• 545 Citations
  • 11 h-Index
20082019

Research output per year

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Personal profile

Research interests

The laboratory of Dr. Ryan Hobbs broadly studies how skin keratinocytes respond to mechanical, chemical and environmental stressors at the cellular and molecular levels. The inability to control stress responses is a key feature in all skin disorders. Thus, the lab's research seeks to identify and understand molecular mechanisms that underlie a number of distinct skin disorders including non-melanoma skin cancers, alopecia, vitiligo, psoriasis and atopic dermatitis.

Major efforts are centered around the study of autoimmune regulator (Aire) in skin keratinocytes. Aire is a unique transcriptional regulator that is classically known as a master regulator of autoimmunity, owing to its abundant expression in a subset of medullary thymic epithelial cells and function as a key regulator of negative selection to eliminate self-reactive T-lymphocytes. Previous findings indicate Aire becomes abundantly expressed in skin keratinocytes in response to acute and chronic stressors. Loss of function mutations in Aire are causative for the disease autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). These patients often present with many skin abnormalities including hair loss, nail dystrophy, vitiligo, and oral mucocutaneous candidiasis. A central focus of the research program is to elucidate when, where, how and why Aire is expressed and functional in skin.

Teaching and educational interests

Dr. Ryan Hobbs is actively engaged in teaching dermatology residents (Basic Science of Skin Discussion), M1 MD/PhD students (BMS 506B, Biological Basis of Human Health and Disease) and PhD students (BMS 597, Cancer Biology Colloquium; MICRO560, Concepts in Immunology).

Dr. Hobbs also serves as a co-representative of the Department of Dermatology to the College of Medicine's Diversity and Inclusion Council.

Education/Academic qualification

Postdoctoral Fellowship, Johns Hopkins University

… → 2017

Life Sciences (Field of Cellular and Molecular Biology), PhD, Northwestern University

… → 2010

Biochemistry, BS, University of Missouri in Columbia

… → 2004

Microbiology, AB, University of Missouri in Columbia

… → 2004

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Research Output

  • 545 Citations
  • 11 h-Index
  • 11 Article
  • 3 Letter
  • 2 Comment/debate
  • 2 Review article

Sam68 is required for the growth and survival of nonmelanoma skin cancer

Fu, K., Sun, X., Xia, X., Hobbs, R. P., Guo, Y., Coulombe, P. A. & Wan, F., Oct 1 2019, In : Cancer medicine. 8, 13, p. 6106-6113 8 p.

Research output: Contribution to journalArticle

Open Access
  • Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden

    Parekh, N. J., Krouse, T. E., Reider, I. E., Hobbs, R. P., Ward, B. M. & Norbury, C. C., Jan 1 2019, In : PLoS pathogens. 15, 10, e1007778.

    Research output: Contribution to journalArticle

    Open Access
  • Antimicrobial action of calprotectin that does not involve metal withholding

    Besold, A. N., Culbertson, E. M., Nam, L., Hobbs, R. P., Boyko, A., Maxwell, C. N., Chazin, W. J., Marques, A. R. & Culotta, V. C., Dec 2018, In : Metallomics. 10, 12, p. 1728-1742 15 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

    Hobbs, R. P., Smith, S. H. & Getsios, S., Jul 2017, In : Journal of Investigative Dermatology. 137, 7, p. 1410-1412 3 p.

    Research output: Contribution to journalComment/debate

  • 2 Scopus citations

    Keratins Are Going Nuclear

    Hobbs, R. P., Jacob, J. T. & Coulombe, P. A., Aug 8 2016, In : Developmental Cell. 38, 3, p. 227-233 7 p.

    Research output: Contribution to journalComment/debate

  • 21 Scopus citations

    Prizes

    Junior Faculty Research Scholar Award

    Ryan Hobbs (Recipient), Nicholas Graziane (Recipient), Hyun Jin Kwun (Recipient) & Jonathan Stine (Recipient), 2018

    Prize