• 1072 Citations
  • 19 h-Index
20022022
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Research Output 2002 2019

  • 1072 Citations
  • 19 h-Index
  • 44 Article
  • 4 Chapter
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Article
2019

Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer

Cook, E. C., Sahu, D., Bastidas, M. & Showalter, S. A., Oct 1 2019, In : Journal of Physical Chemistry B. 123, 1, p. 106-116 11 p.

Research output: Contribution to journalArticle

Transcription factors
Polymers
Transcription Factors
Nuclear magnetic resonance
Proline
12 Citations (Scopus)

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin

Cook, E. C., Featherston, E. R., Showalter, S. A. & Cotruvo, Jr., J. A., Jan 15 2019, In : Biochemistry. 58, 2, p. 120-125 6 p.

Research output: Contribution to journalArticle

Methylobacterium extorquens
Lanthanoid Series Elements
EF Hand Motifs
Rare earth elements
Metals
2017
23 Citations (Scopus)

Application of NMR to studies of intrinsically disordered proteins

Gibbs, E. B., Cook, E. C. & Showalter, S. A., Aug 15 2017, In : Archives of Biochemistry and Biophysics. 628, p. 57-70 14 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Proteins
1 Citation (Scopus)

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

Kranick, J. C., Chadalavada, D. M., Sahu, D. & Showalter, S. A., Aug 2017, In : PloS one. 12, 8, e0182445.

Research output: Contribution to journalArticle

Double-Stranded RNA
double-stranded RNA
MicroRNAs
microRNA
engineering
20 Citations (Scopus)

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Gibbs, E. B., Lu, F., Portz, B., Fisher, M. J., Medellin, B. P., Laremore, T. N., Zhang, Y. J., Gilmour, D. S. & Showalter, S. A., May 12 2017, In : Nature communications. 8, 15233.

Research output: Contribution to journalArticle

RNA Polymerase III
phosphorylation
Phosphorylation
RNA Polymerase II
switches
15 Citations (Scopus)

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Portz, B., Lu, F., Gibbs, E. B., Mayfield, J. E., Rachel Mehaffey, M., Zhang, Y. J., Brodbelt, J. S., Showalter, S. A. & Gilmour, D. S., May 12 2017, In : Nature communications. 8, 15231.

Research output: Contribution to journalArticle

RNA Polymerase III
Phosphorylation
RNA Polymerase II
Drosophila melanogaster
Consensus Sequence

Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain

Gibbs, E. B., Laremore, T. N., Usher, G. A., Portz, B., Cook, E. C. & Showalter, S. A., Nov 7 2017, In : Biophysical journal. 113, 9, p. 1909-1911 3 p.

Research output: Contribution to journalArticle

RNA Polymerase III
Peptide Elongation Factors
RNA Polymerase II
Positive Transcriptional Elongation Factor B
Substrate Specificity
2016
2 Citations (Scopus)

Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA

Acevedo, R., Evans, D., Penrod, K. A. & Showalter, S. A., Jun 21 2016, In : Biophysical journal. 110, 12, p. 2610-2617 8 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Nucleic Acids
RNA
Biological Phenomena
Calorimetry
6 Citations (Scopus)

Quantification of Compactness and Local Order in the Ensemble of the Intrinsically Disordered Protein FCP1

Gibbs, E. B. & Showalter, S. A., Sep 1 2016, In : Journal of Physical Chemistry B. 120, 34, p. 8960-8969 10 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
void ratio
proteins
Proteins
Chemical shift
2015
16 Citations (Scopus)

A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution

Bastidas, M., Gibbs, E. B., Sahu, D. & Showalter, S. A., Jan 1 2015, In : Concepts in Magnetic Resonance Part A: Bridging Education and Research. 44, 1, p. 54-66 13 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Carbon
Nuclear magnetic resonance
Experiments
Biomolecules
3 Citations (Scopus)
Double-Stranded RNA
Microcomputers
Formability
MicroRNAs
Microprocessor chips
6 Citations (Scopus)

Helical defects in MicroRNA influence protein binding by TAR RNA binding protein

Acevedo, R., Orench-Rivera, N., Quarles, K. A. & Showalter, S. A., Jan 21 2015, In : PloS one. 10, 1, e0116749.

