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Personal profile

Research interests

Dr. Shantu Amin is director of the Organic Synthesis Core of Penn State Cancer Institute. His laboratory is nationally recognized for developing synthetic strategies for novel small drug-like molecules for cancer prevention and therapy.

The major focus of Dr. Amin’s research is the synthesis of anti-cancer agents, elucidating their efficacy and investigating their drug metabolism. He has also been involved in structure-activity studies with mutagenic and carcinogenic compounds and using this knowledge to develop appropriate chemopreventive agents.

These studies have resulted in the development of several chemopreventive/ chemotherapeutic agents and an understanding of their mechanisms of action. 

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Projects 1979 2019

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/19

Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen
Carcinogens
Derivatives
Polycyclic Aromatic Hydrocarbons
Metabolites
Purification
Carcinogenesis
Pentanones
Cytochrome P-450 Enzyme System
Lung
Microsomes

SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

Amin, S., Ruehle, P. & Kaplan, J.

National Institutes of Health

3/16/923/15/97

Project: Research project

Carcinogens
Derivatives
Polycyclic Aromatic Hydrocarbons
Polycyclic aromatic hydrocarbons
Metabolites

CANCER CENTER SUPPORT GRANT

Amin, S., Haley, N. J., Rivenson, A., Ronai, Z., Wynder, E., Brunnemann, K., Ng, S., Rozycki, L., Hard, G., Sweeney, N., Nixon, D., Jeffrey, A., Iatropoulos, M., Thompson, S., Prokopczyk, B., Richie, J. & Albino, A.

National Institutes of Health

8/1/7911/30/06

Project: Research project

Synthetic Chemistry Techniques
Photolysis
Neoplasms
Environmental Carcinogens
Assays

Research Output 1971 2019

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents
1 Citation (Scopus)

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

Sulfur
Isothiocyanates
Neoplasms
Organoselenium Compounds
Glucosinolates

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., Feb 1 2019, In : International journal of molecular sciences. 20, 3, 521.

Research output: Contribution to journalArticle

quinoxalines
STAT3 Transcription Factor
Quinoxalines
Transcription
Transducers

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Viruses
Polyomavirus
Stem Cell Transplantation
Stem cells
Cytomegalovirus