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Research Output 1991 2017

  • 3342 Citations
  • 24 h-Index
  • 40 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2017
9 Citations (Scopus)

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

Nguyen, J. Q. & Irby, R. B., Jan 2 2017, In : Cancer Biology and Therapy. 18, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Colonic Neoplasms
Cisplatin
prostate apoptosis response-4 protein
Neoplasms
2013
9 Citations (Scopus)

The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Allen, J. E., Gallant, J. N., Dicker, D. T., Amin, S., Irby, R. B., Sharma, A. K. & El-Deiry, W. S., Mar 12 2013, In : PloS one. 8, 3, e59380.

Research output: Contribution to journalArticle

colorectal neoplasms
Fluorouracil
Colonic Neoplasms
Cells
Tumors
2012
9 Citations (Scopus)

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study

Nyland, S. B., Krissinger, D. J., Clemente, M. J., Irby, R. B., Baab, K. T., Jarbadan, N. R., Sokol, L., Schaefer, E., Liao, J., Cuthbertson, D., Epling-Burnette, P., Paquette, R., List, A. F., Maciejewski, J. P. & Loughran, T. P., May 1 2012, In : Leukemia Research. 36, 5, p. 581-587 7 p.

Research output: Contribution to journalArticle

Large Granular Lymphocytic Leukemia
Paroxysmal Hemoglobinuria
Aplastic Anemia
Myelodysplastic Syndromes
Epitopes
2011
43 Citations (Scopus)

Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway

Gowda, K., Prakasha Gowda, A. S., Tagaram, H. R. S., Carroll, K. F. S. O., Irby, R., Sharma, A. & Amin, S., Oct 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 20, p. 6006-6014 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Isatin
Phosphorylation
Vinblastine
Cells
24 Citations (Scopus)
Nude Mice
Colon
Growth
Neoplasms
Fluorouracil
9 Citations (Scopus)

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Kline, C. L. B. & Irby, R. B., Dec 1 2011, In : Apoptosis. 16, 12, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Fluorouracil
Colonic Neoplasms
Cells
src-Family Kinases

Tyrosine kinase update: Role and response in cancer therapy

Irby, R. B. & Jiang, Y., May 1 2011, In : Current Cancer Therapy Reviews. 7, 2, p. 155-166 12 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Neoplasms
Therapeutics
Drug Delivery Systems
2010
54 Citations (Scopus)

Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway

Yang, J., Liu, X., Nyland, S. B., Zhang, R., Ryland, L. K., Broeg, K., Baab, K. T., Jarbadan, N. R., Irby, R. & Loughran, T. P., Jan 7 2010, In : Blood. 115, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Large Granular Lymphocytic Leukemia
Lymphocytes
Platelet-Derived Growth Factor
T-cells
Survival
8 Citations (Scopus)

Primary cell lines: False representation or model system? A comparison of four human colorectal tumors and their coordinately established cell lines

Pastor, D. M., Poritz, L., Olson, T. L., Kline, C. L., Harris, L. R., Koltun, W., Chinchilli, V. & Irby, R., Mar 9 2010, In : International Journal of Clinical and Experimental Medicine. 3, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

Tumors
Colorectal Neoplasms
Cells
Cell Line
Tissue
37 Citations (Scopus)

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Wang, B. D., Kline, C. L. B., Pastor, D. M., Olson, T. L., Frank, B., Luu, T., Sharma, A. K., Robertson, G., Weirauch, M. T., Patierno, S. R., Stuart, J. M., Irby, R. B. & Lee, N. H., Apr 30 2010, In : Molecular Cancer. 9, 98.

