 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reduced hepatic sterol carrier protein-2 expression in the streptozotocin treated diabetic rat

McLean, M. P., Nanjo, K., Irby, R. B., Warden, K. J. & Billheimer, J. T., Aug 1 1995, In : Endocrine. 3, 8, p. 563-571 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
1994

Enzymatic preparation of [2,4,5,6,8-14C, 5′-3H]guanosine for use in biosynthetic studies of pterinoid and flavin compounds

Irby, R. & Adair, W. L., May 1 1994, In : Analytical Biochemistry. 218, 2, p. 413-416 4 p.

Research output: Contribution to journalArticle

Intermediates in the folic acid biosynthetic pathway are incorporated into molybdopterin the yeast, Pichia canadensis

Irby, R. B. & Adair, W. L., Sep 30 1994, In : Journal of Biological Chemistry. 269, 39, p. 23981-23987 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
1991

Effects of copper and tributyltin on stress protein abundance in the rotifer Brachionus plicatilis

Cochrane, B. J., Irby, R. B. & Snell, T. W., 1991, In : Comparative Biochemistry and Physiology. Part C, Comparative. 98, 2-3, p. 385-390 6 p.

Research output: Contribution to journalArticle

60 Scopus citations