Research output: Contribution to journalArticle

RNA-binding proteins
Double-Stranded RNA
protein binding
double-stranded RNA
MicroRNAs
27 Citations (Scopus)

Quantitative biophysical characterization of intrinsically disordered proteins

Gibbs, E. B. & Showalter, S. A., Feb 17 2015, In : Biochemistry. 54, 6, p. 1314-1326 13 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Thermodynamics
Kinetics
Biophysics
Cell signaling
2014
17 Citations (Scopus)

Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein

Cordek, D. G., Croom-Perez, T. J., Hwang, J., Hargittai, M. R. S., Subba-Reddy, C. V., Han, Q., Lodeiro, M. F., Ning, G., McCrory, T. S., Arnold, J. J., Koc, H., Lindenbach, B. D., Showalter, S. A. & Cameron, C. E., Jan 1 2014, In : Journal of Biological Chemistry. 289, 35, p. 24397-24416 20 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Phosphorylation
RNA Viruses
Viral Proteins
Proteome
26 Citations (Scopus)

Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods

Sahu, D., Bastidas, M. & Showalter, S. A., Mar 15 2014, In : Analytical Biochemistry. 449, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Chemical shift
Carbon
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
7 Citations (Scopus)

Intrinsically disordered proteins: Methods for structure and dynamics studies

Showalter, S. A., Jan 1 2014, In : eMagRes. 3, 2, p. 181-190 10 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Proteins
Nuclear magnetic resonance
Structural Models
Molecular Dynamics Simulation
11 Citations (Scopus)

Role of ordered proteins in the folding-upon-binding of intrinsically disordered proteins

Lawrence, C. W., Kumar, S., Noid, W. G. & Showalter, S. A., Mar 6 2014, In : Journal of Physical Chemistry Letters. 5, 5, p. 833-838 6 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
folding
proteins
Proteins
Thermodynamics
2013
17 Citations (Scopus)

Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the drosha cleavage site

Quarles, K. A., Sahu, D., Havens, M. A., Forsyth, E. R., Wostenberg, C., Hastings, M. L. & Showalter, S. A., Feb 5 2013, In : Biochemistry. 52, 5, p. 795-807 13 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Model structures
MicroRNAs
RNA
Untranslated RNA
9 Citations (Scopus)

Native-based simulations of the binding interaction between RAP74 and the disordered FCP1 peptide

Kumar, S., Showalter, S. A. & Noid, W. G., Mar 21 2013, In : Journal of Physical Chemistry B. 117, 11, p. 3074-3085 12 p.

Research output: Contribution to journalArticle

Transcription factors
Peptides
peptides
Transcription Factors
helices
8 Citations (Scopus)

Thermodynamic and structural determinants of differential pdx1 binding to elements from the insulin and IAPP promoters

Bastidas, M. & Showalter, S. A., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3360-3377 18 p.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Thermodynamics
Transcription Factors
Consensus Sequence
Insulin
2012
21 Citations (Scopus)
Intrinsically Disordered Proteins
Carbon
Nuclear magnetic resonance
proteins
Proteins

NMR investigations of the solution structures of Ru-Zn complexes tethered by oligo(aminoethylglycine) chains

Myers, C. P., Sun, S., Showalter, S. A., Miller, J. R. & Williams, M. E., Jun 19 2012, In : Polyhedron. 40, 1, p. 118-124 7 p.

Research output: Contribution to journalArticle

Titration
titration
strands
Bearings (structural)
Nuclear magnetic resonance
29 Citations (Scopus)

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

Wostenberg, C., Lary, J. W., Sahu, D., Acevedo, R., Quarles, K. A., Cole, J. L. & Showalter, S. A., Dec 13 2012, In : PloS one. 7, 12, e51829.

