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Research Output 1971 2019

2019
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

Research output: Contribution to journalArticle

Open Access
Unfolded Protein Response
Transducers
Bile Acids and Salts
Allergens
Inflammation
1 Citation (Scopus)

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

Sulfur
Isothiocyanates
Neoplasms
Organoselenium Compounds
Glucosinolates
N'-nitrosonornicotine
Oral Leukoplakia
Tobacco
Tongue
Carcinogens

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., Feb 1 2019, In : International journal of molecular sciences. 20, 3, 521.

Research output: Contribution to journalArticle

quinoxalines
STAT3 Transcription Factor
Quinoxalines
Transcription
Transducers

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Viruses
Polyomavirus
Stem Cell Transplantation
Stem cells
Cytomegalovirus
1 Citation (Scopus)

Leishmanicidal activity of isoselenocyanate derivatives

Fernández-Rubio, C., Larrea, E., Guerrero, J. P., Herrero, E. S., Gamboa, I., Berrio, C., Plano, D., Amin, S., Sharma, A. & Nguewa, P. A., Feb 1 2019, In : Antimicrobial agents and chemotherapy. 63, 2, e00904-18.

Research output: Contribution to journalArticle

Leishmania major
Leishmaniasis
Leishmania
Amphotericin B
Cell Cycle
2 Citations (Scopus)

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Metabolism
Hydroxyquinolines
Chemical activation

Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

Shafirovich, V., Kolbanovskiy, M., Kropachev, K., Liu, Z., Cai, Y., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Amin, S., Dadali, A., Broyde, S. & Geacintov, N. E., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

Nucleosomes
DNA Repair
Repair
Nucleotides
Physical properties

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Jan 1 2019, (Accepted/In press) In : Laboratory Investigation.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Aryl Hydrocarbon Receptors
Cholesterol
Ligands
Genes
2018
Metabolites
DNA Damage
Ovary
DNA
Epoxy Compounds
1 Citation (Scopus)

D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex

Yang, Y., Lee, S. M., Imamura, F., Gowda, K., Amin, S. & Mailman, R., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Arrestin
Prefrontal Cortex
Short-Term Memory
Dopamine
Adenylyl Cyclases
4 Citations (Scopus)

Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells

Ramisetti, S. R., Pandey, M. K., Lee, S., Karelia, D., Narayan, S., Amin, S. & Sharma, A., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

Melanoma
Assays
Cells
Derivatives
Cell death
3 Citations (Scopus)

Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

Chen, K-M., Guttenplan, J. B., Sun, Y-W., Cooper, T., Shalaby, N. A. E., Kosinska, W., Benitez, G., Aliaga, C., Zhu, J., Liao, J. J., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Mar 1 2018, In : Cancer Prevention Research. 11, 3, p. 157-164 8 p.

Research output: Contribution to journalArticle

Mutagenesis
Powders
Mouth
Carcinogenesis
DNA Damage

Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids

Dyba, M., Da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D. & Chung, F. L., Aug 20 2018, In : Chemical research in toxicology. 31, 8, p. 772-783 12 p.

Research output: Contribution to journalArticle

DNA Adducts
Unsaturated Fatty Acids
Monoclonal Antibodies
Deoxyguanosine
Tissue
3 Citations (Scopus)
Androgen Receptors
Reactive Oxygen Species
Prostatic Neoplasms
Apoptosis
Prostate-Specific Antigen
2017
9 Citations (Scopus)

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Weng, M. W., Lee, H. W., Choi, B., Wang, H. T., Hu, Y., Mehta, M., Desai, D., Amin, S., Zheng, Y. & Tang, M. S., Jan 1 2017, In : Oncotarget. 8, 11, p. 18213-18226 14 p.

Research output: Contribution to journalArticle

Aflatoxin B1
DNA Adducts
Aldehydes
Codon
DNA Repair
7 Citations (Scopus)

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., Amin, S., Glick, A. B. & Perdew, G. H., Jan 1 2017, In : Toxicological Sciences. 160, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Neutrophil Activation
Chemotactic Factors
Keratinocytes
Skin

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A., Sep 8 2017, (Accepted/In press) In : Polycyclic Aromatic Compounds. p. 1-11 11 p.

Research output: Contribution to journalArticle

Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography
4 Citations (Scopus)

A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis

Pandey, M. K., Gowda, K., Sung, S., Abraham, T., Budak-Alpdogan, T., Talamo, G., Dovat, S. & Amin, S., Sep 1 2017, In : Experimental Hematology. 53, p. 31-42 12 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Osteogenesis
Microtubules
Polymerization
Cell Survival
10 Citations (Scopus)

Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry

El-Bayoumy, K., Chen, K-M., Zhang, S. M., Sun, Y-W., Amin, S., Stoner, G. & Guttenplan, J. B., Jan 1 2017, In : Chemical Research in Toxicology. 30, 1, p. 126-144 19 p.

