• 15232 Citations
  • 59 h-Index
1971 …2020

Research output per year

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Personal profile

Research interests

Dr. Shantu Amin is director of the Organic Synthesis Core of Penn State Cancer Institute. His laboratory is nationally recognized for developing synthetic strategies for novel small drug-like molecules for cancer prevention and therapy.

The major focus of Dr. Amin’s research is the synthesis of anti-cancer agents, elucidating their efficacy and investigating their drug metabolism. He has also been involved in structure-activity studies with mutagenic and carcinogenic compounds and using this knowledge to develop appropriate chemopreventive agents.

These studies have resulted in the development of several chemopreventive/ chemotherapeutic agents and an understanding of their mechanisms of action. 

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Projects

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Kester, M., Cabot, M. C., Loughran, T. P. & Kester, M.

National Institutes of Health

9/10/138/31/19

Project: Research project

  • SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

    Amin, S., Ruehle, P. & Kaplan, J.

    National Institutes of Health

    3/16/923/15/97

    Project: Research project

  • CANCER CENTER SUPPORT GRANT

    Amin, S., Haley, N. J., Rivenson, A., Ronai, Z., Wynder, E., Brunnemann, K., Ng, S., Rozycki, L., Hard, G., Sweeney, N., Nixon, D., Jeffrey, A., Iatropoulos, M., Thompson, S., Prokopczyk, B., Richie, J. & Albino, A.

    National Institutes of Health

    8/1/7911/30/06

    Project: Research project

  • Research Output

    An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

    Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  • Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

    Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

    Research output: Contribution to journalArticle

  • Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

    Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

    Research output: Contribution to journalArticle

  • Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

    Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In : Laboratory Investigation. 100, 2, p. 250-264 15 p.

    Research output: Contribution to journalArticle