Projects per year
Personal profile
Research interests
Dr. Shantu Amin is director of the Organic Synthesis Core of Penn State Cancer Institute. His laboratory is nationally recognized for developing synthetic strategies for novel small drug-like molecules for cancer prevention and therapy.
The major focus of Dr. Amin’s research is the synthesis of anti-cancer agents, elucidating their efficacy and investigating their drug metabolism. He has also been involved in structure-activity studies with mutagenic and carcinogenic compounds and using this knowledge to develop appropriate chemopreventive agents.
These studies have resulted in the development of several chemopreventive/ chemotherapeutic agents and an understanding of their mechanisms of action.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 2 Finished
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Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.Research output: Contribution to journal › Article › peer-review
Open Access -
Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis
Kaur, R., Desai, D., Amin, S., Raza, K., Bhalla, A., Yadav, P. & Kaushal, N., Mar 2023, In: Molecular and Cellular Biochemistry. 478, 3, p. 621-636 16 p.Research output: Contribution to journal › Article › peer-review
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Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells
Chen, K. M., Sun, Y. W., Sun, D., Gowda, K., Amin, S. & El-Bayoumy, K., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2152-2159 8 p.Research output: Contribution to journal › Article › peer-review
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Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells
Chen, K. M., Sun, Y. W., Krebs, N. M., Sun, D., Krzeminski, J., Reinhart, L., Gowda, K., Amin, S., Mallery, S., Richie, J. P. & El-Bayoumy, K., Sep 19 2022, In: Carcinogenesis. 43, 8, p. 746-753 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Prizes
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Outstanding Collaborative Research Team
Adair, James Hansell (Recipient), Amin, Shantu (Recipient), Claxton, David (Recipient), Desai, Dhimant (Recipient), Hengst, Jeremy (Recipient), Liao, Jiangang "Jason" (Recipient), Paulson, Robert (Recipient), Sharma, Arun (Recipient), Stanley, Bruce (Recipient), Wang, Hong-Gang (Recipient), Yun, Jong (Recipient) & Zhu, Junjia (Recipient), 2015
Prize