Research output: Contribution to journalReview article

Mouth Neoplasms
Mouth
Environmental Carcinogens
Carcinogenesis
Animal Models
8 Citations (Scopus)

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity

Karelia, D. N., Sk, U. H., Singh, P., Gowda, A. S. P., Pandey, M. K., Ramisetti, S. R., Amin, S. & Sharma, A., Jan 1 2017, In : European Journal of Medicinal Chemistry. 135, p. 282-295 14 p.

Research output: Contribution to journalArticle

Naphthalimides
Type II DNA Topoisomerase
Melanoma
Cells
Growth
3 Citations (Scopus)

Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts

Guttenplan, J. B., Chen, K-M., Sun, Y-W., Lajara, B., Shalaby, N. A. E., Kosinska, W., Benitez, G., Gowda, K., Amin, S., Stoner, G. & El-Bayoumy, K., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2159-2164 6 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Mutagenesis
DNA Adducts
Fibroblasts
DNA Damage
5 Citations (Scopus)
Environmental Pollutants
Alcohol Drinking
DNA Damage
Alcohols
Carcinogenesis
5 Citations (Scopus)
Tobacco
Mouth Neoplasms
Biomarkers
carcinogens
Early Detection of Cancer
8 Citations (Scopus)

Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport

Gowda, R., Inamdar, G. S., Kuzu, O., Dinavahi, S. S., Krzeminski, J., Battu, M. B., Voleti, S. R., Amin, S. & Robertson, G., Jan 1 2017, In : Oncotarget. 8, 17, p. 28260-28277 18 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Cholesterol
Lysosomes
Neoplasms
Computer Simulation
5 Citations (Scopus)

Inhibition of retrograde transport limits polyomavirus infection in vivo

Maru, S., Jin, G., Desai, D., Amin, S., Shwetank, Lauver, M. D. & Lukacher, A., Nov 1 2017, In : mSphere. 2, 6, e00494-17.

Research output: Contribution to journalArticle

Polyomavirus Infections
Polyomavirus
BK Virus
JC Virus
Kidney
3 Citations (Scopus)

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses

Muku, G. E., Lahoti, T. S., Murray, I. A., Podolsky, M. A., Smith, K. J., Hubbard, T. D., Kuzu, G., Gowda, K., Amin, S. & Perdew, G. H., Dec 1 2017, In : Laboratory Investigation. 97, 12, p. 1471-1487 17 p.

Research output: Contribution to journalArticle

Macrophages
Ligands
Uric Acid
Lipopolysaccharides
Inflammation
1 Citation (Scopus)
Sulfolobus solfataricus
DNA Polymerase beta
Deoxyguanosine
Benzo(a)pyrene
DNA-Directed DNA Polymerase
9 Citations (Scopus)

Potent inhibition of human cytomegalovirus by modulation of cellular SNARE syntaxin 5

Cruz, L., Streck, N. T., Ferguson, K., Desai, T., Desai, D., Amin, S. & Buchkovich, N., Jan 1 2017, In : Journal of virology. 91, 1, e01637-16.

Research output: Contribution to journalArticle

Human herpesvirus 5
Qa-SNARE Proteins
SNARE Proteins
Virus Assembly
Cytomegalovirus
5 Citations (Scopus)

Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. F., Feith, D. J., Desai, D., Amin, S., Kester, M., Loughran, T. P. & Cabot, M. C., Apr 15 2017, In : Biochemical Pharmacology. 130, p. 21-33 13 p.

Research output: Contribution to journalArticle

Ceramides
P-Glycoprotein
Glycosylation
Tamoxifen
Neoplasms

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

2016
22 Citations (Scopus)

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Tan, S. F., Liu, X., Fox, T. E., Barth, B. M., Sharma, A., Turner, S. D., Awwad, A., Dewey, A., Doi, K., Spitzer, B., Shah, M. V., Morad, S. A. F., Desai, D., Amin, S., Zhu, J., Liao, J. J., Yun, J., Kester, M., Claxton, D., Wang, H-G. & 5 others, Cabot, M. C., Schuchman, E. H., Levine, R. L., Feith, D. J. & Loughran, T. P., Jan 1 2016, In : Oncotarget. 7, 50, p. 83208-83222 15 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Acute Myeloid Leukemia
Ceramides
Sphingolipids
Myeloid Cells
4 Citations (Scopus)

A selenium containing inhibitor for the treatment of hepatocellular cancer

Tagaram, H. R. S., Desai, D., Li, G., Liu, D., Rountree, C. B., Gowda, K., Berg, A., Amin, S., Staveley-O’carroll, K. F. & Kimchi, E. T., Mar 24 2016, In : Pharmaceuticals. 9, 2, 18.

Research output: Contribution to journalArticle

Liver Neoplasms
Selenium
Hepatocellular Carcinoma
Phosphatidylinositol 3-Kinases
Neoplasms
44 Citations (Scopus)

Design, Synthesis, and Biological Evaluation of Novel Selenium (Se-NSAID) Molecules as Anticancer Agents

Plano, D., Karelia, D. N., Pandey, M. K., Spallholz, J. E., Amin, S. & Sharma, A., Mar 10 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

Selenium
Antineoplastic Agents
Colorectal Neoplasms
Anti-Inflammatory Agents
Cell Cycle
9 Citations (Scopus)

Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells

Guttenplan, J. B., Chen, K-M., Sun, Y-W., Kosinska, W., Zhou, Y., Kim, S. A., Sung, Y., Gowda, K., Amin, S., Stoner, G. D. & El-Bayoumy, K., Aug 1 2016, In : Cancer Prevention Research. 9, 8, p. 704-712 9 p.