Research output: Contribution to journalArticle

MicroRNAs
Fluorouracil
Colonic Neoplasms
HT29 Cells
Apoptosis
13 Citations (Scopus)

Tumor necrosis factor α induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines

Pastor, D. M., Irby, R. & Poritz, L., Mar 1 2010, In : Diseases of the colon and rectum. 53, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Tumor Necrosis Factor-alpha
HT29 Cells
Apoptosis
Cell Line
135 Citations (Scopus)

Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

House, C. D., Vaske, C. J., Schwartz, A. M., Obias, V., Frank, B., Luu, T., Sarvazyan, N., Irby, R., Strausberg, R. L., Hales, T. G., Stuart, J. M. & Lee, N. H., Sep 1 2010, In : Cancer Research. 70, 17, p. 6957-6967 11 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Regulator Genes
Colonic Neoplasms
Small Interfering RNA
Staining and Labeling
2009
25 Citations (Scopus)

Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU

Kline, C. L., Shanmugavelandy, S. S., Kester, M. & Irby, R., Oct 10 2009, In : Cancer Biology and Therapy. 8, 19, p. 1831-1837 7 p.

Research output: Contribution to journalArticle

Nude Mice
Fluorouracil
Colon
Plasmids
Colonic Neoplasms
8 Citations (Scopus)

Src activity alters α3 integrin expression in colon tumor cells

Kline, C. L. B., Olson, T. L. & Irby, R., Feb 1 2009, In : Clinical and Experimental Metastasis. 26, 2, p. 77-87 11 p.

Research output: Contribution to journalArticle

Integrins
Colon
Neoplasms
Colonic Neoplasms
Neoplasm Metastasis
2008
86 Citations (Scopus)

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

Shah, M. V., Zhang, R., Irby, R., Kothapalli, R., Liu, X., Arrington, T., Frank, B., Lee, N. H. & Loughran, T. P., Aug 1 2008, In : Blood. 112, 3, p. 770-781 12 p.

Research output: Contribution to journalArticle

Large Granular Lymphocytic Leukemia
Sphingolipids
T-cells
Lymphocytes
Chemical activation
14 Citations (Scopus)

Src kinase induces tumor formation in the c-SRC C57BL/6 mouse

Kline, C. L. B., Jackson, R., Engelman, R., Pledger, W. J., Yeatman, T. J. & Irby, R., Jun 15 2008, In : International Journal of Cancer. 122, 12, p. 2665-2673 9 p.

Research output: Contribution to journalArticle

src-Family Kinases
Inbred C57BL Mouse
Transgenes
Colonic Neoplasms
Carcinogenesis
2005
30 Citations (Scopus)

Iterative microarray and RNA interference-based interrogation of the Src-induced invasive phenotype

Irby, R. B., Malek, R. L., Bloom, G., Tsai, J., Letwin, N., Frank, B. C., Verratti, K., Yeatman, T. J. & Lee, N. H., Mar 1 2005, In : Cancer Research. 65, 5, p. 1814-1821 8 p.

Research output: Contribution to journalArticle

RNA Interference
Phenotype
Genes
src Genes
src-Family Kinases
75 Citations (Scopus)

Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression

Cook, A. C., Tuck, A. B., McCarthy, S., Turner, J. G., Irby, R., Bloom, G. C., Yeatman, T. J. & Chambers, A. F., Aug 1 2005, In : Molecular Carcinogenesis. 43, 4, p. 225-236 12 p.

Research output: Contribution to journalArticle

Osteopontin
Breast Neoplasms
Gene Expression
Neoplasms
Genes
226 Citations (Scopus)

Role of Stat3 in regulating p53 expression and function

Niu, G., Wright, K. L., Ma, Y., Wright, G. M., Huang, M., Irby, R., Briggs, J., Karras, J., Cress, W. D., Pardoll, D., Jove, R., Chen, J. & Yu, H., Sep 1 2005, In : Molecular and cellular biology. 25, 17, p. 7432-7440 9 p.

Research output: Contribution to journalArticle

Neoplasms
Mutation
p53 Genes
Up-Regulation
Binding Sites
2004
62 Citations (Scopus)

Osteopontin regulates multiple functions contributing to human colon cancer development and progression

Irby, R., McCarthy, S. M. & Yeatman, T. J., Oct 1 2004, In : Clinical and Experimental Metastasis. 21, 6, p. 515-523 9 p.

Research output: Contribution to journalArticle

Osteopontin
Colonic Neoplasms
Transfection
Neoplasms
Microvessels
2003
44 Citations (Scopus)

Osteopontin identified as colon cancer tumor progression marker

Agrawal, D., Chen, T., Irby, R., Quackenbush, J., Chambers, A. F., Szabo, M., Cantor, A., Coppola, D. & Yeatman, T. J., Jan 1 2003, In : Comptes Rendus - Biologies. 326, 10-11, p. 1041-1043 3 p.