Research output: Contribution to journalArticle

double-stranded RNA
MicroRNAs
microRNA
small interfering RNA
RNA
2011
15 Citations (Scopus)

Atomistic simulations reveal structural disorder in the RAP74-FCP1 complex

Wostenberg, C., Kumar, S., Noid, W. G. & Showalter, S. A., Nov 24 2011, In : Journal of Physical Chemistry B. 115, 46, p. 13731-13739 9 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Transcription
RNA
Molecular dynamics
Entropy
18 Citations (Scopus)

The disordered C-terminus of the RNA Polymerase II phosphatase FCP1 is partially helical in the unbound state

Lawrence, C. W., Bonny, A. & Showalter, S. A., Jul 8 2011, In : Biochemical and Biophysical Research Communications. 410, 3, p. 461-465 5 p.

Research output: Contribution to journalArticle

General Transcription Factors
Intrinsically Disordered Proteins
RNA Polymerase II
Recycling
Transcription
2010
18 Citations (Scopus)

Dynamic origins of differential RNA binding function in two dsRBDs from the miRNA "Microprocessor" complex

Wostenberg, C., Quarles, K. A. & Showalter, S. A., Dec 21 2010, In : Biochemistry. 49, 50, p. 10728-10736 9 p.

Research output: Contribution to journalArticle

Microcomputers
MicroRNAs
Microprocessor chips
Ribonuclease III
RNA
45 Citations (Scopus)

Entropy localization in proteins

Li, D. W., Showalter, S. A. & Brüschweiler, R., Dec 9 2010, In : Journal of Physical Chemistry B. 114, 48, p. 16036-16044 9 p.

Research output: Contribution to journalArticle

Entropy
entropy
proteins
Proteins
Dihedral angle
12 Citations (Scopus)

MD simulations of the dsRBP DGCR8 reveal correlated motions that may aid pri-miRNA binding

Wostenberg, C., Noid, W. G. & Showalter, S. A., Jul 7 2010, In : Biophysical journal. 99, 1, p. 248-256 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Ribonuclease III
Nucleic Acid Conformation
Antiviral Agents
Proteins
2009
8 Citations (Scopus)

Heterometallic ferrocene-rhenium complexes linked by an aminoethylglycine scaffold

Levine, L. A., Kirin, S. I., Myers, C. P., Showalter, S. A. & Williams, M. E., Feb 19 2009, In : European Journal of Inorganic Chemistry. 5, p. 613-621 9 p.

Research output: Contribution to journalArticle

Rhenium
Carbon Monoxide
Scaffolds
Fluorescence spectroscopy
Emission spectroscopy
31 Citations (Scopus)

Incorporating 1H chemical shift determination into 13C-direct detected spectroscopy of intrinsically disordered proteins in solution

O'Hare, B., Benesi, A. J. & Showalter, S. A., Oct 1 2009, In : Journal of Magnetic Resonance. 200, 2, p. 354-358 5 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Chemical shift
chemical equilibrium
Spectrum Analysis
Chemical Evolution
10 Citations (Scopus)
Terminal Repeat Sequences
RNA Polymerase II
Transcription Factors
Nuclear magnetic resonance
General Transcription Factors
70 Citations (Scopus)

Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: Quantitative and absolute determination of backbone motion in ubiquitin

Salmon, L., Bouvignies, G., Markwick, P., Lakomek, N., Showalter, S., Li, D. W., Walter, K., Griesinger, C., Brüschweiler, R. & Blackledge, M., May 25 2009, In : Angewandte Chemie - International Edition. 48, 23, p. 4154-4157 4 p.

Research output: Contribution to journalArticle

Ubiquitin
Molecular dynamics
Trajectories
Nuclear magnetic resonance
Proteins
30 Citations (Scopus)

Structural dynamics of protein backbone ψ angles: Extended molecular dynamics simulations versus experimental 3J scalar couplings

Markwick, P. R. L., Showalter, S. A., Bouvignies, G., Brüschweiler, R. & Blackledge, M., Jul 24 2009, In : Journal of Biomolecular NMR. 45, 1-2, p. 17-21 5 p.

Research output: Contribution to journalArticle

Structural dynamics
Molecular Dynamics Simulation
Molecular dynamics
Computer simulation
Reproduction
2008
15 Citations (Scopus)

A multifaceted approach to the interpretation of NMR order parameters: A case study of a dynamic α-helix

Johnson, E., Showalter, S. A. & Brüschweiler, R., May 15 2008, In : Journal of Physical Chemistry B. 112, 19, p. 6203-6210 8 p.