Research output: Contribution to journalArticle

DNA Adducts
Mutagenesis
Carcinogens
Oxidative Stress
Carcinogenesis
7 Citations (Scopus)

Gambogic acid and its role in chronic diseases

Pandey, M. K., Karelia, D. & Amin, S., Sep 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 375-395 21 p. (Advances in Experimental Medicine and Biology; vol. 928).

Research output: Chapter in Book/Report/Conference proceedingChapter

Spices
Chronic Disease
Garcinia
Ayurvedic Medicine
Dermatitis
16 Citations (Scopus)

Novel seleno- and thio-urea derivatives with potent in vitro activities against several cancer cell lines

Alcolea, V., Plano, D., Karelia, D. N., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., May 4 2016, In : European Journal of Medicinal Chemistry. 113, p. 134-144 11 p.

Research output: Contribution to journalArticle

Urea
Cells
Derivatives
Cell Line
Carcinoma
4 Citations (Scopus)
Benzo(a)pyrene
Epoxy Compounds
Quercetin
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Interleukin-6
10 Citations (Scopus)

Radon exposure, IL-6 promoter variants, and lung squamous cell carcinoma in former uranium miners

Leng, S., Thomas, C. L., Snider, A. M., Picchi, M. A., Chen, W., Willis, D. G., Carr, T. G., Krzeminski, J., Desai, D., Amin, S., Lin, Y., Jacobson, M. R. & Belinsky, S. A., Apr 1 2016, In : Environmental health perspectives. 124, 4, p. 445-451 7 p.

Research output: Contribution to journalArticle

Radon
Uranium
Squamous Cell Carcinoma
Interleukin-6
Lung Neoplasms
21 Citations (Scopus)

Targeting cell survival proteins for cancer cell death

Pandey, M. K., Prasad, S., Tyagi, A. K., Deb, L., Huang, J., Karelia, D. N., Amin, S. & Aggarwal, B. B., Mar 1 2016, In : Pharmaceuticals. 9, 1, 11.

Research output: Contribution to journalReview article

Cell Survival
Cell Death
Neoplasms
Proteins
Apoptosis
2015
82 Citations (Scopus)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

Indoles
Microbiota
Hydrocarbons
Ligands
Gastrointestinal Tract
28 Citations (Scopus)
Aryl Hydrocarbon Receptors
Dioxins
Response Elements
Xenobiotics
Cell Differentiation
3 Citations (Scopus)

Erratum: Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function (PLoS ONE (2015) 10:9 (e0137124) DOI:10.1371/journal.pone.0137124)

Liu, Z., Ding, S., Kropachev, K., Jia, L., Amin, S., Broyde, S. & Geacintov, N. E., Oct 29 2015, In : PLoS One. 10, 10, e0142068.

Research output: Contribution to journalComment/debate

guanine
Guanine
DNA repair
DNA Repair
DNA
29 Citations (Scopus)

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Van Den Bogaard, E. H., Podolsky, M. A., Smits, J. P., Cui, X., John, C., Gowda, K., Desai, D., Amin, S., Schalkwijk, J., Perdew, G. H. & Glick, A. B., May 22 2015, In : Journal of Investigative Dermatology. 135, 5, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Keratinocytes
Pharmacology
Skin
Dermatology
2 Citations (Scopus)

Implication of a chromosome 15q15.2 locus in regulating UBR1 and predisposing smokers to MGMT methylation in lung

Leng, S., Wu, G., Collins, L. B., Thomas, C. L., Tellez, C. S., Jauregui, A. R., Picchi, M. A., Zhang, X., Juri, D. E., Desai, D., Amin, S., Crowell, R. E., Stidley, C. A., Liu, Y., Swenberg, J. A., Lin, Y., Wathelet, M. G., Gilliland, F. D. & Belinsky, S. A., Aug 1 2015, In : Cancer Research. 75, 15, p. 3108-3117 10 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
Chromosomes
Lung
DNA
197 Citations (Scopus)

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z. Z., Takahashi, S., Tanaka, N., Desai, D., Amin, S., Albert, I., Patterson, A. D. & Gonzalez, F. J., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 386-402 17 p.

Research output: Contribution to journalArticle

Ceramides
Liver
Anti-Bacterial Agents
Bile Acids and Salts
Triglycerides
134 Citations (Scopus)

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S., Bisson, W. H., Liu, Y., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Dec 15 2015, In : Nature communications. 6, 10166.

Research output: Contribution to journalArticle

obesity
intestines
Glycine
glycine
Intestines
25 Citations (Scopus)

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H-G. & Cohen, G. M., Jan 1 2015, In : Oncotarget. 6, 14, p. 12668-12681 14 p.

Research output: Contribution to journalArticle

Apoptosis
Reactive Oxygen Species
Down-Regulation
Electron Transport Complex I
Caspase 9