Research output: Contribution to journalArticle

osteopontin
Osteopontin
Tumor Biomarkers
colorectal neoplasms
Colonic Neoplasms
15 Citations (Scopus)
Peroxisome Proliferators
Peroxisome Proliferator-Activated Receptors
Response Elements
Retinoid X Receptors
Genes
78 Citations (Scopus)

Regulation of caspase expression and apoptosis by adenomatous polyposis coli

Chen, T., Yang, I., Irby, R., Shain, K. H., Wang, H-G., Quackenbush, J., Coppola, D., Cheng, J. Q. & Yeatman, T. J., Aug 1 2003, In : Cancer Research. 63, 15, p. 4368-4374 7 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Caspases
Apoptosis
Caspase 7
Polyps
2002
77 Citations (Scopus)

Identification of Src transformation fingerprint in human colon cancer

Malek, R. L., Irby, R. B., Guo, Q. M., Lee, K., Wong, S., He, M., Tsai, J., Frank, B., Liu, E. T., Quackenbush, J., Jove, R., Yeatman, T. J. & Lee, N. H., Jan 1 2002, In : Oncogene. 21, 47, p. 7256-7265 10 p.

Research output: Contribution to journalArticle

Dermatoglyphics
Colonic Neoplasms
Genes
Human Development
Transcriptome
118 Citations (Scopus)

Increased Src activity disrupts cadherin/catenin-mediated homotypic adhesion in human colon cancer and transformed rodent cells

Irby, R. & Yeatman, T. J., May 1 2002, In : Cancer Research. 62, 9, p. 2669-2674 6 p.

Research output: Contribution to journalArticle

Catenins
Cadherins
Colonic Neoplasms
Rodentia
Focal Adhesion Protein-Tyrosine Kinases
351 Citations (Scopus)

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling

Agrawal, D., Chen, T., Irby, R., Quackenbush, J., Chambers, A. F., Szabo, M., Cantor, A., Coppola, D. & Yeatman, T. J., Apr 3 2002, In : Journal of the National Cancer Institute. 94, 7, p. 513-521 9 p.

Research output: Contribution to journalArticle

Osteopontin
Colonic Neoplasms
Tumor Biomarkers
Neoplasms
Gene Expression Profiling
2001
366 Citations (Scopus)

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A. & Jove, R., Jun 19 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 13, p. 7319-7324 6 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Transducers
src-Family Kinases
Fibroblasts
STAT Transcription Factors

v-Src transformation is mediated through farnesylated proteins

Teng, S., Sun, J., Irby, R., Hamilton, A. D., Sebti, S. & Yeatman, T. J., Jan 1 2001, In : Journal of Surgical Research. 99, 2, p. 343-346 4 p.

Research output: Contribution to journalArticle

Transferases
Proteins
Western Blotting
Prenylation
Antibodies
1999
417 Citations (Scopus)

Activating SRC mutation in a subset of advanced human colon cancers

Irby, R., Mao, W., Coppola, D., Kang, J., Loubeau, J. M., Trudeau, W., Karl, R., Fujita, D. J., Jove, R. & Yeatman, T. J., Feb 1 1999, In : Nature Genetics. 21, 2, p. 187-190 4 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Mutation
Rous sarcoma virus
src-Family Kinases
Nucleic Acid Regulatory Sequences
1998
70 Citations (Scopus)

Analysis of colorectal cancer by comparative genomic hybridization: Evidence for induction of the metastatic phenotype by loss of tumor suppressor genes

Paredes-Zaglul, A., Kang, J. J., Essig, Y. P., Mao, W., Irby, R., Wloch, M. & Yeatman, T. J., Apr 1 1998, In : Clinical Cancer Research. 4, 4, p. 879-886 8 p.

