• 519 Citations
  • 11 h-Index
20082019
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Personal profile

Research interests

The laboratory of Dr. Ryan Hobbs broadly studies how skin keratinocytes respond to mechanical, chemical and environmental stressors at the cellular and molecular levels. The inability to control stress responses is a key feature in all skin disorders. Thus, the lab's research seeks to identify and understand molecular mechanisms that underlie a number of distinct skin disorders including non-melanoma skin cancers, alopecia, vitiligo, psoriasis and atopic dermatitis.

Major efforts are centered around the study of autoimmune regulator (Aire) in skin keratinocytes. Aire is a unique transcriptional regulator that is classically known as a master regulator of autoimmunity, owing to its abundant expression in a subset of medullary thymic epithelial cells and function as a key regulator of negative selection to eliminate self-reactive T-lymphocytes. Previous findings indicate Aire becomes abundantly expressed in skin keratinocytes in response to acute and chronic stressors. Loss of function mutations in Aire are causative for the disease autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). These patients often present with many skin abnormalities including hair loss, nail dystrophy, vitiligo, and oral mucocutaneous candidiasis. A central focus of the research program is to elucidate when, where, how and why Aire is expressed and functional in skin.

Teaching and educational interests

Dr. Ryan Hobbs is actively engaged in teaching dermatology residents (Basic Science of Skin Discussion), M1 MD/PhD students (BMS 506B, Biological Basis of Human Health and Disease) and PhD students (BMS 597, Cancer Biology Colloquium; MICRO560, Concepts in Immunology).

Dr. Hobbs also serves as a co-representative of the Department of Dermatology to the College of Medicine's Diversity and Inclusion Council.

Education/Academic qualification

Postdoctoral Fellowship, Johns Hopkins Unversity

… → 2017

Life Sciences (Field of Cellular and Molecular Biology), PhD, Northwestern University

… → 2010

Biochemistry, BS, University of Missouri in Columbia

… → 2004

Microbiology, AB, University of Missouri in Columbia

… → 2004

Fingerprint Dive into the research topics where Ryan Hobbs is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Keratin-17 Medicine & Life Sciences
Desmoplakins Chemical Compounds
Intermediate Filaments Medicine & Life Sciences
Keratins Medicine & Life Sciences
Keratinocytes Medicine & Life Sciences
Plakophilins Medicine & Life Sciences
Intermediate Filament Proteins Medicine & Life Sciences
Epithelium Medicine & Life Sciences

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Research Output 2008 2019

  • 519 Citations
  • 11 h-Index
  • 10 Article
  • 3 Letter
  • 2 Comment/debate
  • 2 Review article

Sam68 is required for the growth and survival of nonmelanoma skin cancer

Fu, K., Sun, X., Xia, X., Hobbs, R., Guo, Y., Coulombe, P. A. & Wan, F., Jan 1 2019, (Accepted/In press) In : Cancer medicine.

Research output: Contribution to journalArticle

Open Access
Skin Neoplasms
Mitosis
Keratinocytes
DNA Damage
Survival
2 Citations (Scopus)

Antimicrobial action of calprotectin that does not involve metal withholding

Besold, A. N., Culbertson, E. M., Nam, L., Hobbs, R., Boyko, A., Maxwell, C. N., Chazin, W. J., Marques, A. R. & Culotta, V. C., Dec 1 2018, In : Metallomics. 10, 12, p. 1728-1742 15 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Metals
Pathogens
Escherichia coli
Growth
2 Citations (Scopus)

Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes

Hobbs, R., Smith, S. H. & Getsios, S., Jul 1 2017, In : Journal of Investigative Dermatology. 137, 7, p. 1410-1412 3 p.

Research output: Contribution to journalComment/debate

Keratinocytes
Psoriasis
Interleukin-17 Receptors
Genes
Transcriptome
17 Citations (Scopus)

Keratins Are Going Nuclear

Hobbs, R., Jacob, J. T. & Coulombe, P. A., Aug 8 2016, In : Developmental Cell. 38, 3, p. 227-233 7 p.

Research output: Contribution to journalComment/debate

Keratin-17
Cytoskeletal Proteins
Cell proliferation
Keratins
Gene expression
14 Citations (Scopus)

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo

Hobbs, R., Batazzi, A. S., Han, M. C. & Coulombe, P. A., Oct 27 2016, In : Oncogene. 35, 43, p. 5653-5662 10 p.

Research output: Contribution to journalArticle

Keratin-17
Carcinogenesis
Cytokines
Papillomaviridae
Uterine Cervical Neoplasms