Research output: Contribution to journalArticle

helices
Nuclear magnetic resonance
nuclear magnetic resonance
proteins
Proteins
69 Citations (Scopus)

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft

Showalter, S. A., Bruschweiler-Li, L., Johnson, E., Zhang, F. & Brüschweiler, R., May 21 2008, In : Journal of the American Chemical Society. 130, 20, p. 6472-6478 7 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Oncogene Proteins
Ligands
Proteins
Tumors
23 Citations (Scopus)

Structure and Dynamics of Ca2 +-Binding Domain 1 of the Na +/Ca2 + Exchanger in the Presence and in the Absence of Ca2 +

Johnson, E., Bruschweiler-Li, L., Showalter, S. A., Vuister, G. W., Zhang, F. & Brüschweiler, R., Mar 28 2008, In : Journal of Molecular Biology. 377, 3, p. 945-955 11 p.

Research output: Contribution to journalArticle

Binding Sites
Cardiac Myocytes
Magnetic Resonance Spectroscopy
Cell Membrane
Calcium
2007
84 Citations (Scopus)

Quantitative molecular ensemble interpretation of NMR dipolar couplings without restraints

Showalter, S. A. & Brüschweiler, R., Apr 11 2007, In : Journal of the American Chemical Society. 129, 14, p. 4158-4159 2 p.

Research output: Contribution to journalArticle

Statistical mechanics
Molecular Dynamics Simulation
Ubiquitin
Thermodynamics
Molecular dynamics
56 Citations (Scopus)

Toward quantitative interpretation of methyl side-chain dynamics from NMR by molecular dynamics simulations

Showalter, S. A., Johnson, E., Rance, M. & Brüschweiler, R., Nov 21 2007, In : Journal of the American Chemical Society. 129, 46, p. 14146-14147 2 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Molecular dynamics
Nuclear magnetic resonance
Calbindins
Benchmarking
150 Citations (Scopus)
Biomolecules
field theory (physics)
Molecular dynamics
Nuclear magnetic resonance
molecular dynamics
2005
27 Citations (Scopus)

Correlated motions in the U1 snRNA stem/loop 2:U1A RBD1 complex

Showalter, S. A. & Hall, K. B., Sep 2005, In : Biophysical journal. 89, 3, p. 2046-2058 13 p.

Research output: Contribution to journalArticle

RNA
Nucleotides
Proteins
Molecular Dynamics Simulation
Thermodynamics
28 Citations (Scopus)

Iron responsive element RNA flexibility described by NMR and isotropic reorientational eigenmode dynamics

Showalter, S. A., Baker, N. A., Tang, C. & Hall, K. B., Jul 1 2005, In : Journal of Biomolecular NMR. 32, 3, p. 179-193 15 p.

Research output: Contribution to journalArticle

Iron
Nuclear magnetic resonance
RNA
Ribose
Molecular Dynamics Simulation
8 Citations (Scopus)

Isotropic reorientational eigenmode dynamics complements NMR relaxation measurements for RNA

Showalter, S. A. & Hall, K. B., Jan 1 2005, In : Methods in enzymology. 394, p. 465-480 16 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
RNA
Iron
Barreling
Dynamic analysis
2004
31 Citations (Scopus)

Altering the RNA-binding Mode of the U1A RBD1 Protein

Showalter, S. A. & Hall, K. B., Jan 9 2004, In : Journal of Molecular Biology. 335, 2, p. 465-480 16 p.

Research output: Contribution to journalArticle

RNA
Glycine
Proteins
Salts
Valine
2002
38 Citations (Scopus)

A functional role for correlated motion in the N-terminal RNA-binding domain of human U1A protein

Showalter, S. A. & Hall, K. B., Jan 1 2002, In : Journal of Molecular Biology. 322, 3, p. 533-542 10 p.

Research output: Contribution to journalArticle

RNA
Amino Acid Substitution
Molecular Dynamics Simulation
U1A protein
RNA-Binding Motifs