Research output: Contribution to journalArticle

Comparative Genomic Hybridization
Tumor Suppressor Genes
Colorectal Neoplasms
Phenotype
Neoplasm Metastasis
1997
172 Citations (Scopus)

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

Mao, W., Irby, R., Coppola, D., Fu, L., Wloch, M., Turner, J., Yu, H., Garcia, R., Jove, R. & Yeatman, T. J., Dec 18 1997, In : Oncogene. 15, 25, p. 3083-3090 8 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Epidermal Growth Factor Receptor
Proto-Oncogene Proteins c-met
Ligands
Receptor Protein-Tyrosine Kinases
37 Citations (Scopus)

Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential

Irby, R., Mao, W., Coppola, D., Jove, R., Gamero, A., Cuthbertson, D., Fujita, D. J. & Yeatman, T. J., Dec 1 1997, In : Cell Growth and Differentiation. 8, 12, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Growth
Neoplasms
Neoplasm Metastasis
Phenotype
1996
16 Citations (Scopus)

Altered ovarian sterol carrier protein expression in the pregnant streptozotocintreated diabetic rat

McLean, M. P., Warden, K. J., Sandhoff, T. W., Irby, R. B. & Hales, D. B., Jul 1996, In : Biology of reproduction. 55, 1, p. 38-46 9 p.

Research output: Contribution to journalArticle

3-Hydroxysteroid Dehydrogenases
Messenger RNA
Progesterone
Fetus
Enzymes

Rat sterol carrier protein-X expression is induced by a peroxisome proliferator-activated receptor

Irby, R. B. & McLean, M. P., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1380

Research output: Contribution to journalArticle

chloramphenicol acetyltransferase
Peroxisome Proliferator-Activated Receptors
Chloramphenicol O-Acetyltransferase
Peroxisome Proliferators
transport proteins
1995
29 Citations (Scopus)

Differential expression of hepatic sterol carrier proteins in the streptozotocin-treated diabetic rat

Mc Lean, M. P., Billheimer, J. T., Warden, K. J. & Irby, R. B., Aug 1995, In : Endocrinology. 136, 8, p. 3360-3368 9 p.

Research output: Contribution to journalArticle

Streptozocin
Liver
Cholesterol
sterol carrier proteins
Proteins
20 Citations (Scopus)

Prostaglandin f2α mediates ovarian sterol carrier protein-2 expression during luteolysis

Mc lean, M. P., Billheimer, J. T., Warden, K. J. & Irby, R. B., Nov 1995, In : Endocrinology. 136, 11, p. 4963-4972 10 p.

Research output: Contribution to journalArticle

Luteolysis
Dinoprost
Messenger RNA
3-Hydroxysteroid Dehydrogenases
Progesterone
3 Citations (Scopus)

Reduced hepatic sterol carrier protein-2 expression in the streptozotocin treated diabetic rat

McLean, M. P., Nanjo, K., Irby, R. B., Warden, K. J. & Billheimer, J. T., Aug 1 1995, In : Endocrine. 3, 8, p. 563-571 9 p.

Research output: Contribution to journalArticle

Streptozocin
Liver
Cholesterol
Hypercholesterolemia
Proteins
1994

Enzymatic preparation of [2,4,5,6,8-14C, 5′-3H]guanosine for use in biosynthetic studies of pterinoid and flavin compounds

Irby, R. & Adair, W. L., May 1 1994, In : Analytical Biochemistry. 218, 2, p. 413-416 4 p.

Research output: Contribution to journalArticle

Guanosine
Ribose
Guanine
Flavins
Pterins
17 Citations (Scopus)

Intermediates in the folic acid biosynthetic pathway are incorporated into molybdopterin the yeast, Pichia canadensis

Irby, R. B. & Adair, W. L., Sep 30 1994, In : Journal of Biological Chemistry. 269, 39, p. 23981-23987 7 p.

Research output: Contribution to journalArticle

Pichia
Biosynthetic Pathways
Folic Acid
Yeast
Yeasts
1991
60 Citations (Scopus)

Effects of copper and tributyltin on stress protein abundance in the rotifer Brachionus plicatilis

Cochrane, B. J., Irby, R. B. & Snell, T. W., 1991, In : Comparative Biochemistry and Physiology. Part C, Comparative. 98, 2-3, p. 385-390 6 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Copper
Pentachlorophenol
Sodium Azide
Tin